Carol Thompson

University of Sydney, Sydney, New South Wales, Australia

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Publications (3)7.6 Total impact

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    ABSTRACT: This study investigates human papillomavirus (HPV) infection in the oral cavities of 88 Australian renal transplant recipients and 88 immunocompetent controls. Oral cavities were examined for lesions and brushings collected for HPV analysis by consensus PCR. No warts were identified; HPV DNA was detected in 18% of transplant versus 1% control samples (P<0.001). Cutaneous HPVs predominated. One patient had HPV16 in samples taken four years apart without evidence of associated lesions or malignancy. Transplant recipients were more likely than controls to have current cutaneous warts (P<0.001), fewer sexual partners (P=0.001), and to have never consumed alcohol (P=0.01). Among the transplant group, the risk of an HPV-positive sample was higher among older patients (P=0.05), and those with past cutaneous warts (P=0.04). This study extends previous surveys by encompassing overt and asymptomatic infection, a broad spectrum of cutaneous and genital HPVs, and by providing new data on risk factors for oral HPV infection.
    No preview · Article · Aug 2006 · Transplantation
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    ABSTRACT: To identify particular characteristics that might help explain the markedly higher rate of invasive cervical cancer in southern China as compared with Australia. One hundred eighty-five women with cervical cancer were recruited between 1999 and 2001: 106 from Guangzhou and Changsha (southern China), and 79 from Sydney (southeast Australia). Demographic and risk factor information was obtained by questionnaire; clinicopathologic data were extracted from hospital records. The human papillomavirus (HPV) status of cancer biopsies was ascertained by consensus PCR assays, direct sequencing and/or Amplicor trade mark hybridisation. The mean age of the Chinese was significantly lower than the Australians (44 versus 53 years), although mean age at first sexual intercourse was similar. Australian women were more likely to smoke, to report multiple sexual partners and to have a history of sexually transmitted diseases (but not of genital warts). However, they were better educated, were more frequent users of barrier contraception and were far more likely to report regular Pap smears before diagnosis. The HPV positivity rate of Chinese cancers (83%) was less than Australian tumours (90%); but HPV 16 and 18 were the most common genotypes in both populations (59% and 77%), and predominated in cancers from younger women. HPV types 58 or 59 were amplified from 12 (14%) of the Chinese but from only one Australian cancer. Cervical cancer is not only more common in China but also develops at a younger age than in Australia. While significant differences in some risk factors were observed, the much lower participation in cervical screening in southern China is likely to be of greatest consequence.
    No preview · Article · Oct 2004 · Gynecologic Oncology
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    ABSTRACT: To investigate the infection rate and genotypes of HPV in cervical cancer and analyse the clinicopathological characteristics and risk factors for cervical cancer with HPV infection in Chinese and Australian patients. The human papillomavirus (HPV) DNA in cervical cancer specimens from 115 Chinese women and 79 Australian women was detected by polymerase chain reaction.HPV types were determined by sequencing and reverse hybridization. The relationship a between the HPV types and the clinicopathological characteristics of cervical cancer in Chinese and Australian women were analyzed. HPV DNA positive rate was 76. 5% in the Chinese women (88/115) and 89.9% in the Australian women (71/79, P = 0. 017). There were no significant differences of HPV 16 and HPV 18 prevalence between the two groups (P = 0. 806). HPV 58 and 59 were more prevalent in Chinese women (both 6. 8%) than in Australian women (1. 4% and 0). In China, HPV 58 prevalence rate was significantly higher in the Hunan region than in the Guangdong region (P = 0. 007). The mean ages at diagnosis was 44. 24 +/- 11. 31 years for Chinese and 53.08 +/- 16. 54 years for Australian women (P <0. 001). Combining the two groups, no relationship was found between HPV positivity/negativity and the FIGO stage, macroscopic features, histological type and grade of tumour, as well as pelvic lymphatic metastasis. However, HPV type wa significantly correlated with the histological type (P < 0. 001 ) and grade of cervical tumour (P = 0. 028). In comparison with the Chinese group, the Australian group presented more advanced cancers, a greater proportion of endocervical patterns, and more non-squamous cell carcinoma. There were no significant differences in grade of tumour and lymphatic node status between the two groups. The HPV infection rate in cervical cancer patients is significantly higher among Australians than among Chinese, which may be caused by more sexual transmitted diseases and more sex partners among the former group. HPV 58 and HPV 59 tie for third common genotypes in cervical cancers in China, however, these types are uncommon in Australia. There was a significant variation in types of HPV infection among different histological type and grade of cervical tumors. Both HPV 18 and 59 appear to be associated with the malignancy of cervical cancer.
    No preview · Article · Jun 2003 · Zhonghua yi xue za zhi