Abbas Afrasiabi

Tabriz University of Medical Sciences, Tebriz, East Azerbaijan, Iran

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Publications (12)15.43 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: Simple, chip and rapid analytical methods are required in biomedical analysis laboratories to support therapeutic drug monitoring units in hospitals. The present work aimed to provide such a method for quantitative determination of carvedilol in plasma samples. Results: A new, simple, precise and efficient method was developed for the determination of carvedilol in human plasma using a dispersive liquid-liquid microextraction based on solidification of floating organic droplet, followed by spectrofluorimetry method. Some important parameters such as types and volumes of extraction and disperser solvents, pH, salt effect and sample volume were optimized. Under the optimized experimental conditions, the method provided a linear range of 40 to 300 ng ml(-1), with a correlation coefficient of 0.996. The limit of detection, lower limit of quantification and upper limit of quantification were 18, 40 and 300 ng ml(-1), respectively. The found recovery was from 98.2 to 102.2%, the mean intra- and inter-day precisions were 8.3 and 6.4%, respectively. The relative error for accuracy varied from 0.4 to 2.2%. The short-term temperature and freeze-thaw stability studies showed that carvedilol in human plasma was stable for sample preparation and analysis after storage. Conclusion: The proposed method provided reasonable acceptable results and could be used for therapeutic monitoring of carvedilol.
    No preview · Article · Feb 2013 · Bioanalysis
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    ABSTRACT: Congenital heart disease (CHD) patients bear a higher risk of scoliosis during their lifetime compared to their normal counterparts. On the other hand, operation on chest wall has been shown to increase the risk of scoliosis. However, the data are inconclusive. The present retrospective analysis is undertaken to determine the frequency of post-thoracotomy/sternotomy scoliosis in children with CHD. One hundred and eighty children with CHD who underwent thoracotomy/sternotomy and had a minimum followup of 3 years in a teaching center from 1997 to 2010 were recruited. After operation, all the patients were regularly examined for the development of scoliosis. 102 patients underwent thoracotomy and 78 sternotomy. Student's t test, Chi-square test, Fisher's exact test were used for statistical analyses. Eighty-eight males and 92 females with a mean age of 9.95 ± 2.31 (range: 5-15) years were enrolled. The mean age at operation was 2.59 ± 1.66 (range: 0-9) years and the mean follow-up period was 7.36 ± 2.12 (range: 5-13) years. Scoliosis was confirmed in two patients (1.1%): 1 (1%) in the thoracotomy group (a 12-year-old female operated 2 years earlier with a spinal 22° convexity to the right and 78° kyphosis) and another (1.1%) in the sternotomy group (an 8-year-old female operated during her neonatal period with a spinal 23° convexity to the left). Scoliosis is not a common finding among the operated children with CHD in our center.
    No preview · Article · Mar 2012 · Indian Journal of Orthopaedics
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    ABSTRACT: We assessed the association between common carotid and common femoral artery intima-media thickness (ccIMT and cfIMT, respectively), histopathologic severity of atherosclerosis in the ascending aorta/aortic arch, and the extent of coronary artery disease (CAD) in 150 candidates for elective coronary artery bypass grafting (CABG). One-, 2-, and 3-vessel diseases were present in 20%, 25.9%, and 54.1%, respectively. Although no significant relationship was present between the ccIMT and the number of occluded coronary vessels (P = .41), both the cfIMT and severity of atherosclerosis in the ascending aorta/aortic arch were predictive of more extensive CAD (P = .03 and .01, respectively). Neither the ccIMT nor the cfIMT was correlated with the severity of aortic atherosclerosis (P = .81 and .63, respectively). In conclusion, both cfIMT and atherosclerosis of ascending aorta/aortic arch are independent predictors of CAD extent. However, interrelationships between these 2 variables as well as the ccIMT are complex in CABG candidates.
    No preview · Article · Feb 2012 · Angiology
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    ABSTRACT: In humans, the existence of an anterior periaortic fat pad (AFP) containing parasympathetic ganglia has been described in the aortopulmonary window. Changes in the autonomic nervous system (ANS) tone can lead to postoperative atrial fibrillation (POAF). The AFP is usually removed during coronary bypass grafting (CABG) to fully expose the aortic root. The purpose of this study was to evaluate the influence of AFP removal during CABG on the ANS tone, incidence of POAF, hospital stay, and in-hospital morbidity and mortality. A total of 215 patients were randomized in this prospective, double-blind trial to either removal (n=107) or maintenance (n=108) of the AFP during their first CABG. All patients underwent continuous telemetry monitoring after surgery. They underwent at least 1-h Holter monitoring on the second postoperative day. Heart rate variability measurements of both time-domain and frequency-domain analysis were included. POAF was defined as AF for more than 5min or causing hemodynamic instability. The mean age was nearly 58 years, and 76% were male. There was no difference in the incidence of POAF between the retained and removed AFP groups (19.3% vs 17%, respectively; P=0.664, odds ratio=1.16). Mean heart rate and heart rate variability parameters, in-hospital stay, and postoperative morbidity and mortality were similar in both groups. Removal of the AFP during CABG has no significant effect on the incidence of POAF, ANS tone, and postoperative morbidity or mortality.
    Preview · Article · Apr 2011 · European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery
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    ABSTRACT: Objectives: Acute dissection of the ascending aorta requires immediate surgical intervention. Use of the re-implantation technique in patients with severe aortic insufficiency remains controversial. In this study we assessed the feasibility and outcome of the valve-sparing aortic root re-implantation technique in patients with severe preoperative aortic insufficiency. Methodology: Between April 2005 and March 2008, 19 patients with acute aortic dissection of the ascending aorta (Stanford type A) underwent valve sparing aortic root reconstruction. Their ages ranged from 24 to 76 years (51.7±13.2, 58% males). Transesophageal echocardiography was carried out for diagnosis of disease, left ventricle ejection fraction and valve insufficiency. Length of hospitalization, echocardiographic and clinical follow-up, complications and mortality were analyzed. Results: Four patients (21%) died of non-valve-related complications. Major complications after operation were seen in three patients (15.8%). Mean length of stay in the intensive care unit (ICU) was nine days, and the mean duration of hospitalization were 16 days. Comparison of pre- operative and post-operative clinical profiles of patients showed that left ventricle ejection fraction and severity of aortic insufficiency were significantly altered (P<0.05). Comparison of patients who survived with those who died showed that only cardio pulmonary bypass time had statistically significant difference (P=0.04). Conclusion: Valve sparing aortic root reconstruction in patients with type A dissection can be performed with acceptable intra-operative mortality and morbidity and excellent results during follow-up.
    Full-text · Article · Mar 2011 · Pakistan Journal of Medical Sciences Online
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    ABSTRACT: A 20-year old female with a rare anomaly of aortocaval tunnel to superior vena cava is presented. Rare cases of congenital communications between aorta and right sided of the heart has been reported previously. The patient underwent surgical repair and had uneventful recovery.
    Preview · Article · Jan 2011
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    ABSTRACT: Coronary artery bypass graft (CABG) surgery is one of the most commonly performed surgical procedures worldwide, and it may be accompanied by postoperative neurocognitive impairment. Although this complication has been attributed to the use of cardiopulmonary bypass, it is still a matter of debate whether the switch from on-pump to off-pump technique affects the cognitive function. The aim of this study was to compare the impact of the on-pump and off-pump techniques on neurocognitive impairment in low-risk CABG surgery groups. In a descriptive and analytic study, 201 CABG patients with left-ventricular ejection fraction >30%, and without cardiac arrhythmia were enrolled. Before the elective operation, all patients underwent neurological examination and neurocognitive test, Mini-Mental State Examination (MMSE). Two months following the operation, both on- and off-pump, the patients were re-examined by MMSE to detect any neurocognitive impairment. Out of 154 patients included in the study, 95 (61.6%) and 59 (38.3%) patients were in off-pump and on-pump groups, respectively. Mean age of the patients was 57.17 ± 9.82 years. A 2-month postoperative neurocognitive impairment was detected among 17 patients of on-pump group (28.8%) and in 28 cases of off-pump group (29.4%) (P = 0.54). The mean postoperative MMSE scores were not comparable between groups (25.01 ± 4.49 in off-pump group versus 23.73 ± 4.88 in on-pump group, P = 0.09). The present study revealed that in low-risk patients undergoing CABG surgery, either the techniques of on-pump or off-pump did not differ regarding the neurocognitive outcome 2 months after the procedure.
    Full-text · Article · Nov 2010 · Neuropsychiatric Disease and Treatment
  • N. Eshraghi · M. Tarzamni · A. Afrasiabi · N. Safaie · M. Halimi · A. Eshraghi
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    ABSTRACT: Background: A correlation between coronary artery disease (CAD) and atherosclerosis of peripheral arteries and the determination of noninvasive indexes for its existence and extent have been sought by many researchers. Some studies report that the intimamedia thickness (IMT) of peripheral arteries could play this role. This study evaluated the correlation between the IMTs of common carotid and common femoral arteries and the degree of atherosclerosis in aortic arch and to evaluate the severity of CAD in candidates of coronary artery bypass grafting (CABG). Methods: In a cross-sectional analytic-descriptive study, The severity of CAD, the grade of atherosclerosis of the aortic arch, and the IMTs of the common carotid and common femoral arteries were determined. Results: There was a significant weak positive correlation between the IMT of common carotid artery (ρ = 0.193, p = 0.039) and common femoral artery (ρ = 0.206, p = 0.028) with the number of involved carotid vessels; the mean of these two parameters was not significantly different between the three CAD groups. There was not any significant relation between the IMTs of common carotid and common femoral arteries with the severity of atherosclerosis in the aortic arch too. There was not any significant relation between the presences of atherosclerotic plaque in the common carotid or the common femoral arteries with the severity of CAD. The severe atherosclerosis of the aortic arch was significantly higher in patients with three vessel disease. Conclusion: According to our results, the IMTs of common carotid and/or common femoral arteries may increase with the severity of CAD; however, these parameters are not a surrogate for predicting the CAD severity.
    No preview · Article · Oct 2010 · Tehran University Medical Journal

  • No preview · Article · Jun 2010 · Atherosclerosis Supplements
  • Mehrnoush Toufan · Abbas Afrasiabi · Leili Pourafkari
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    ABSTRACT: Cardiac hydatidosis is rarely encountered. A case of isolated cardiac hydatid cyst of the left ventricle in a young woman is described. The diagnosis was suggested by echocardiography and was confirmed later by pathological evaluation. Serological tests were negative. The patient underwent a successful operation for cyst resection.
    No preview · Article · Feb 2010 · Kardiologia polska
  • M Toufan · A Afrasiabi
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    ABSTRACT: This cross-sectional study was performed in patients following coronary interventions, to evaluate the effect of cardiac rehabilitation on functional capacity, maximum heart rate on exercise and serum lipid profiles. Consecutive patients after coronary artery intervention randomly referred to cardiac rehabilitation. All patients underwent based exercise tolerance test to define exercise capacity. Blood samples were obtained to measure based plasma lipid profiles and nutritional counseling provided to all participants. Also, psychological evaluation was performed with the some documented questionnaire to explore emotional, behavioral and psychological state. After completion of cardiac rehabilitation in all patients, reassessment of work capacity, plasma lipid profile and psychological state were performed. After cardiac rehabilitation for 8-12 weeks, functional capacity improved in 83% of patients (p<0.001) and maximal heart rate at the same time on exercise decreased in 72%. The average time on treadmill was 7.76 min before and 9.56 min after cardiac recreation (p<0.001). After cardiac rehabilitation, plasma total cholesterol, low-density lipoprotein and triglyceride significantly decreased. At the end, 97% of patients returned to work and had sense of well-being. Cardiac rehabilitation has important impacts on improving functional capacity, well being sensation, return to work and decreasing serum lipid profiles in coronary patients.
    No preview · Article · Oct 2009 · Pakistan Journal of Biological Sciences
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    ABSTRACT: Atherosclerosis is a pathogenesis which is common in both coronary and intracranial arterial diseases. Therefore, we designed a group of coronary artery bypass graft (CABG) surgery patients for transcranial Doppler (TCD) to assess intracranial artery diseases and carotid duplex studies to assess carotid artery diseases. In a prospective randomized study, 129 elective CABG patients with proven coronary artery disease by angiography, were examined by TCD and 45 patients by carotid duplex preoperatively. Neurologic examination was carried out pre- and post- operatively. This study was carried out from April 2001 to August 2002 at Imam Hospital of Tabriz Medical Science University, Iran. Out of the 129 CABG patients, there were 105 males and 24 females, with an average age of 57+\-9.9 years. Risk factors were as follows: smoking in 44.8%, hypertension in 38%, hypercholesterolemia in 29%, and diabetes mellitus in 18.6%. The TCD findings of 30 patients (23.2%, 11 female and 19 male) revealed the following abnormalities: stenosis of basilar artery in 7 patients (5.4%), carotid siphon in 3 (2.3%), intracranial internal carotid in 5 (3.9%), middle cerebral artery in 3 (2.3%) and vertebral artery in one patient (0.8%). Multiple vessel abnormality was detected in 11 patients (8.5%). There was a significant correlation between severity of coronary artery disease in angiography and abnormality in TCD (p=0.008). The TCD abnormality was detected more in females (p=0.008) or hypertensive patients (p=0.004). In the carotid duplex study of the randomized 45 patients, 23 (51.1%) had abnormal results as follows: stenosis <50% in 17 (38%) cases, stenosis between 50-70% in 5 (11%), and hemodynamically significant stenosis (>70%) only in one (2%) patient. There was also significant correlation between severity of coronary involvement and carotid involvement (p<0.01). No stroke occurred in the first postoperative week following CABG surgery. Stenosis of intracranial and carotid arteries was more common in CABG patients with more than 2-coronary vessel involvement or hypertensive or female patients. We recommend TCD and carotid duplex studies in these patients for prevention of probable cerebrovascular accidents.
    No preview · Article · Jul 2004 · Neurosciences