Tahsin Selçuk

Karaman State Hospital, Laranda, Karaman, Turkey

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Publications (11)9.85 Total impact

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    ABSTRACT: The diagnostic role of cyclooxygenase-2 (COX-2) expression in laryngeal atypical hyperplasia, vocal fold nodule, and laryngeal squamous cell carcinoma was examined. Specimens obtained from patients diagnosed with vocal fold nodule (n = 35), atypical hyperplasia (n = 35), laryngeal squamous cell carcinoma (n = 35), and clinical parameters were evaluated retrospectively. Although no staining was observed in patients with vocal fold nodules, staining was noted in laryngeal atypical hyperplasia and squamous cell carcinoma. The percentage of COX-2 staining was the highest in the carcinoma group. It was determined that COX-2 staining was significantly associated with laryngeal squamous cell carcinoma. It should be noted that overexpression of COX-2, a potentially important factor in the evolution of carcinogenesis in precancerous lesions, might be an indicator of the development of carcinoma. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
    No preview · Article · Jan 2013 · Head & Neck
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    ABSTRACT: Success rates for revision dacryocystorhinostomy (DCR) are lower than primary DCR. Scarring of the sac may limit the surgeon's ability to achieve good nasal and lacrimal mucosa apposition. The aims of this study were to assess the long term safety and efficacy of intra-operative use of adjunctive mitomycin C (MMC) treatment in endoscopic revision DCR surgery over 12-24 (mean 17) months. This was a prospective, nonrandomized consecutive case series that included 20 adult patients (20 eyes) with failed primary external DCR who underwent revision surgery under assisted local anaesthesia. During revision endoscopic DCR, intra-operative adjunctive MMC (0.2 mg/mL) was applied to the osteotomy site of the lacrimal sac and scar tissue surrounding the surgical osteum for 5 minutes. The surgical success rate was determined based on the patency of the nasolacrimal system by irrigation and resolution of patient symptoms. Endoscopic revision DCR surgery with MMC was successful in 90% of cases (18 of 20 cases). No adverse effects (eg, abnormal nasal bleeding, mucosal necrosis, infection) or any other surgical adverse events were observed. Adjunctive intra-operative MMC application with endoscopic DCR surgery had a good success rate in patients with nasolacrimal duct obstruction that required revision surgery. Further large, double blind, placebo controlled, randomized studies are needed to confirm these findings.
    No preview · Article · Aug 2012 · B-ENT
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    ABSTRACT: External auditory canal tick bites are quite rare conditions. Ticks are arthropods that mediate transmission of many diseases including Crimean-Congo hemorrhagic fever. Climatic changes caused by global warming, seasonal changes and geographic location are factors facilitating the reproduction of tick population and increasing the occurence of tick borne diseases. The aim of this report was to present patients who presented to our clinic with tick bite. One patient presented with a sense of mobile foreign body in the ear and another one with ear obstruction. While the third patient had excessive itching, the fourth one had an earache. The patients did not have other systemic or local complaints. The examination of the external auditory canal revealed a tick attached to the posterior upper part of the right external auditory canal in the first patient. A tick was attached to the left tympanic membrane in the second patient with ear obstruction, in the third and the fourth patients, ticks were close to the skin of the left external auditory canal. Ticks were removed carefully from the external auditory canal and they were obtained alive. The patients were monitored in an outpatient setting for 14 days after being informed about the complaints. No additional problems developed on follow-up. The technique of removal of the ticks from the body and follow up measures were presented in this paper.
    No preview · Article · Jun 2012 · Turkiye Klinikleri Journal of Medical Sciences
  • S. Ozdemir · O. Gorgulu · Y. Akbas · T. Selcuk · G. Donmez
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    ABSTRACT: Anomalies of the first branchial cleft are rare congenital malformations of the head and neck, making up 8% of all branchial cleft anomalies. Presented here is a case of a 41-year-old female patient with a 30-year history of mild swelling inferior to the left lobulus auriculae, who complained of discharge from the left ear which responded to external otitis media treatment. She presented with discharge from a fistula opening on the posteroinferior aspect of the left mandibular angle of one-year duration. Following extensive workup and surgical exploration, it was discovered that the fistula tract traversed across the midline of the neck, deep to the main trunk of the facial nerve with an opening at a point anteroinferior to the left external acoustic meatus. The main trunk of the facial nerve and it branches were first isolated, followed by complete excision of the fistula tract along with surrounding skin and cartilage which formed part of the external acoustic meatus. The patient did not show any signs of postoperative facial weakness. In spite of their rarity and the difficulties associated with making a correct diagnosis, anomalies of the first branchial cleft should always be considered in the differential diagnosis, particularly in patients with ear discharge resistant to treatment despite the presence of an intact ear drum.
    No preview · Article · May 2012 · Journal of International Advanced Otology
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    ABSTRACT: Rhinoliths are nasal stones that result from mineralisation of salts around an endogenous or exogenous nidus within the nasal cavity. They are uncommon nasal masses and usually unilateral and single, situated in the floor of the nose. The patient typically presents with nasal obstruction, facial pain and foul-smelling nasal secretion. To the best of our knowledge, the occurrence of squamous cell carcinoma with rhinolithiasis has not been previously reported in the English-language literature. In this article, we present a 63-year-old man, who had unilateral rhinolithiasis with squamous cell carcinoma within the nasal cavity.
    No preview · Article · Sep 2011 · Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • S Ozdemir · O Gorgulu · T Selcuk · Y Akbas · C Sayar · H Sayar
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    ABSTRACT: We report an extremely rare case of giant fibrovascular polyp of the hypopharynx. We present a 49-year-old man who had increasing difficulty swallowing, advanced respiratory distress and weight loss, as well as a hypopharyngeal mass protruding from his mouth. Diagnosis was confirmed by endoscopic examination and computed tomography. A tracheostomy was required due to laryngeal obstruction by the regurgitated mass. The giant polyp was removed via per-oral endoscopic excision under general anaesthesia. Fibrovascular polyps occur most commonly in the cervical oesophagus, and are extremely rare in the hypopharynx. They can grow to a very large size over several years. We discuss the symptoms, diagnosis and surgical treatment techniques for upper aerodigestive tract fibrovascular polyps, in the light of the literature.
    No preview · Article · May 2011 · The Journal of Laryngology & Otology
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    O Gorgulu · T Selcuk · S Ozdemir · C Sayar · Y Beyazit · Y Akbas
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    ABSTRACT: Metabolic changes in head and neck carcinogenesis are often non-specifically correlated with carcinomas. The study of metabolic disorders can improve the understanding of tumourigenesis at the cellular level. This study was designed to evaluate the role of serum homocysteine, folate, and vitamin B(12) levels in the pathogenesis of laryngeal squamous cell cancer (LSCC) by measuring serum levels in 60 consecutive untreated patients with LSCC and 60 controls (30 smokers and 30 non-smokers). Compared with smoker and non-smoker control groups, significantly lower levels of vitamin B(12) were found in patients with LSCC. Folate levels in patients with LSCC were also significantly lower than in the smoker and non-smoker control groups. There were no significant differences in the homocysteine levels between these three groups. Metabolic alterations in vitamin B(12) and folate levels, particularly hypofolataemia, could be associated with the development of LSCC, although further research is required to confirm their roles definitively.
    Full-text · Article · Dec 2010 · The Journal of international medical research
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    ABSTRACT: Rhinolithiasis is masses that result from the deposition of salts around an intranasal foreign body. Rhinoliths are rare and rhinolithiasis is generally reported in the literature in single case studies. This study presents 21 cases of rhinolithiasis with a large series of clinical findings, diagnosis, and treatment. A total of 21 patients diagnosed with rhinolithiasis were identified. Clinical presentations, signs, and symptoms of the patients with radiological findings are presented, and x-ray diffraction analyses of three of the removed rhinoliths were performed to assess their mineralogical composition. A total of 21 patients (9 male and 12 female patients; age range, 4-63 years) diagnosed with rhinolithiasis were reviewed in this study. The most common symptoms were noted as purulent rhinorrhea and nasal obstruction. The other symptoms were headache, oral malodor, and recurrent epistaxis. Nasal endoscopic examination was used for diagnosis of all patients. Endoscopic nasal examinations and computerized tomography (CT) findings revealed that rhinolithiasis was accompanied by sinusitis, chronic vestibulitis, allergic rhinitis, septum deviation, and squamous cell carcinoma. Rhinoliths were fully excised by using endoscopic nasal surgery. Mineralogical analyses of the three removed stones revealed dahllite [Ca(5)(PO(4),CO(3))(3)OH]. Cases of rhinolithiasis are seen rarely. It should always be considered in patients complaining from long-term unilateral nasal obstruction and unilateral purulent rhinorrhea. The treatment involves the removal of the rhinolith and the use of appropriate antibiotic therapy to control local infection. Rigid nasal endoscopy is the most important method to be used in diagnosis and treatment.
    No preview · Article · Oct 2010 · American Journal of Rhinology and Allergy
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    ABSTRACT: Sinüs histiocytozis with massive lymphadenopaty (SHML), also known as Rosai-Dorfman disease, is a rare clinicopathologic entity of unknown etiology . The disease is characterized by painless cervical lympadenopathy , variably associated with fever, elevated er yt r ocyt e sedi ment at i on r at e, Wei ght l oss, pol i cl onal hypergammaglobulinemia and involment of extranodal organs such as skin, upper respiratory trakt, bone and central nervous system. Although it affects all age groups, it is more commonly seen in their first or second decades. A 14 years old woman presented with an enlarged bilateral cervical lymphadenopathy . The precise diagnosis is performed by lymp node fine-needle aspiration and biopsy
    No preview · Article · Jan 2010

  • No preview · Article · Jan 2010 · Turkiye Klinikleri Journal of Medical Sciences
  • S. Özdemir · T. Selçuk · E. Canpolat · Y. Akbafl
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    ABSTRACT: Özet Amaç: Rinolitler, nazal kavitede endojen veya ekzojen bir nidus etraf›nda tuzlar›n birikmesiyle meydana gelen tafllard›r. Nadir görülürler ve uzun süre boyunca tan› konulmazsa nazal obs- trüksiyona yol açacak kadar büyüyebilirler. Genellikle burun t›- kan›kl›¤› ve kötü kokulu ak›nt› hastalar›n doktora esas baflvuru sebepleridir. Tan›da nazal endoskopi en önemli yeri tutar. Bo- yut ve çevre dokularla iliflkisini saptamak amac›yla sinüs grafisi ve bilgisayarl› tomografi istenebilir. Tedavisi cerrahi olarak rino- litin ç›kar›lmas›d›r. Literatür incelendiinde rinolityazis genelde tek olgular halinde raporlanm›flt›r. Bu çal›flmada rinolityazisi olan 16 hastal›k genifl seri klinik bulgular, tan› ve tedavi aç›s›n- dan incelenerek sunulmufltur. Yöntem: Ocak 2005 ile Haziran 2008 tarihleri aras›nda kliniimiz- de rinolityazis tan›s› alan 16 hasta retrospektif olarak incelendi. Bulgular: Rinolityazis tan›s› alan 16 hasta (5 erkek, 11 bayan) incelendi. Hastalar›n ortalama yafl› 17.8 (4 ila 34 yafllar aras›) idi. Burun t›kan›kl›¤›, pis kokulu burun ak›nt›s›, burun ve a¤›z- da kötü koku en s›k flikayetler olarak not edildi. Tan› için nazal endoskopik muayene en önemli yeri oluflturdu. Radyolojik in- celeme için Water's grafisi veya bilgisayarl› tomografi kullan›l- d›. Hastalarda rinolityazise efllik eden hastal›klar aras›nda sinü- zit (%50), kronik vestibülit (%37), alerjik rinit (%18), septum deviasyonu (%12.5) vard›. Tedavide; rinolitler 7 hastada lokal, 9 hastada genel anestezi alt›nda endoskopik cerrahi yöntemiy- le ç›kar›ld›. Septum deviasyonu olan 2 hastaya ayn› seansta en- doskopik septoplasti yap›ld›. Sonuç: Rinolityazis olgular› nadir görülmesine ramen özellikle uzun süreli burun t›kan›kl›¤›, kötü kokulu burun ak›nt›s› ile bu- run ve a¤›zda kötü koku flikayeti olan hastalarda mutlaka akla gelmelidir. Tedavide rinolitlerin ç›kar›lmalar› gereklidir. Rijit na- zal endoskoplar, tan›da ve tedavide önemli ölçüde yard›mc›d›r.
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