[Show abstract][Hide abstract] ABSTRACT: Fibrous bone lesions are classified as ossifying fibroma, fibrous dysplasia, and cement-osseous dysplasia. Ossifying fibroma is further classified into juvenile psammomatoid ossifying fibroma (JPOF) and juvenile trabecular ossifying fibroma (JTOF). Although JPOF is histologically benign, it is locally invasive, which is very rare for a benign tumor. Here, we report a rare case of left ethmoid sinus JPOF that underwent endoscopic tumorectomy. The patient was a 7-years and 5-month-old boy, who developed left ophthalmocele 2 months before he visited the ophthalmology department. MRI of orbits revealed a solid tumor within the left ethmoid sinus, so the patient was referred to us. The tumor was 38 × 24mm in size, and exhibited high-intensity signal on T2-weighted image and relatively high intensity signal on T1-weighted image. Plain CT showed that the tumor had relatively high-density areas inside, compressed surrounding bone, and displaced the left eye-orbit lateral wall with partial wall defects. The patient did not have visual field defect or impairment of vision. He underwent endoscopic tumorectomy with an inferior nasal and parasinus approach under general anesthesia. The tumor was elastic and hard, surrounded by an ossifying septal structure, and the interior of the tumor was hemorrhagic. Partial defect of the medial orbital wall was found and the bleeding amount was significant. Thus, we only removed the ossifying septum of the tumor at the middle nasal meatus for diagnostic purposes and left the septum of the tumor at the orbit side. Pathological examination revealed JPOF.
[Show abstract][Hide abstract] ABSTRACT: Of the patients seen for cervical neurinomas at our department between April 2005 and March 2014, 31 underwent intercapsular resection. Of them, we investigated 10 in whom the condition originated in the vagus nerve. 3 patients showed postoperative neurological deficit. One patient improved within 3 months, but the others did not improve. Hoarseness, dysphagia and coughing attack may be caused in cases by a neurinoma operation in the vagus nerve, which may greatly affect a patient's occupation and quality of life. Before operation, informed consent must be obtained, and relevant surgical experience should be acquired in addition to taking any disadvantages into account.
[Show abstract][Hide abstract] ABSTRACT: We review 38 cases in whom intercapsular resection for neck schwannoma was carried out at our center from April 2005 to January 2015. We examined the age, sex, neurological symptoms before the operation, size of tumor, and neurological symptoms after the operation. The same surgeon conducted all of the intercapsular resections.The results indicated that postoperative neurological deficits occurred in 8 cases (21.1%). Among these cases, paralysis which did not improve occurred in 2 cases (5.3%) and temporary paralysis in 6 cases (15.8%). However, the patients did not suffer problems for daily living. It is considered that surgery by this method is an option instead of follow-up. We must also explain the merits and demerits of follow-up and operation.
[Show abstract][Hide abstract] ABSTRACT: Aims:
In recent years, there has been an increase in patients with arteriosclerosis and the risk of lifestyle-related diseases. However, the pathogenesis and medication of atherosclerosis have not been elucidated. We developed a rat model of lifestyle-related diseases by feeding a high-fat diet and 30% sucrose solution (HFDS) to spontaneously hypertensive hyperlipidemic rats (SHHR) and reported that this model is a useful model of early atherosclerosis. In order to elucidate the pathogenesis of early atherosclerosis, we searched for atherosclerosis-related genes by microarray analysis using the aortic arch rat model of lifestyle-related diseases.
Four-month-old male Sprague-Dawley rats and SHHR were each divided into two normal diet (ND) groups and two HFDS groups. After a four-month treatment, the expression of mRNA in the aortic arch was detected using the oligo DNA microarray one-color method and quantified using real-time PCR.
In this study, we detected 39 genes in microarray analysis. Esm1, Retnlb Mkks, and Grem2 showed particularly marked changes in gene expression in the SHHR-HFDS group. Compared with the SD-ND group, the SHHR-HFDS group had an increase in Mkks gene expression of about 26-fold and an approximately 22-fold increase in the expression of Grem2. Similarly, the expression of Esm1 increased by about 12-fold and that of Retnlg by about 10-fold as shown by quantitative real-time PCR.
This study suggested that these four genes might be important in early atherosclerosis development.
[Show abstract][Hide abstract] ABSTRACT: The recently developed technology of real-time cell analysis (RTCA) was designed to analyze cell migration and invasion in vitro. In this study, we investigated these cellular factors in oral squamous cell carcinomas (OSCCs) of the tongue and floor of the mouth with RTCA. We also examined the associated matrix metalloproteinases (MMPs) and integrins. We used the cell lines SCC-4 and SAS, which are human poorly differentiated OSCCs from the tongue, and HO-1-u-1, which are human poorly differentiated OSCCs from the floor of the mouth. Using RTCA, cell migration was assessed on fibronectin–coated CIM-Plates, and invasion was assessed on fibronectin- and matrigel-coated CIM-Plates. SCC-4 cells demonstrated a high ability for cell migration and invasion compared with SAS and HO-1-u-1 cells. The SCC-4 cells also expressed high levels of MMP-9 and integrin α1 mRNA compared with SAS and HO-1-u-1 cells. The MMP inhibitor Marimastat blocked migration and invasion of all OSCCs. The findings suggest that MMP-9 is associated with cell migration and invasion in OSCCs, and indicate that RTCA will be useful for analyzing the metastatic capability of OSCCs and developing more effective new drugs for this disease.
[Show abstract][Hide abstract] ABSTRACT: Laryngeal cancer is one of the most common types of head and neck cancer. Numerous studies have reported treatment outcomes, and therapeutic approaches and results are generally well established. However, the widespread use of concurrent chemoradiation therapy(CCRT)has led to differences among hospitals in laryngeal preservation rates in patients with T2 and T3 tumors. CCRT is the mainstay of treatment for laryngeal cancer in our department, given our goals of achieving organ and functional preservation, as well as radical cure. Our regimen for CCRT is comprised of chemotherapy with S-1 plus nedaplatin, concurrently with radiation therapy(SN therapy). We report outcomes obtained from 60 patients with laryngeal cancer who received first-line treatment in our department from April 2005 through March 2010. Cumulative survival rates according to disease stage were as follows: Stage I, 100%; Stage II, 96. 2%; Stage III, 83. 3%; and Stage IV, 48. 8%. The complete response rate after SN therapy was 84. 3%. After excluding patients with T4 tumors, the laryngeal preservation rate was 85. 7%.
No preview · Article · Aug 2011 · Gan to kagaku ryoho. Cancer & chemotherapy
[Show abstract][Hide abstract] ABSTRACT: A 68-year-old man was admitted with hoarseness. Laryngofiberscopy showed a tumor that obstructed the posterior hypopharyngeal wall and the larynx, and biopsy revealed well-differentiated squamous cell carcinoma. CT demonstrated bilateral cervical lymph node metastases. The patient was diagnosed as having hypopharyngeal cancer(T4N2cM0)and was treated with concurrent S-1, nedaplatin and radiotherapy(hereafter referred to as SN therapy). CT and endoscopy after primary treatment showed disappearance of the tumor, and the treatment outcome was assessed as complete response(CR). Currently, the patient is being treated with S-1 as adjuvant chemotherapy in the outpatient setting, and no recurrence or metastasis has been observed. These results suggest that SN therapy was effective for advanced hypopharyngeal cancer from the viewpoint of both curative treatment and organ and function preservation.
No preview · Article · Apr 2011 · Gan to kagaku ryoho. Cancer & chemotherapy
[Show abstract][Hide abstract] ABSTRACT: We reported the efficacy of concurrent chemoradiotherapy(CCRT)for cervical lymph node metastasis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma. The subjects were 17 patients with oropharyngeal or hypopharyngeal cancer with cervical lymph node metastasis, who underwent CCRT treatment between January 2005 and December 2009. The proportion of patients showing a complete response(CR)was 64. 7%; however, if patients without any residual viable cancer cells in the specimens obtained by neck dissection were also defined as CR, then, 82. 4% achieved CR. Thus, CCRT showed good efficacy without the need for planned neck dissection(PND). The limited recurrence cases and absence of serious complications associated with neck dissection after CCRT suggested that PND is not necessarily required. However, since assessment of cervical lymph nodes after CCRT is difficult, it would be desirable to develop a reliable examination and to study the most suitable examination for detecting the presence/absence of cervical lymph node metastasis.
No preview · Article · Apr 2011 · Gan to kagaku ryoho. Cancer & chemotherapy
[Show abstract][Hide abstract] ABSTRACT: Carotid body tumors are rare, and surgical resection is the treatment of first choice. Complications of surgical resection include carotid artery injury, tumor hemorrhage, and postoperative nerve damage. An accurate understanding of the positional relationship between the tumor and the carotid artery by preoperative diagnostic imaging is essential to ensure safe and accurate surgical resection. In addition, preoperative embolization and the Balloon Matas test are useful for intraoperative carotid artery manipulation. Here, we report a case of carotid body tumor resection with who presented with carotid artery hemorrhage. Preoperative embolization and intraoperative vessel repair allowed tumor resection without any sequelae. Given that these tumors are associated with intra-and postoperative complications, treatment in cooperation with other medical departments is essential.
No preview · Article · Feb 2011 · Oto-Rhino-Laryngology Tokyo
[Show abstract][Hide abstract] ABSTRACT: Desmoids, although pathologically benign, are called "locally malignant tumors", due to their infiltrative growth and tendency to recur locally. They are roughly classified as abdominal (90%) or extraabdominal (10%), with 12-20% of extra abdominal occurring on the head and neck. We report a case of extra abdominal frontal neck desmoid. A 47-year-old woman was seen for a frontal neck. Unable to pathologically diagnose the tumor preoperatively, we suspected a schwannoma, leiomyoma, or solitary fibrous tumor. After two total resections and immediate local recurrence, we suggested that she undergo neck radiotherapy. No recurrence has occurred in the 6 months since postoperative 50 Gy radiation. Neck tumor occurrence should thus suggest the possibility of desmoids.
[Show abstract][Hide abstract] ABSTRACT: Many reports have been published on the treatment for hypopharyngeal cancer, and the treatment modalities and results have become uniform to some extent. More specifically, reconstruction by means of free jejunal grafts has become widespread, and the results of surgical treatments have stabilized. On the other hand concurrent chemoradiotherapy has been widely performed, and the results from the standpoint of organ and function preservation have revealed the various differences between institutions. In our department, we have been using concurrent chemoradiotherapy for advanced cancer with a view to organ and function preservation. In this article, we report 6 cases with hypopharyngeal cancer treated by concurrent chemoradiotherapy with S-1 plus nedaplatin(SN therapy)in our department between January 2005 and December 2008. The complete response rate after SN therapy was 83. 3%, and the laryngeal preservation rate was 100%.
No preview · Article · Feb 2011 · Gan to kagaku ryoho. Cancer & chemotherapy
[Show abstract][Hide abstract] ABSTRACT: A primary head and neck adenocarcinoma is a comparatively rare disease, and surgical resection has been the first choice for its treatment. In the present study, we performed chemotherapy with weekly administration of docetaxel in 3 cases with unresectable or recurrent adenocarcinoma of the head and neck on an outpatient basis, resulting in long-term maintenance of the patients' QOL. Each case had submandibular gland carcinoma, parotid gland carcinoma, or parathyroid gland carcinoma. Their observation period was 42, 76, or 87 months, respectively. Docetaxel was administered for 18, 19, or 28 courses, respectively. No adverse events of grade 3 or higher were observed. The present results might suggest that it is possible to treat patients with adenocarcinoma in the head and neck without decreasing patients' QOL.
No preview · Article · Dec 2010 · Gan to kagaku ryoho. Cancer & chemotherapy
[Show abstract][Hide abstract] ABSTRACT: Background IgA nephropathy treatment is usually planned and conducted based on pathological renal biopsy findings, laboratory data, and clinical symptoms. This involves improving the physical condition, diet therapy, and pharmacotherapy. Steroid pulse therapy following tonsillectomy is reported to be effective intending IgA nephropathy. Methods 24 patients that diagnosed with IgA nephropathy in renal biopsy underwent tonsillectomy. We them analyzed of the relationship between pathological renal biopsy findings and the tonsils of those with IgA nephropathy. Results No relationship was seen between the severity in pathological renal biopsy findings and the tonsils, thus showing typical morphological IgA nephrophath features. Conclusions Our study indicated no relationship between pathological renal biopsy findings and tonsils, suggesting that histological tonsils findings play no role in IgA nephrophath status and prognosis, Histological tonsils findings in IgA nephropathy differ from those in chronic tonsillitis, and the tonsils appear to be a unique organ causing initial and/or progressive events generating glomerular IgA deposits.
[Show abstract][Hide abstract] ABSTRACT: Various treatments for oropharynx cancer included radiotherapy, arterial injection chemotherapy (as well as combined chemoradiotherapy), combined concurrent chemoradiotherapy, and surgical resection and reconstruction. There are also treatment differences among facilities. Our department has been providing a treatment modality for head and neck malignancies with the aims of functional and morphological preservation with a high cure rate. We herein report the treatment efficacy in 7 cases of oropharynx cancer (6 cases on lateral wall and 1 case on superior wall)treated with S-1, nedaplatin and radiotherapy (SN therapy) at our department between April 2006 and December 2006. The total of 7 cases included 1 case of T1N1M0, 1 of T2N0M0, 2 of T2N2bM0, 1 of T2N2cM0, 1 of T3N2cM0, and 1 case of T4N2cM0. The patients were all male and their ages ranged from 57 to 76 years old, with the average age of 68.4 years. Six of the 7 cases are surviving without cancer through treatment and their functions and morphologies have been preserved. In the 1 case of T4N2cM0, the tumor did not disappear and the patient expired due to the original lesion. Although SN therapy supposedly enables functional and morphological preservation, it is necessary to increase the number of cases and examine the efficacy of SN therapy for oropharynx cancer for functional and morphological preservation and the survival rate.
No preview · Article · Aug 2010 · Gan to kagaku ryoho. Cancer & chemotherapy
[Show abstract][Hide abstract] ABSTRACT: It is not rare to observe multiple cancers in cases of head and neck carcinoma. Such cancers are important factors for deciding the therapeutic strategy. Complications of esophageal cancer are particularly frequent in cases of hypopharyngeal cancer in comparison to other head and neck tumors. At our department, for organ and functional preservation, and radical cure, we have used simultaneous therapy instead of separate therapy for head and neck tumors and esophageal cancer. We have been implementing concurrent S-1, nedaplatin/radiation therapy (hereinafter called SN therapy) for cases of advanced cancer of the head and neck, and we applied the same therapy for cases of head and neck carcinoma with esophageal cancer. The subjects comprised 5 cases of head and neck tumors complicated by esophageal cancer for which therapy was conducted at our department between April 2005 and March 2009. The histologic type was squamous cell carcinoma in all of the cases. There were 2 cases of laryngeal cancer (T3N2cM0, T3N0M0) and 3 cases of hypopharyngeal cancer (T3N2cM0, T4N2cM0, T3N2bM0). As a result, 3 out of the 5 cases have remained cancer-free, and the average observation period was 29. 3 months. One case expired due to an unrelated cause as a result of cardiac disease, while in the remaining case, the tumor did not disappear and the patient died due to the disease. It is necessary to continue examining the survival rate by increasing the number of cases.
No preview · Article · Jul 2010 · Gan to kagaku ryoho. Cancer & chemotherapy
[Show abstract][Hide abstract] ABSTRACT: We performed a study of 33 patients with tumors of the submandibular glands who underwent surgical treatment during the 4-year period between September 2005 and August 2009, in order to examine the age distribution, tumor size, histopathological classification, disease duration and the usefulness of fine-needle aspiration cytology in these patients. Among the 26 patients with benign tumors, most (20 patients) had pleomorphic adenoma. Malignant tumor, adenocarcinoma, adenoid cystic carcinoma, cancer in pleomorphic adenoma, salivary duct cancer, mucoepidermoid tumor, squamous cancer, and other types of cancer were confirmed in one each of 7 patients. Among these patients, malignant tumors accounted for 21.2% of all tumors. In regard to the age distribution, the incidence of malignant tumors was higher in elderly female patients, while no difference in the tumor size or the disease duration was observed among the patients with either benign or malignant tumors. The accuracy, sensitivity and specificity of perioperative fine-needle aspiration cytology were 92.3%, 66.7%, and 100%, respectively. Although the usefulness of fine-needle aspiration cytology was confirmed, the false-negative rate was 33.3%. Thus, careful consideration must be given during consultation, to obtain informed consent for this examination.
No preview · Article · Apr 2010 · Oto-Rhino-Laryngology Tokyo