K U Schentke

Technische Universität Dresden, Dresden, Saxony, Germany

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Publications (58)61.43 Total impact

  • W. Leonhardt · S. Niese · W. Jaroβ · M. Hanefeld · K. U. Schentke · D. Meiβner
    [Show abstract] [Hide abstract] ABSTRACT: Teile von Leberbiopsieproben des Menschen von etwa 0,4 mg Masse werden auf ihren Gehalt an Mangan, Kupfer und Zink untersucht. Die Proben werden gefriergetrocknet und in Quarzröhrchen im Rossendorfer Forschungsreaktor bei einem Fluβ thermischer Neutronen von 2 · 1013 n cm−2 s−1 aktiviert. Nach chemischer Auftrennung an einem Anionenaustauscher werden die Aktivitäten von 56Mn, 64Cu und 69mZn im NaJ(Tl)-Szintillationsdetektor gemessen. In jeder Probe wird gesondert der Leber-Triglyzeridgehalt bestimmt. 20 Proben von Normalpersonen mit kontrolliertem Kohlenhydrat- und Fettstoffwechsel wiesen 6,3 ppm Mn, 30 ppm Cu und 164ppm Zn, bezogen auf Trockenmasse, auf. Diese Konzentrationen stimmen mit Literaturangaben etwa überein. Bei Fettleber und Hypertriglyzeridamie waren die Metallkonzentrationen verringert. Es wurden zwischen den Metallkonzentrationen untereinander positive Korrelationen und zwischen Metall- und Triglyzerid-konzentrationen negative Korrelationen festgestellt.
    No preview · Article · Aug 2008 · Isotopenpraxis
  • M Taha · W Schimming · KU Schentke
    No preview · Article · Apr 1999 · Gastroenterology
  • M Taha · KU Schentke
    No preview · Article · Apr 1999 · Gastroenterology
  • Source
    [Show abstract] [Hide abstract] ABSTRACT: Based on the positive therapeutic results with ursodeoxycholic acid (UDCA) in patients with primary biliary cirrhosis, in whom we observed a clinical improvement in conjunction with the normalization of the low pretreatment dipeptidyl peptidase (DPIV, CD26) expression of peripheral blood lymphocytes (PBL), we hypothesized that the very low DPIV expression in AIDS patients could be positively influenced by UDCA. Four young male AIDS patients were therefore treated with 750 mg of UDCA for 4 months. The low CD26 expression (2-8% of the PBL versus 18-28% in healthy controls) at the beginning of the study rose to 10-16% after UDCA therapy. Simultaneously we observed a two-to-three-fold elevation of the absolute number of lymphocytes as well as a slight increase of CD4+ cells. These effects were similar in all examined patients. Further investigations should be conducted on this potentially beneficial effect of UDCA.
    Preview · Article · Feb 1999 · Clinical & Experimental Immunology
  • E Stoelben · M Koch · S Hanke · A Lossnitzer · H J Gaertner · K U Schentke · A Bunk · H D Saeger
    [Show abstract] [Hide abstract] ABSTRACT: Two cases with spontaneous regression of a histologically confirmed hepatocellular carcinoma (HCC) are presented. This rarely seen phenomenon of a spontaneous tumor involution is discussed and compared with the current literature. The clinical symptoms were very similar to that of a liver abscess. A 56-year-old male suffered from a multicentric, highly differentiated, trabecular HCC. First symptoms were epigastric pain, septic fever and arthritis. The tumor marker AFP was constantly normal and no hepatitis could be verified. A resection of the tumor was performed. In patient 2, a 74-year-old male, a multicentric, clear cell HCC was found. The patient had completely recovered from hepatitis type B and within the liver tissue no viruses could be identified. Clinical symptoms were mainly characterized by upper abdominal pain and septic fever. AFP was excessively elevated (3850 ng/ml) but returned to normal preoperatively. In both cases, the specimen showed a subtotal necrotic HCC with insignificant amounts of vital tumor cells. Neither patient had a liver cirrhosis macroscopically, however patient 2 had local periportal fibrosis histologically. After 24 and 41 months of follow-up, respectively, both patients are in good health
    No preview · Article · Jan 1999 · Langenbeck s Archives of Surgery
  • K U Schentke
    No preview · Article · Mar 1998 · Zeitschrift für Gastroenterologie
  • K U Schentke · S Subat
    No preview · Article · Jul 1995 · DMW - Deutsche Medizinische Wochenschrift
  • K. U. Schentke · S. Subat
    No preview · Article · Jan 1995 · DMW - Deutsche Medizinische Wochenschrift
  • J Krappweis · G Petereit · K U Schentke · W Kirch
    [Show abstract] [Hide abstract] ABSTRACT: A 65-year-old woman, known to have peptic ulcers, developed nausea and retching. Clinical examination demonstrated pain on pressure in the epigastrium with otherwise normative findings for age. Two gastric ulcers and gastritis with erosions were seen at endoscopy. The patient, who was being treated with digitoxin for heart failure, reported having taken up to four digitoxin tablets (0.07 mg each) daily because she had insomnia. The plasma digitoxin level was between 150 and 160 nmol/l (therapeutic range 17-33 nmol/l), while the ECG showed no signs of digitalis intoxication. Initially the platelet count was 40,000/microliter: there had been no history of thrombocytopenia or symptoms of abnormal haemostasis. Other laboratory tests were within normal limits. After digitoxin had been discontinued, the platelet count rose without further treatment to 373,000/microliter 3 weeks after hospital admission by which time the digitoxin level had fallen to 48.9 nmol/l. The gastrointestinal symptoms regressed completely on treatment with omeprazole (40 mg three times daily for 8 days) and ranitidine (150 mg twice daily).
    No preview · Article · Jan 1995 · DMW - Deutsche Medizinische Wochenschrift
  • J. Krappweis · G. Petereit · K. U. Schentke · W. Kirch
    No preview · Article · Jan 1994 · DMW - Deutsche Medizinische Wochenschrift
  • D Kürktschiev · S Subat · D Adler · K U Schentke
    [Show abstract] [Hide abstract] ABSTRACT: Peripheral blood lymphocytes of 22 patients with primary biliary cirrhosis under ursodeoxycholic acid therapy were examined for selected lymphocyte activation markers. The percentage of dipeptidyl peptidase IV positive Peripheral blood lymphocytes of primary biliary cirrhosis patients by using immune- and enzyme-histochemical staining was found to be low (5-12%), with healthy controls exhibiting a normal range of 18-27%. After pokeweed mitogen stimulation in vitro the interleukin-2 production by peripheral blood lymphocytes in primary biliary cirrhosis patients was significantly decreased (3.135 pg/ml mean value), compared to healthy subjects (61.167 pg/ml mean value). After 4-20 weeks ursodeoxycholic acid treatment the dipeptidyl peptidase IV expression and IL-2 production were normalised. These results provide evidence for the immunomodulating effect of ursodeoxycholic acid.
    No preview · Article · Aug 1993 · Journal of Hepatology
  • D Adler · D Kürktschiev · S Subat · H U Lehmann · K U Schentke
    [Show abstract] [Hide abstract] ABSTRACT: Investigations concerning changes of dipeptidyl-peptidase IV-positive (DP IV+) lymphocytes in the peripheral blood (PBL) were undertaken in 22 patients with primary biliary cirrhosis (PBC) under therapy with ursodeoxycholic acid (750 mg/day). We found that after 4-8 weeks of therapy the number of DP IV+ PBL was raised from an initially low, suppressed level of 5-12% to 18-33% corresponding to the range observed in healthy subjects. Concurrently liver function parameters of the patients were significantly improved. The identity of DP IV+ CD 26+ peripheral T-cells could be shown by the combination of cytochemical DP IV-staining with the indirect immuno-fluorescence of the lymphocyte marker CD 26. These results show that the UDCA-therapy in patients with PBC has a direct effect on the immune system and a positive influence on the immuno-regulative capacity.
    No preview · Article · Mar 1993 · Zeitschrift für Gastroenterologie
  • D Kürktschiev · D Adler · S Subat · H U Lehmann · K U Schentke
    [Show abstract] [Hide abstract] ABSTRACT: Investigations concerning changes of dipeptidyl-peptidase IV-positive (DP IV+) lymphocytes in the peripheral blood (PBL) were undertaken in 22 patients with primary biliary cirrhosis (PBC) under therapy with ursodeoxycholic acid (750 mg/day). We found that 4-8 weeks after therapy beginning the number of DP IV+ PBL was raised from a low initial suppressed level of 5-12% into a range of 18-33% corresponding to that of a healthy. Concurrently liver function parameters of the patients were improved significantly. The identity of DP IV+ and CDw26+ of peripheral T-cells could be shown by combination of the cytochemical DP IV-staining with the indirect immunofluorescence of the lymphocyte marker CDw26. These results show that the UDCA-therapy in patients with PBC has a direct effect on the immune system and a positive influence on the immuno-regulative capacity.
    No preview · Article · Mar 1993 · Zeitschrift für Gastroenterologie
  • K U Schentke · E Kobe · M Taha · W Schimming
    [Show abstract] [Hide abstract] ABSTRACT: The spectrum of causes of cholestasis ranges from microscopically recognizable damage to the parenchymal cells of the liver to obstruction of the ductus choledochus und papilla Vateri. Liver biopsy on the one hand and ERCP on the other therefore constitute the morphological methods that come closest to the pathological substrate. Obligatory sonography serves the restriction of diagnosis to a large extent. Laparoscopy is nearly always dispensable. Even in case of liver biopsy the therapeutic consequences should have an influence. Consequently, for transpapillary endoscopic methods in obstructive jaundice it is essential to remove the obstruction (papillotomy and extraction of the calculus or nasobiliary probe or intraluminal tube) if possible in one and the same session. The purely diagnostic ERC possibly causes dangerous cholangitis in mechanical icterus. Transpapillary and percutaneous transhepatic endoscopic methods are becoming more and more sophisticated and new indications are being discovered. However, the results of sonography and endoscopy in obstructive jaundice depend very much on the equipment available and experience of the investigator. He should realistically estimate what he is able to do as well as the patients' chances of recovery. In addition he should maintain contact to large departments of surgery and endoscopy.
    No preview · Article · Mar 1993 · Zeitschrift für Gastroenterologie
  • No preview · Article · Nov 1992 · Zeitschrift für ärztliche Fortbildung
  • A Schramm · M Weise · K U Schentke
    [Show abstract] [Hide abstract] ABSTRACT: The development and establishment of intensive care units for adult patients requires a far-reaching subdivision into surgical and conservatively oriented intensive care for qualitative and quantitative reasons. Insufficiently substantiated claims to monopolization of intensive care techniques that are polemically asserted have to be strongly contradicted. The present paper is concerned with approved structural concepts of intensive care developed by Deutsche Krankenhausgesellschaft and various medical societies. They are supplemented by personal experience in the field of internal intensive care.
    No preview · Article · Apr 1991 · Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete
  • C Strohbach · T Grammatté · K U Schentke
    [Show abstract] [Hide abstract] ABSTRACT: The effects of 4 non-ulcer drugs and the M1-antagonist pirenzepine on the nocturnal intragastric pH were investigated in 12 healthy volunteers. We tested single doses of pirenzepine (100 mg), Chlorprothixene (30 mg), clonidine (75 micrograms), ketotifen (3 mg) and nifedipine (30 mg) in an randomized, single-blind, cross-over study. The nocturnal intraluminal pH is significantly elevated not only by pirenzepine but also by the other substances. As expected pirenzepine (mean nocturnal pH = 2.49 +/- 0.22) shows the most distinct effect, nifedipine (mean nocturnal pH = 1.72 +/- 0.20) the most sparsely effect. The other drugs are nearly half as effective as pirenzepine. The acid suppressive side effect of the non-ulcer remedies is considered to be important for the treatment of ulcer patients with concomitant diseases.
    No preview · Article · Feb 1991 · Gastroenterologisches Journal: Organ der Gesellschaft für Gastroenterologie der DDR
  • M Zillmann · K U Schentke
    [Show abstract] [Hide abstract] ABSTRACT: The intra- and interindividual variations of gallbladder motility were sonographically studied in 10 healthy subjects. We investigated the following criteria: a) the gallbladder volumes after overnight fasting on 5 consecutive days, b) the spontaneous motility under fasting over 12 or 24h at hourly intervals, c) the emptying rate and time of maximal contraction after stimulation with sorbitol, and d) the emptying rate and time (like c) after premedication with "cholagogic" drugs (Cholecysmon, Divalol), nifedipine, indomethacin or N-butylscopolaminiumbromide. We found a great intrapersonal and interpersonal variability in gallbladder volumes after overnight fasting in consecutive days. In subjects fasting over 24h phases of dilatation with maxima at 12 AM and 4 PM alternated with phases of contraction with maxima at 8 AM and 4 PM. After premedication with nifedipine, indomethacin and N-butylscopolaminiumbromide a significant decrease of the emptying rate was observed. The time of maximal contraction did not differ however. After premedication we found a distinct intra- and interindividual variability too. Cautious interpretation of gallbladder motility studies is necessary.
    No preview · Article · Feb 1991 · Gastroenterologisches Journal: Organ der Gesellschaft für Gastroenterologie der DDR
  • W Schimming · K U Schentke · S Gehrich · W Jaross · E Kobe
    [Show abstract] [Hide abstract] ABSTRACT: 40 women, average age 52.5 years, with varying stages of primary biliary cirrhosis, were observed. One third of them suffered from a mild anaemia, mean plasma concentrations of ALAT were increased four times and those of AP six times. Despite the hepatocellular damage products of the liver synthesis such as transport proteins or coagulation factors were found to be normal or enhanced. 60% of the patients had a hypercholesterolaemia. The risk factors low density lipoprotein (LDL)- and very low density lipoprotein (VLDL)-cholesterol showed normal levels, but the protective factor high density lipoprotein (HDL)-cholesterol was clearly increased. Apart from the low blood pressure in most of the patients and the absence of other risk factors these observations explain, why patients with PBC and hypercholesterolaemia don't usually develop arteriosclerotic complications. Only in case of severe cholestasis a lipid constellation comes into being accompanied by high risk for the blood vessels, but in these cases the terminal stage of PBC limits the survival. Positive correlations between markers of cholestasis and lipid parameters let an enhanced production and simultaneous impaired excretion of cholesterol be assumed.
    No preview · Article · Feb 1991 · Gastroenterologisches Journal: Organ der Gesellschaft für Gastroenterologie der DDR
  • K U Schentke · U Kobe
    No preview · Article · Feb 1991 · Verhandlungen der Deutschen Gesellschaft für Innere Medizin

Publication Stats

135 Citations
61.43 Total Impact Points

Institutions

  • 1995-1999
    • Technische Universität Dresden
      • Medizinische Klinik und Poliklinik I
      Dresden, Saxony, Germany
  • 1978-1999
    • Carl Gustav Carus-Institut
      Pforzheim, Baden-Württemberg, Germany