Robert P Carlyon

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Publications (236)

  • Source
    Alex Billig · Matthew H. Davis · Robert P. Carlyon
    File available · Poster · Nov 2016
  • Hedwig E. Gockel · Robert P. Carlyon
    [Show abstract] [Hide abstract] ABSTRACT: It was assessed whether Zwicker tones (ZTs) (an auditory afterimage produced by a band-stop noise) have a musical pitch. First (stage I), musically trained subjects adjusted the frequency, level, and decay time of an exponentially decaying diotic sinusoid to sound similar to the ZT they perceived following the presentation of diotic broadband noise, for various band-stop positions. Next (stage II), subjects adjusted a sinusoid in frequency and level so that its pitch was a specified musical interval below that of either a preceding ZT or a preceding sinusoid, and so that it was equally loud. For each subject the reference sinusoid corresponded to their adjusted sinusoid from stage I. Subjects selected appropriate frequency ratios for ZTs, although the standard deviations of the adjustments were larger for the ZTs than for the equally salient sinusoids by a factor of 1.0–2.2. Experiments with monaural stimuli led to similar results, although the pitch of the ZTs could differ for monaural and diotic presentation of the ZT-exciting noise. The results suggest that a weak musical pitch may exist in the absence of phase locking in the auditory nerve to the frequency corresponding to the pitch (or harmonics thereof) at the time of the percept.
    Article · Oct 2016 · The Journal of the Acoustical Society of America
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    Etienne Gaudrain · John M. Deeks · Robert P. Carlyon
    [Show abstract] [Hide abstract] ABSTRACT: Cochlear implants (CIs) convey fundamental-frequency information using primarily temporal cues. However, temporal pitch perception in CI users is weak and, when measured using rate discrimination tasks, deteriorates markedly as the rate increases beyond 300 pulses-per-second. Rate pitch may be weak because the electrical stimulation of the surviving neural population of the implant recipient may not allow accurate coding of inter-pulse time intervals. If so, this phenomenon should prevent listeners from detecting when a pulse train is physically temporally jittered. Performance in a jitter detection task was compared to that in a rate-pitch discrimination task. Stimuli were delivered using direct stimulation in cochlear implants, on a mid-array and an apical electrode, and at two different rates (100 and 300 pps). Average performance on both tasks was worse at the higher pulse rate and did not depend on electrode. However, there was a large variability across and within listeners that did not correlate between the two tasks, suggesting that rate-pitch judgement and regularity detection are to some extent limited by task-specific processes. Simulations with filtered pulse trains presented to NH listeners yielded broadly similar results, except that, for the rate discrimination task, the difference between performance with 100- and 300-pps base rates was smaller than observed for CI users.
    Full-text available · Article · Sep 2016 · Journal of the Association for Research in Otolaryngology
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    Stefano Cosentino · Robert P. Carlyon · John M. Deeks · [...] · Julie A. Bierer
    [Show abstract] [Hide abstract] ABSTRACT: Cochlear implant (CI) users have poor temporal pitch perception, as revealed by two key outcomes of rate discrimination tests: (i) rate discrimination thresholds (RDTs) are typically larger than the corresponding frequency difference limen for pure tones in normal hearing listeners, and (ii) above a few hundred pulses per second (i.e. the "upper limit" of pitch), CI users cannot discriminate further increases in pulse rate. Both RDTs at low rates and the upper limit of pitch vary across listeners and across electrodes in a given listener. Here, we compare across-electrode and across-subject variation in these two measures with the variation in performance on another temporal processing task, gap detection, in order to explore the limitations of temporal processing in CI users. RDTs were obtained for 4-5 electrodes in each of 10 Advanced Bionics CI users using two interleaved adaptive tracks, corresponding to standard rates of 100 and 400 pps. Gap detection was measured using the adaptive procedure and stimuli described by Bierer et al. (JARO 16:273-284, 2015), and for the same electrodes and listeners as for the rate discrimination measures. Pitch ranking was also performed using a mid-point comparison technique. There was a marginal across-electrode correlation between gap detection and rate discrimination at 400 pps, but neither measure correlated with rate discrimination at 100 pps. Similarly, there was a highly significant across-subject correlation between gap detection and rate discrimination at 400, but not 100 pps, and these two correlations differed significantly from each other. Estimates of low-rate sensitivity and of the upper limit of pitch, obtained from the pitch ranking experiment, correlated well with rate discrimination for the 100- and 400-pps standards, respectively. The results are consistent with the upper limit of rate discrimination sharing a common basis with gap detection. There was no evidence that this limitation also applied to rate discrimination at lower rates.
    Full-text available · Article · Apr 2016 · Journal of the Association for Research in Otolaryngology
  • Antje Ihlefeld · Robert P. Carlyon · Alan Kan · [...] · Ruth Y. Litovsky
    [Show abstract] [Hide abstract] ABSTRACT: Bilaterally implantedcochlear implant users were tested on monaural rate discrimination and binauralinteraural time difference(ITD) discrimination, as a function of pulse rate, to examine the hypothesis that deterioration in performance at high rates occurs for the two tasks due to a common neural basis. For the rate discrimination task, pulse trains were presented to one electrode, located in the apical, middle, or basal part of the array, and in either the left or the right ear. In each two-interval trial, the standard stimulus had a rate of 100, 200, 300, or 500 pulses-per-second and the signal stimulus had a rate 35% higher. For the ITD discrimination task, performance between pitch-matched electrode pairs was measured for the same standard rates as in the rate discrimination task, and with an ITD of + /− 500 µs. Sensitivity (d′) on both tasks decreased with increasing rate. Results show that ITD scores for different pairs of electrodes correlated with the lower of the rate discrimination scores for those two electrodes.Statistical analysis, which partialed out overall differences between listeners, electrodes, and rates, supports the hypothesis that monaural and binaural temporal processing limitations are at least partly due to a common mechanism.
    Article · Apr 2016 · The Journal of the Acoustical Society of America
  • Robert P. Carlyon · Stefano Cosentino · John M. Deeks · [...] · Julie A. Bierer
    [Show abstract] [Hide abstract] ABSTRACT: Two experiments studied the deterioration in rate discrimination and pitch perception for pulse trains presented to single electrodes at high pulse rates. The first measured rate discrimination DLs (“RDLs”) for 100-pps and 400-pps standard rates, for each of 4–5 electrodes and for 10 Advanced Bionicscochlear implant users. Thresholds were measured using two interleaved adaptive tracks, corresponding to the 100- and 400-pps standard rates. Gap detection thresholds (“GDTs”) for a 1031-pps pulse train were also measured. There was a highly significant across-subject correlation between GDT and the 400-pps but not the 100-pps RDL, and these two correlations differed significantly from each other. Similarly, the across-electrode correlation between GDT and the 400-pps RDL was marginally significant, whereas there was no correlation between GDT and the 100-pps RDL. These findings are consistent with the deterioration in high-rate temporal processing sharing a common basis with the mechanisms involved in gap detection, but not with the limitations in low-rate temporal processing. We will also report the results of a second experiment that measured rate discrimination and pitch ranking at low and high rates, both on the same day that patients’ implants were activated and after two months of listening experience.
    Article · Apr 2016 · The Journal of the Acoustical Society of America
  • Stefano Cosentino · Lindsay De Vries · Rachel Scheperle · [...] · Robert Carlyon
    Conference Paper · Mar 2016
  • Source
    Hedwig E. Gockel · Robert P. Carlyon
    [Show abstract] [Hide abstract] ABSTRACT: It has been argued that musical pitch, i.e. pitch in its strictest sense, requires phase locking at the level of the auditory nerve. The aim of the present study was to assess whether a musical pitch can be heard in the absence of peripheral phase locking, using Zwicker tones (ZTs). A ZT is a faint, decaying tonal percept that arises after listening to a band-stop (notched) broadband noise. The pitch is within the frequency range of the notch. Several findings indicate that ZTs are unlikely to be produced mechanically at the level of the cochlea and, therefore, there is unlikely to be phase locking to ZTs in the auditory periphery. In stage I of the experiment, musically trained subjects adjusted the frequency, level, and decay time of an exponentially decaying sinusoid so that it sounded similar to the ZT they perceived following a broadband noise, for various notch positions. In stage II, subjects adjusted the frequency of a sinusoid so that its pitch was a specified musical interval below that of either a preceding ZT or a preceding sinusoid (as determined in stage I). Subjects selected appropriate frequency ratios for ZTs, although the standard deviations of the adjustments were larger for the ZTs than for the equally salient sinusoids by a factor of 1.1–2.2. The results suggest that a musical pitch may exist in the absence of peripheral phase locking.
    Full-text available · Chapter · Jan 2016
  • Philip A Gomersall · Richard E Turner · David M Baguley · [...] · Robert P Carlyon
    [Show abstract] [Hide abstract] ABSTRACT: We assessed auditory sensitivity to three classes of temporal-envelope statistics (modulation depth, modulation rate, and comodulation) that are important for the perception of 'sound textures'. The textures were generated by a probabilistic model that prescribes the temporal statistics of a selected number of modulation envelopes, superimposed onto noise carriers. Discrimination thresholds were measured for normal-hearing (NH) listeners and users of a MED-EL pulsar cochlear implant (CI), for separate manipulations of the average rate and modulation depth of the envelope in each frequency band of the stimulus, and of the co-modulation between bands. Normal-hearing (NH) listeners' discrimination of envelope rate was similar for baseline modulation rates of 5 and 34 Hz, and much poorer than previously reported for sinusoidally amplitude-modulated sounds. In contrast, discrimination of model parameters that controlled modulation depth was poorer at the lower baseline rate, consistent with the idea that, at the lower rate, subjects get fewer 'looks' at the relevant information when comparing stimuli differing in modulation depth. NH listeners could discriminate differences in co-modulation across bands; a multidimensional scaling study revealed that this was likely due to genuine across-frequency processing, rather than within-channel cues. CI users' discrimination performance was worse overall than for NH listeners, but showed a similar dependence on stimulus parameters.
    Article · Dec 2015 · Hearing research
  • Robert P. Carlyon · John M. Deeks
    [Show abstract] [Hide abstract] ABSTRACT: Four experiments measured the perceptual and neural correlates of the temporal pattern of electrical stimulation applied to one cochlear-implant (CI) electrode, for several subjects. Neural effects were estimated from the electrically evoked compound action potential (ECAP) to each pulse. Experiment 1 attenuated every second pulse of a 200-pps pulse train. Increasing attenuation caused pitch to drop and the ECAP to become amplitude modulated, thereby providing an estimate of the relationship between neural modulation and pitch. Experiment 2 showed that the pitch of a 200-pps pulse train can be reduced by delaying every second pulse, so that the inter-pulse-intervals alternate between longer and shorter intervals. This caused the ECAP to become amplitude modulated, but not by enough to account for the change in pitch. Experiment 3 replicated the finding that rate discrimination deteriorates with increases in baseline rate. This was accompanied by an increase in ECAP modulation, but by an amount that produced only a small effect on pitch in experiment 1. Experiment 4 showed that preceding a pulse train with a carefully selected "pre-pulse" could reduce ECAP modulation, but did not improve rate discrimination. Implications for theories of pitch and for limitations of pitch perception in CI users are discussed.
    Article · Nov 2015 · The Journal of the Acoustical Society of America
  • B. Kenway · Y.C. Tam · Z. Vanat · [...] · P. Axon
    [Show abstract] [Hide abstract] ABSTRACT: Objective: To assess differences in pitch-ranking ability across a range of speech understanding performance levels and as a function of electrode position. Study Design: An observational study of a cross-section of cochlear implantees. Setting: Tertiary referral center for cochlear implantation. Patients: A total of 22 patients were recruited. All three manufacturers' devices were included (MED-EL, Innsbruck, Austria, n=10; Advanced Bionics, California, USA, n=8; and Cochlear, Sydney, Australia, n=4) and all patients were long-term users (more than 18 months). Twelve of these were poor performers (scores on BKB sentence lists <60%) and 10 were excellent performers (BKB >90%). Intervention: After measurement of threshold and comfort levels, and loudness balancing across the array, all patients underwent thorough pitch-ranking assessments at 80% of comfort levels. Main Outcome Measure: Ability to discriminate pitch across the electrode array, measured by consistency in discrimination of adjacent pairs of electrodes, as well as an assessment of the pitch order across the array using the midpoint comparison task. Results: Within the poor performing group there was wide variability in ability to pitch rank, from no errors, to a complete inability to reliably and consistently differentiate pitch change across the electrode array. Good performers were overall significantly more accurate at pitch ranking (p=0.026). Consistent pitch ranking was found to be a significant independent predictor of BKB score, even after adjusting for age. Users of the MED-EL implant experienced significantly more pitch confusions at the apex than at more basal parts of the electrode array. Conclusions: Many cochlear implant users struggle to discriminate pitch effectively. Accurate pitch ranking appears to be an independent predictor of overall outcome. Future work will concentrate on manipulating maps based upon pitch discrimination findings in an attempt to improve speech understanding.
    Article · Oct 2015
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    Stefano Cosentino · John M. Deeks · Robert P. Carlyon
    [Show abstract] [Hide abstract] ABSTRACT: Behavioral measures of spatial selectivity in cochlear implants are important both for guiding the programing of individual users’ implants and for the evaluation of different stimulation methods. However, the methods used are subject to a number of confounding factors that can contaminate estimates of spatial selectivity. These factors include off-site listening, charge interactions between masker and probe pulses in interleaved masking paradigms, and confusion effects in forward masking. We review the effects of these confounds and discuss methods for minimizing them. We describe one such method in which the level of a 125-pps masker is adjusted so as to mask a 125-pps probe, and where the masker and probe pulses are temporally interleaved. Five experiments describe the method and evaluate the potential roles of the different potential confounding factors. No evidence was obtained for off-site listening of the type observed in acoustic hearing. The choice of the masking paradigm was shown to alter the measured spatial selectivity. For short gaps between masker and probe pulses, both facilitation and refractory mechanisms had an effect on masking; this finding should inform the choice of stimulation rate in interleaved masking experiments. No evidence for confusion effects in forward masking was revealed. It is concluded that the proposed method avoids many potential confounds but that the choice of method should depend on the research question under investigation.
    Full-text available · Article · Sep 2015 · Trends in hearing
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    Stefano Cosentino · Etienne Gaudrain · John M Deeks · Robert P Carlyon
    [Show abstract] [Hide abstract] ABSTRACT: Objective: Electrically evoked compound action potentials (ECAPs) have been employed as a measure of neural activation evoked by cochlear implant (CI) stimulation. A forward-masking procedure is commonly used to reduce stimulus artefacts. This method estimates the joint neural activation produced by two electrodes - one acting as probe and the other as masker; as such, the measured ECAPs depend on the activation patterns produced by both. We describe an approach - termed Panoramic ECAP ("PECAP") - that allows reconstruction of the underlying neural activation pattern of individual channels from ECAP amplitudes. Methods: The proposed approach combines two constrained nonlinear optimization stages. PECAP was validated against simulated and physiological data from CI users. The physiological data consisted of ECAPs measured from four users of Cochlear® devices. For each subject, an 18×18 ECAP amplitude matrix was measured using a forward-masking method. Results: The results from computer simulations indicate that our approach can reliably estimate the underlying activation patterns from ECAP amplitudes even for instances of neural "dead regions" or cross-turn stimulation. The operating signal-to-noise ratio (SNR) for the proposed algorithm was 5 dB or higher, which matched well the SNR measured from human physiological data. Human ECAPs were fitted with our procedure to determine neural activation patterns. Conclusion: PECAP can be used to identify undesirable features of the neural activation pattern of individual CI users. Significance: Our approach may have clinical application as an objective measure of electrode-to-neuron interface and may be used to devise ad hoc stimulation strategies.
    Full-text available · Article · Sep 2015 · IEEE transactions on bio-medical engineering
  • [Show abstract] [Hide abstract] ABSTRACT: The frequency following response (FFR) is a scalp-recorded measure of phase-locked brainstem activity to stimulus-related periodicities. Three experiments investigated the specificity of the FFR for carrier and modulation frequency using adaptation. FFR waveforms evoked by alternating-polarity stimuli were averaged for each polarity and added, to enhance envelope, or subtracted, to enhance temporal fine structure information. The first experiment investigated peristimulus adaptation of the FFR for pure and complex tones as a function of stimulus frequency and fundamental frequency (F0). It showed more adaptation of the FFR in response to sounds with higher frequencies or F0s than to sounds with lower frequency or F0s. The second experiment investigated tuning to modulation rate in the FFR. The FFR to a complex tone with a modulation rate of 213 Hz was not reduced more by an adaptor that had the same modulation rate than by an adaptor with a different modulation rate (90 or 504 Hz), thus providing no evidence that the FFR originates mainly from neurons that respond selectively to the modulation rate of the stimulus. The third experiment investigated tuning to audio frequency in the FFR using pure tones. An adaptor that had the same frequency as the target (213 or 504 Hz) did not generally reduce the FFR to the target more than an adaptor that differed in frequency (by 1.24 octaves). Thus, there was no evidence that the FFR originated mainly from neurons tuned to the frequency of the target. Instead, the results are consistent with the suggestion that the FFR for low-frequency pure tones at medium to high levels mainly originates from neurons tuned to higher frequencies. Implications for the use and interpretation of the FFR are discussed.
    Article · Jul 2015 · Journal of the Association for Research in Otolaryngology
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    Robert P Carlyon · John M Deeks · Colette M McKay
    [Show abstract] [Hide abstract] ABSTRACT: To further understand the response of the human brainstem to electrical stimulation, a series of experiments compared the effect of pulse rate and polarity on detection thresholds between auditory brainstem implant (ABI) and cochlear implant (CI) patients. Experiment 1 showed that for 400-ms pulse trains, ABI users' thresholds dropped by about 2 dB as pulse rate was increased from 71 to 500 pps, but only by an average of 0.6 dB as rate was increased further to 3500 pps. This latter decrease was much smaller than the 7.7-dB observed for CI users. A similar result was obtained for pulse trains with a 40-ms duration. Furthermore, experiment 2 showed that the threshold difference between 500- and 3500-pps pulse trains remained much smaller for ABI than for CI users, even for durations as short as 2 ms, indicating the effect of a fast-acting mechanism. Experiment 3 showed that ABI users' thresholds were lower for alternating-polarity than for fixed-polarity pulse trains, and that this difference was greater at 3500 pps than at 500 pps, consistent with the effect of pulse rate on ABI users' thresholds being influenced by charge interactions between successive biphasic pulses. Experiment 4 compared thresholds and loudness between trains of asymmetric pulses of opposite polarity, in monopolar mode, and showed that in both cases less current was needed when the anodic, rather than the cathodic, current was concentrated into a short time interval. This finding is similar to that previously observed for CI users and is consistent with ABI users being more sensitive to anodic than cathodic current. We argue that our results constrain potential explanations for the differences in the perception of electrical stimulation by CI and ABI users, and have potential implications for future ABI stimulation strategies.
    Full-text available · Article · Jul 2015 · Journal of the Association for Research in Otolaryngology
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    Antje Ihlefeld · Robert P Carlyon · Alan Kan · [...] · Ruth Y Litovsky
    [Show abstract] [Hide abstract] ABSTRACT: Monaural rate discrimination and binaural interaural time difference (ITD) discrimination were studied as functions of pulse rate in a group of bilaterally implanted cochlear implant users. Stimuli for the rate discrimination task were pulse trains presented to one electrode, which could be in the apical, middle, or basal part of the array, and in either the left or the right ear. In each two-interval trial, the standard stimulus had a rate of 100, 200, 300, or 500 pulses per second and the signal stimulus had a rate 35 % higher. ITD discrimination between pitch-matched electrode pairs was measured for the same standard rates as in the rate discrimination task and with an ITD of +/- 500 μs. Sensitivity (d') on both tasks decreased with increasing rate, as has been reported previously. This study tested the hypothesis that deterioration in performance at high rates occurs for the two tasks due to a common neural basis, specific to the stimulation of each electrode. Results show that ITD scores for different pairs of electrodes correlated with the lower rate discrimination scores for those two electrodes. Statistical analysis, which partialed out overall differences between listeners, electrodes, and rates, supports the hypothesis that monaural and binaural temporal processing limitations are at least partly due to a common mechanism.
    Full-text available · Article · Jun 2015 · Journal of the Association for Research in Otolaryngology
  • [Show abstract] [Hide abstract] ABSTRACT: One task intended to measure sensitivity to temporal fine structure (TFS) involves the discrimination of a harmonic complex tone from a tone in which all harmonics are shifted upwards by the same amount in hertz. Both tones are passed through a fixed bandpass filter centered on the high harmonics to reduce the availability of excitation-pattern cues and a background noise is used to mask combination tones. The role of frequency selectivity in this "TFS1" task was investigated by varying level. Experiment 1 showed that listeners performed more poorly at a high level than at a low level. Experiment 2 included intermediate levels and showed that performance deteriorated for levels above about 57 dB sound pressure level. Experiment 3 estimated the magnitude of excitation-pattern cues from the variation in forward masking of a pure tone as a function of frequency shift in the complex tones. There was negligible variation, except for the lowest level used. The results indicate that the changes in excitation level at threshold for the TFS1 task would be too small to be usable. The results are consistent with the TFS1 task being performed using TFS cues, and with frequency selectivity having an indirect effect on performance via its influence on TFS cues.
    Article · May 2015 · The Journal of the Acoustical Society of America
  • Christopher van den Honert · Zachary Smith · Christopher J. Long · [...] · Robert P. Carlyon
    [Show abstract] [Hide abstract] ABSTRACT: Assessment of neuron excitation is implemented by quantifying the interaction between focused and unfocused stimulation applied to a cochlear array. By applying focused and unfocused stimulation to the electrode array and comparing the difference in the responses to the two types of stimulation the interaction may be determined. The magnitude of the interaction may be related to neural excitation and using this data a neural excitation profile may be determined.
    Patent · Mar 2015
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    [Show abstract] [Hide abstract] ABSTRACT: Cochlear implant (CI) users usually exhibit marked across-electrode differences in detection thresholds with Bfocused^ modes of stimulation, such as partial-tripolar (pTP) mode. This may reflect differences either in local neural survival or in the distance of the electrodes from the modiolus. To shed light on these two explanations, we compared stimulus-detection thresholds and gap-detection thresholds (GDTs) at comfortably loud levels for at least four electrodes in each of ten Advanced Bionics CI users, using 1031-pps pulse trains. The electrodes selected for each user had a wide range of stimulus-detection thresholds in pTP mode. We also measured across-electrode variations in both stimulus-detection and gap-detection tasks in monopolar (MP) mode. Both stimulus-detection and gap-detection thresholds correlated across modes. However, there was no significant correlation between stimulus-detection and gap-detection thresholds in either mode. Hence, gap-detection thresholds likely tap a source of across-electrode variation additional to, or different from, that revealed by stimulus-detection thresholds. Stimulus-detection thresholds were significantly lower for apical than for basal electrodes in both modes; this was only true for gap detection in pTP mode. Finally, although the across-electrode standard deviation in stimulus-detection thresholds was greater in pTP than in MP mode, the reliability of these differences—assessed by dividing the across-electrode standard deviation by the stan-dard deviation across adaptive runs for each electrode—was similar for the two modes; this metric was also similar across modes for gap detection. Hence across-electrode differences can be revealed using clinically available MP stimula-tion, with a reliability comparable to that observed with focused stimulation.
    Full-text available · Article · Feb 2015 · Journal of the Association for Research in Otolaryngology
  • Olivier Macherey · Robert P Carlyon
    [Show abstract] [Hide abstract] ABSTRACT: Five normally hearing listeners pitch-ranked harmonic complexes of different fundamental frequencies (F0s) filtered in three different frequency regions. Harmonics were summed either in sine, alternating sine-cosine (ALT), or pulse-spreading (PSHC) phase. The envelopes of ALT and PSHC complexes repeated at rates of 2F0 and 4F0. Pitch corresponded to those rates at low F0s, but, as F0 increased, there was a range of F0s over which pitch remained constant or dropped. Gammatone-filterbank simulations showed that, as F0 increased and the number of harmonics interacting in a filter dropped, the output of that filter switched from repeating at 2F0 or 4F0 to repeating at F0. A model incorporating this phenomenon accounted well for the data, except for complexes filtered into the highest frequency region (7800-10 800 Hz). To account for the data in that region it was necessary to assume either that auditory filters at very high frequencies are sharper than traditionally believed, and/or that the auditory system applies smaller weights to filters whose outputs repeat at high rates. The results also provide evidence on the highest pitch that can be derived from purely temporal cues, and corroborate recent reports that a complex pitch can be derived from very-high-frequency resolved harmonics.
    Article · Dec 2014 · The Journal of the Acoustical Society of America