Giray Aynali

T.C. Süleyman Demirel Üniversitesi, Hamitabat, Isparta, Turkey

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Publications (20)14.71 Total impact

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    ABSTRACT: There are several factors (viral infections, metabolic and ototoxic disorders etc.) accused for the development of sudden sensorineural hearing loss. Some prognostic factors (late onset of treatment etc.) had been evaluated in the literature. There is no sufficient data on the effect of routine laboratory parameters on the development and/or prognosis of sudden sensorineural hearing loss. The aim of this study is to investigate the effects of routine blood chemistry and hematological parameters on the development and prognosis of disease in patients with idiopathic sudden sensorineural hearing loss. One hundred and forty-seven patients with the diagnosis of idiopathic sudden sensorineural hearing loss followed up during the periods of 2000–2010 years were included in this study. One hundred and three septoplasty patients with no otologic complaints were enrolled as control group. Following the clinical and demographic evaluations, patients with idiopathic sudden sensorineural hearing loss and control groups, and patients treated successfully and patients with poor outcome were compared with each other. Data were analyzed by T test. All hematological and biochemical parameters were compared. Hemoglobin, hematocrit, white blood cell count, total and direct bilirubin, fasting blood glucose level and aspartate aminotransferase were significantly different between idiopathic sudden sensorineural hearing loss and control groups. There was no significantly different parameter between patients treated successfully and patients with poor outcome. Hemoglobin, hematocrit, white blood cell count, total and direct bilirubin, fasting blood glucose level and AST all can be risk factors for SHL, or they can be the result of undetermined pathology, because these parameters have no effect on the prognosis. Other routine parameters seem to have no effect on the development and/or prognosis of idiopathic sudden sensorineural hearing loss.
    No preview · Article · Dec 2013 · Indian Journal of Otolaryngology and Head & Neck Surgery
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    ABSTRACT: Objective: To investigate the relationship between development of laryngeal cancer and the presence of polymorphisms of the MnSOD Val16Ala, CAT-262 C < T and GPx1 Pro198Leu genes in a smoking population. Patients and methods: Single nucleotide polymorphisms were determined in DNA from the peripheral blood erythrocytes of 48 heavy smokers (25 patients with laryngeal cancer and 23 cancer-free controls), using polymerase chain reaction. Results: There were no significant differences in age, smoking duration or smoking intensity, comparing the two groups. The homozygous AA genotype of MnSOD Val16Ala was significantly more prevalent in the cancer group than the control group (92 vs 13 per cent, respectively), while the heterozygous AV genotype of MnSOD Val16Ala was more prevalent in the control group than the cancer group (87 vs 8 per cent, respectively) (p < 0.001). There were no significant differences between the cancer and control groups regarding GPx1 Pro198Leu or CAT-262 C < T polymorphisms. Conclusion: Polymorphism of the MnSOD Val16Ala gene may contribute to susceptibility to laryngeal cancer among smokers.
    No preview · Article · Oct 2013 · The Journal of Laryngology & Otology
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    ABSTRACT: Objectives: This study aims to evaluate the serum levels of hemoglobin, vitamin B12 and folic acid in patients with recurrent minor aphthous stomatitis. Patients and methods: Between June 2010 and January 2012, a total of 112 patients including 57 with recurrent aphthous stomatitis (study group; 30 males 27 females; mean age 36.7±13.9 years; range 13 to 74 years) and 45 with chronic tinnitus patients without recurrent aphthous stomatitis (control group; 18 males 27 females; mean age 39.7±15.1 years; range 20 to 80 years) who were admitted to our clinic were included in this study. The serum hemoglobin, vitamin B12 and folic acid levels of the patients were measured and statistically compared. Results: There was no significant difference in serum levels of hemoglobin and folic acid between the groups. Serum levels of vitamin B12 were significantly lower in the study group, compared to the control group (p<0.05). Serum levels of hemoglobin and folic acid were significantly lower in women compared to men in both groups (p<0.05). Conclusion: Vitamin B12 deficiency, but not lower levels of folic acid and hemoglobin, may play a role in the underlying etiology of aphthous stomatitis. Vitamin B12 supplements may be added to the treatment of recurrent aphthous stomatitis.
    No preview · Article · May 2013 · Kulak burun bogaz ihtisas dergisi: KBB = Journal of ear, nose, and throat
  • A.M. Ceyhan · I. Erturan · G. Meriç · V. Kaya · G. Aynali
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    ABSTRACT: Acute and chronic radiodermatitis are common complications of radiotherapy, whereas postradiation acne eruptions are unusual and late side effects of radiotherapy. However, acne vulgaris, were among the first of dermatological indications for radiotherapy, before the discovery of retinoids. The aethiology of post irradiaton acne is unknown. It is proposed that pilosebaseus remnants act as foreign bodies leading inflammatory reactions. In addition, radiation therapy is known to play a role in the pathogenesis of acne by reducing sebum secretion and changing its composition. Lesions developed about two months after completion of radiotherapy and the lesions are limited to the post radiation area. Herein, a 36 years old man with acne lesions on right side of his face after radiation therapy for nasopharynx carcinoma is presented.
    No preview · Article · Apr 2013 · Turkiye Klinikleri Dermatoloji
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    ABSTRACT: It is well known that oxidative stress induces larynx cancer, although antioxidants induce modulator role on etiology of the cancer. It is well known that electromagnetic radiation (EMR) induces oxidative stress in different cell systems. The aim of this study was to investigate the possible protective role of melatonin on oxidative stress induced by Wi-Fi (2.45 GHz) EMR in laryngotracheal mucosa of rat. For this purpose, 32 male rats were equally categorized into four groups, namely controls, sham controls, EMR-exposed rats, EMR-exposed rats treated with melatonin at a dose of 10 mg/kg/day. Except for the controls and sham controls, the animals were exposed to 2.45 GHz radiation during 60 min/day for 28 days. The lipid peroxidation levels were significantly (p < 0.05) higher in the radiation-exposed groups than in the control and sham control groups. The lipid peroxidation level in the irradiated animals treated with melatonin was significantly (p < 0.01) lower than in those that were only exposed to Wi-Fi radiation. The activity of glutathione peroxidase was lower in the irradiated-only group relative to control and sham control groups but its activity was significantly (p < 0.05) increased in the groups treated with melatonin. The reduced glutathione levels in the mucosa of rat did not change in the four groups. There is an apparent protective effect of melatonin on the Wi-Fi-induced oxidative stress in the laryngotracheal mucosa of rats by inhibition of free radical formation and support of the glutathione peroxidase antioxidant system.
    No preview · Article · Mar 2013 · Archives of Oto-Rhino-Laryngology
  • A.M. Ceyhan · I. Erturan · G. Meriç · G. Aynali · Y. Ugan · M. Şahin
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    ABSTRACT: PFAPA syndrome is a recently identified clinical entity of unknown etiology characterized by recurrent episodes of abrupt onset of high fever, aphthous stomatitis, pharyngitis and cervical lymphadenopathy. The associated symptoms do not regress with antibiotic therapy. The dramatic response of symptoms to single dose corticosteroids is hallmark feature of this syndrome. PFAPA syndrome usually begins under 5 years of age and in most cases resolves spontaneously until ten years old. PFAPA syndrome is extremely rare in adults, and to our knowledge, only about 20 cases have been described to date. Although PFAPA syndrome is increasingly reported in the pediatric literature, and is a known condition for the pediatricians, most dermatologists are unfamiliar with this entity. In this report, we describe a late onset of PFAPA syndrome in a 25-year-old boy who presented to our clinic for his recurrent aphthous stomatitis and fever.
    No preview · Article · Jan 2013 · Turk Dermatoloji Dergisi
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    ABSTRACT: Trihcofolliculoma is an uncommon, benign hamartomatous neoplasm of the hair follicle, most commonly occurring in the head and neck region of the adults. It tends to locate on the face and scalp. Other rare sites of occurrence include vulva, eyelid and upper lip. Clinically, the lesions are small, range from 0.2 to 0.5 cm in diameter, and appear as whitish-red or pearly papules or as smooth nodules, sometimes with a central pore containing wool-like wisps of immature hair. External auditory canal is an extremely rare localization of trichofolliculoma, and to the best of our knowledge, only three cases have been reported in the literature until now. In this report, we presented an unusual case of trichofolliculoma localized in the external auditory canal leading to hearing loss. In this case, surgical excision was enough to treat external auditory canal mass which was a trichofolliculoma.
    No preview · Article · Jan 2013 · Turkiye Klinikleri Journal of Medical Sciences
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    ABSTRACT: Objective: To investigate the effects of repetitive nasopharyngeal HCl/Pepsin infusion on Eustachian tube and protective effects of artificial saliva against HCl/Pepsin in sialoadenectomised rats. Material and Methods: Thirty albino sialoadenectomised rats were divided into three groups. Group 1 was defined as the control group. The rats in Group 2 were administered HCl/Pepsin and in Group 3 HCl/Pepsin plus artificial saliva. On the seventh day of HCl/Pepsin exposure all animals were sacrified and cross section of Eustachian tube specimens were obtained. Specimens were examined for goblet cell density, submucosal inflammatory cell infiltration, hypertrophy and degeneration level of the submucosal glands and submucosal connective tissue thickening and findings were compared between groups. Results: There was no difference between groups regarding goblet cell density and fibrous tissue proliferation. Submucosal inflammatory tissue density was higher in Group 2 and 3 than in the control group (Group 1). Submucosal gland damage was higher in HCL-pepsin group (Group 2) compared to Group 1 and 3. In contrast, submucosal gland damage was similar in Group1, 2, and 3. Submucosal gland hypertrophy was lower in HCL-pepsin and artificial saliva group (Group 3) than in Group 1 and 2 but it was similar in Group 1 and 2. Conclusion: The experimental gastric reflux (HCL-pepsin) may increase submucosal gland damage. Artificial saliva may protect the Eustachian tube from gland hypertrophy and gland damage in early stages of experimental xerostomia in rats. Artificial saliva has no beneficial effects on fibrous tissue proliferation and submucosal tissue infiltration.
    No preview · Article · Jan 2013 · Turkiye Klinikleri Journal of Medical Sciences
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    ABSTRACT: Although myiasis is not a frequently encountered case in otorhinolaryngology practice, reported cases often involved the nose, ear and pharynx in rank order. Myiasis of tracheotomy wound is extremely rare. Lucilia larvae tend to infest the wound tissue (e.g. tracheotomy) rather than healthy tissues. Older and lonely patients with tracheotomy should be controlled by primary health care periodically. We report a Lucilia sericata myiasis in tracheotomy wound of an 80-year-old male patient who lived alone and had decreased hearing and vision due to senility.
    Full-text · Article · Dec 2012 · Turkiye Klinikleri Journal of Medical Sciences
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    L Yavuz · G Aynali · A Aynali · A Alaca · S Kutuk · B G Ceylan
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    ABSTRACT: To determine the effect of immunoglobulin (Ig)M-enriched Ig therapy on mortality rate and renal function in sepsis-induced multiple organ dysfunction syndrome (MODS), using the Acute Physiology and Chronic Health Evaluation II (APACHE II) score. Retrospective study of patients with sepsis-induced MODS treated with standard antibiotic plus supportive therapy (control group) or IgM-enriched Ig therapy adjuvant to control group therapy (IVIg group). Total length of stay in the intensive care unit (ICU), overall mortality rate and 28-day case fatality rate (CFR), as well as APACHE II scores and renal function parameters at day 1 and day 4 of therapy, were recorded. A total of 118 patients were included (control group, n = 62; IVIg group, n = 56). In both groups, day 4 APACHE II scores decreased significantly compared with day 1 scores; the effect of treatment on renal function was minimal. Length of ICU stay, overall mortality rate and 28-day CFR were significantly lower in the IVIg group compared with the control group. Adding IgM-enriched Ig therapy to standard therapy for MODS improved general clinical conditions and significantly reduced APACHE II scores, overall mortality rate and 28-day CFR, although effects on renal function were minimal.
    Preview · Article · Jun 2012 · The Journal of international medical research
  • M. Ozkan · M. Yariktas · G. Aynali · F. Unal · H. Yasan · M. Tuz · M. Ciris
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    ABSTRACT: Objective: The aim of this study is to evaluate the effect of calcium-rich feed in the development of tympanosclerosis in rats with acute otitis media and otitis media with effusion and to compare the effects of these conditions in the formation process of tympanosclerosis. Materials and Methods: Thirty rats were equally divided into six groups. The first two groups were used as control. The first group was fed calcium-normal feed, while the second group was fed calcium-rich feed. The third group (otitis media with effusion) and fourth group (otitis media with effusion) were calcium-normal and calcium-rich feed, respectively. The fifth (acute otitis media) and sixth groups (acute otitis media) were fed calcium-normal and calcium-rich feed, respectively. Otitis media with effusion was induced with transtympanic injection of histamine dihydrochloride. Acute otitis media was induced with transtympanic injection of suspension of Streptococcus pneumonia. Calcium content of feeding for calcium-normal and calcium-rich feed were 0.67% and 3%, respectively. Results: Total serum calcium values were higher in calcium-rich feed groups than calcium-normal feed groups. However, total serum calcium levels were within normal limits in both groups (2,61±0,07 mmol/lt and 2,54±0.07 mmol/lt, respectively). Comparing the groups of otitis media with effusion, the formation process of tympanosclerosis was higher in the calcium-rich feed group than in the calcium-normal feed group; there was a statistically significant difference. However, here was no statistically significant difference between calcium-rich and calcium-normal feed groups in the acute otitis media and control groups regarding the formation process of tympanosclerosis. There was also no statistically significant difference between the otitis media with effusion and acute otitis media groups. Conclusion: Experimental otitis media with effusion and acute otitis media are effective in the formation of tympanosclerosis. There is no significant difference between the effects of these pathologies in the formation process of tympanosclerosis. Calcium-rich feed is effective in experimental otitis media with effusion in the formation process of tympanosclerosis but not in acute otitis media. Furthermore, calcium-rich feed is not the reason for hypercalcemia.
    No preview · Article · May 2012 · Journal of International Advanced Otology
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    Ali Murat Ceyhan · Gonca Meriç · Giray Aynali

    Preview · Article · Mar 2012 · Deri Hastaliklari ve Frengi Arsivi
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    ABSTRACT: Availability and utilization of computed tomography angiography has been increasing recently. We aimed to assess the effectiveness of low amount of contrast media and low kV value in order to reduce possible side effects of contrast media and to provide optimization of kV value in the evaluation of the carotid artery with multi-detector computed tomography angiography. Forty one patients were randomized into two groups. Contrast media was administered at a dose of 1 ml/kg in group A patients and of 0.5 ml/kg in group B patients. kV value of 120 in group A and 100 in group B were chosen. Bolus tracking technique was used. Attenuation values of certain arterial segments were measured, and values over 200 HU were considered as significant. North American Symptomatic Carotid Endartherectomy Trial criteria were utilized in the evaluation of stenosis. Image quality in arterial segments of all cases was found to be sufficient for diagnosis. Arterial attenuation values were found to be higher in group B than group A. When compared separately in all arterial segments, there was no statistically significant difference between the groups. For stenosis, 615 arterial segments were evaluated. Moderate stenosis in eight segments and severe stenosis in three segments were identified in group A. Occlusion in three segments, severe stenosis in three segments, and moderate stenosis in 25 segments were detected in group B. Better image quality can be obtained, and the amount of contrast media can be reduced using low kV technique in carotid artery multi-detector computed tomography angiography examination.
    Full-text · Article · Jun 2011 · European journal of radiology

  • No preview · Article · May 2011 · European journal of dermatology: EJD
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    ABSTRACT: OBJECTIVES: The aim of this prospective clinical study was to compare the subjective tonsil size (grade) with real palatine tonsil volume, body mass index, body surface area, age, and gender. PATIENTS AND METHODS: Two hundred and ninety-two patients with the diagnosis of recurrent acute tonsillitis, ages 3-15 years, (156 male and 136 female) who underwent tonsillectomy were enrolled into this study. The correlation of subjective tonsil size to objective tonsil volume, body mass index, body surface area, age, and gender size was investigated. The statistical correlations were evaluated by Pearsons' bivariate correlation method. RESULTS: There was statistically significant correlation between objective volume of tonsils and subjective grading of tonsils (p<0.001). There was statistically significant correlation between objective volume of tonsils (both right and left tonsil) and body mass index (p=0.008 and 0.013) respectively. There was statistically significant correlation between objective volume of tonsils and body surface area (p=0.009). There was statistically significant correlation between volume of tonsils and age (p=0.017). CONCLUSIONS: Objective tonsil volume is correlated with subjective tonsil size, body mass index, body surface area and age in patients with recurrent acute tonsillitis. Follow-up of palatine tonsil status (volume) of patients with recurrent acute tonsillitis may be decided according to the subjective tonsil size. The correlations of aforementioned parameters to objective tonsil volume should be searched for other pathologies of palatine tonsils.
    No preview · Article · Mar 2011 · International journal of pediatric otorhinolaryngology
  • A.M. Ceyhan · G. Meriç · G. Aynali · M. Çiriş
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    ABSTRACT: Erosive oral lichen planus (EOLP) is a rare form of mucosal lichen planus characterized by intractable symptoms and complications that significantly impact patients' quality of life. It usually results in pain which can lead to severe problems in daily activities such as eating, drinking, speech, and interpersonal relationships. EOLP usually has a chronic course and spontaneous remissions are scarce. Although there are many treatment options for EOLP including both topical and systemic immunosuppressive agents, therapeutic results are frequently disappointing and effective treatment modality remains elusive. It is often resistant to topical steroid and the use of systemic agents is limited by side effects. Tacrolimus is a new non-steroidal topical immunomodulator agent approved for the treatment of atopic dermatitis. In recent years, it is shown to be effective in other persistent inflammatory skin and mucosal diseases as well as atopic dermatitis. Herein, we report on a 76-year-old male with recalcitrant EOLP of the lower lip who had a excellent improvement of his lesion following a four-week course of topical 0.1% tacrolimus ointment.
    No preview · Article · Jan 2011 · Turkiye Klinikleri Dermatoloji
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    ABSTRACT: The present study aimed to investigate the effects of indomethacine, montelukast and methylprednisolone in management of experimental otitis media with effusion. Forty Wistar albino rats of which the weights ranged between 310 and 370 g were included in this study. Middle ear effusion was created by transtympanic histamine injection. The presence of effusion was confirmed by otomicroscopic examination. Thirty-seven rats with effusion were divided into 4 groups (methylprednisolone, montelukast, indomethacine and saline-control groups). All agents were administered for a period of consecutive 10 days. At the 11th days of administration, the recovery of effusion was confirmed by otomicroscopic examination. Tympanic bullae of the rats were removed and histopathological examinations were carried out. In the histopathological examination, the neutrophil leukocytes accumulated in the middle ear submucosa were counted. The mean numbers of submucosal neutrophils in the methylprednisolone, montelukast, indomethacine, and saline groups were 24.6±8.1, 54.1±6.2, 52.3±7.3, 55.7±8.3, respectively. The otomicroscopic recovery rates of effusion in the methylprednisolone, montelukast, indomethacine, and saline groups were 18/18 (100%), 8/18 (44%), 2/14 (14%), 2/18 (11%) respectively. Methylprednisolone and montelukast ameliorate the middle ear effusion. However, only methylprednisolone reduces the submucosal infiltration of the neutrophil leukocytes which are the most evident cell of inflammatory process. Montelukast is effective in the resolution of experimental otitis media with effusion.
    No preview · Article · Oct 2010 · International journal of pediatric otorhinolaryngology
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    ABSTRACT: Many different methods have been described to obtain sinus culture from patients with chronic sinusitis. However, these methods presented limited information how they had prevented from the contamination with nasal flora. The purpose of this study is to demonstrate and describe a contamination-free technique to obtain culture from involved sinus during endoscopic sinus surgery (ESS). We prepared a cotton-tipped contamination-free swab. This applicator was inserted inside the sinus through ostium or inside the cavity directly established during ESS, and the swab was introduced directly into the implicated area. Thirty-five adult patients with chronic sinusitis who underwent ESS participated in the study. During ESS, the number of cultivated pathogenic microorganisms of the cultures obtained by our method was statistically significantly higher than the cultures obtained by the classic nasal cavity cultures (P = .0296). However, the number of cultivated bacteria (coagulase-negative Staphylococcus, alpha-hemolytic Streptococcus, and Corynebacterium spp.) after the contamination was lower than those of nasal cavity culture (P = .0296). During ESS, the identification of the pathogen in sinusitis with endoscopically guided narrow-bore sinus culture applicator is a reliable diagnostic method compared with the classic culture techniques.
    Full-text · Article · Jun 2007 · Diagnostic Microbiology and Infectious Disease
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    ABSTRACT: Allergic rhinitis is the most common chronic disease in the upper respiratory tract, requiring better diagnostic methodology to counteract its onslaught. The purpose of this study was to investigate the association between Toxocara seropositivity and allergic rhinitis. Sixty-four consecutive patients with allergic rhinitis and 61 healthy volunteers in the control group were included in this study. The diagnosis of allergic rhinitis was defined by positive epicutaneous prick test. The diagnosis of toxocariasis was established by IgG and specific IgE antibodies against Toxocara by ELISA method. All cases were examined for intestinal parasites also. The seropositive cases with Toxocara were reevaluated for symptoms and signs of toxocariasis. Higher toxocariasis seropositivity (ELISA IgG; 28.1%) rate was determined in the patients with allergic rhinitis and compared with the control groups (11.5%; p < 0.05). Specific IgE seropositivity (17.2%) was high for the patients with allergic rhinitis compared with the control group (3.3%; p < 0.05). Our results show that there was a possible causal relationship between Toxocara infection and allergic rhinitis. Patients with allergic rhinitis from a region with high prevalence for this parasitic infection should be evaluated for Toxocara infection.
    Full-text · Article · Mar 2007 · American Journal of Rhinology
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    ABSTRACT: ZET Amiloidoz sıklıkla sistemik olan fakat nadiren farklı organlarda lokal olarak da tutulum gösterebilen bir hastalıktır. Lokal olarak en sık tutulan organlar arasında görülen larenks, baş-boyunda tutulum açısından ilk sırada yer alır. Nadir bir durum olan larenks amiloidozunun tedavisinde cerrahi ve CO2 lazer kullanılmaktadır. Tedavi sonrasında rekürrens sıktır. Kliniğimize ara ara ortaya çıkan nefes darlığı ve ses kısıklığı şikayeti ile başvuran olgunun, sağ ariepiglottik plikasında 3x2 cm boyutlarında kitle tespit edildi. Lokal ve topikal anestezi altında alınan biyopsinin sonucu amiloidoz olarak rapor edildi. Operasyon öncesi yapılan değerlendirmede, biyopsi alınan ve 3x2 cm olan kitlenin küçülüp 1x1 cm boyutlarına gerilediği görüldü. Takipleri devam eden olgunun 3. ay kontrolündeki kitle boyutları 0.5x0.5 cm'dir. Sonuç olarak larengeal amiloidozda spontan regresyon olabilir. Anahtar Sözcükler: Amiloidoz, larenks, regresyon, larengeal neoplazm A CASE OF LARYNGEAL AMYLOIDOSIS SUMMARY Amyloidosis is a disease demonstrated to be frequently in systemic form, but sometime it may be found as localized form in some organs. Larynx, which is the first in frequency of organ involvement, is the most frequently involved site of localized amyloidosis. Laryngeal amyloidosis, which is an infrequent entity, is treated by surgery or CO2 laser. Recurrence is frequent following intervention. We have determined 3x2 cm mass in the right aryepiglottic fold in a patient with the complaints of intermittant dyspnea and dysphonia. Histopathologic evaluation of biopsy specimen taken under local anesthesia has revealed amyloidosis. During preoperative evaluation, the volume of mass seems to be regressed from 3x2 to 1x1 cm. The volume of mass was 0.5x0.5 cm at third month after biopsy and follow-up period is going on.
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