L. Hirschberg

Wroclaw Medical University, Vrotslav, Lower Silesian Voivodeship, Poland

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Publications (3)2.24 Total impact

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    ABSTRACT: Renal transplant recipients (RTRs) are regarded to be predisposed to oral candidiasis. This study was undertaken to evaluate the activity of hydrolytic enzymes in strains causing oral candidiasis in RTR. A total of 123 Candida albicans and 10 Candida krusei strains were isolated from 200 RTRs (39 RTRs suffered from symptomatic candidiasis, the remaining patients had no clinical symptoms of infection). All fungi were identified based on routine mycological procedures. Because of a small number of non-albicans strains, only C. albicans isolates were compared for enzymatic activity. The activity of 19 hydrolytic enzymes was assessed by API ZYM(®) test. The usage of mycophenolate mofetil was connected with higher ratio of clinically apparent oral candidiasis compared to immunosuppressive regimens without this drug (74.4% vs. 46.8%, respectively, P < 0.01). Candida albicans from RTRs showed higher enzymatic activity compared with strains from immunocompetent patients. Only two enzymes were found to be more active in C. albicans causing symptomatic candidiasis in RTRs (cystine arylamidase: P = 0.001, and α-fucosidase: P = 0.01) compared with saprophytic strains. Atrophic candidiasis showed higher activity of esterase lipase (C8) and α-mannosidase compared with the pseudomembraneous type. We suggest that the enhanced enzymatic activity is responsible for higher invasiveness of Candida residing in the oral cavity of RTRs.
    Full-text · Article · Jul 2011 · Mycoses
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    ABSTRACT: Introduction: The hydrolytic enzyme activity may determine the virulence of yeasts found on mucous membranes of humans. The aim of the study was to compare the activity of hydrolytic enzymes between Candida candida and C. krusei isolated from oral mucosa. Material and methods: A total of 142 C. albicans and 11 C. krusei strains were isolated and analyzed. All fungi were identified based on routine mycological procedures. The activity of 19 hydrolytic enzymes was assessed by API ZYM® test. Results: C. albicans strains showed slightly higher number of active enzymes (mean: 7.6±1.8) than C. krusei strains (mean: 6.8±1.8, p=0.2). On the other hand, the expressed enzymes were usually more active in C. krusei. Eleven out of 19 hydrolytic enzymes showed different activity between C. albicans and C. krusei, namely alkaline phosphatase, esterase-(C4), esterase lipase-(C8), leucine arylamidase, acid phosphatase, β-galactosidase, α-glucosidase, β-glucosidase, n-acetyl-β-glucosamidase, α-mannosidase, and α-fucosidase. Conclusions: We could speculate that the differences in enzymatic activity between various Candida species may explain differences in the prevalence of these pathogens in human oral mucosa.
    No preview · Article · Jan 2010 · Mikologia Lekarska
  • A. Reich · J. Szepietowski · L. Hirschberg · E. Baran
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    ABSTRACT: Cutaneous tinea caused by Trichophyton verrucosum occurs in Poland very seldom. A 19-year-old woman was admitted to the department because of a large, inflammatory tumour located in right inguinal area and multiple round erythematous plaques located within the whole body surface. First skin lesions appeared about 3 weeks before admission on the abdomen and in inguinal region. On examination in the right inguinal region and partially on the pubic mound a large, painful tumour (kerion) with several pustules and fistulas with purulent secrete was stated. Hair within the lesion were easily to remove. Moreover, on abdomen, on the back, buttocks and upper limbs multiple, well demarcated, erythematous patches covered with yellowish crusts were observed. Within the skin lesions pustules were present. The direct mycological examination revealed numerous segmented hyphae in skin lesions on the trunk and a sheath of large conidia on the surface of infected hair. The culture resulted in identification of Trichophyton verrucosum. Itraconazole in a dose of 100 mg was introduced, leading to significant clinical improvement. However, because of cutaneous side effects, the treatment with itraconazole was discontinued and terbinafine 250 mg once daily for the next 2 months was employed. The treatment resulted in a complete cure of the patient. Nowadays only post-inflammatory hyperpigmentation of previously lesional skin is noticed.
    No preview · Article · Jan 2005 · Mikologia Lekarska

Publication Stats

9 Citations
2.24 Total Impact Points

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  • 2011
    • Wroclaw Medical University
      • Department of Dermatology, Venerology and Allergology
      Vrotslav, Lower Silesian Voivodeship, Poland