Yong He

Third Military Medical University, Ch’ung-ch’ing-shih, Chongqing Shi, China

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Publications (500)582.06 Total impact

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    ABSTRACT: The special production process of carbon black prohibits the application of traditional, mature flue gas treatments (e.g., SNCR and SCR) to reduce NOx emissions. However, simultaneous removal of sulfur and nitrogen by the combination of ozone oxidation with limestone-gypsum wet scrubbing is suitable for the conditions found in carbon black flue gas. This paper presents the first industrial-size deployment of this technology in a 100,000 t/y carbon black production line (flue gas volume 60000 Nm3/h). Optimizations were performed by studying the effectiveness of desulfurization and denitration for various operating parameters such as O3/NOx molar ratio, spray tower liquid-gas ratio, NOx initial concentration and forced oxidation. Results show that: (1) the O3/NOx molar ratio is the determining factor in denitration efficiency; (2) both forced oxidation and increasing initial NOx concentration improve denitration efficiency while reduce desulfurization efficiency; (3) increasing the liquid-gas ratio can improve the desulfurization efficiency but has little effect on denitration. The maximum desulfurization and denitration efficiencies of the system can be up to 98% and 95%, with SO2 and NOx levels of 1000 mg/Nm3 (6% O2) and 900 mg/Nm3 (6% O2) dropping to 20 mg/Nm3 (6% O2) and 45 mg/Nm3 (6% O2), respectively.
    No preview · Article · Jan 2016 · Energy & Fuels
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    ABSTRACT: Lung adenocarcinoma is the most common subtype of non-small cell lung cancer (NSCLC), leading to the largest number of cancer-related deaths worldwide. The high mortality rate may be attributed to the delay of detection. Therefore, it is of great importance to explore the mechanism of lung adenocarcinoma metastasis and the strategy to block metastasis of the disease. We searched and downloaded mRNA and miRNA expression data and clinical data from The Cancer Genome Atlas (TCGA) database to identify differences in mRNA and miRNA expression of primary tumor tissues from lung adenocarcinoma that did and did not metastasize. In addition, combined with bioinformatic prediction, we constructed an miRNA-target gene regulatory network. Finally, we employed RT-qPCR to validate the bioinformatic approach by determining the expression of 10 significantly differentially expressed genes which were also putative targets of several dysregulated miRNAs. RT-qPCR results indicated that the bioinformatic approach in our study was acceptable. Our data suggested that some of the genes including PKM2, STRAP and FLT3, may participate in the pathology of lung adenocarcinoma metastasis and could be applied as potential markers or therapeutic targets for lung adenocarcinoma.
    No preview · Article · Jan 2016 · Oncology Reports
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    ABSTRACT: A series of experiments were performed to investigate the relationship between syngas composition (H2/CO/CO2/N2/O2) and NO formation. Laser-saturated fluorescence measurements of NO in a premixed syngas flat flame from a heat flux burner were recorded for various fuel compositions, dilution ratios and equivalence ratios. Quantitative measurements were compared with the predictions from CHEMKIN software using four different chemical mechanisms, i.e., GRI mech 3.0, Chemical Reaction Engineering and Chemical Kinetics 1407, GDF-Kin 3.0, and the Mendiara and Glarborg mechanism; each mechanism included reaction subsets for NOx formation. These models were validated against a CH4 flame; the GDF-Kin 3.0 mechanism produced the best agreement with measurements. NO measurements for CO/H2 syngas fuel with 50% CO2 dilution at various equivalence ratios found the maximum NO production near stoichiometry. The majority of NO produced for these conditions is predicted to come from the combination of the NNH and N2O pathways. Investigation of NO production during combustion of different CO/H2 ratio syngas diluted with 60% N2 showed that increasing the H2 fraction decreased the total NO concentration. However, normalizing the NO production rate by the fuel mass consumption rate showed H2 produces more NO per gram of fuel consumed. Predictions of temperature and NO rate of production along the flame axis showed that the syngas with high H2 content had a flame front closer to the burner exit and NO production rate greater than the high CO case. Dilution of CO/H2 syngas fuel with N2 and CO2 showed that CO2 has a stronger reduction in NO emission than N2. GDF-Kin 3.0 predicted that dilution with CO2 caused a greater reduction in flame temperature than the same volume of N2. Predicted NO rate of production and reaction sensitivity analysis predicted that the Zel’dovich pathway was dominant for undiluted syngas. However, as the flame temperature reduced, the Zel’dovich pathway was inhibited to a greater extent than the N2O and NNH pathways so that, at high dilution, NO production was driven by the N2O and NNH pathways.
    Full-text · Article · Dec 2015
  • Yun Zhao · Xing Xu · Yong He
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    ABSTRACT: Near-infrared hyperspectral imaging technology was adopted in this study to discriminate among varieties of raisins produced in Xinjiang Uygur Autonomous Region, China. Eight varieties of raisins were used in the research, and the wavelengths of the hyperspectral images were from 900 to 1700 nm. A novel waveform resolution method is proposed to reduce the hyperspectral data and extract the features. The waveform-resolution method compresses the original hyperspectral data for one pixel into five amplitudes, five frequencies, and five phases for 15 feature values in all. A neural network was established with three layers-eight neurons for the first layer, three neurons for the hidden layer, and one neuron for the output layer-based on the 15 features used to determine the varieties of raisins. The accuracies of the model, which are presented as sensitivity, precision, and specificity, for the testing data set, are 93.38, 81.92, and 99.06%. This is higher than the accuracies of the model using a conventional principal component analysis feature-extracting method combined with a neural network, which has a sensitivity of 82.13%, precision of 82.22%, and specificity of 97.45%. The results indicate that the proposed waveform-resolution feature-extracting method combined with hyperspectral imaging technology is an efficient method for determining varieties of raisins.
    No preview · Article · Nov 2015 · Applied Spectroscopy
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    ABSTRACT: Serious fouling and slagging problems are associated with the combustion of Chinese Zhun-Dong coal due to its high content of sodium (Na). Understanding the release characteristic of Na during the combustion is essential to viable utilization of this coal. In this work, coal samples were treated with a sequence of solvents: water (H2O), ammonium acetate (NH4Ac), hydrochloric acid (HCl), and the release characteristics of various classes of Na during coal combustion were investigated using the technique of laser-induced breakdown spectroscopy. The relative contribution of various Na classes to the Na release during each combustion stage was found to be similar, in the order of H2O-soluble Na > NH4Ac-soluble Na > HCl-soluble Na > insoluble Na. Sodium released during the devolatilization stage can be attributed to each of the sodium classes. After the devolatilization stage, H2O-soluble Na and NH4Ac-soluble Na dominated the Na release during both char and ash stages. Over 64 % of the total Na released during combustion comes from the H2O-soluble Na, which suggests that the Na release during the combustion of Zhun-Dong coal can be reduced effectively after treatment by H2O washing. © 2015, Science China Press and Springer-Verlag Berlin Heidelberg.
    No preview · Article · Nov 2015
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    ABSTRACT: Raman spectroscopy was first adopted for rapid detecting a hazardous substance of lead chrome green in tea, which was illegally added to tea to disguise as high-quality. 160 samples of tea infusion with different concentrations of lead chrome green were prepared for Raman spectra acquirement in the range of 2804 cm -1 -230 cm -1 and the spectral intensities were calibrated with relative intensity standards. Then wavelet transformation (WT) was adopted to extract information in different time and frequency domains from Raman spectra, and the low-frequency approximation signal (ca4) was proved as the most important information for establishment of lead chrome green measurement model, and the corresponding partial least squares (PLS) regression model obtained good performance in prediction with R p and RMSEP of 0.936 and 0.803, respectively. To further explore the important wavenumbers closely related to lead chrome green, successive projections algorithm (SPA) was proposed. Finally, 8 characteristic wavenumbers closely related to lead chrome green were obtained and a more convenient and fast model was also developed. These results proved the feasibility of Raman spectroscopy for nondestructive detection of lead chrome green in tea quality control.
    No preview · Article · Oct 2015 · Scientific Reports
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    ABSTRACT: Interstitial lung disease (ILD) is a serious side-effect of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) treatment. Therefore, it is necessary to study underlying mechanisms for the development of pulmonary fibrosis induced by EGFR-TKI and potential approaches to attenuate it. Metformin is a well-established and widely prescribed oral hypoglycemic drug, and has gained attention for its potential anticancer effects. Recent reports have also demonstrated its role in inhibiting epithelial-mesenchymal transition and fibrosis. However, it is unknown whether metformin attenuates EGFR-TKI-induced pulmonary fibrosis. The effect of metformin on EGFR-TKI-induced exacerbation of pulmonary fibrosis was examined in vitro and in vivo using MTT, Ki67 incorporation assay, flow cytometry, immunostaining, Western blot analysis, and a bleomycin-induced pulmonary fibrosis rat model. We found that in lung HFL-1 fibroblast cells, TGF-β or conditioned medium from TKI-treated lung cancer PC-9 cells or conditioned medium from TKI-resistant PC-9GR cells, induced significant fibrosis, as shown by increased expression of Collegen1a1 and α-actin, while metformin inhibited expression of fibrosis markers. Moreover, metformin decreased activation of TGF-β signaling as shown by decreased expression of pSMAD2 and pSMAD3. In vivo, oral administration of gefitinib exacerbated bleomycin-induced pulmonary fibrosis in rats, as demonstrated by HE staining and Masson staining. Significantly, oral co-administration of metformin suppressed exacerbation of bleomycin-induced pulmonary fibrosis by gefitinib. We have shown that metformin attenuates gefitinib-induced exacerbation of TGF-β or bleomycin-induced pulmonary fibrosis. These observations indicate metformin may be combined with EGFR-TKI to treat NSCLC patients.
    Preview · Article · Oct 2015 · Oncotarget
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    Yan-Ru Zhao · Ke-Qiang Yu · Yong He
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    ABSTRACT: Chemometrics methods coupled with hyperspectral imaging technology in visible and near infrared (Vis/NIR) region (380-1030 nm) were introduced to assess total soluble solids (TSS) in mulberries. Hyperspectral images of 310 mulberries were acquired by hyperspectral reflectance imaging system (512 bands) and their corresponding TSS contents were measured by a Brix meter. Random frog (RF) method was used to select important wavelengths from the full wavelengths. TSS values in mulberry fruits were predicted by partial least squares regression (PLSR) and least-square support vector machine (LS-SVM) models based on full wavelengths and the selected important wavelengths. The optimal PLSR model with 23 important wavelengths was employed to visualise the spatial distribution of TSS in tested samples, and TSS concentrations in mulberries were revealed through the TSS spatial distribution. The results declared that hyperspectral imaging is promising for determining the spatial distribution of TSS content in mulberry fruits, which provides a reference for detecting the internal quality of fruits.
    Full-text · Article · Oct 2015 · Journal of Analytical Methods in Chemistry
  • Shuiguang Deng · Yifei Xu · Xiaoli Li · Yong He
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    ABSTRACT: Near infrared (NIR) hyperspectral imaging has been used as a rapid non-destructive technique to predict moisture content of tea. To improve the performance of predicting, we first find and validate the fact that the texture near the veins is continues and directional. And then we propose Three-Dimension Gabor Filter (TDGF) and its corresponding filterbank to describe the textures of tealeaf. After that we construct two types of models based on partial least squares (PLS) regression. Experiments are conducted to predict the moisture content of Longjing tea, and different regression models based on different types of features are built for comparison. The results show that the proposed filterbank is able to detect the optimal direction of water flow and the model combining the spectrum and TDGF textures outperform the other comparative models.
    No preview · Article · Oct 2015 · Computers and Electronics in Agriculture
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    ABSTRACT: A tentative and interesting experiment was conducted for perceiving the origins of international important Ramsar wetland ecological habitat scenes (WEHS) in China. Four different categories of international importance wetlands in the Ramsar list, including DongZhai Harbor inter-tidal mangrove wetland in Hainan Province, Lashi Lake alpine peat wetland in Yunnan Province, Zoige plateau freshwater lake wetland in Sichuan Province and Yancheng coastal saline wetland in Jiangsu Province, in China were investigated. The spatial envelope (SE) algorithm was used to extract the ecological features of the WEHS. The multi-resolution spectral functions of the SE algorithm in the spatial-frequency domain were rearranged to be approximately orthogonal. The original ecological image was transferred through such optimized channels and some valid features were obtained, which can be used to represent the WEHS. The principal component analysis algorithm was used to extract the principal components from these optimum characteristics. Three kinds of nonlinear recognition methods including conditional maximum entropy regression, multi-class support vector machine (SVM) and scaled conjugate gradient multi-layer perceptron were used to determine the logical ecological habitat attributions using the obtained principal components. The first-ranking perceiving accuracy and mean average precision (mAP) scores achieved 70% and 0.791 by using the multi-class SVM, respectively. The results demonstrated that the proposed methods could be preliminarily used to perceive the origins of the typical WEHS in China.
    No preview · Article · Oct 2015 · Computers and Electronics in Agriculture
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    ABSTRACT: Acquired resistance has become the bottleneck affecting the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment. Studies have shown that the antidiabetic drug metformin could effectively increase the sensitivity of TKI-resistant lung cancer cells to EGFR-TKI. This study aimed to evaluate the effect of metformin in combination with EGFR-TKI on the prognosis of non-small cell lung cancer (NSCLC) patients with diabetes mellitus type 2 (DM2). Data of NSCLC patients with DM2 who received treatment in six hospitals in china between January 2006 and January 2014 were reviewed retrospectively. They were divided into two groups: Group A, where the patients (n=44) received EGFR-TKI plus metformin; and Group B, where the patients (n=46) received EGFR-TKI plus hypoglycemic agents other than metformin. Prognostic differences between the two groups were assessed. The median progression-free survival (PFS) and median overall survival (OS) in Group A were significantly longer than those in Group B (19.0 months vs. 8.0 months, P= .005; 32.0 months vs. 23.0 months, P= .002). The objective response rate (ORR) and disease control rate (DCR) in Group A were significantly higher than those in Group B (70.5% vs. 45.7%, P= .017; 97.7% vs. 80.4%, P= .009). Secondary data analysis showed that metformin use significantly prolonged the median PFS in subgroups using either first-line EGFR-TKI or second-line EGFR-TKI. Metformin and EGFR-TKI have a synergistic effect in the treatment of DM2 NSCLC patients harboring EGFR-activating mutations. Metformin use is associated with improved survival and delayed onset of acquired resistance to EGFR-TKI. Copyright © 2015. Published by Elsevier Ireland Ltd.
    No preview · Article · Sep 2015 · Cancer letters
  • Yong He

    No preview · Article · Aug 2015 · New England Journal of Medicine
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    ABSTRACT: Hyperspectral imaging combined with feature extraction methods were applied to determine soluble sugar content (SSC) in mature and scatheless strawberry. Hyperspectral images of 154 strawberries covering the spectral range of 874-1,734 nm were captured and the spectral data were extracted from the hyperspectral images, and the spectra of 941~1,612 nm were preprocessed by moving average (MA). Nineteen samples were defined as outliers by the residual method, and the remaining 135 samples were divided into the calibration set (n = 90) and the prediction set (n = 45). Successive projections algorithm (SPA), genetic algorithm partial least squares (GAPLS) combined with SPA, weighted regression coefficient (Bw) and competitive adaptive reweighted sampling (CARS) were applied to select 14, 17, 24 and 25 effective wavelengths, respectively. Principal component analysis (PCA) and wavelet transform (WT) were applied to extract feature information with 20 and 58 features, respectively. PLS models were built based on the full spectra, the effective wavelengths and the features, respectively. All PLS models obtained good results. PLS models using full-spectra and features extracted by WT obtained the best results with correlation coefficient of calibration (r(c)) and correlation coefficient of prediction (r(p)) over 0.9. The overall results indicated that hyperspectral imaging combined with feature extraction methods could be used for detection of SSC in strawberry.
    No preview · Article · Jul 2015 · Guang pu xue yu guang pu fen xi = Guang pu
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    ABSTRACT: To explore the critical value and possible influencing factors of fractional exhaled nitric oxide (FeNO) in suspected asthma patients. 923 suspected asthmatics consecutively referred to our hospital during December 2012 to July 2014 were selected. All cases were carried out FeNO measurement at first; next, spirometry, bronchoprovocation tests or bronchodilation tests were used to confirm or exclude asthma. Receiver operating characteristic curve (ROC) was used to determine the best cut-off value of FeNO for asthma diagnosis. In bronchoprovocation test, 125 cases were diagnosed as asthma, other 283 were non-asthmatics. FeNO levels of asthmatics were significantly higher than non-asthmatics (median, 64.8 ppb vs. 27.9 ppb, P < 0.01). In this group of patients, 64 ppb was the best cut-off value of FeNO to identify asthma with sensitivity of 52.0% and specificity of 94.35%. In bronchodilation test, 185 patients were diagnosed as asthma, other 330 were non-asthmatics. FeNO levels of asthmatics were significantly higher than non-asthmatics (median, 60.6 ppb vs. 29.05 ppb, P < 0.01). In bronchodilation test patients, 41 ppb was the best cut-off value of FeNO to identify asthma with sensitivity of 72.43% and specificity of 74.85%. Influencing factors analysis showed that sex was an independent factor affecting patients' FeNO level. FeNO was an effective auxiliary diagnosis method for bronchial asthma. 64 ppb and 41 ppb was the best cut-off value of FeNO to identify asthma in bronchoprovocation test or bronchodilation test, respectively. Sex was an independent factor affecting patients' FeNO level.
    No preview · Article · Jul 2015 · International journal of clinical and experimental pathology
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    ABSTRACT: The pyrolysis characteristics of two Chinese coals, two biomass materials, and their blends were investigated by both experimental and numerical methods. Single particles of the coal and biomass were prepared for the pyrolysis experiment through grinding and pressing, while the blended particles were made by mixing the coal and biomass powder with different ratios before the pressing. Sample particles pyrolyzed in a single-particle reactor system, with the time history of the particle temperature and mass recorded. The analysis of the measured pyrolysis data of the coal, biomass, and coal–biomass blends indicate the absence of a synergistic effect between the coal and biomass pyrolysis. A numerical method coupling the chemical percolation devolatilization (CPD) model with a particle energy equation was employed to analyze the pyrolysis process. The model prediction agreed well with the experimental data for different particle diameters, fuel types, and blend mixing conditions. The fact that the co-pyrolysis of blended coal–biomass particles is well-predicted by the simple addition of the individual pyrolysis characteristics of its components also corroborates the lack of synergistic interactions. These findings will be useful for the co-combustion modeling of coal–biomass blends.
    No preview · Article · Jul 2015 · Energy & Fuels
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    ABSTRACT: Crizotinib treatment significantly prolongs progression-free survival, increases response rates, and improves the quality of life in patients with ALK-positive non-small-cell lung cancer. Droplet Digital PCR (ddPCR), a recently developed technique with high sensitivity and specificity, was used in this study to evaluate the association between the abundance of ALK rearrangements and crizotinib effectiveness. FFPE tissues were obtained from 103 consecutive patients with lung adenocarcinoma. Fluorescent in situ hybridization (FISH) and ddPCR were performed. The results revealed that 14 (13.6%) of the 103 patients were positive by dual-color, break-apart FISH. Three variants (1, 2, and 3) of the EML4-ALK gene rearrangements were detected. Thirteen of 14 ALK-positive cases identified by FISH were confirmed by ddPCR (four with variant 1, two with variant 2, and seven with variant 3). The case missed by ddPCR was identified as KIF5B-ALK gene rearrangement by PCR-based direct sequencing. Sixteen patients were detected with low copy numbers of EML4-ALK gene rearrangement, which failed to meet the positive cutoff point of FISH. Two of them responded well to crizotinib after unsuccessful chemotherapy. Our study indicates that ddPCR can be used as a molecular analytical tool to accurately measure the EML4-ALK rearrangement copy numbers in FFPE samples of lung adenocarcinoma patients. Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.
    No preview · Article · Jul 2015 · The Journal of molecular diagnostics: JMD
  • Feng-le Zhu · Yong He · Yong-ni Shao
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    ABSTRACT: Near-infrared hyperspectral imaging technique was employed in the present study to determine water contents in salmon flesh rapidly and nondestructively. Altogether 90 samples from different positions of salmon fish were collected for hyperspectral image scanning, and mean spectra were extracted from the region of interest (ROI) inside each image. Sixty samples were randomly selected as calibration set, and the remaining 30 samples formed prediction set. The full-spectrum and water contents were correlated using partial least squares regression (PLSR) and least-squares support vector machines (LS-SVM), which were then applied to predict water contents for prediction samples. A novel variable extraction method called random frog was applied to select effective wavelengths (EWs) from the full-spectrum. PLSR and LS-SVM calibration models were established respectively to detect water contents in salmon based on the EWs. Though the performances of EWs-based models were worse than models using full-spectrum, only 12 wavelengths were used to substitute for the original 151 wavelengths, thus models were greatly simplified and more suitable for practical application. For EWs-based PLSR and LS-SVM models, satisfactory results were achieved with correlation coefficient of prediction (Rp) of 0. 92 and 0. 93 respectively, and root mean square error of prediction (RMSEP) of 1. 31% and 1. 18% respectively. The results indicated that near-infrared hyperspectral imaging combined with chemometrics allows accurate prediction of water contents in salmon flesh, providing important reference for the rapid inspection of fish quality.
    No preview · Article · May 2015 · Guang pu xue yu guang pu fen xi = Guang pu
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    ABSTRACT: Visible near infrared spectra technology was adopted to detect soil total nitrogen content. 394 soil samples were collected from Wencheng, Zhejiang province to be used for calibration model (n=263) and independent prediction set (n=131). Raw spectra and wavelength-reduced spectra with five different pretreatment methods (SG smoothing, SNV, MSC, 1st-D and 2nd-D) were compared to determine the optimal wavelength range and pretreatment method for analysis. The results with 5 different pretreatment methods were not improved compared to that both of full spectra PLS model and wavelength reduction spectra model. Spectral variable selection is an important strategy in spectrum modeling analysis, because it tends to parsimonious data representation and can lead to multivariate models with better performance. In order to simply calibration models, the wavelength variables selected by two different variable selection methods (i.e. regression coefficient analysis (RCA) and successive projections algorithm (SPA) were proposed to be the inputs of calibration methods of PLS, MLR and LS-SVM models separately. These calibration models were also compared to select the best model to predict soil TN. In total, 9 different models were built and the best results indicated that PLS, MLR and LS-SVM obtained the highest precision with determination coefficient of prediction Rpre2=0.81, RMSEP=0.0031 and RPD=2.26 based on wavelength variables selected by RCA (0.0002) and SPA as inputs of models. SPA-MLR model and other three models based on 7 sensitive variables selected by RC using 0.0002 regression coefficient threshold value obtained the best result with Rpre2, RMSEP and RPD as 0.81, 0.0031 and 2.26. This prediction accuracy is classied to be very good. For all the models, it could be concluded that RCA and SPA could be very useful ways to selected sensitive wavelengths, and the selected wavelengths were effective to estimate soil TN. It is recommended to adopt SPA variable selection or RCA variable selection method with both linear and nonlinear calibration models for measurement of the soil TN using Vis-NIR spectroscopy technology, and wavelengths selection could be very useful to reduce collinearity and redundancies of spectra.
    No preview · Article · May 2015 · Guang pu xue yu guang pu fen xi = Guang pu
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    ABSTRACT: Pleural effusion induced by lung cancer exerts a negative impact on quality of life and prognosis. The aim of the present study was to evaluate the value of the recombinant adenoviral human p53 gene (rAd-p53) in the local treatment of lung cancer and its synergistic effect with chemotherapy. The present study retrospectively recruited 210 patients with lung cancer-mediated pleural effusion who had adopted a treatment strategy of platinum chemotherapy. Pleurodesis was performed via the injection of cisplatin or rAd-p53. Long-term follow-up was conducted to investigate the therapeutic effects of cisplatin and rAd-p53 administration on pleural effusion and other relevant clinical indicators. The short-term effect of pleurodesis was as follows: The efficacy rate of rAd-p53 therapy was significantly higher compared with cisplatin therapy (71.26 vs. 54.47%), and the efficacy of treatment with ≥2×1012 viral particles of rAd-p53 for pleurodesis was significantly greater than treatment with 40 mg cisplatin (P<0.05). Furthermore, efficacy analysis performed 6 and 12 months after pleurodesis indicated that the efficacy rate of rAd-p53 was significantly greater than that of cisplatin (P<0.05). A comparison of median progression-free survival (PFS) time identified a significant difference (P<0.05) between rAd-p53 and cisplatin therapy (3.3 vs. 2.7 months); however, a comparison of median overall survival time identified no significant difference (P>0.05) between rAd-p53 and cisplatin therapy (9.6 vs. 8.7 months). In addition, Cox regression analysis indicated that PFS was not affected by clinical indicators such as age, gender, prognostic staging and smoking status; however, PFS was affected by pathological subtype (adenocarcinoma or squamous carcinoma) in the rAd-p53 group. rAd-p53 administration for pleurodesis exerts long-term therapeutic effects on the local treatment of lung cancer. Thus, a combination of rAd-p53 and chemotherapy may exert a synergistic effect and reverse multidrug resistance.
    Preview · Article · May 2015 · Oncology letters
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    ABSTRACT: Classification is a critical step to make full use of the hyperspectral data. The most current approaches perform well for analyzing the macro texture, but they often fail to deal with the micro texture. Thus, this study proposes a general framework for the material with micro texture based on Hyperspectral Image (HSI) technique. In this framework, Local Response Pattern (LRP) is firstly proposed to describe 2D image texture to preserve more structural information and keep less sensitive to image conditions. Then, LRP is extended to represent HSI with Texture Enhancement (TE) by considering opponent relationships between pairs of bands. After that, Discriminated Locality Preserving Projection (DLPP) is proposed to reduce data dimension in a linearizing nonlinear manifold way. Finally, experiments on the hyperspectral images of fresh and frozen-thawed fish fillets are conducted. The results demonstrate that the proposed framework is efficient in terms of both recognition rates and robustness.
    No preview · Article · Apr 2015 · Information Sciences

Publication Stats

5k Citations
582.06 Total Impact Points


  • 2007-2016
    • Third Military Medical University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
  • 1970-2015
    • Zhejiang University
      • • State Key Lab of Clean Energy Utilization
      • • School of Biosystems Engineering and Food Science
      • • School of Medicine
      • • Department of Mathematics
      Hang-hsien, Zhejiang Sheng, China
  • 2013
    • Lund University
      • Division of Combustion Physics
      Lund, Skåne, Sweden
  • 2009-2010
    • University of Texas MD Anderson Cancer Center
      • Department of Thoracic Cardiovascular Surgery
      Houston, Texas, United States
    • Hangzhou Normal University
      Hang-hsien, Zhejiang Sheng, China
  • 2008
    • Xiamen University
      • Department of Physics
      Amoy, Fujian, China