Zongxian Jiao

Lanzhou University, Kao-lan-hsien, Gansu Sheng, China

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Publications (2)6.15 Total impact

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    ABSTRACT: Brain protein kinase B (Akt) and glycogen synthase kinase-3 (GSK-3) activities are adaptable to changes of peripheral blood glucose level in vivo. GSK-3 phosphorylates microtube-associated protein tau at multiple sites, which can be antagonized by protein phosphatase-2A (PP-2A). The imbalance among these enzymes might have potential connections with diabetes mellitus (DM) and Alzheimer's disease (AD). In this study hyperglycemia rat DM model was achieved by streptozotocin (STZ) treatment. The phosphorylation of tau in the rat hippocampus was detected with specific antibodies. Insulin and Li(2)CO(3) administration were also employed to find out the regulatory efforts of the kinases. We observed that rat hippocampus tau was hyperphosphorylated at Ser(396)/Ser(404) (PHF-1 sites) in STZ-induced DM model, accompanied by lowered phosphorylation levels of Akt, GSK-3 and PP-2A. Lithium, a specific GSK-3 inhibitor, nearly reversed all phosphorylation of tau at above sites in 30days. Insulin administration restored the blood glucose level in DM rats but suppressed PP-2A activity, resulting in the PHF-1 sites of tau not being dephosphorylated. These findings strongly suggest that STZ-induced hyperglycemia may cause disorder of Akt/GSK-3/PP-2A regulations in rat brain and further lead to abnormal phosphorylation of hippocampus tau.
    No preview · Article · Apr 2011 · Brain research
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    ABSTRACT: Oesophageal gastrointestinal stromal tumours (GISTs) are extremely rare. The preoperative diagnosis is complicated by lack of specificity and the clinical features of patients with oesophageal GISTs need to be fully studied. We have reviewed retrospectively the medical records of those patients who are treated surgically for oesophageal GISTs in our two hospitals. Eight oesophageal GISTs were identified among the 63 oesophageal mesenchymal tumours in our two hospitals in the past 30 years. Of the eight patients, the male:female ratio was 5:3; the median age of the patients was 57 years (range 49-71 years). Dysphagia was the most common symptom, and all cases were diagnosed postoperatively. The tumours were resected by enucleation or oesophagectomy. The median follow-up was 59 months, ranging from 14 to 202 months, with four of the patients succumbing to the disease, among them two with recurrence and another two with metastasis. Our study indicates that oesophageal GIST is rather rare, and it has relatively high recurrence and mortality rates, especially for patients with large tumours (larger than 9 cm). At present, surgical resection and postoperative diagnosis remain the mainstay for treatment of patients with oesophageal GISTs in China.
    No preview · Article · Mar 2010 · European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery