[Show abstract][Hide abstract] ABSTRACT: In six patients affected by chronic renal failure we evaluated the effects of oral calcitriol pulse therapy on biohumoral and radiographic changes secondary to severe hyperparathyroidism. After two months of therapy with the administration of 2 μg of calcitriol on alternative evenings all patients showed a significant decrease of serum iPTH levels. In four patients with a follow-up of five months or longer serum iPTH concentrations showed a further decrease. After five months of treatment skeletal phalangeal changes improved consequently to an important regression of subperiosteal resorption. In two cases ultrasonographic size of parathyroid glands resulted in a decrease confirming an efficacious effect of calcitriol pulse therapy in regression of diffuse hyperplasia. No adverse drug effect complicated the trial. In conclusion the treatment of secondary hyperparathyroidism should be modified according to the stage of uremia. In absence of a beneficial prevention the oral calcitriol pulse therapy results in obtaining a favourable inhibition of parathyroid hyperactivity.
No preview · Article · Sep 1996 · Italian Journal of Mineral and Electrolyte Metabolism
[Show abstract][Hide abstract] ABSTRACT: Three cases of successful pregnancy after renal transplantation are reported. Available data of the literature concerning these patients suggest that pregnancy can have a good outcome although higher maternal and fetal risks can occur. Our cases share some complications reported in previous series. Planned pregnancy must be followed by careful monitor of renal and placental function in order to assure the best chances for these patients.
No preview · Article · May 1996 · Giornale Italiano di Ostetricia e Ginecologia