Shih-Chi Wang

Chung Shan Medical University, 臺中市, Taiwan, Taiwan

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Publications (5)26.81 Total impact

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    ABSTRACT: Coordination polymers of metal-croconate (C5O52−) complex, {[Ni2(bpe)2(C5O5)2]·H2O}n (1) (bpe = 1,2-bis(-4-pyridyl)ethylene)) with two-dimensional (2D) metal–organic frameworks (MOF), have been synthesized under hydrothermal conditions and characterized by single-crystal X-ray diffraction studies. Structural determination reveals that compound 1 contains two crystallographically independent Ni(II) ions which both lie in a distorted octahedral environment bonded to two bpenitrogen atoms and four oxygen donors from two croconates. The croconate acts as a bridging ligand with two different bridging modes, one presents a bis-bidentate adjacent μ3-coordination mode and the other a bis-bidentate μ4-coordination mode. A 2D brick-wall-like layered framework is formed by using a rectangle grid as a basic building unit through the connectivity of NiII with hybrid μ3-, μ4-croconates and bpe ligands. Two layers are then cross-linked by the other bpe ligands to complete a 2D bi-layered MOF. The TGA associated with in situ XRD measurements demonstrated that 1 have quite high thermo-stability that keep their crystalline forms up to 350 °C. Magnetic measurements show the long range magnetic ordering and spin canting behavior in 1 below the critical temperature of 22 K with an approximate canting angle of 0.79°. A large coercivity of 3.5 kOe in the hysteresis loop is observed at 1.8 K, indicating that 1 is a weak hard magnet.
    Full-text · Article · Dec 2010 · CrystEngComm
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    ABSTRACT: We analyzed autoantibodies against tumor-associated antigens (TAAs) in the serum of patients with endometrioma and healthy controls to determine whether autoantibodies can be accurate biomarkers for the diagnosis of ovarian endometrioma. Serum samples were obtained from 56 patients with endometriosis and 66 healthy women who served as normal controls. The titers of antibodies against a panel of eight TAAs were analyzed using enzyme-linked immunosorbent assay. We found that the serum IGFII mRNA-binding protein 1 (IMP1) autoantibody and cyclin B1 autoantibody could discriminate between healthy controls and endometriosis patients (AUC-ROC 0.777; 95% confidence interval [CI] 0.694-0.860, P<0.0005, and AUC-ROC 0.614; 95%confidence interval [CI] 0.513-0.714, P=0.031, respectively). Using 0.073 and 0.007 as the cutoff values for IMP1 and Cyclin B1 autoantibody, respectively, the sensitivity and specificity of IMP1 were 85.7 and 63.6%, respectively. When cylcin B1 was combined with IMP1, the specificity increased to 72.7% and the sensitivity slightly decreased to 83.9%. Our data suggest that IMP1 alone or combined with cyclin B1 seems to fulfill the requirements of sensitivity and specificity to become a useful clinical biomarker of endometrioma. However, further studies will be required to establish the predictive value and to support the clinical use of IMP1/cyclin B1 in the diagnosis and/or screening of endometriosis.
    No preview · Article · Sep 2010 · Journal of Clinical Laboratory Analysis
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    ABSTRACT: A library of 27 sialosides, including seventeen 2,3-linked and ten 2,6-linked glycans, has been prepared to construct a glycan array and used to profile the binding specificity of different influenza hemagglutinins (HA) subtypes, especially from the 2009 swine-originated H1N1 and seasonal influenza viruses. It was found that the HAs from the 2009 H1N1 and the seasonal Brisbane strain share similar binding profiles yet different binding affinities toward various α2,6 sialosides. Analysis of the binding profiles of different HA subtypes indicate that a minimum set of 5 oligosaccharides can be used to differentiate influenza H1, H3, H5, H7, and H9 subtypes. In addition, the glycan array was used to profile the binding pattern of different influenza viruses. It was found that most binding patterns of viruses and HA proteins are similar and that glycosylation at Asn27 is essential for receptor binding.
    Full-text · Article · Sep 2010 · Journal of the American Chemical Society
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    ABSTRACT: Two new polymorphs (C and D) of [t-Fe(abpt)(2)(NCS)(2)] are characterized, a commensurate modulated structure with the c axis tripled in the thermally quenched metastable high spin state at 25 K is found in polymorph C.
    No preview · Article · Dec 2009 · Chemical Communications
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    ABSTRACT: Inspired by polyhydroxylated pyrrolidine alkaloid natural products, a 18-membered library of 2-aryl polyhydroxylated pyrrolidines has been efficiently prepared in two or three synthetic steps from the known chiral cyclic nitrones with high yield and purity and excellent stereoselectivity. The inhibitory activity of all these compounds against various glycosidase enzymes was evaluated. Interestingly, 15 and 19 show better inhibitory activities than radicamine A (20) and B (18) against alpha-glucosidases. The IC(50) values of 15 and 19 are 1.1 and 0.5 microM, respectively. In this study, we also discovered the substituent(s) on the aryl ring could affect the inhibition potency and selectivity against glycosidases.
    No preview · Article · Jan 2009 · Bioorganic & medicinal chemistry

Publication Stats

141 Citations
26.81 Total Impact Points


  • 2010
    • Chung Shan Medical University
      臺中市, Taiwan, Taiwan
    • National Yang Ming University
      T’ai-pei, Taipei, Taiwan
  • 2009-2010
    • National Taiwan University
      • Department of Chemistry
      T’ai-pei, Taipei, Taiwan
    • Academia Sinica
      • Genomics Research Center
      T’ai-pei, Taipei, Taiwan