[Show abstract][Hide abstract] ABSTRACT: The BioGRID database is an extensive repository of curated genetic and protein interactions for the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe, and the yeast Candida albicans SC5314, as well as for several other model organisms and humans. This protocol describes how to use the BioGRID website to query genetic or protein interactions for any gene of interest, how to visualize the associated interactions using an embedded interactive network viewer, and how to download data files for either selected interactions or the entire BioGRID interaction data set.
[Show abstract][Hide abstract] ABSTRACT: The Biological General Repository for Interaction Datasets (BioGRID) is a freely available public database that provides the biological and biomedical research communities with curated protein and genetic interaction data. Structured experimental evidence codes, an intuitive search interface, and visualization tools enable the discovery of individual gene, protein, or biological network function. BioGRID houses interaction data for the major model organism species including yeast, nematode, fly, zebrafish, mouse, and human with particular emphasis on the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe as pioneer eukaryotic models for network biology. BioGRID has achieved comprehensive curation coverage of the entire literature for these two major yeast models, which is actively maintained through monthly curation updates. As of September 2015, BioGRID houses approximately 335,400 biological interactions for budding yeast and approximately 67,800 interactions for fission yeast. BioGRID also supports an integrated post- translational modification (PTM) viewer that incorporates more than 20,100 yeast phosphorylation sites curated through its sister database, the PhosphoGRID.
[Show abstract][Hide abstract] ABSTRACT: The Biological General Repository for Interaction Datasets (BioGRID: http//thebiogrid.org) is an open access archive of genetic and protein interactions that are curated from the primary biomedical literature for
all major model organism species. As of September 2012, BioGRID houses more than 500 000 manually annotated interactions from
more than 30 model organisms. BioGRID maintains complete curation coverage of the literature for the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe and the model plant Arabidopsis thaliana. A number of themed curation projects in areas of biomedical importance are also supported. BioGRID has established collaborations
and/or shares data records for the annotation of interactions and phenotypes with most major model organism databases, including
Saccharomyces Genome Database, PomBase, WormBase, FlyBase and The Arabidopsis Information Resource. BioGRID also actively
engages with the text-mining community to benchmark and deploy automated tools to expedite curation workflows. BioGRID data
are freely accessible through both a user-defined interactive interface and in batch downloads in a wide variety of formats,
including PSI-MI2.5 and tab-delimited files. BioGRID records can also be interrogated and analyzed with a series of new bioinformatics
tools, which include a post-translational modification viewer, a graphical viewer, a REST service and a Cytoscape plugin.
Full-text · Article · Nov 2012 · Nucleic Acids Research
[Show abstract][Hide abstract] ABSTRACT: The goal of the Biological General Repository for Interaction Datasets (BioGRID) (http://www.thebiogrid.org) is to archive and freely disseminate collections of genetic and protein interactions from major model organisms. BioGRID currently houses over 335,000 interactions curated from high-throughput datasets and individual focused studies found in the primary literature, as derived from some 23,000 publications. Complete coverage of the entire literature for both the budding yeast _Saccharomyces cerevisiae_ and the fission yeast _Schizosaccharomyces pombe_ has been achieved, resulting in the curation of over 246,000 interactions, and efforts to expand curation across multiple species are underway. Through collaborations with the Gene Ontology (GO) Consortium and the Linking Animal Models to Human Disease Initiative (LAMHDI), we are focusing our curation efforts across model organisms on particular areas of biology to enable insights into conserved networks and pathways that are relevant to human health. The BioGRID 3.0 web interface contains new search and display features that enable rapid queries across multiple data types and sources. A dedicated Interaction Management System (IMS) is used to track all curation and to prioritize publications across multiple curation projects. BioGRID data are incorporated in several model organism databases and other biological databases. The entire BioGRID interaction collection may be downloaded in multiple file formats, including PSI MI XML, and source code for BioGRID is freely available without any restrictions. This work is supported by NIH NCRR grant R01 RR024031 to MT and KD, and by grants from the CIHR and BBSRC to MT.
[Show abstract][Hide abstract] ABSTRACT: The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic
and protein interaction data from model organisms and humans (http://www.thebiogrid.org). BioGRID currently holds 347 966 interactions (170 162 genetic, 177 804 protein) curated from both high-throughput data
sets and individual focused studies, as derived from over 23 000 publications in the primary literature. Complete coverage
of the entire literature is maintained for budding yeast (Saccharomyces cerevisiae), fission yeast (Schizosaccharomyces pombe) and thale cress (Arabidopsis thaliana), and efforts to expand curation across multiple metazoan species are underway. The BioGRID houses 48 831 human protein interactions
that have been curated from 10 247 publications. Current curation drives are focused on particular areas of biology to enable
insights into conserved networks and pathways that are relevant to human health. The BioGRID 3.0 web interface contains new
search and display features that enable rapid queries across multiple data types and sources. An automated Interaction Management
System (IMS) is used to prioritize, coordinate and track curation across international sites and projects. BioGRID provides
interaction data to several model organism databases, resources such as Entrez-Gene and other interaction meta-databases.
The entire BioGRID 3.0 data collection may be downloaded in multiple file formats, including PSI MI XML. Source code for BioGRID
3.0 is freely available without any restrictions.
Full-text · Article · Nov 2010 · Nucleic Acids Research