E Dreher

Inselspital, Universitätsspital Bern, Berna, Bern, Switzerland

Are you E Dreher?

Claim your profile

Publications (56)120.48 Total impact


  • No preview · Article · Dec 2009 · Gynäkologisch-geburtshilfliche Rundschau
  • N. A. Bersinger · E. Dreher · M. D. Mueller

    No preview · Article · Sep 2005 · Fertility and Sterility
  • A Kuhn · E Dreher
    [Show abstract] [Hide abstract]
    ABSTRACT: Emergency consultations happen frequently in gynaecology and may be due to abdominal pain, itching, utero-vaginal bleeding, rape, emergency contraception, insertion of foreign bodies, prolapse and urinary tract infection. Considering pregnancy in patients with child bearing potential is essential. Vaginal bleeding may be due to atrophy, infection, carcinoma or pregnancy. In the latter it is crucial to differentiate between ectopic, pathologic or physiologic pregnancy. In postmenopausal women further investigations by the gynaecologist are mandatory to exclude malignancy. Patients who have been raped need psychological, forensic and gynaecological support. Sexually transmitted disease including HIV must be considered and prophylactic drugs should be administered. If unprotected intercourse has occurred the "morning after pill" can be considered within 72 hours after intercourse or an IUD up to five days. Prolapse occurs rarely as an acute problem but may induce urinary retention. Urinary tract infection is a common complaint and should be treated with antibiotics.
    No preview · Article · Jul 2005 · Therapeutische Umschau
  • A. Kuhn · E. Dreher

    No preview · Article · Jun 2005 · Therapeutische Umschau
  • K. C. Nessensohn · E. Dreher · A. Kuhn

    No preview · Article · Sep 2004 · Geburtshilfe und Frauenheilkunde
  • Source

    Full-text · Article · Aug 2004 · Ultrasound in Obstetrics and Gynecology
  • [Show abstract] [Hide abstract]
    ABSTRACT: We report two women who presented with a recurrent, mildly painful, bluish nodule in the umbilicus. Both patients complained of local tenderness and occasional bleeding that increased during menstruation. Neither patient had had previous pelvic surgery. Excision of the lesions revealed a primary umbilical endometriosis; in one case, a simultaneous laparoscopy showed a pelvic endometriosis. We review the current literature and discuss the possible etiopathogenesis and when a laparoscopy is indicated to diagnose a concomitant pelvic endometriosis. Umbilical endometriosis is a very rare disease but should be considered in the differential diagnosis of umbilical lesions.
    No preview · Article · Mar 2004 · Surgical Endoscopy
  • E. Dreher · L. Bronz · U. Haller

    No preview · Article · Jan 2004

  • No preview · Article · Jan 2004
  • [Show abstract] [Hide abstract]
    ABSTRACT: Metastases of thyroid carcinoma to the breast are rare. We report herein the first case resulting from an anaplastic thyroid carcinoma. A 56 year old female patient consulted for a breast lump after a trauma. The initial diagnosis was compatible with a hematoma. Three months later, a fine needle aspiration of a cold lump in the thyroid identified an anaplastic carcinoma. The performed core-biopsy of the same breast lump confirmed the presence of anaplastic carcinoma, which was retrospectively the first manifestation of this thyroid cancer. The anaplastic carcinoma is a poorly differentiated tumor characterized by a rapid growth with local compression and is considered very aggressive. The patient died shortly after the diagnosis. Breast metastasis of anaplastic thyroid carcinoma are extremely rare. Breast hematomas after a history of trauma should be carefully controlled until they resolve completely.
    No preview · Article · Jan 2004
  • A Kuhn · F Anthony · A Monga · E Dreher · I Cameron

    No preview · Article · Dec 2003 · Geburtshilfe und Frauenheilkunde
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Members of the Eph family of tyrosine kinases have been implicated in embryonic pattern formation and vascular development; however, little is known about their role in the adult organism. We have observed estrogen-dependent EphB4 expression in the normal breast suggesting its implication in the hormone-controlled homeostasis of this organ. Since the endometrium is a similarly hormone dependent organ and endometrial carcinoma is thought to result from estrogenic stimulation, we have investigated EphB4 expression in normal human endometrium and during its carcinogenesis. EphB4 expression was analyzed immunohistochemically in 26 normal endometrium specimens, 15 hyperplasias and 102 endometrioid adenocarcinomas and correlated with clinical and prognostic tumor characteristics. In normal endometrial tissue no EphB4 protein was detected. Strikingly, we observed a drastic increase (P <0.0001) in the number of EphB4 protein-expressing glandular epithelial cells in the majority of hyperplasias and carcinomas. Moreover, we found a statistically highly significant positive correlation between EphB4 expression and post-menopausal stage of the patient (P = 0.007). These findings indicate that in the endometrium, EphB4 is an early indicator of malignant development and, thus, EphB4 may represent a potent tool for diagnosis and therapeutic intervention.
    Preview · Article · Feb 2003 · Annals of Oncology
  • Source

    Full-text · Article · Jan 2003 · Ultrasound in Obstetrics and Gynecology
  • I. Dingeldein · T. Eggimann · E. Dreher · A. Kuhn
    [Show abstract] [Hide abstract]
    ABSTRACT: Purpose: We evaluated the medium-term results obtained with the Tension-free Vaginal Tape operation. Methods: Over a 3-year period a total of 122 patients underwent a Tension-free Vaginal Tape operation for treatment of genuine stress incontinence. All patients were studied prospectively and underwent urodynamic studies before and after surgery. Postoperatively patients underwent urodynamic testing and subjective assessment at 6-12 and at 12-24 months. Results: The subjective and objective cure rates were 70% and 61%, respectively. Perioperative complications included bleeding, bladder perforation, voiding problems and de novo urgency. Preoperative urgency seemed to improve postoperatively. Conclusion: Overall there were few complications and the procedure was successful despite a mixed level of surgical experience.
    No preview · Article · Nov 2002 · Geburtshilfe und Frauenheilkunde
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Axl, a member of a family of receptor tyrosine kinases characterized by an extracellular domain resembling cell adhesion molecules and an intracellular conserved tyrosine kinase domain has been reported to induce cell proliferation and transformation. In mice, axl is expressed in the normal mammary gland and over-expressed in aggressive mammary tumors. We have investigated the expression of axl immunohistochemically in 23 normal human breast samples and in 111 consecutive breast carcinomas. Expression of axl was correlated with tumour characteristics (lymph node involvement, stage, grade) and immunohistochemical expression of ER, PR, Ki-67 and c-erbB-2. In normal tissue, axl localizes to the membrane of breast epithelial cells. Axl protein shows membrane associated staining in high correlation (P = 0.004) with the expression of the estrogen receptor (ER). Axl expression was found in a subset of breast carcinomas and was also correlated with high significance (P < 0.0001) with the presence of ER. Our results suggest that axl may serve as a mediator of estrogen stimulation preventing the completion of the breast epithelial life cycle and that estrogen induced axl expression may give a survival signal to cancerous cells, preventing them from dying through apoptosis.
    Full-text · Article · Jul 2001 · Annals of Oncology
  • M. D. Mueller · E. Dreher · R. N. Taylor

    No preview · Article · Dec 2000 · Geburtshilfe und Frauenheilkunde
  • S Balli · M F Fey · W Hänggi · D Zwahlen · G Berclaz · E Dreher · S Aebi
    [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this study was to investigate the prognostic importance of the health insurance status in 145 consecutive patients with ovarian cancer diagnosed between 1984 and 1996. All patients had basic (Type III) insurance to cover outpatient treatment and hospital expenses for a per diem flat fee; some patients had one of two types of supplemental private insurance (Type I and Type II) to cover the treatment by physicians of their choice and fee-for-service hospital treatment. The prognostic impact of health insurance was evaluated by multivariate statistical methods. The median follow-up was 81.9 months (range: 21-181); the 5-year probability of survival was 72% (standard error of the mean (SEM) 9.8%) for stage I, 53% (SEM 16.2%) for stage II, 17% (SEM 5. 9%) for stage III and 11% (SEM 5.5%) for stage IV cancer. Age, stage, histological grade and debulking surgery were independent predictors of survival in multivariate proportional hazards regression analysis. Patients with private insurance were younger and received more chemotherapy than patients with basic insurance. In multivariate analysis, insurance was an independent predictor of survival: patients with Type II insurance had a hazard ratio of 2.31 (95% confidence interval (CI): 1.05-5.04), and patients with Type III insurance had a hazard ratio of 3.30 (95% CI 1.52-7.17) compared with the reference group of Type I insured patients. Health insurance status was an independent predictor of survival in ovarian cancer. Research is needed to devise strategies to improve the medical care of patients with basic insurance.
    No preview · Article · Nov 2000 · European Journal of Cancer

  • No preview · Article · Sep 2000 · Gynäkologisch-geburtshilfliche Rundschau
  • G. Berclaz · C. Hofmann · S. Aebi · S. Brugger · M. Fey · W. Hanggi · E. Dreher
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective: Bone scintigraphy, ultrasonography of the liver, and chest radiography are used as routine staging procedures in patients with breast cancer at our department. The value of these studies has been questioned because of their cost and low yield of metastases. We aimed to analyze the results of staging tests at our department and to survey staging procedures at other departments in Switzerland. Methods: We reviewed 266 consecutive patients with breast cancer and complete staging between 1992 and 1996. The presence of metastases was analyzed according to tumor stage, regional lymph node status, tumor grade, estrogen and progesterone receptor status. We also surveyed all 79 public hospital gynecology departments in Switzerland with a written questionnaire about their practice of staging breast cancer. Results: 23 patients (8.6%) had metastases at the time of diagnosis but only three (1.1%) were asymptomatic and detected by the routine staging tests. The presence of metastases was strongly correlated with advanced stage (T2-T4) and positive axillary lymph nodes (p<0.0001). The response rate to the survey questionnaire was 84%. Most (85%) of the responding departments performed the same routine staging tests as we did. Discussion: These data confirm that the diagnostic yield of routine bone scintigraphy, ultrasonography of the liver, and chest radiography in asymptomatic patients with negative axillary nodes is low. We no longer perform these tests in such patients. This procedure would appear to save time and money without adversely affecting the prognosis.
    No preview · Article · Aug 2000 · Geburtshilfe und Frauenheilkunde
  • [Show abstract] [Hide abstract]
    ABSTRACT: iyk, a member of the frk family of non-receptor tyrosine kinases, was originally isolated from normal mouse mammary glands and is characterized by a nuclear localizing signal within the SH2 domain. We have investigated the expression and subcellular localization of iyk in the normal human breast and in malignant breast diseases. Immuno-histochemical analyses revealed that in normal tissue iyk localizes to both cytoplasmic and nuclear compartments of breast epithelial cells. The subcellular distribution was dependent on the hormonal state, being mostly cytoplasmic during the follicular, proliferative phase of the menstrual cycle, whereas frequent nuclear staining was observed in the resting stages during the luteal phase and, most prominently, after menopause. Strikingly, invasive carcinomas, irrespective of tumor type or hormonal status of the patient, exhibited almost complete loss of iyk expression in both the cytoplasm and the nucleus. In contrast, in situ breast carcinomas from post-menopausal patients showed a clear reduction of the nuclear iyk localization while retaining cytoplasmic staining. Our results indicate that iyk expression is gradually lost during carcinogenesis; thus, iyk may be classified as a tumor-suppressor gene.
    No preview · Article · Apr 2000 · International Journal of Cancer

Publication Stats

332 Citations
120.48 Total Impact Points

Institutions

  • 1993-2005
    • Inselspital, Universitätsspital Bern
      • Department of Obstetrics and Gynaecology
      Berna, Bern, Switzerland
  • 2004
    • Kantonsspital Münsterlingen
      Münsterlingen, Thurgau, Switzerland
  • 1992-1999
    • Universität Bern
      • Department of Clinical Research
      Berna, Bern, Switzerland