Govidan Muralikrishnan

University of Benghazi, Bengasi, Banghāzī, Libya

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Publications (5)5.64 Total impact

  • Govidan Muralikrishnan · Sarjeel Kaleem · Faiyaz Shakeel
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    ABSTRACT: The effect of vitamin C on carbohydrate metabolizing enzymes in cyclophosphamide, methotrexate and 5-fluorouracil treated fibrosarcoma bearing rats was evaluated in the present study, since the effect of vitamin C are beneficial on the abnormalities induced by cyclophosphamide, methotrexate and 5-fluorouracil. The fibrosarcoma cell lines induced rats were treated with cyclophosphamide, methotrexate and 5-fluorouracil and vitamin C (cyclophosphamide 10mg/kg, methotrexate 1mg/kg, 5-fluorouracil 10mg/kg and vitamin C 200mg/kg body weight) individually and in combination for 120 days. Since some definite correlation exists between tumor progression and the activities of glycolytic and gluconeogenic enzymes, assessment of alterations in the activity was considered as successful markers of diagnosis. The untreated as well as cyclophosphamide, methotrexate and 5-fluorouracil treated fibrosarcoma bearing rats showed significantly decrease in the activity of glycolytic enzymes and increasing gluconeogenic enzyme activities were found to be normalized by co-administration of vitamin C. These results suggested that the abnormalities of cyclophosphamide, methotrexate and 5-fluorouracil were corrected by co-administration of vitamin C in tumor stress condition.
    No preview · Article · Aug 2012 · Current Topics in Nutraceutical Research
  • G Muralikrishnan · S.K. Pillai · F Shakeel
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    ABSTRACT: The antioxidant effects of Ocimum sanctum in experimental streptozocin-induced diabetic rats was evaluated in this study. Streptozocin, 55 mg kg(-1) body weight, was injected intraperitoneally once daily for 30 days to induce diabetes mellitus in rats. Streptozocin-induced diabetic rats were orally treated with an aqueous extract of O. sanctum once daily for 30 days. After the experimental period, thiobarbituric acid reacting substances (TBARS) and antioxidant enzymes such as catalase, superoxide dismutase (SOD) and glutathione peroxidase were measured. Administration of O. sanctum to streptozocin-induced diabetic rats for 30 days significantly reduced the plasma level of TBARS and improved the status of the antioxidant enzymes catalase, SOD and glutathione peroxidase in vital organs such as the liver and kidney. These results confirmed that the Indian medicinal plant O. sanctum has a protective effect and it may be useful in controlling complications resulting from diabetes.
    No preview · Article · Jul 2011 · Natural product research
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    ABSTRACT: Vitamin C is a water-soluble chain-breaking antioxidant that has beneficial effects on lipid-metabolizing enzymes. In the present study, the level of thiobarbituric acid (TBA) substances and antioxidant enzymes such as catalase, superoxide dismutase (SOD), glutathione peroxidase and glutathione-S-transferase were assayed. The level of TBA substances and antioxidant enzymes was determined in plasma and RBC hemolysates, respectively, in 60 postmenopausal women with breast cancer. The data obtained from the study revealed that the levels of TBA and the antioxidant enzymes catalase, SOD, glutathine peroxidase and glutathine-S-transferse were significantly normalized by vitamin C treatment in the RBC hemolysate. The results compared vitamin C-treated breast cancer patients with normal individuals and showed that co-administration of vitamin C is more beneficial in breast cancer patients treated with tamoxifen.
    No preview · Article · Aug 2010 · Chemotherapy
  • Govidan Muralikrishnan · Safiullah Amanullah · Mohamed I Basha · Amit K Dinda · Faiyaz Shakeel
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    ABSTRACT: The aim of the present investigation was to evaluate the efficacy of Withania somnifera on tricarboxylic acid (TCA) cycle enzymes and electron transport chain in azoxymethane-induced experimental colon cancer in mice. Azoxymethane at the dose of 15 mg/kg body weight was induced intraperitoneally once in a week for 28 days. The progression in colon tumor development was correlated with the appearance of the histological biomarker and aberrant crypt foci (ACF). Azoxymethane-induced colon cancer animals were treated with 400 mg/kg body weight of W. somnifera once in a week orally for 28 days. After the experimental period, the animals were killed and analyzed for TCA cycle key enzymes, such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH), and alpha-keto glutarate dehydrogenase (alpha-KGDH). The modulating effect of W. somnifera on TCA cycle key enzymes and electron transport chain complexes were investigated against colon cancer induced by azoxymethane in Swiss albino mice. Decreased activities of TCA cycle key enzymes such as ICDH, SDH, MDH, and alpha-KGDH in colon cancer bearing animals were observed. W. somnifera administration normalized these enzyme levels in azoxymethane-induced experimental mice. These results suggested that W. somnifera is the promising chemotherapeutic agent for the treatment of colon cancer.
    No preview · Article · Feb 2010 · Immunopharmacology and Immunotoxicology
  • Govidan Muralikrishnan · Amit K Dinda · Faiyaz Shakeel
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    ABSTRACT: The efficacy of Withania somnifera on immunomodulation was tested in experimental azoxymethane induced colon cancer in mice. Azoxymethane is a potential carcinogen to induce the colon cancer in Swiss albino mice. Azoxymethane 15 mg/kg body weight was injected intraperitoneally once a week for 28 days. The colon cancer was confirmed by the appearance of aberrant crypt foci (ACF) in the colons of the experimental mice. The progression in colon tumor development was correlated with the appearance of the histological biomarker and ACF. Azoxymethane induced colon cancer animals were treated with 400 mg/kg body weight of W. somnifera extract once a week for four weeks orally. After the experimental period, the animals were sacrificed and analyzed for immunocompetent cells, immune complexes and immunoglobulins. W. somnifera significantly altered the level of leucocytes, lymphocytes, neutrophils, immune complexes and immunoglobulins (Ig) A, G and M. The azoxymethane induced colon cancer and immune dysfunction was better controlled by W. somnifera. These results suggested that the immunomodulatory effects of W. somnifera could be useful in the treatment of colon cancer.
    No preview · Article · Jan 2010 · Immunological Investigations

Publication Stats

32 Citations
5.64 Total Impact Points

Institutions

  • 2012
    • University of Benghazi
      • Faculty of Science
      Bengasi, Banghāzī, Libya
  • 2011
    • Andhra Pradesh Horticultural University
      Tādepalligūdem, Andhra Pradesh, India
  • 2010
    • AIIMS Bhopal All India Institute of Medical Sciences
      Bhopal, Madhya Pradesh, India