Publications (3)1.68 Total impact

  • B. Yang · G.-P. Li · J.-S. Zhang · X.-Q. Kong · H.-B. Xu · L. Ma · H.-Y. Ye · Y.-Q. Cai · Y.-G. Gao · D.-H. Liu
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    ABSTRACT: Objective: To investigate the central nervous system mechanisms of active of movement switch in the patients with Tourette's syndrome (TS), and to explore the possible underlying distinct neural networks for tic trigger and generation. Methods: Participants were 14 patients with TS and 14 age- and gender-matched healthy volunteers with no history of physical, psychiatric or neurological disease. All patients were assessed with functional magnetic resonances imaging (fMRI) of the brain during the intermittent performance of finger-tapping switch tasks, Blood-oxygen-level dependent-fMRI was performed using a 3.0 Tesla MR. The area over which the activation was distributed was calculated, and the activation volumes were also compared between the patients with TS and the control subjects. Results: The regions activated in the patients with TS and in the volunteers were similar in several brain regions, including contralateral precentral and postcentral gyrus, contralateral mesia pre-front gyrus, contralateral cingulate gyrus, contralateral insula and ipsilataral cerebellum. There were also many different activation areas between the patients and the control subjects. The patients with TS demonstrated more significant and extended activation in the contralateral pre- and postcentral gyrus than the healthy volunteers. The volume of the left pre- and postcentral gyrus of the TS patients was (8.024 ± 0.071) cm, while the volume of the left pre-and postcentral gyrus of the control subjects was (6.480 ± 0.026) cm (t = 3.026, P < 0.01); The volume of the right pre- and postcentral gyrus was(6.192 ± 0.019) cm in the TS cases, while there was (5.608 ± 0.037) cm in the control subjects (t =2.752, P < 0.05). There were significant differences in the volumes of bilateral pre- and postcetral gyrus between the TS and control subjects. The activations of conralateral thalamus without contralateral insula were found in the patients with TS. Conversely, the contralateral insula activation without thalamus activation could be found in the healthy volunteers. Conclusion: The thalamus might play an important role in the aetiological and physiopathologic mechanisms of the TS. The thalamus along with the parietal cortex, cingulate cortex and insular cortex appear to constitute a distinct neural network for tic trigger and generation.
    No preview · Article · Aug 2012
  • B. Yang · G.-P. Li · J.-S. Zhang · X.-Q. Kong · H.-B. Xu · L. Ma · H.-Y. Ye · Y.-Q. Cai · Y.-G. Gao
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    ABSTRACT: Objective: To study the changes of the putamen metabolites with magnetic resonance spectrum (MRS), and to explore possible underlying unrecongnised aetiological factor and pathophysiology mechanism in the central nervous system of the patients with Tourette's syndrome. Methods: Twenty-two cases of Tourette's syndrome, and twenty-two gender and age-matched subjects (the control subjects) were performed on a clinical 3.0 T MRI system. Proton prob-voxel spectroscopy imaging ( 1H-MRS) was obtained from two sides of the putamen. The metabolites included N-acetylaspartate (NAA), creatine and phosphocreatine (Cr), choline-containing compounds (Cho), and myoinositol (MI). The value of the NAA, Cr, Cho, and MI were calculated by integration of their peaks. The ratios of NAA/Cr, Cho/Cr, MI/Cr were calculated respectively. Repeated measures analysis of variance (ANOVA) was used to test both the value of NAA/Cr, Cho/Cr, MI/Cr of the putamen for group difference, with group as between-subjects factor and side as within-subjects factor. Results: The NAA/Cr ratio in patients (left: 1.29 ± 0.13; right: 1.34 ±0.15) was significantly lower than that in the control subjects (left: 1.50 ± 0.08, T = 1.962, P < 0.05; right: 1.52 ± 0.11, T = 1.865, P < 0.05). There was no significant difference in the Cho/Cr and MI/Cr ratio between both groups. Conclusion: The abnormalities of the structure and (or) function in the putamens of patients may be the one of the underlying anaetiological factors and pathophysiology mechanisms of the Tourette's syndrome.
    No preview · Article · Jun 2012
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    C Zhu · D L Hu · YQ Liu · Q J Zhang · F K Chen · X Q Kong · K J Cao · J S Zhang · L M Qian
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    ABSTRACT: Fatty acid binding protein 3 (FABP3) is a member of a family of binding proteins. The protein is mainly expressed in cardiac and skeletal muscle cells, and it has been linked to fatty acid metabolism, trafficking, and signaling. Using suppression subtractive hybridization, we previously found that FABP3 is highly regulated in ventricular septal defect (VSD) patients and may play a significant role in the development of human VSD. We therefore aimed to identify the biological characteristics of the FABP3 gene in embryonic myocardial cells. On the basis of RT-PCR and western blotting analyses, we demonstrated that the expression levels of FABP3 mRNA and protein were up-regulated initially and then gradually decreased with P19 cell differentiation. MTT assays and cell cycle analysis showed that FABP3 inhibits P19 cell proliferation, and data from annexin V-FITC assays revealed that FABP3 can promote apoptosis of P19 cells. Further data from quantitative real-time RT-PCR revealed lower expression levels of cardiac muscle-specific molecular markers (cTnT, alpha-MHC, GATA4, and MEF2c) in FABP3-overexpressing cell lines than in the control cells during differentiation. Our results demonstrate that FABP3 may be involved in the differentiation of cardiac myocytes.
    Preview · Article · Feb 2011 · Cell biochemistry and biophysics