- [Show abstract] [Hide abstract] ABSTRACT: Inflammatory breast cancer (IBC) is the most aggressive and fatal form of invasive breast cancer. The disease affects approximately 2.5% of breast cancer patients in the United States typically with younger age of onset and higher incidence in African-Americans. Incidence rates vary due to the clinical nature, rather than pathological, of the diagnosis. Changes to the SEER coding rules will also likely have an impact on IBC reporting rates. Epidemiological observations have also suggested geographic differences in the incidence of IBC but without resulting in the identification of risk factors. Few risk factors have been established but associations have been noted with African American race and younger age of onset, as well as high BMI. Decreased survival rates in patients with ER-negative tumors have also been noted. An ongoing registry is being conducted at The University of Texas MD Anderson Cancer Center to address this issue. It is a prospective registry, and although relatively small, some observations of note can be made. The patients enrolled on the registry have a mean age at diagnosis of 55 years and over half of the patients present with ER-negative tumors. Also 18% of the patients reported a first-degree relative with breast cancer. The majority was overweight or obese and were former or still currently smokers. The registry includes sites in both the United States and internationally and information collected in the registry will be used in order to further elucidate the etiology and risk factors for IBC.
- [Show abstract] [Hide abstract] ABSTRACT: Inflammatory breast cancer (IBC) is a rare and aggressive form of invasive breast cancer accounting for 2.5% of all breast cancer cases. It is characterized by rapid progression, local and distant metastases, younger age of onset, and lower overall survival compared with other breast cancers. Historically, IBC is a lethal disease with less than a 5% survival rate beyond 5 years when treated with surgery or radiation therapy. Because of its rarity, IBC is often misdiagnosed as mastitis or generalized dermatitis. This review examines IBC's unique clinical presentation, pathology, epidemiology, imaging, and biology and details current multidisciplinary management of the disease, which comprises systemic therapy, surgery, and radiation therapy.