J Fleta

University of Zaragoza, Caesaraugusta, Aragon, Spain

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Publications (73)197.96 Total impact

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    ABSTRACT: We examined the association of physical activity (PA), cardiovascular fitness (CVF) and fatness with total homocysteine (tHcy) concentrations in European adolescents. The present study comprised 713 European adolescents aged 14.8±1.2 y (females 55.3%) from the multicenter HELENA cross-sectional study. PA was assessed through accelerometry, CVF by the 20-m shuttle run test, and body fat by skinfold thicknesses with the Slaughter equation. Plasma folate, cobalamin, and tHcy concentrations were measured. To examine the association of tHcy with PA, CVF, and fatness after controlling for a set of confounders including age, maturity, folate, cobalamin, creatinine, smoking, supplement use, and methylenetetrahydrofolate reductase 677 genotype (CC 47%, CT 43%, TT 10%), bivariate correlations followed by multiple regression models were performed. In the bivariate correlation analysis, tHcy concentrations were slightly negatively correlated (p<0.0 5) with CVF in females (measured both by stages: r=-0.118 and by VO2max: r=-0.10 2) and positively with body mass index (r=0.10 0). However, daily time spent with moderate and vigorous PA showed a weak positive association with tHcy in females (p<0.0 5). tHcy concentrations showed a tendency to decrease with increasing CVF and increase with increasing BMI in female European adolescents. However, tHcy concentrations were positively associated with moderate and vigorous PA in female European adolescents. © 2015, Center for Academic Publications Japan. All rights reserved.
    No preview · Article · Jan 2015 · Journal of Nutritional Science and Vitaminology
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    ABSTRACT: Objective: To assess five years trends in total and abdominal fat in Spanish adolescents. Design: Two cross-sectional studies: adolescents from the city of Zaragoza (Spain) assessed during 2001-2002 and 2006-2007. Subjects: 399 adolescents in 2001-02 and 392 adolescents in 2006-07. Main outcome measurements: Socio-economic status was assessed using the education level of both parents. A complete anthropometric assessment was performed in both surveys using the same methodology: weight, height, skinfold thickness (biceps, triceps, subscapular, suprailiac, thigh and calf) and circumferences (waist and hip). The body mass index (BMI) and the sum of 6 skinfold thicknesses were calculated. Body fat percentage (BF%) was also calculated by the formulas described by Slaughter et al. Results: After adjusting for age and pubertal status, only females showed a significantly decrease in weight, BMI and waist circumference, and a significant increase in the sum of 6 skinfolds (all P < 0.05 and Cohen's d ≥ 0.25) in 2006-2007, when compared to values obtained in 2001-2002. Males did not show any significant change between the two surveys. Concerning centile values, a slight general reduction was observed in weight, BMI and waist circumference for both males and females. On the contrary, the sum of 6 skinfolds and the BF% were higher in 2006-2007 than in 2001-2002. Conclusion: According to these results, there might be a levelling-off in the trends of BMI, BF% and waist circumference in male adolescents from Zaragoza. In females, despite a trend towards higher body fat mass, there was a trend towards lower BMI and waist circumference values.
    No preview · Article · Jun 2012 · Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
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    ABSTRACT: Resumen Objetivo: Evaluar las tendencias de cinco años de la grasa total y abdominal de adolescentes españoles. Diseño: Dos estudios transversales: adolescentes de la ciudad de Zaragoza (España) evaluados durante 2001-2002 y 2006-2007. Sujetos: 399 adolescentes en 2001-02 y 392 adolescentes en 2006-07. Principales variables estudiadas: El estado socioeco-nómico se evaluó usando el nivel educativo de ambos progenitores. Se realizó una evaluación antropométrica completa en ambos estudios con la misma metodología: peso, talla, grosor del pliegue (bíceps, tríceps, subesca-pular, suprailíaco, muslo y pantorrilla) y circunferen-cias (cintura y cadera). Se calcularon el índice de masa corporal (IMC) y la suma del grosor de 6 pliegues. Tam-bién se calculó el porcentaje de grasa corporal (%GC) con las fórmulas descritas por Slaughter et al. Resultados: tras ajustar por edad y estado puberal, sólo las chicas mostraron un descenso significativo del peso, IMC y la circunferencia de la cintura, y un aumento significativo en la suma de los 6 pliegues cutá-neos (todos ellos P < 0,05 y d de Cohen ≥ 0,25) en 2006-2007, en comparación con los valores obtenidos en 2001-2002. Los chicos no mostraron cambios significativos entre ambos estudios. Con respecto a los percentiles, se observó una reducción leve del peso, IMC y circunferen-cia de la cintura en chicos y chicas. Por el contrario, la suma de los 6 pliegues cutáneos y el %GC fueron mayo-res en 2006-2007 que en 2001-2002. Conclusión: de acuerdo con estos resultados, podría haber un resultado neutro en las tendencias del IMC, %GC y circunferencia de la cintura en los adolescentes varones de Zaragoza. En las chicas, a pesar de una mayor tendencia a una mayor grasa corporal, hubo una tendencia a unos menores valores de IMC y de circunfe-rencia de la cintura. Abstract Objective: To assess five years trends in total and abdo-minal fat in Spanish adolescents. Design: Two cross-sectional studies: adolescents from the city of Zaragoza (Spain) assessed during 2001-2002 and 2006-2007. Subjects: 399 adolescents in 2001-02 and 392 adoles-cents in 2006-07. Main outcome measurements: Socio-economic status was assessed using the education level of both parents. A complete anthropometric assessment was performed in both surveys using the same methodology: weight, height, skinfold thickness (biceps, triceps, subscapular, suprailiac, thigh and calf) and circumferences (waist and hip). The body mass index (BMI) and the sum of 6 skinfold thick-nesses were calculated. Body fat percentage (BF%) was also calculated by the formulas described by Slaughter et al. Results: After adjusting for age and pubertal status, only females showed a significantly decrease in weight, BMI and waist circumference, and a significant increase in the sum of 6 skinfolds (all P < 0.05 and Cohen's d ≥ 0.25) in 2006-2007, when compared to values obtained in 2001-2002. Males did not show any significant change between the two surveys. Concerning centile values, a slight general reduction was observed in weight, BMI and waist circumference for both males and females. On the contrary, the sum of 6 skinfolds and the BF% were higher in 2006-2007 than in 2001-2002. Conclusion: According to these results, there might be a levelling-off in the trends of BMI, BF% and waist circumfe-rence in male adolescents from Zaragoza. In females, despite a trend towards higher body fat mass, there was a trend towards lower BMI and waist circumference values.
    Full-text · Article · Jan 2012 · Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
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    ABSTRACT: Cited By (since 1996):2, Export Date: 18 October 2014
    No preview · Article · Jan 2011
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    ABSTRACT: Cited By (since 1996):2, Export Date: 18 October 2014
    No preview · Article · Jan 2011
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    ABSTRACT: Lifestyle plays an important role in the development of obesity during childhood and adolescence. We provide up-to-date information about the relationship between obesity and food intake and dietary patterns in adolescents. Scientific evidence is increasing about the dietary factors associated with this relationship, specifically a low meal frequency, skipping breakfast, and a high consumption of sugar sweetened beverages. Maybe some of the reviewed dietary factors could cluster in the same population of adolescents, increasing the individual risk. There is little information about dietary patterns and current time trends in adolescents; however, the available data seem to show that the tendency in the adolescent population worldwide is to increase those dietary factors related with obesity development. Public health efforts should be emphasized in order to decrease the current tendency. Regular family meals could serve as role models for healthy eating behaviors. Educational intervention programs for parents, aiming to modify the healthfulness of the diet, seems to be one of the most adequate tools to deal with the worldwide obesity epidemic.
    No preview · Article · Feb 2010 · Critical reviews in food science and nutrition
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    ABSTRACT: To present body fat patterning reference standards to identify children with a predominant distribution of body fat in the abdominal or truncal region of the body. Cross-sectional study in a representative sample of Spanish adolescents aged 13-18 years. A total of 2160 adolescents with a complete set of anthropometric measurements (1109 males and 1051 females). Weight, height, body mass index, skinfold thickness (biceps, triceps, subscapular, suprailiac, thigh, calf) and waist and hip circumferences. In the majority of the age groups, subscapular/triceps skinfolds ratio, trunk-to-total skinfolds percent (TTS%)and waist circumference values were significantly higher in males than in females; hip circumference was higher in females than in males, except at 15.5 years. In males, age showed a significant effect for all the body fat distribution indices; however, in females, the effect was only significant for triceps skinfold, waist and hip circumferences and waist-to-hip ratio. Smoothed age- and sex-specific triceps skinfold, subscapular skinfold, subscapular/triceps skinfolds ratio, TTS%, waist circumference and hip circumference, waist-to-hip and waist-to-height ratio percentile values for male and female adolescents have been established. These reference data for waist circumference and the other fat patterning indices, together with data from other countries, will help to establish international central obesity criteria for adolescents. The presented percentile values will give the possibility to estimate the proportion of adolescents with high or low regional adiposity amounts.
    Preview · Article · Jan 2008 · International Journal of Obesity

  • No preview · Article · Jan 2007

  • No preview · Article · Dec 2006 · Annals of the New York Academy of Sciences
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    ABSTRACT: To try to improve the International Obesity Task Force (IOTF) BMI cut-off values, in terms of prediction of body fat percentage assessed by dual-energy X-ray absorptiometry (DXA), in adolescents. Cross-sectional survey of the adolescents from the city of Zaragoza (Spain). For this analysis we have included 286 adolescents (116 boys and 170 girls) aged 13.0-17.9 years. Body mass index (BMI) was calculated as body weight (kg), divided by height (m) squared. The percentage of body fat (BF%) was estimated by the use of DXA. We have calculated, new BMI cut-off values (AVENA cut-offs) to predict BF%, for boys and girls in each age group. In male adolescents, sensitivity was higher with the IOTF cut-offs (0.71, 95th C.I.: 0.44, 0.90) than with the AVENA ones (0.53, 95th C.I.: 0.28, 0.77), and specificity was very similar with both cut-off values (0.86 and 0.88, respectively), the differences being not statistically significant. In girls, both sensitivities (0.75 and 0.79, respectively) and specificities (0.90 and 0.92, respectively) were very similar with both cut-off values, and the differences, not significant. Optimization of the IOTF BMI cut-off values, in terms of BF%, seems not to be possible in adolescents. The IOTF criteria should be used only for overweight and obesity screening; however, in clinical settings, a more accurate measure of body fat should be recommended.
    Full-text · Article · Nov 2006 · Journal of the American College of Nutrition
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    ABSTRACT: Background: In adults, obesity is characterized by a state of chronic low-grade inflammation accompanied by moderately high concentrations of acute phase inflammatory proteins. Recent results regarding C-reactive protein (CRP) point to a similar status in adolescents; however, studies of associations of the serum inflammatory proteins CRP, ceruloplasmin, and complement factors C3 and C4 with body fat distribution remain scarce. Objective: We aimed to establish the possible relations of serum inflammatory proteins with body fat estimates and body fat distribution in an apparently healthy adolescent population. Design: This report included 472 adolescents (248 males and 224 females) aged 13-18.5 y who were recruited from the Spanish cross-sectional multicenter AVENA Study for whom anthropometric and immunologic data were complete. The concentrations of the serum proteins and the in vitro production of cytokines (interleukin 6 and tumor necrosis factor α) by isolated and stimulated white blood cells were measured. Relations with anthropometric measurements were explored by using simple and partial correlations. Results: CRP, C3, and C4 were correlated with central obesity (as measured by waist circumference) and total body fat in both sexes (P < 0.01) and with ceruloplasmin in females only. After further adjustment for BMI, C3 remained independently associated with central obesity (P < 0.05). Production of the cytokines by white blood cells did not seem to be affected by an excess of body fat. Conclusions: Total body fat seems to be associated with a chronic low-grade systemic inflammation in apparently healthy adolescents. Central obesity is independently associated with C3 concentrations, which makes this marker especially interesting for further studies of obesity-related diseases.
    No preview · Article · Sep 2006 · American Journal of Clinical Nutrition
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    ABSTRACT: To determine reference values for body mass index (BMI), sum of six skinfolds (sigma6 skinfolds) and body fat percentage (BF%) in Spanish adolescents aged 13-18 years, included in the AVENA Study (Alimentación y Valoración del Estado Nutricional en Adolescentes: Food and Assessment of the Nutritional Status of Adolescents). Multicentre cross-sectional study. Representative sample of Spanish adolescents. The population was selected by means of a multiplestep, simple random sampling. The final number of subjects included in the AVENA Study was 2859 adolescents; 2160 adolescents had a complete set of anthropometric measurements and were then included in this study (1109 males and 1051 females). Weight, height and six skinfold thicknesses were measured. As indices of total adiposity, we calculated BMI, summation sigma6 skinfolds and BF% with the formulas described by Slaughter et al. Sigma6 skinfolds and BF% in each age group were significantly higher in females than in males. In males, age showed a significant effect for BMI, sigma6 skinfolds and BF%; however, in females, the effect was only significant for BF%. The percentile distribution was more disperse towards higher sigma6 skinfolds and BF% values in males when compared with females. The presented percentile values will help us to classify adolescents in comparison with a well-established reference population, and to estimate the proportion of adolescents with high or low adiposity amounts. The AVENA-Study was supported by the Spanish Ministry of Health (FIS 00/0015), and grants from Panrico SA, Madaus SA and Procter and Gamble SA. This study was also supported by Instituto de Salud Carlos III (Spain), RCESP (C03/09) and Spanish Ministry of Education (AP2003-2128).
    Preview · Article · Mar 2006 · European Journal of Clinical Nutrition
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    ABSTRACT: To compare the most commonly used equations to predict body fatness from skinfold thickness, in male and female adolescents, with dual-energy X-ray absorptiometry (DXA) as a reference method of fatness measurement. Cross-sectional nutrition survey. General adolescent population from Zaragoza (Spain). A total of 238 Caucasian adolescents (167 females and 113 males), aged 13.0-17.9 y, were recruited from 15 school groups in 11 public and private schools. The percentage fat mass (%FM) was calculated by using skinfold-thickness equations. Predicted %FM was compared with the reference %FM values, measured by DXA. The lack of agreement between methods was assessed by calculating the bias and its 95% limits of agreement. Most equations did not demonstrate good agreement compared with DXA. However, in male adolescents, Slaughter et al equations showed relative biases that were not dependent on body fatness and the limits of agreement were narrower than those obtained from the rest of equations. In females, Brook's equation showed nonsignificant differences against DXA and the narrowest 95% limits of agreement. Only biases from Brook and Slaughter et al equations were not dependent on body fatness in female adolescents. Accuracy of most of the skinfold-thickness equations for assessment of %FM in adolescents was poor at the individual level. Nevertheless, to predict %FM when a relative index of fatness is required in field or clinical studies, Slaughter et al equations may be used in adolescents from both sexes and the Brook equation in female adolescents.
    Full-text · Article · Nov 2005 · European Journal of Clinical Nutrition
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    LA Moreno · A Sarría · J Fleta · A Marcos · M Bueno
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    ABSTRACT: Two studies, in 1995 and 2000-02, were compared to assess changes in waist circumference in adolescents. Between the two time periods, waist circumference increased significantly in males at 13 years and in females at 14 years. Significant changes in waist circumference were observed during the study period; the rates of change were 0.53 and 0.86 cm/y in boys and 0.67 and 0.87 cm/y in girls. Future morbidity in adolescents may be affected due to accumulation of excess central fat.
    Preview · Article · Sep 2005 · Archives of Disease in Childhood
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    ABSTRACT: The aim of this study was to compare heart abnormalities in a group of young women with anorexia nervosa at diagnosis and after weight restoration. A total of 40 young women with anorexia nervosa were evaluated, at baseline, (diagnosis) and follow-up (9 to 18 months later) and matched with 40 healthy women of the same age and of normal weight. QT interval was measured from surface electrocardiograms. QT dispersion was defined as the difference between maximum QT and minimum QT occurring in any of the 12 leads. Left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left ventricular mass, left ventricular mass index, cardiac output, fractional shortening and fractional ejection, were measured by echocardiography. In anorexia nervosa patients, corrected QT interval and QT dispersion, significantly decreased from baseline to follow-up. Left ventricular end-diastolic dimension, left ventricular mass index, and cardiac output, in anorexia nervosa were significantly lower at diagnosis than at follow-up after weight restoration. CONCLUSION: Adolescents with anorexia nervosa have significant functional and structural cardiac abnormalities; weight gain was associated with improvement. Appropriate attention should be paid to cardiac involvement.
    No preview · Article · Jul 2005 · European Journal of Pediatrics
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    ABSTRACT: To describe the prevalence of overweight and obesity in the Spanish adolescent population and its relationship with the socioeconomic status, and to assess their body fat composition and compare these results with previous data from our own country. Cross-sectional multicenter study conducted in five Spanish cities (Granada, Madrid, Murcia, Santander and Zaragoza) in 2000-2002. 2,320 adolescents with complete set of anthropometric measurements, 1,192 boys and 1,128 girls. Body mass index calculated from weight and height measurements, and body fat percentage calculated from skinfold thickness measurements. Overweight + obesity prevalences were 25.69 and 19.13% in boys and girls, respectively. Overweight + obesity prevalence increased in boys from high to medium-low socioeconomic status categories (p = 0.015); meanwhile, there was not a significant effect of socioeconomic status in girls. In males, overweight + obesity prevalence changed from 1985 to 2000-2002 from 13 to 35% and in females from 16 to 32%. The rate of change in overweight + obesity prevalences seems to increase in the last years; from 0.88 (1985 to 1995) to 2.33%/year (1995 to 2000-2002) in males and from 0.5 (1985 to 1995) to 1.83%/year (1995 to 2000-2002) in females. The rate of body fat percentage increase was similar between 1980 and 1995 and between 1995 and 2000-2002: 0.26 and 0.23%/year, respectively, at 13 years of age, and 0.16 and 0.17%/year, respectively, at 14 years of age. We observed elevated overweight and obesity prevalences in Spanish adolescents, similar to those observed in other European countries. There is a significant inverse relationship between socioeconomic status and overweight + obesity, but only in boys. The rate of change in overweight prevalence in Spanish adolescents seems to increase, and the rate of increase of body fat percentage seems to be similar as in previous years.
    Full-text · Article · Mar 2005 · Annals of Nutrition and Metabolism
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    ABSTRACT: To compare heart abnormalities in a group of malnourished children with a control group and to describe their predictive variables. Thirty children with malnutrition were matched with thirty healthy children. Anthropometry, plasma levels of albumin and electrolytes were determined. Among others, corrected QT interval (QTc) and QT dispersion (QTd: difference between the maximum and the minimum QT) were measured in 12-lead electrocardiogram; and left ventricular mass (LVm) and left ventricular mass index (LVmi) were measured by echocardiography. Regression analyses were performed with cardiac findings as dependent variables and anthropometric and biochemical data as independent variables. Plasma levels of albumin, potassium and calcium were lower in malnourished children. QTc and QTd were significantly greater in patients with malnutrition than in controls (QTc: 445.9 +/- 31.4 vs. 400.9 +/- 17.7 ms, p = 0.000; QTd: 76.4 +/- 34.1 vs. 47.9 +/- 10.2 ms, p = 0.000). LVm and LVmi were significantly lower in malnourished children (LVm: 55.3 +/- 10.3 vs. 71.4 +/- 6.9 g, p = 0.000; LVmi: 46.5 +/- 6.6 vs. 60.5 +/- 4.9 g/m2, p = 0.000). The body mass index (kg/m2) was the most powerful predictor of the variability in QTc (39.1%), LVm (48.1%) and LVmi (51.2%). Important electrocardiographic and echocardiographic abnormalities have been found in malnourished children associated with their nutritional status. Special precaution must be taken about the possibility of occurrence of arrhythmias and sudden death related with malnutrition.
    No preview · Article · Mar 2005 · Journal of the American College of Nutrition

  • No preview · Article · Jun 2004 · Journal of Pediatric Gastroenterology and Nutrition
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    ABSTRACT: The aim of the study was to assess body composition by anthropometry in school-age children playing football (soccer) and to compare the results with those of a reference group. We studied 239 children aged 9.0 to 14.9 years who played this sport in a local league. We compared them with a reference population of 453 children in the same age range. We measured weight, height, four skinfold thicknesses, and two circumferences; and we calculated body mass index, total body fat percentage, fat free mass, arm fat percentage, and arm muscle area. Body mass index do not showed any significant difference between football (soccer) and reference groups in any age category. The percentage of total body fat was significantly lower in the football (soccer) group than in the reference group at 9, 11, 12, and 14 years. In studies aiming to assess the effect of physical activity on body composition, it will be necessary to measure, not only body mass index, but other measures of the body fat compartment. Football (soccer) can be proposed as a physical activity practice aiming to prevent or treat obesity and its comorbidities.
    No preview · Article · Mar 2004 · Nutrition Research
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    ABSTRACT: This paper describes serum iron-status in children with intestinal parasitic infection and three months after treatment without infection. Twenty-six children with Giardia lamblia infection were treated with tinidazole and metronidazole and forty-two children with Enterobius vermicularis were treated with pyrantel pamoate. Paired t test showed significant differences for serum iron and serum ferritin between the patients with and without Giardia lamblia and serum iron, serum ferritin and transferrin saturation in the patients with and without Enterobius vermicularis, three months later. These findings could reflect a more affected intestinal mucous in patients with intestinal parasitic infection, and support the opportunity to treat these parasitic infections and to begin iron supplementation.
    No preview · Article · Jan 2004 · Nutrition Research

Publication Stats

2k Citations
197.96 Total Impact Points

Institutions

  • 1989-2012
    • University of Zaragoza
      • • Department of Pediatrics, Radiology and Physical Medicine
      • • Faculty of Medicine
      Caesaraugusta, Aragon, Spain
  • 1987-2005
    • Hospital Clínico Universitario Lozano Blesa, Zaragoza
      Caesaraugusta, Aragon, Spain
  • 1995
    • Hospital Clínico Universitario de Valencia
      Valenza, Valencia, Spain
  • 1993
    • Hospital Clínico San Carlos
      • Servicio de Neurología
      Madrid, Madrid, Spain