Chinna Raju

Loma Linda University, Loma Linda, CA, United States

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Publications (6)4.01 Total impact

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    ABSTRACT: Hydrotherapy and whirlpool are used to increase skin blood flow and warm tissue. However, recent evidence seems to show that part of the increase in skin blood flow is not due to the warmth itself but due to the moisture content of the heat. Therefore, two series of experiments were accomplished on 10 subjects with an average age of 24.2 +/- 9.7 years and free of diabetes and cardiovascular disease. Subjects sat in a 37 degrees C hydrotherapy pool under two conditions: one in which a thin membrane protecting their skin from moisture while their arm was submerged in water and the second where their arm was allowed to be exposed to the water for 15 minutes. During this period of time, skin and body temperature were measured as well as skin blood flow by a Laser Doppler Imager. The results of the experiments showed that the vapor barrier blocked any change in skin moisture content during submersion in water, and while skin temperature was the same as during exposure to the water, the blood flow with the arm exposed to water increased from 101.1 +/- 10.4 flux to 224.9 +/- 18.2 flux, whereas blood flow increased to only 118.7 +/- 11.4 flux if the moisture of the water was blocked. Thus, a substantial portion of the increase in skin blood flow associated with warm water therapy is probably associated with moisturizing of the skin rather than the heat itself.
    No preview · Article · Feb 2010 · Physiotherapy Theory and Practice
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    ABSTRACT: Vascular endothelial and autonomic damage are hallmarks of type 1 and type 2 diabetes. However, while much has been published on impairment of the autonomic nervous system, much less has been published on the interrelationship between autonomic damage and exercise. The present investigation examined the change in heart rate, blood pressure, skin and limb blood flow, and sweat during non-fatiguing (10% and 25% maximum strength [maximal voluntary contraction (MVC)]) and a fatiguing isometric contraction (40% MVC) in people with type 2 diabetes compared to younger and older controls to see if a simple handgrip test could show the extent of autonomic damage in people with diabetes. Fifteen younger subjects (30.6 +/- 8.6 years), 15 older subjects (65.8 +/- 8.8 years), and 15 subjects with diabetes (63.4 +/- 14.4 years) whose average percentage body fat was 40.1 +/- 12.9%, 36.1 +/- 9.3%, and 39.6 +/- 15.5%, respectively, participated in these studies. Whole forearm blood flow, skin blood flow, and sweat on the forearm, chest, and forehead were measured at rest and during and after a contraction at 10% MVC, 25% MVC, and 40% MVC. Blood flows and sweat rates were greatest in younger subjects, significantly less in older subjects, and even significantly less in subjects with diabetes (P < 0.05). The heart rate response was unaltered during contractions at 10% and 25% MVC and less in diabetes than in the other two groups with 40% MVC. Strength was about half in the diabetes group than with the other two groups, but endurance was similar. Diabetes is associated with a reduction in handgrip strength and significantly impaired autonomic function during and after isometric exercise.
    No preview · Article · Jul 2009 · Diabetes Technology & Therapeutics
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    ABSTRACT: Numerous studies have examined the effect of local and global heating of the body on skin blood flow. However, the effect of the moisture content of the heat source on the skin blood flow response has not been examined. Thirty-three subjects, without diabetes or cardiovascular disease, between the ages of 22 and 32 were examined to determine the relationship between the effects of dry vs. moist heat applied for the same length of time and with the skin clamped at the same skin temperature on the blood flow response of the skin. The skin, heated with an infrared heat lamp (skin temperature monitored with a thermocouple) to 40 degrees C for 15 min, was either kept moist with wet towels or, in a separate experiment, kept dry with Drierite (a desiccant) between the towels to remove any moisture. Before and after heat exposure of the forearm, blood pressure, heart rate, skin moisture content, skin temperature, and skin blood flow were recorded. The results of the experiment showed that there was no change in skin moisture after 15 min exposure to dry heat at 40 degrees C. However, with moist heat, skin moisture increased by 43.7%, a significant increase (P < 0.05). With dry heat, blood flow increased from the resting value by 282.3% whereas with moist heat, blood flow increased by 386% over rest, a significant increase over dry heat (P < 0.05). Thus, with a set increase in skin temperature, moist heat was a better heating modality than dry heat. The reason may be linked to moisture sensitivity in calcium channels in the vascular endothelial cell.
    No preview · Article · May 2009 · Archives for Dermatological Research
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    ABSTRACT: Pennes first described a model of heat transfer through the limb based only on calories delivered from a heat source, calories produced by metabolism and skin blood flow. The purpose of this study was to determine the effect of a moist versus a dry heat source on the skin in eliciting a blood flow response to add data to this model. Ten subjects were examined, both male and female, with a mean age of 32.5 +/- 11.6 years, mean height of 172.8 +/- 12.3 cm, and mean weight of 77.6 +/- 19.5 kg. Skin temperature was measured by a thermocouple placed on the skin and skin blood flow measured by a laser Doppler flow meter. The results of the experiments using a dry heat pack (commercially available chemical 42 degrees C cell dry heat source), moist hydrocollator pack (72.8 degrees C) separated from the skin by eight layers of towels, and whirlpool at 40 degrees C, showed that moist heat caused a significantly higher skin blood flow (about 500% greater) than dry heat (p < 0.01). Most of the greater increase in skin blood flow with moist heat was due to the greater rate of rise of skin temperature with moist versus dry heat while some of the increase in blood flow was due to the moisture itself. This could either be related to the greater heat flux across the skin with moist air or due to changing the ionic environment around skin thermo receptors by keeping the skin moist during heating. Skin thermo receptors are believed to be temperature sensitive calcium gated channels in endothelial cells which couple calcium influx to a release of nitric oxide. If true, reducing moisture in the skin might have the effect of altering ionic flux through these receptors. A correct model of skin heat flux should therefore take heat moisture content into consideration.
    No preview · Article · May 2009 · Journal of Medical Engineering & Technology
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    ABSTRACT: Surface heating modalities are commonly used in physical therapy and physical medicine for increasing circulation, especially in deep tissues, to promote healing. However, recent evidence seems to indicate that in people who are overweight, heat transfer is impaired by the subcutaneous fat layer. The present investigation was conducted on 10 subjects aged 22-54 years, whose body mass index averaged 25.8+/-4.6. Subcutaneous fat above the quadriceps muscle varied from 0.51 to 0.86 cm of thickness. Three heating modalities were examined: the application of dry heat with a commercial chemical heat pack, hydrocollator heat packs (providing a type of moist heat), and a whirlpool, where conductive heat loss through water contact would be very high. The temperature of the skin and the temperature in the muscle (25 mm below the skin surface) were assessed by thermocouples. The results of the experiments showed that for heating modalities that are maintained in skin contact for long periods of time, such as dry heat packs (in place for 6 hours), subcutaneous fat did not impair the change in deep muscle temperature. In contrast, when rapid heat modalities were used, such as the hydrocollator and the whirlpool (15 minutes of sustained skin contact), the transfer of heat from the skin to deep muscle was significantly impaired in people with thicker subcutaneous fat layers. We observed that the greater the impairment in heat transfer to muscle from skin covered by body fat, the warmer the skin temperature increase during the modality.
    No preview · Article · Feb 2009 · Journal of Medical Engineering & Technology
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    ABSTRACT: Sixty female subjects in the age range of 20 - 65 years participated in a series of experiments to determine the effectiveness of a 1-hour aerobic dance video used each day for a total of 10 days, combined with a dietary plan in promoting weight loss and increasing cardiovascular fitness. The experiment was a single-blinded, randomized design study, and subjects were randomly assigned into 1 of 2 groups. One group of subjects participated in the exercise and diet program (30 subjects) and the other group served as controls, and participated in the measurements only (30 subjects). The diet consisted of 1,306 calories per day and was a balance between Carbohydrates, Fats and, Proteins. For the control subjects (non-exercising), there was no difference in blood pressure, heart rate, girth, or body weight over the 10-day period. In contrast, for the group of subjects that exercised, at 7 days, the average weight loss was 1.22 ± 0.75 kg, and the average loss in girth at the waist was 1.74 ±3.0 cm. The top 10% of the subjects reduced their weight by 2.53 ± 0.6 kg and waist circumference by 5.86 ± 2.1cm. Heart rate and blood pressure decreased significantly at 7 days (p<0.05). By the 10 th day, the average weight loss was 2.1 ± 0.61 kg, average loss in body fat was 3.0 ±1.1 % of body weight, and the average reduction of girth at the waist was 3.7 ± 1.1 cm. For the top 10% of the group, the weight loss was 3.4±1.4 kg at 10 days, and for the waist, the average reduction of girth was 8.16±2.3 cm. There was a 28.6% increase in the strength of the core muscles.
    No preview · Article · Jan 2008