[Show abstract][Hide abstract] ABSTRACT: Lipomatous lesions of the uterus are uncommon and the few cases reported only describe those lesions associated with neoplasia of the soft tissue such as leiomyomas, or pure, characterizing lipomas, and there are no reports on the diffuse or neoplastic form. A 34-year-old woman, para 1, abortion 1, presented with discrete leukorrhea without other complaints. On speculum examination, polypoid papillary ectopia was observed macroscopically which may have been caused by epithelial hyperplasia due to papillomavirus infection or the use of anovulatory drugs. Histologic examination revealed diffuse infiltration of the endocervical stroma by mature adipocytes, characterizing choristoma. The patient did not receive any treatment and was found to be well 2 years after a biopsy. The presence of mature heterotopic non-neoplastic adipose tissue in the uterine cervix has not been previously reported. The histogenesis of the lesion has not been defined; however, the hypothesis has been raised that smooth muscle cells of the cervical stroma are directly transformed into adipocytes, as demonstrated by immuno-histochemical analysis.
No preview · Article · May 1998 · Revista do Hospital das Clínicas
[Show abstract][Hide abstract] ABSTRACT: The authors refer to a 21-year-old Caucasian (white) woman, who in 1977 presented fever and cervical and axillary adenopathy, whose biopsy showed nodular sclerosis Hodgkin's Disease, stage IIIB. The patient received six chemotherapy cycles associated with immunotherapy and supplemented with radiation therapy with good response. RESULTS--In 1985, after routine gynaecological examination and a hysterectomy, cervical intraepithelial neoplasia grade 3 (CIN 3) and atypic leiomyoma of the uterine body were diagnosed. Five years later, biopsies diagnosed invasive duct carcinoma in the right breast and homolateral axillary and cervical nodes. The patient was submitted to chemo and radiation therapy and died nine months later. CONCLUSION--The possibility of later occurrence of a second or multiple new malignancies in patients successfully treated for Hodgkin's Disease points out the need for a more complete long-term follow-up, including periodic mammography.
No preview · Article · Jan 1995 · Revista da Associação Médica Brasileira