Aysegül Uner

Hacettepe University, Engüri, Ankara, Turkey

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Publications (19)31.14 Total impact

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    ABSTRACT: Tamoxifen has been in the center of management of hormone-sensitive breast cancer. Furthermore, it represents the best example of chemo-prevention: It reduces the incidence of invasive breast cancer. However, it has some side effects, several of them are severe. Oncologists, hematologists, internal medicine specialists and gynecologists must know this agent in detail. Authors report a very rare side effect, thrombocytopenia, and discuss it briefly.
    No preview · Article · Feb 2007 · Medical Oncology
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    ABSTRACT: In this study, tumour tissue samples of 85 primary breast cancer patients were evaluated for phosphatase and tensin homolog deleted on chromosome ten (PTEN), cyclin D1 and P27/Kip1 expression patterns. The results were correlated with clinicopathological parameters. Loss of PTEN protein expression was present in 32.5% of the cases. Cyclin D1 was overexpressed in 54.2% and P27/Kip1 in 89.3% of the cases. Statistically significant associations were found between PTEN and cyclin D1 expression patterns, and cyclin D1 expression and tumour size.
    No preview · Article · Mar 2006 · Bulletin du cancer
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    ABSTRACT: A 13-year-old boy was referred to the authors' hospital following a right inguinal orchiectomy for a right scrotal mass. Histopathological examination revealed Burkitt lymphoma. The left testis was found to be small with heterogeneous parenchyma by scrotal ultrasound (US) and other systemic investigations were negative for lymphoma involvement. Ultrasound-guided fine-needle aspiration biopsy showed no evidence of involvement in the left testis. Considering stage I Burkitt lymphoma, chemotherapy was started. Following the first course, US findings changed: the volume of the left testis decreased and the parenchyma became homogeneous. The left testis was considered to be involved by lymphoma at initial diagnosis and chemotherapy was intensified. At the end of 5 months of chemotherapy the left testis was again heterogeneous in US. A wedge-biopsy was negative for lymphoma. The patient is under regular follow-up and is in complete remission 19 months after the end of chemotherapy. Primary testicular lymphoma is quite rare in children and experience is limited. Changes in testicular size and parenchyma by US should not necessarily indicate involvement by lymphoma in pubertal boys.
    No preview · Article · Jan 2006 · Pediatric Hematology and Oncology
  • Ayşegül H Uner · Arzu Sağlam · Unsal Han · Mutlu Hayran · Arzu Sungur · Sevket Ruacan
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    ABSTRACT: PTEN is a tumor suppressor gene located on chromosome 10q23 and is amongst the most commonly mutated genes in human cancers. The lipid phosphatase activity of Pten enables it to dephosphorylate PIP3, thereby antagonizing growth factor stimulated PI3-kinase signaling mediated by AKT/PKB. The growth inhibition effect of PTEN has been shown to be mediated by p27 which is one of the important effector molecules downstream of the AKT pathway. Recently the importance of the Pten and AKT pathway in the regulation of the immune system and development of hematological malignancies has been shown. Loss of Pten and p27 expressions were examined immunohistochemically in 45 patients with peripheral T- and NK-cell lymphoma. Partial or complete loss of Pten was detected in 66.7% of the cases of anaplastic large cell lymphoma (ALCL) compared to only 12.5% of all other mature T-/NK-cell lymphomas combined. Loss of p27 was identified in 64.9% of cases, which showed a positive correlation with Pten loss. In this study, we showed that loss of Pten is more frequent in ALCL as compared to other mature T-/NK-cell lymphomas, which strongly correlates with the loss of p27 expression. Our findings provide further evidence for the importance of the deregulation of the PI3K-AKT pathway in ALCL.
    No preview · Article · Nov 2005 · Leukemia and Lymphoma
  • Aysegül Uner · Emin Kansu · James Mc Arthur

    No preview · Article · Nov 2005 · Hematology
  • A Sağlam · G Güler · M Taşkin · A Ayhan · A H Uner
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    ABSTRACT: We present a case of a 35-year-old woman whose myomectomy specimen revealed a leiomyoma nodule diffusely infiltrated by lymphocytes which were shown to be clonal in nature. Lymphoid infiltration of leiomyomas is a rare occurrence, and this is the first case with molecular analysis.
    No preview · Article · Jan 2005 · International Journal of Gynecological Cancer
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    A Terzi · K Altundag · A Saglam · A Gurlek · S Aksoy · E Baltali · AH Uner
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    ABSTRACT: A 38-yr-old woman with a history of malignant melanoma (MM) presented with a thyroidal nodule. Fine needle aspiration biopsy of the thyroid was consistent with metastatic MM. The patient underwent thyroidectomy: microscopic examination revealed a follicular carcinoma nodule harboring a focus of metastatic melanoma. On review of the fine needle aspiration biopsy specimen, the population of cells with more uniform nuclei with focal follicle formation, which initially was interpreted as cells originating from normal thyroid tissue, was seen to actually represent the follicular carcinoma component. Tumor-to-tumor metastasis is an interesting phenomenon and there are only few cases of MM metastasis to other tumors. MM metastasis into a neoplastic thyroid nodule is a very rare combination and may be explained because the nodule in question represents the most highly vascularized component of the thyroid.
    Full-text · Article · Dec 2004 · Journal of endocrinological investigation
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    ABSTRACT: Introduction The vagina as a primary site of malignant lymphoma in woman is extremely rare. Case report We report here a 30-year-old patient with a primary vaginal non-Hodgkin's lymphoma stage IEA, follicular large cell of B lineage, with an excellent response to cytotoxic chemotherapy (CHOP) and event-free survival of 28 months. Conclusion Primary involvement of the vagina can be successfully treated by pelvic irradiation, but in young women chemotherapy should be considered to preserve fertility, as well as quality of life.
    No preview · Article · Apr 2004 · Archives of Gynecology and Obstetrics
  • Emin Kansu · Aysegül Uner · James R McArthur

    No preview · Article · Mar 2004 · Hematology
  • H Abali · O O Eren · M Erman · AH Uner · F Kose · N Guler
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    ABSTRACT: The diagnosis of cervical squamous cell carcinoma with concurrent T-cell rich B cell lymphoma in dissected lymph nodes has not been reported to our knowledge. In our case, the biopsy of an exophytic lesion at the uterine cervix showed squamous cell carcinoma in a 50-year-old woman presenting with postcoital bleeding. Type III hysterectomy, bilateral salpingo-oophorectemy, bilateral pelvic, para-aortic lymph node dissections were performed. Pathologic examination revealed a T-cell rich B cell lymphoma in some lymph nodes beside squamous cell carcinoma in several of others. ELISA for human immuno-deficiency virus (HIV) was negative. The cervical carcinoma was staged as FIGO clinical stage IB1 and the lymphoma as Ann Arbor IIA. Six cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolon) chemotherapy for the lymphoma and concomitant pelvic chemoradiotherapy with cisplatin for cervical cancer were given. In this rare coincidence, the best available therapy for each of the diseases should be considered individually. We also suggest that HIV screennig test be carried out, because both diseases may be related to human immuno-deficiency virus, although our patient is HIV-negative.
    No preview · Article · Sep 2003 · International Journal of Gynecological Cancer
  • James R McArthur · Emin Kansu · Aysegül Uner

    No preview · Article · Sep 2003 · Hematology
  • H. Abali · O. O. Eren · M. Erman · A. H. Uner · F. Kose · N. Guler
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    ABSTRACT: The diagnosis of cervical squamous cell carcinoma with concurrent T-cell rich B-cell lymphoma in dissected lymph nodes has not been reported to our knowledge. We report such a case. The biopsy of an exophytic lesion at the uterine cervix showed squamous cell carcinoma in a 50-year-old woman presenting with postcoital bleeding. Type III hysterectomy, bilateral salpingo-oophorectemy, bilateral pelvic, paraaortic lymph node dissections were performed. Pathologic examination revealed a T-cell rich B-cell lymphoma in some lymph nodes beside squamous cell carcinoma in several of others. ELISA for human immuno-deficiency virus (HIV) was negative. The cervical carcinoma was staged as FIGO clinical stage IB1 and the lymphoma as Ann Arbor IIA. Six cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisone) chemotherapy for the lymphoma and concomitant pelvic chemo-radiotherapy with cisplatin for cervical cancer were given. In this rare coincidence; the best available therapy for each of the diseases should be considered individually. We also suggest that HIV screening test be carried out, because both diseases may be related to human immuno-deficiency virus, although our patient was HIV-negative.
    No preview · Article · Aug 2003 · International Journal of Gynecological Cancer
  • James R McArthur · Emin Kansu · Aysegül Uner

    No preview · Article · May 2003 · Hematology
  • James R McArthur · Emin Kansu · Aysegül Uner

    No preview · Article · Mar 2003 · Hematology
  • James R McArthtur · Emin Kansu · Aysegül Uner

    No preview · Article · Nov 2002 · Hematology
  • James R McArthtur · Emin Kansu · Aysegül Uner

    No preview · Article · Sep 2002 · Hematology
  • James R McArthtur · Emin Kansu · Aysegül Uner

    No preview · Article · Jul 2002 · Hematology
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    ABSTRACT: CD44 variant exon 6 (v6) belongs to a family of transmembrane glycoproteins involved in cell adhesion. To determine the prognostic role of CD44v6 in laryngeal cancer and to examine its relation with other clinicopathologic prognostic factors. A retrospective cohort study was designed with 93 laryngeal cancer cases. They were selected randomly from patients treated with laryngectomy between January 1, 1983, and December 31, 1993. Faculty of Medicine, Hacettepe University, Ankara, Turkey. The ages of the patients ranged from 31 to 73 years. Eighty-eight patients were men and 5 were women. Three had stage I, 33 had stage II, 27 had stage III, and 30 had stage IV disease at the time of surgery. Histological sections of tumors and metastatic lymph nodes were reevaluated for several histopathological factors. Sections were stained using anti-CD44v6 monoclonal antibody by immunohistochemical methods. CD44v6 expression was seen only in the lower one third of the normal squamous epithelium but in all layers of dysplasia and in situ carcinoma. Besides a general evaluation of tumor staining, immunostaining was evaluated separately for cell groups located in the center of neoplastic islands (nonbasal cells), at the periphery of the neoplastic islands (basal cells), and at the infiltration zones (marginal cells). Decreased disease-free survival was noted when there was extensive staining in the general evaluation and in cases with extensive staining in marginal and nonbasal cells (P =.03). Using Cox regression analysis, the greatest dimension of the largest metastatic lymph node and extensive expression of CD44v6 in nonbasal tumor cells were independent prognostic factors. Our results suggest that CD44v6 expression is an important prognostic factor in laryngeal cancer.
    No preview · Article · May 2002 · Archives of Otolaryngology - Head and Neck Surgery
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    ABSTRACT: Myasthenia gravis (MG) is an autoimmune neuromuscular junction disease. An association between thymic epithelial neoplasms and MG is well known. However, it is rarely associated with hematologic malignancies. In particular, very few cases of lymphoblastic lymphoma involving the thymus and MG have been reported. Here we report a case T-cell lymphoblastic lymphoma involving the thymus who developed MG after the initial diagnosis. The patient initially presented with a mediastinal mass which was diagnosed as lymphoblastic lymphoma. MG was diagnosed during leukemic relapse in this patient and was based on clinical presentation and neurophysiologic studies including single fiber electromyography (EMG) and repetitive nerve stimulation tests. In contrast to the other cases with such an association, the myasthenic symptoms presented nine months after the diagnosis of lymphoma by thymectomy. The patient had a highly aggressive clinical course and was resistant to various chemotherapy regimens.
    No preview · Article · Aug 2001 · Leukemia and Lymphoma

Publication Stats

74 Citations
31.14 Total Impact Points

Institutions

  • 2001-2006
    • Hacettepe University
      • • Department of Pathology
      • • Institute of Oncology
      Engüri, Ankara, Turkey
  • 2002-2003
    • University of Washington Seattle
      Seattle, Washington, United States