[Show abstract][Hide abstract] ABSTRACT: Staphylococcus aureus infections account for the majority of skin and soft tissue infections in the United States. Staphylococcus aureus is rapidly evolving resistance to contemporary topical as well as systemic antibiotics. Alternatives to current treatment options for skin and soft tissue infections are needed for more effective treatment now and in the future. Nitric oxide's proven roles in both wound repair and as an antimicrobial agent make it an excellent candidate for the treatment of skin infections. Recent attempts at novel nitric oxide therapies, in the form of nitric oxide donors, have shown limited potential in treating cutaneous infection. However, more recent developments in nitric oxide delivery, using nitric oxide nanoparticle technology, demonstrate substantial promise in the promotion of wound repair and eradication of skin and soft tissue infections.
Full-text · Article · Jun 2010 · Journal of Clinical and Aesthetic Dermatology
[Show abstract][Hide abstract] ABSTRACT: Iron levels are tightly regulated in the body to maintain homeostasis. When homeostatic mechanisms malfunction, excess iron accumulation in the body has deleterious effects with important health consequences worldwide. Different degrees of iron accumulation complicate pathological conditions such as hereditary hemochromatosis (HH), porphyria cutanea tarda (PCT), venous stasis ulcers, diabetic wounds, skin cancer and sunburn. Despite the known association of systemic iron excess with cutaneous findings, little is known about the mechanism by which a surplus of systemic iron affects the skin. This paper explores the link between excess iron and dermatologic findings in the conditions listed above in order to illustrate potential mechanisms by which iron overload exacerbates the cutaneous manifestations associated with each disease.
No preview · Article · Jun 2010 · Journal of drugs in dermatology: JDD