Qihong Wang

Fudan University, Shanghai, Shanghai Shi, China

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Publications (3)7.49 Total impact

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    ABSTRACT: In the present study, a biomimetic phosphorylcholine group was employed in the end-capping modification of PEO-PPO-PEO tri-block co-polymers (Pluronic(®)). The structures of the resulting materials were characterized by (1)H-NMR and GPC. The effects of the additional phosphorylcholine end-groups to the thermo-sensitive sol-gel transition behaviors of the aqueous solutions of the resulting polymers were studied by rheology test in neutral (0.1 M NaCl) aqueous solutions and in acidic solutions (pH 3). It was found that the phosphorylcholine-end-capped Pluronic hydrogels still kept their thermo-sensitive mechanical properties with a slight change on the sol-gel transition behaviors. The phosphorylcholine-modified Pluronics exhibited a response to the change of the pH value, which made this kind of material a multi-sensitive hydrogel system. Also, the resulting polymers showed improved hemocompatibilities in the blood coagulation test using full human blood.
    No preview · Article · Jan 2011 · Journal of Biomaterials Science Polymer Edition
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    Sheng Meng · Zongjun Liu · Wei Zhong · Qihong Wang · Qiangguo Du
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    ABSTRACT: In this paper, the synthesis, characterization, and properties of a novel biodegradable polymer with improved hemocompatibility is reported. It was synthesized by combining chitosan with phosphorylcholine (PC) groups through a heterogeneous reaction process. The structure of the obtained polymer was confirmed using solid state 13C NMR, 31P NMR, and elemental analysis. The phosphorylcholine modification increased water absorption while it decreases bovine serum albumin (BSA) adsorption of chitosan. Some biological properties of the resulting polymer (PC-chitosan) were tested and compared with native chitosan. The hemocompatibility of PC-chitosan was estimated using full human blood. Better resistance to coagulation was observed during the blood contacting process, with prolonged activated partial thromboplastin time (APTT). Material-cell interaction was evaluated using human umbilical vein endothelial cells (HUVECs). Good biocompatibility and cytophilicity of PC-chitosan was observed with less influence to cell differentiation and multiplication.
    Full-text · Article · Aug 2007 · Carbohydrate Polymers
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    ABSTRACT: In this study, the synthesis, characterization, and properties of a novel biodegradable polymer with improved hemocompatibility were introduced. It was synthesized by end-capping poly-ε-caprolactone (PCL) with phosphorylcholine (PC) groups. The polyester backbone provided the mechanical stability and biodegradability, while the PC-end groups improved its hemocompatibility. The obtained polymer was characterized using 1H NMR, 31P NMR, FTIR, and GPC, its crystallization behavior was studied by DSC. Compared with original PCL, the resulting polymer (PC-PCL) showed a lower crystallization capability and a faster degradation rate in PBS. The degradation rate of the polymer blends of PCL/PC-PCL increased with increasing PC-PCL content. The results of water contact angle measurements revealed a more hydrophilic surface property of PC-PCL than neat PCL. The hemocompatibility of PC-PCL was estimated using rabbit platelet-rich plasma, a better resistance to platelet adhesion and activation was observed. During the human blood plasma contacting process, PC-PCL showed a prolonged activated partial thromboplastin time over neat PCL. Material–cell interaction was evaluated with human umbilical vein endothelial cell, the result indicated that PC-PCL may to some extent have an antihyperplasia property, compared with neat PCL. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 989–997, 2007
    Full-text · Article · Jan 2007 · Journal of Applied Polymer Science