Abdullah Alfadley

King Faisal Specialist Hospital and Research Centre, Ar Riyāḑ, Ar Riyāḑ, Saudi Arabia

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Publications (27)67.99 Total impact

  • Muzamil Chisti · Nusrat Banka · Abdullah Alfadley
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    ABSTRACT: Background: The typical presentation of infantile hemangioma is well known and is easily recognizable. However, it may have many atypical presentations, as reported in the literature. Most of the hemangiomas are not visible at birth and become apparent at about 3 to 4 weeks of age. There are very few case reports of hemangioma presenting as a pale patch in the dermatology literature, and none of them describe the etiopathogenesis of this presentation and its clinical implications. Objective and conclusion: We report a case of an infantile hemangioma with a trichrome presentation: an erythematous oval patch with a dark red macule at the periphery enclosed by a hypopigmented halo. A brief description of the etiopathogenesis of the pallor sign is also given.
    No preview · Article · Dec 2012 · Journal of Cutaneous Maedicine and Surgery
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    ABSTRACT: Cutaneous T-cell lymphoma is a rare subtype of posttransplantation lymphoproliferative disease, with only 29 cases reported in the literature to date, the majority of which are post-renal transplantation. Only a few were reported after pancreas, heart, and bone marrow transplantation. There have been no reports of cutaneous T-cell lymphoma following liver transplantation to date. We report a case of a 76-year-old male who developed generalized eczematous eruption 13 years after a liver transplantation. Investigations showed that it was Epstein-Barr virus-negative, CD3-positive, and CD4-positive cutaneous T-cell lymphoma with Sézary cells in the blood. This shows that cutaneous T-cell lymphoma/Sézary syndrome can also develop after liver transplantation. To our knowledge, there are no similar reports in the English literature.
    No preview · Article · Jan 2012 · Journal of Cutaneous Maedicine and Surgery
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    ABSTRACT: Anetoderma (focal loss of dermal elastic tissue) can either be primary, which is an idiopathic occurrence of anetoderma in normal areas of the skin, or secondary, which is preceded by an inflammatory dermatosis in the same location. Sporadic reports of lupus erythematosus-associated anetoderma have been described in the literature. All reported cases were positive for antiphospholipid antibodies. We present a patient with primary and secondary anetoderma with chronic lupus dermatitis and negative antiphospholipid antibodies. A middle-aged woman presented with a soft nodule with a wrinkled surface on her left arm and an erythematous atrophic plaque with a nodular surface on the chest. Skin biopsy from the left arm showed epidermal atrophy without inflammatory changes. Histologic findings of the lesion on the chest were consistent with chronic lupus dermatitis and secondary anetoderma. Laboratory investigations showed positive antinuclear antibody anti-double-stranded deoxyribonucleic acid (DNA) antibody but negative antiphospholipid antibodies. Primary and secondary anetodermas may occur in patients of lupus dermatitis without positive antiphospholipid antibodies.
    No preview · Article · Jan 2012 · Journal of Cutaneous Maedicine and Surgery
  • Mansoor Haider · Abdullah Alfadley · Razan Kadry · Abdulmonem Almutawa
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    ABSTRACT: Cutis laxa is a rare disorder resulting from degradation and clumping of elastic fibers in dermis. Type II acquired cutis laxa, shows only cutaneous changes without any systemic involvement. We describe an infant with acquired cutis laxa type II following a generalized inflammatory dermatitis.
    No preview · Article · Jan 2010 · Pediatric Dermatology
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    ABSTRACT: A total of 27 T-lymphocyte cell strains were established from skin biopsies of 24 patients with various stages of cutaneous T-cell lymphoma (CTCL) by addition of the T-cell growth factors interleukin (IL)-2 and IL-4. Cellular proliferation and phenotypic changes were measured over 3 months in culture, and T-cell clones were studied using T-cell receptor-? re-arrangement techniques. An average outgrowth of 134 million T-lymphocytes from a 4-mm skin biopsy was observed over 2 months. Initially, most T-cells expressed the CD4+ phenotype. In 17 cell strains from patients with early CTCL a statistically significant predominance of CD8+ T-lymphocytes developed over 8-weeks' culture, indicating that CD8+ T-cells controlled the growth of CD4+ T cells, whereas CD4+ T-cells were predominant in cell strains from advanced CTCL (p <0.05). TCR-? re-arrangement studies revealed, on average, 12 T-cell clones per cell strain, which was reduced over time to 6 T-cell clones per cell strain. Lymphocytes from peripheral blood could kill lymphocytes from an autologous cell strain, suggesting the presence of autoreactive cytotoxic T-cells. Our study suggests how skin-homing CD8+ T-lymphocytes from patients with early stage CTCL can suppress the in vitro growth of skin-homing CD4+ T-lymphocytes, indicating immune surveillance.
    Full-text · Article · Feb 2007 · Acta Dermato Venereologica
  • N Banka · A Alfadley

    No preview · Article · Sep 2006 · Journal of the European Academy of Dermatology and Venereology
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    ABSTRACT: Papillon-Lefèvre syndrome is an autosomal recessive disorder characterized by palmoplantar hyperkeratosis and aggressive periodontitis. The aim of the study was to identify underlying cathepsin C mutations in 39 subjects with Papillon-Lefèvre syndrome and to explore any phenotypic associations. Genotyping and mutation analyses were performed using standard molecular techniques, and dermatological and oral characteristics were assessed with a semiquantitative clinical score. Three genotypes were present at microsatellite marker D11S1780 and two underlying mutations were identified. The most common genotype (183/183) was associated with an 815G --> C mutation in exon 6 resulting in an arginine to proline change at amino acid 272 (R272P). Patients with the 173/173 genotype revealed an exon 7 G300D mutation resulting in a glycine to aspartic acid change at amino acid 300. The mutation in a family with 189/189 genotype remained unknown. A significant difference in hyperkeratosis of the feet was found between the patients with mutations G300D and R272P ( p < 0.05), but not regarding hands or periodontal condition. Young girls displayed significantly less palmoplantar hyperkeratosis ( p < 0.05) than young boys. In conclusion, considerable phenotypic heterogeneity was observed within the two cardinal mutations and in the 189/189 genotype.
    Full-text · Article · Feb 2006 · Acta Dermato Venereologica
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    Abdullah Alfadley · Bo Hainau · Ahmed Al Robaee · Nusrat Banka
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    ABSTRACT: Becker's melanosis is a distinct clinical entity. It usually presents in adolescence as a unilateral, hyperpigmented, hairy cutaneous hamartoma. We report herein 12 cases of Becker's melanosis that differ in their presentation from classical Becker's melanosis, and we believe that such presentations are not uncommon.
    Preview · Article · Feb 2005 · International Journal of Dermatology
  • Ahmed Al Robaee · Issam R Hamadah · Sultan Khuroo · Abdullah Alfadley
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    ABSTRACT: Although the involvement of mucous membranes in Darier's disease is relatively uncommon, Darier's disease has been associated with mucosal lesions, especially in the oral mucosa. In the English literature there is only one report describing the involvement of esophageal mucous membranes in a patient with Darier's disease. Herein, we report the second case of Darier's disease with esophageal involvement.
    No preview · Article · Dec 2004 · International Journal of Dermatology
  • Ahmad Al Robaee · Nusrat Banka · Abdullah Alfadley
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    ABSTRACT: We describe a 23-month-old child with phakomatosis pigmentovascularis type IIb associated with Sturge-Weber syndrome. Phakomatosis pigmentovascularis type IIb is a rare cutaneous malformation characterized by the simultaneous occurrence of nevus flammeus and melanocytic nevi. A brief review of the literature is presented and classification of this rare disease is discussed.
    No preview · Article · Nov 2004 · Pediatric Dermatology
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    Al Robaee A · Al Hamadah I · Khuroo S · Alfadley A

    Full-text · Article · Jan 2004 · International Journal of Dermatology
  • Abdullah Alfadley · Ali Aljubran · Bo Hainau · Abdullah Alhokail
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    ABSTRACT: The papular-purpuric "gloves and socks" syndrome (PPGSS) is a unique exanthem characterized by petechiae with painful edema of the hands and feet extending proximally with less severity. Constitutional symptoms of fever, lethargy, and arthralgia have also been described. Human parvovirus B19 has been implicated in most cases as the causative agent. We describe a mother and her daughter presenting with the characteristic findings of PPGSS and demonstrating the seroconversion of human parvovirus B19 a few days after the onset of their illness. Additional clinical findings of cutaneous vesicles, bullae, and conjunctivitis are reported in the mother's case. To our knowledge, these are the first 2 cases of PPGSS in a household setting.
    No preview · Article · Jul 2003 · Journal of the American Academy of Dermatology
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    ABSTRACT: A 37-year-old man was first seen on 20 March 1997 for a 5-year history of widespread, persistent, and intensely pruritic skin lesions on all the extremities. Two years following the appearance of prurigo nodularis (PN), the patient developed a major depressive disorder for which he was given antidepressant agents (amitriptyline and clonazepam) by the psychiatrist. His past history also revealed hepatitis B virus infection. Examination revealed numerous, excoriated, erythematous papules and nodules on all extremities of variable size (ranging from 1 to 3 cm), accompanied by secondary pigmentary changes and scars ( Fig. 1). Investigations revealed normal complete blood count (CBC), urea, creatinine, and liver enzymes. Hepatitis B surface antigen was positive. The patient was treated with several modalities, including antihistamines and topical and intralesional corticosteroids, but with no significant improvement. His depressive symptoms failed to respond and he continued to deteriorate such that he started to exhibit suicidal gestures. On assumption that the continuous itching caused by PN was a major factor in his depression and with the risk of suicide, the decision was made to start thalidomide.On 20 July 1997, thalidomide was started at a dose of 100 mg twice a day after normal baseline work-up, which included a nerve conduction study, CBC, urea, creatinine, and liver function tests. Because of the history of hepatitis B infection, ultrasound of the liver was performed and was reported to be normal. All topical corticosteroids and antihistamines were discontinued and the patient was allowed to use emollient.On 10 August 1997, pruritus had decreased, but with no change in the skin lesions. The patient tolerated thalidomide, and the dose was increased to 100 mg every morning and 200 mg every evening.On 22 March 1998, there was no pruritus, and skin examination revealed the clearance of most of the lesions and flattening of others ( Figs 2 and 3). Central nervous system examination revealed mild sensory loss over both ankles. These changes were seen after a cumulative dose of 79 g. The dose was reduced to 100 mg orally twice a day. A nerve conduction study in May 1998 of three nerves (medial, perennial and surreal) confirmed the clinical findings of mild sensory neuropathy. Because of his very extensive and still active disease, the failure of previous therapeutic modalities, and history of suicidal gestures, full discussion concerning thalidomide side-effects was carried out with the patient and the neurologist, and the decision was made to taper his thalidomide gradually and to monitor for a worsening of neuropathy. During the last 3 months prior to the discontinuation of thalidomide (December 1998 to February 1999), the patient was on a maintenance dose of 50 mg every other day, reaching a cumulative dose of 111 g. A nerve conduction study at the end of treatment (February 1999), compared to the previous study in May 1998, showed a continuous decrease in amplitude of the sensory nerve action potential with unchanged sensory conduction velocity. His hemogram and blood chemistry remained within the normal range during treatment. Four months after the discontinuation of thalidomide, the patient is still in remission with residual hypo- and hyperpigmentation and a few scars, and his peripheral neuropathy has improved significantly.
    Full-text · Article · Jun 2003 · International Journal of Dermatology
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    ABSTRACT: We describe 2 patients with systemic lupus erythematous whose widespread discoid lupus erythematosus was unresponsive to systemic steroids and antimalarial agents. They showed dramatic improvement to thalidomide at a dose of 300 mg/d, with maximum benefit achieved within 15 weeks of therapy. Dosages of 50 to 100 mg/d were effective in maintaining remission for 1 year. However, thalidomide-induced neuropathy was observed in both cases.
    No preview · Article · Jun 2003 · Journal of the American Academy of Dermatology
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    ABSTRACT: Papillon-Lefèvre syndrome is an autosomal recessive disorder characterized by palmoplantar hyperkeratosis and early development of aggressive periodontal infection. The aims of this study were to rank the severity of dermatologic and oral affections using a semiquantitative scoring system, and to evaluate whether the severity of the dermatologic changes were correlated to age, degree of periodontal infection, or both. The study included 47 patients with Papillon-Lefèvre syndrome. With no exception both skin and oral changes developed early in life. The dermatologic involvement showed no correlation with age, whereas the periodontal infection was significantly worse in young children with deciduous teeth. A strong correlation was found between the condition of feet and hands, although the scores for the feet were significantly higher. No significant correlation could be demonstrated between the level of periodontal infection and severity of skin affections, supporting the concept that these 2 major components of Papillon-Lefèvre syndrome are unrelated to each other.
    No preview · Article · Apr 2003 · Journal of the American Academy of Dermatology
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    Khalid Al Aboud · Khalid Al Hawsawi · Abdullah Alfadley

    Full-text · Article · Feb 2003 · Acta Dermato Venereologica
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    Abdullah Alfadley · Khalid Al Hawsawi · Khalid Al Aboud
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    ABSTRACT: Ichthyosis follicularis (IF) is a very rare neurocutaneous, X-linked recessive condition affecting the skin, hair, eyes, and central nervous system (CNS). This report describes a child with facial dysmorphism, mental retardation, psychomotor delay, congenital alopecia of the scalp, eyebrows, and eyelashes, and extensive spiny follicular papules. A skin biopsy specimen showed the characteristic absence of sebaceous glands. We also reviewed the literature on this very rare entity. Additional findings observed in our patient, including hepatosplenomegaly, undescended testicles, and ptosis, have not been reported before.
    Full-text · Article · Jan 2003 · Pediatric Dermatology
  • Abdullah Alfadley · Khalid Al Hawsawi · Bo Hainau · Khalid Al Aboud
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    ABSTRACT: Keratosis follicularis spinulosa decalvans is a rare, X-linked disorder affecting both the skin and eyes. There are few reports about this entity. The aim of this report is to describe 2 brothers with progressive scarring alopecia of the scalp, hypotrichosis with follicular prominence of the eyelashes, and extensive keratosis pilaris. The second patient has Down syndrome with palmoplantar keratoderma and partial alopecia of the eyebrows. We also reviewed the literature about this uncommon entity.
    No preview · Article · Dec 2002 · Journal of the American Academy of Dermatology
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    Full-text · Article · Sep 2002 · International Journal of Dermatology
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    ABSTRACT: A 27-year-old man presented with a history of the absence of the nails of all the fingers and toes since birth. His parents were first-degree cousins and there was no other case in the family. The past medical history was unremarkable. Examination revealed the absence of all the nails of all the toes and fingers (Fig. 1). The teeth and hair were normal and there were no significant skin lesions. Other systemic examinations were normal. X-Ray of the hands and feet showed the presence of terminal phalangeal bones. The patient was diagnosed with anonychia congenita totalis simplex. Figure 1. Hands showing the absence of all the fingernails Download figure to PowerPoint
    No preview · Article · Aug 2002 · International Journal of Dermatology

Publication Stats

341 Citations
67.99 Total Impact Points

Institutions

  • 2000-2012
    • King Faisal Specialist Hospital and Research Centre
      • • Division of Internal Medicine
      • • Department of Medicine
      • • Department of Dermatology
      Ar Riyāḑ, Ar Riyāḑ, Saudi Arabia
  • 2001
    • King Khalid University
      Ebha, Minţaqat ‘Asīr, Saudi Arabia