J Balachandar

Jawaharlal Institute of Postgraduate Medical Education & Research, Pondichéry, Pondicherry, India

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Publications (11)16.06 Total impact

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    ABSTRACT: Background: Cardiovascular diseases (CVDs) are the major cause of mortality and morbidity worldwide. Myocardial infarction (MI) is a complex multi-factorial, polygenic disorder arising from an interaction between genetic makeup of individuals and various environmental factors. CYP2C8, CYP2C9 and CYP2J2 involved in the metabolism of arachidonic acid, generates epoxyeicosatrienoic acids (EETs) that mediate dilation of coronary arteries improving post-ischemic cardiac contractile function, reduce vascular inflammation, and increase intravascular fibrinolysis. The study is aimed at analyzing the association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms and MI risk in the South Indian population. Method: This retrospective study consisted of 287 MI patients, 279 risk control patients and 321 healthy controls. Blood samples were collected from all the subjects and DNA was isolated using standard phenol-chloroform method. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and real time-polymerase chain reaction (RT-PCR) methods were used for genotyping. To test the potential independent association between polymorphisms and the risk of MI, Multiple-logistic regression analysis was performed. Results: Our findings displayed a significant association between CYP2J2*7 (p=0.04; OR = 2.0) polymorphism and MI compared to risk controls. We did not observe any association of CYP2C8*2, CYP2C8*3, CYP2C9*2 and CYP2C9*3 with MI. Conclusion: Our results suggest that individuals with any conventional risk factor for MI along with CYP2J2*7 variant allele may be predisposed to risk of MI in south Indian population.
    No preview · Article · Aug 2014 · Pharmacological reports: PR
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    ABSTRACT: Introduction: Hypertension is a result of interaction between complex environmental and genetic factors. The genes cytochrome (CYP) 2C8, CYP2C9, and CYP2J2 are involved in the metabolism of arachidonic acid, which releases endothelium derived hyperpolarizing factors responsible for mediating the smooth muscle relaxation. Aim: The study is aimed to analyze the association of CYP2C8, CYP2C9, and CYP2J2 gene polymorphisms with the risk of hypertension in the South Indian population. Methods and Results: The case–control study consisted of 279 hypertensive patients and 321 healthy controls aged ranges between 30 and 60 years. The deoxyribonucleic acid was extracted using standard phenol-chloroform method. Genotyping was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism and real-time-PCR methods. Multiple-logistic regression analysis was used to analyze the association between polymorphisms and the risk of hypertension. We did not observe any association of CYP2C8*2, CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2J2*7 with hypertension. Conclusion: Our results suggest that CYP2C8*2, CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2J2*7 are not associated with hypertension in South Indian population
    Full-text · Article · May 2014 · Journal of Young Pharmacists
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    ABSTRACT: Myocardial infarction (MI) is a complex multi-factorial, polygenic disorder which results from an interaction between a person's genetic makeup and various environmental factors. Nitric oxide (NO), a potent vasodilator produced by endothelial cells, plays an important role in the regulation of blood pressure, regional blood flow and also inhibits platelet aggregation, vascular smooth muscle cell proliferation and leukocyte adhesion to vascular endothelium. Our aim was to analyze the association of NOS3 (endothelial nitric oxide synthase 3) 894G>T and -786T>C gene polymorphisms and MI risk in the South Indian population. A total of 287 MI patients, 279 risk control patients and 321 healthy controls were recruited for the retrospective study. Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). There was no significant association observed between NOS3 894G>T, -786T>C polymorphisms and MI. A significant difference was observed in the distribution of GT genotype of the NOS3 894G>T polymorphism between the cases and the risk controls (p = 0.05) but the odds ratio (0.6) did not show risk for MI. The present study showed lack of association between NOS3 gene polymorphisms and MI in South Indian population.
    Full-text · Article · Oct 2012 · Molecular Biology Reports
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    ABSTRACT: In association with candidate genes, the observed trait may be due to either one of the variant alleles or the interaction of variant alleles at different loci, which are in linkage disequilibrium. The objective of this study was to investigate the baseline allele and genotype frequencies, linkage disequilibrium (LD) patterns, and haplotype structures of common variants of the CYP2C8, CYP2C9, and ADRB1 genes located on chromosome 10. Two hundred and forty-five healthy subjects were recruited from South India and were compared with the HapMap Project's population for LD pattern, allele and genotype frequencies, and haplotype structures. Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism and TaqMan assay on real-time polymerase chain reaction. A significant ethnic difference was found in the LD patterns among the variant alleles between the South Indian population and other major ethnic groups, namely African, European, Chinese, and Japanese. This study established the normative allele and genotype frequencies, haplotype structure, and LD patterns of common variants of the CYP2C8, CYP2C9, and ADRB1 genes in a South Indian population (Tamilian). The data may be helpful to plan candidate gene-trait association studies in this population.
    Full-text · Article · Mar 2011 · Genetic Testing and Molecular Biomarkers
  • L H Ghotekar · D Pai · A Sibbal · T K Dutta · W Taggu · J Balachandar

    No preview · Article · Sep 1998 · The Journal of the Association of Physicians of India
  • Ashok Kumar Das · Subramanian Chandrasekar · Jayaraman Balachandar
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    ABSTRACT: Systolic time intervals (STI) were evaluated in 45 diabetics without any cardiac signs and symptoms in order to study the left ventricular function. The STI parameters revealed an impairment of left ventricular function, thus implying preclinical myocardial involvement. This left ventricular dysfunction was more marked in patients in poor metabolic control and in cases with evidence of microangiopathy in kidney and retina, thus favoring the view that the primary myocardial disease is the result of metabolic and vascular components. Significant improvement in STI parameters was observed when good metabolic control was achieved, thus indicating that strict metabolic control is indeed worthwhile.
    No preview · Article · Oct 1986 · Acta Diabetologica
  • K R Sethuraman · R Sriram · J Balachandar
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    ABSTRACT: In a prospective study of 1012 patients above the age of 12 years, we detected 4 (0.4%) cases of left ventricular false tendon (LVFT) by echocardiography. Two patients had significant heart disease and LVFT was perhaps a chance occurrence; two others had no significant heart disease and LVFT probably had a causal association with S3 gallop in one and systolic murmur in the other. Diagnosis of LVFT may help to explain cardiac findings of uncertain origin.
    No preview · Article · Oct 1984 · International Journal of Cardiology
  • K R Sethuraman · J Balachandar · S Chandrasekar
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    ABSTRACT: An adult patient with a hypoplastic right heart with intact ventricular septum, pulmonary atresia, secundum ASD and a PDA was studied by 2-D echocardiography. A striking flap valve motion of the primum portion of the interatrial septum was observed. This is perhaps the first report of its kind in an adult.
    No preview · Article · Aug 1984 · International Journal of Cardiology
  • A Kirubakaran · J Balachandar · S Chandrasekar

    No preview · Article · Aug 1982 · Journal of the Indian Medical Association
  • K R Sethuraman · J Balachandar · S Chandrasekar

    No preview · Article · · Indian Heart Journal
  • A K Das · S Chandrasekar · J Balachandar
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    ABSTRACT: Systolic time intervals (STI) were evaluated in 45 diabetics without any cardiac signs and symptoms in order to study the left ventricular function. The STI parameters revealed an impairment of left ventricular function, thus implying preclinical myocardial involvement. This left ventricular dysfunction was more marked in patients in poor metabolic control and in cases with evidence of microangiopathy in kidney and retina, thus favoring the view that the primary myocardial disease is the result of metabolic and vascular components. Significant improvement in STI parameters was observed when good metabolic control was achieved, thus indicating that strict metabolic control is indeed worthwhile.
    No preview · Article · · Acta diabetologica latina