[Show abstract][Hide abstract] ABSTRACT: A class of shape-persistent metallodendrimer has been developed through a self-assembly strategy, in which 〈tpy-RuII-tpy〉 or 〈tpy-FeII-tpy〉 connectivity is utilized, as branching moieties or nodes. These metallomacromolecules were fully characterized by 1H and 13C NMR, traveling wave ion mobility mass spectrometry (TWIM MS), single crystal X-ray, UV-vis absorption, photoluminescence, and cyclic voltammetry. Significant increase in the drift times of the same charge states was observed with increasing generation of these complexes, which is in line with the change of molecular size. Moreover, the photophysical properties (molar extinction coefficients) and electrochemical stability of the complexes were noticeably different depending on size and metal ion center.
Full-text · Article · Jan 2012 · New Journal of Chemistry
[Show abstract][Hide abstract] ABSTRACT: The reactions of HCl, PCl(5), and a crown ether (12-crown-4 or 18-crown-6) in CHCl(3) under anaerobic conditions give complexes of the superacid HPCl(6): [H(12-crown-4)][PCl(6) ] and [H(18-crown-6)(2)][PCl(6)]. The crystal structures indicate that the proton lies roughly in the center of the 12-crown-4 molecule in [H(12-crown-4)][PCl(6) ] whereas it lies between two oxygen atoms of two different 18-crown-6 molecules in [H(18-crown-6)(2)][PCl(6)].
No preview · Article · Nov 2010 · Journal of the American Chemical Society
[Show abstract][Hide abstract] ABSTRACT: The pressing need to treat multi-drug resistant bacteria in the chronically infected lungs of cystic fibrosis (CF) patients has given rise to novel nebulized antimicrobials. We have synthesized a silver-carbene complex (SCC10) active against a variety of bacterial strains associated with CF and chronic lung infections. Our studies have demonstrated that SCC10-loaded into L-tyrosine polyphosphate nanoparticles (LTP NPs) exhibits excellent antimicrobial activity in vitro and in vivo against the CF relevant bacteria Pseudomonas aeruginosa. Encapsulation of SCC10 in LTP NPs provides sustained release of the antimicrobial over the course of several days translating into efficacious results in vivo with only two administered doses over a 72 h period.
[Show abstract][Hide abstract] ABSTRACT: Several silver N-heterocyclic carbene complexes have been synthesized and tested for their anticancer activity. In vitro studies have shown these complexes to be active against ovarian, breast, melanoma, colon, renal, bladder, and prostate human cancer cell lines. An in vivo study on a silver carbene complex using an ovarian cancer (OVCAR-3) xenograft model in athymic nude mice has produced encouraging results. The administration of the silver complex subcutaneously into the tumor site resulted in necrosis of the tumors with no adverse effects to surrounding tissues or internal organs. Building on earlier results the silver complexes were encapsulated in nanoparticles in order to provide a platform for receptor targeting of specific cancer cells and to improve the stability of the complexes for systemic injection. We are currently investigating poly(lactic-co-glycolic acid) coupled with polyethylene glycol and utilizing folic acid receptors to provide this mode of delivery.