C. Sivaraj

University of Madras, Chennai, Tamil Nadu, India

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Publications (12)10.15 Total impact

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    ABSTRACT: The current study was aimed at evaluation of Antioxidant & Anti proliferative potential of the methanol extract of Debregeasia longifolia leaves and to elucidate its phytochemical profile using antiproliferative activity. The methanol extract of leaves of D. longifolia was screened for its antioxidant potential by dot-plot assay, DPPH radical scavenging assay and hydroxyl radical scavenging assay. Since the results were quite encouraging, it stimulated the investigators to proceed further to screen the phytochemical profiles by qualitative and quantitative methods which were further extended to thin layer chromatography, and antiproliferative activity. The result indicates that the methanol extract of leaves of G. rottlariformis showed significant radical scavenging activity, potent toxicity to liver cancer cells. Since the results are promising, D. longifolia could be considered as a significant source of Antioxidant and Anti proliferative agents. © 2014, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.
    No preview · Article · Sep 2014 · International Journal of Pharmacognosy and Phytochemical Research
  • N. Ravisankar · C. Sivaraj · S. Seeni · J. Joseph · N. Raaman
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    ABSTRACT: Objective: The present investigation was an attempt to evaluate the phytochemical constituents, free radical scavenging activities and antioxidant properties of the methanol extract of leaves of Hypericum hookerianum. Methods: The total antioxidant activity was assayed by DPPH free radical scavenging assay method. The phytochemicals in the methanol extract of leaves of Hypericum hookerianum were determined qualitatively and quantitatively using standard methods. Results: The study indicated that the presence of most of the major phytochemicals viz. flavonoids and phenols in the methanol extract of leaves of H. hookerianum were 280mg/g and 128mg/g respectively. The DPPH radical scavenging activity of methanol extract of leaves of H. hookerianum was recorded as 90.24% and chelating activity of methanol extract was recorded as 62.92% at 21μg/mL concentration. The ferric reducing power assay showed maximum activity of 0.84 and also the phosphomolybdenum reduction assay showed maximum activity of 0.069 at 21μg/mL concentration which were compared with the standards. The IC50 of methanol extract of leaves of H. Hookerianum for DPPH and Fe2+ chelating assay were 3.03 and 13.95 μg/mL respectively and showed significant results when compared with the standards. Conclusion: The present study revealed that the leaves of methanol extract of H. hookerianum showed the highest antioxidant activity as well as phenolic content. This study suggests that the methanol extract of leaves of H. hookerianum is a potential source of natural antioxidants.
    No preview · Article · Jan 2014 · International Journal of Pharmacy and Pharmaceutical Sciences
  • N. Ravisankar · C. Sivaraj · S. Seeni · J. Joseph · N. Raaman
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    ABSTRACT: Objective: The present investigation was an attempt to study the anticancer activity of the methanol extract of the leaves of H. hookerianum. GC-MS analysis revealed that the methanol extract of leaves contained important secondary metabolites viz. oxygenated hydrocarbons and phenolic hydrocarbons. These phytochemicals we r e p r e s ume d responsible for various pharmacological actions like antioxidant, and anticancer activities. Cytotoxic changes observed in MCF 7 cell line by the treatment of methanol extract included cell aggregation, cell rounding and cell death. The overall result indicates that the methanol extract of leaves of H. hookerianum showed promising baseline information for its potential use as an anti cancer agent.
    No preview · Article · Jan 2014 · International Journal of Pharmacy and Pharmaceutical Sciences
  • N. Ravisankar · C. Sivaraj · S. Seeni · J. Joseph · N. Raaman
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    ABSTRACT: The work was aimed to develop a method for extraction and identification of the marker compounds of Hypericum species, hyperforin and hypericin present in the buds and leaf extracts of Hypericum hookerianum, a lesser known species of Asia. LC-MS hyphenated techniques were used and the data indicated the presence of both these active compounds in the methanol extract of both buds and leaves. ABTS·+ (2, 2'- azinobis [3-ethylbenzthiazoline]-6-sulfonic acid) radical cation scavenging assay using the extract showed concentration dependent increase in inhibition indicating free radical scavenging and antioxidant properties. Further, the extract (500μg) showed a broad spectrum antibacterial activity especially against the drug resistant Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia and Salmonella typhimurum which is characteristic of hyperforin. Hyperforin and hypericin when docked with the protein tyrosine kinase C using bioinformatics tools predicted anticancer potential of the extract to be validated by wetlab experiments. The results suggest methanolic extract of Hypericum hookerianum is a valuable commodity with potent antibacterial and anticancer activities. Though the shoot extracts of Hookerianum are reported to be antiHSV-1, the extracts subjected to P-24 antigen assay for HIV screening in the present investigation did not yield positive results upto 300 μg.
    No preview · Article · Jan 2014 · International Journal of Pharma and Bio Sciences
  • N. Raaman · C. Sivaraj · Tenzing
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    ABSTRACT: Export Date: 18 October 2014
    No preview · Article · Jan 2014 · International Journal of Pharmacy and Pharmaceutical Sciences
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    ABSTRACT: The current study was aimed at evaluation of Antioxidant & Anti proliferative potential of the methanol extract of Heracleum sprengelianum leaves and to elucidate its phytochemical profile using GC-MS analysis. The methanol extract of leaves of H. sprengelianum as screened for its antioxidant potential by dot-plot assay, DPPH radical scavenging assay and hydroxyl radical scavenging assay. Since the results were quite encouraging, it stimulated the investigators to proceed further to screen the phytochemical profiles by qualitative and quantitative methods which were further extended to thin layer chromatography, GC-MS analysis and antiproliferative activity. The result indicates that the methanol extract of leaves of H. sprengelianum showed significant radical scavenging activity, potent toxicity to liver cancer cells and also less toxicity to normal cells. The GC-MS result showed the presence of important active metabolites such as fatty acids and phenolic acids. Since the results are promising, H. sprengelianum could be considered as a significant source of Antioxidant and Anti proliferative agents.
    No preview · Article · Jan 2014 · International Journal of Pharma and Bio Sciences
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    ABSTRACT: Curcuma zedoaria and Curcuma amada rhizome solvent extracts were evaluated for their anticancer and antioxidant activity. The isopropyl extract of C. zedoaria exhibited high anticancer activity compared to acetone extract of C. amada. Crude protein of C. zedoaria showed good anticancer activity when compared to crude protein of C. amada. Acetone extract of C. zedoaria showed high radical scavenging activity of 88.7% and superoxide scavenging activity recording 83.15%. Acetone extract of C. zedoaria showed 82.5% hydroxyl radical scavenging activity.
    Full-text · Article · Jul 2012
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    ABSTRACT: Helicteres isora dried fruit solvent extracts were evaluated for their antioxidant and anticancer activity. Acetone fruit extract H. isora showed (96.44%) strong antioxidant activity compared to hexane, and iso-propyl alcohol (IPA). Acetone extract exhibited better cytotoxicity against human lung cancer cells (NCI-H460) whereas; acetone and crude protein extracts showed activity against reactive oxygen species.
    Full-text · Article · Jul 2012
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    ABSTRACT: A new series of acyclic mononuclear copper(II) complexes have been prepared by Schiff-base condensation derived from 5-methylsalicylaldehyde, diethylenetriamine, tris(2-aminoethyl) amine, triethylenetetramine, N,N-bis(3-aminopropyl)ethylene diamine, N,N-bis(aminopropyl) piperazine, and copper perchlorate. All the complexes were characterized by elemental and spectral analyses. Electronic spectra of the complexes show a d–d transition in the range 500–800 nm, electrochemical studies of the complexes show irreversible one-electron-reduction process around −1.10 to −1.60 V. The reduction potential of the mononuclear copper(II) complexes shifts toward anodic direction upon increasing the chain length of the imine compartment. ESR spectra of the mononuclear copper(II) complexes show four lines, characteristic of square-planar geometry, with nuclear hyperfine spin 3/2. The copper(II) complexes show a normal room temperature magnetic moment value μ eff = 1.72–1.76 BM, close to the spin-only value of 1.73 BM. Electrochemical and catalytic studies of the complexes were compared on the basis of increasing the chain length of the imine compartment. All the complexes were screened for antifungal and antibacterial activities.
    No preview · Article · Feb 2011 · Journal of Coordination Chemistry
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    ABSTRACT: BF(3).Et(2)O-catalysed O-glycosylation of 1,2,3-tri-O-acetyl-4,6-O-butylidene- and ethylidene-beta-d-glucopyranose with different aliphatic and aromatic alcohols proceeds for the most part with complete retention of anomeric configuration. Antioxidant activity of O-glycosides shows significant inhibition (IC(50) approximately 77%). 1,3-Dipolar cycloaddition of terminal alkyne derivatives of O-glycosides with glycosyl azide results in disaccharides.
    No preview · Article · Aug 2010 · Carbohydrate research
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    G Ganesh · C Sivaraj · P S Kannan · N Raaman · A Subbiahpandi
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    ABSTRACT: In the title compound, C(6)H(12)O(5), the cyclo-hexane ring adopts a chair conformation. The absolute configuration is not defined. However, the relative configuration can be assigned as 1R*,3R*,4S*,S*. In the crystal structure, mol-ecules are linked by strong inter-molecular O-H⋯O hydrogen bonds, producing a three-dimensional network.
    Full-text · Article · May 2009 · Acta Crystallographica Section E Structure Reports Online

  • No preview · Article · Jan 2009