M. Gabrashanska

Bulgarian Academy of Sciences, Ulpia Serdica, Sofia-Capital, Bulgaria

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Publications (31)29.68 Total impact

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    ABSTRACT: The study was carried out on the biochemical indices (oxidant/ antioxidant status) and histological response after implantation of modified hydroxyapatite in rat calvarial defects. Three groups of rats were used in the experiment: 1st group – control – healthy animals, 2nd group – rats received critical size skull defect (CSD) with no scaffold implantation and 3rd group – animals received a critical size skull defect (CSD) and hydroxyapatite implants. Biochemical and histological studies were done 3 months after the implantation. Serum was analyzed for free radical index contents MDA, SOD, GPx and GSH. Quantitative tissue response towards the implant was histologically investigated. MDA level was higher in group 2 compared to the rest groups. GSH content was the highest in group 1. GPx is the lowest in group 3. There were no differences in SOD activity among the groups. No signs of inflammation were noted from the scaffold 2 months after the implantation. Evidence was provided in our study for good biocompatibility of the newly biomaterial. Key words: calvaria, hydroxyapatite implant, MDA, SOD, GPx, GSH
    Full-text · Conference Paper · Nov 2015
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    ABSTRACT: The study was carried out on the biochemical indices (oxidant/ antioxidant status) and histological response after implantation of modified hydroxyapatite in rat calvarial defects. Three groups of rats were used in the experiment: 1st group – control – healthy animals, 2nd group – rats received critical size skull defect (CSD) with no scaffold implantation and 3rd group – animals received a critical size skull defect (CSD) and hydroxyapatite implants. Biochemical and histological studies were done 3 months after the implantation. Serum was analyzed for free radical index contents MDA, SOD, GPx and GSH. Quantitative tissue response towards the implant was histologically investigated. MDA level was higher in group 2 compared to the rest groups. GSH content was the highest in group 1. GPx is the lowest in group 3. There were no differences in SOD activity among the groups. No signs of inflammation were noted from the scaffold 2 months after the implantation. Evidence was provided in our study for good biocompatibility of the newly biomaterial. Key words: calvaria, hydroxyapatite implant, MDA, SOD, GPx, GSH
    Full-text · Conference Paper · Nov 2015
  • Dimitar Ivanov · Raina Gavazova · Margarita Gabrashanska · Radka Argirova
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    ABSTRACT: Glycosyltransferases are present in the Golgi apparatus in a membrane- bound form and are released from cells after cleavage by certain proteases. N-acetylglucosaminyltransferase catalyzes branching of N-acetylglucosamine on asparagine-linked oligosaccharides of the cell proteins. Their expressions are elevated during malignant transformation in various types of cancer. In the present study we investigated the exogenous and endogenous N-acetylglucosaminyltransferase activity in normal serum and in serum of rats with Zajdela ascitic hepatoma in different phases of tumour development. Our results disclose that there is a parallel augmentation in the enzyme activity in the serum which correlates with the increase of tumour cells number. The exogenous and endogenous N-acetylglucosaminyltransferase activity towards ovalbumin as an acceptor in microsomal fraction from normal and host liver and Zajdela hepatoma cells was measured and an increase in this activity in tumour cells as well as in host liver was found. The results contribute to the biochemical characterization of rat Zajdela hepatoma.
    No preview · Article · Aug 2015 · Comptes rendus de l'Académie bulgare des sciences: sciences mathématiques et naturelles
  • Dimitar Ivanov · Rositsa Milcheva · Svetlozara Petkova · Margarita Gabrashanska
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    ABSTRACT: Sialic acids a large family of neuraminic acid derivatives, are acidic monosaccharides, present as terminal component of oligosaccharide chains of many glycoproteins and glycolipids. They play an important role in many physiological and pathological processes like cell-cell communications, cell-substrate interaction, adhesion, maintenance of serum glycoproteins in circulations, regulation of the immune response, and protein targeting. Studies have shown that the serum sialic acid evaluation can be a valuable indicator for diagnostics and prognosis of many inflammatory diseases. In the present study we investigated the content of free, lipid and protein bound sialic acid in normal serum and in serum of rats with Trichinella spiralis infection in different phases of the disease. The experiment covered 8 weeks post infection. The data analysis disclosed that the serum sialic acid concentrations in the Trichinella infected rats were significantly higher (at week 8) than those found in the healthy controls. A strong positive correlation was observed between the serum levels of different forms of sialic acid and the development of the disease.
    No preview · Article · Jan 2014 · Comptes rendus de l'Académie bulgare des sciences: sciences mathématiques et naturelles
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    ABSTRACT: Our study was to assess the accumulation of heavy metals in hares (Lepus europeaus Pallas, 1778) infected with endoparasites. Ihe effect of cesfodes Mosgovayia pectinata or nematodes Tichostrcngylus retortaefonnis on Cd, Pb, Co, Hg, Zn and Cu concentrafions uvas esfab/rshed. Hosfs infected with cestodes had lower Cd and Pb levels than hosts infected with nematodes. Leyels of Co, Zn and Cu were similar in the hosts infected with cestodes or nematodes. The concentration of Cd. Pb and Cu was higher in kidneys than in livers. The content of heavy metals rn hosfs was decreasing with incrcasing of cesfode burden.
    Full-text · Conference Paper · Jun 2011
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    ABSTRACT: This study was undertaken to determine the dietary supplements of Zn containing diet on the antioxidant status in chickens experimentally infected with Eimeria acervulina. The antioxidant status was monitored via determination of MDA concentrations and erythrocyte SOD and CAT activities, as well as vitamin E, vitamin C, Cu, and Zn in liver, muscle, and serum. The results showed increased MDA (P < .05), CAT (P < .001), and decreased SOD (P < .001) in the infected birds. Significant changes in Cu and Zn concentrations and dramatically reduction of vitamin C and E concentrations in the infected chickens were found. The observed deviations in the studied enzymes and nonenzymatic parameters evidence the occurrence of oxidative stress following the infection and impaired antioxidant status of chickens, infected with Eimeria acervulina. Our results proved the ameliorating role of CuZn(OH)(3)Cl (0.170 g per kg food) against Eimeria acervulina-induced oxidative damage in infected chickens.
    Full-text · Article · Mar 2011 · Veterinary Medicine International
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    Georgieva N.V. · M. Gabrashanska · V. Koinarski · S. Ermidou-Pollet
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    ABSTRACT: The effect of sodium selenite on the antioxidant status in broiler chickens infected with Eimeria acervulina was studied. Antioxidant status was measured via blood plasma malonyl dialdehyde (MDA), serumglutathione peroxidase (GPx), erythrocyte catalase (CAT) and superoxide dismutase (SOD) activities and plasma levels of selenium (Se), vitamins A, C and E with respect to parasitological and production traits. The study was performed on 100, 20-day old broiler chickens. Four groups of chickens were formed: the 1st – control, the 2nd – control and receivedNa2SeO3 (0.3mg/kg diet for 10 days), the 3rd – infected with 3 × 105 sporulated E. acervulina oocysts and the 4th –infected with E. acervulina oocysts and received the same dose Na2SeO3. Blood samples were taken on Day 8 after the first inoculation. Increased MDA and CAT, reduced SOD and GPx and Se content, and hypovitaminoses A, C and E in the infected chicks, compared to the healthy controls were observed. The changes in the small intestine, lesion scores and oocyst index, and body weight were indicative for a severe E. acervulina infection. Inorganic Se supplementation increased vitamin E, Se content, pGPx-activity, and improved body weights, but it did not influence the parasitological indices.
    Full-text · Article · Jan 2011 · Trace Elements and Electrolytes
  • V. Nanev · M. Gabrashanska · I. Vladov · Y. Gunchev
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    ABSTRACT: The purpose of our study is to examine the lung oxidative stress status in mouflons naturally infected with the nematode Diciyocaulus viviparus by determination of the malondyaldehyde (MDA) concentration as a biomarker of lipid peroxidation and its relation to the antioxidant status (glutathione, vitamin A, vitamin E, vitamin C, enzymes SOD, CAT, GPx and the trace elements selenium and zinc). 16 mouflons, non-infected and infected with D. viviparus were studied. Animals were shot in a hunt during the hunting season in ecological areas (naturally and anthropogenically non-polluted) in the Rhodope Mountains in Bulgaria. Antioxidant/oxidant imbalance occurred in the animals with dictyocaulosis. Levels of vitamin A, C and E, GSH and selenium were reduced, SOD, GPx and CAT activity was suppressed, whereas MDA level was increased in the lungs infected with D. viviparus compared to the non-infected. The zinc level was not changed in the infected animals. The results of the present study indicate that the antioxidant/oxidant imbalance was expressed mainly by significant reduction of the antioxidant enzyme activities. The present findings confirm that parasitic infection correlates well with OS status which can be assessed using enzymatic and nonenzymatic biomarkers. The pathogenesis of D. viviparus infection needs to be re-examined in order to understand more deeply the consequences of such an infection in the animal body.
    No preview · Article · Jan 2011 · Trace Elements and Electrolytes
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    ABSTRACT: Selenium (Se) supplementation may prevent the formation of free radicals and lipid peroxidation processes in trichinellosis. The oxidative-antioxidant status of male Wistar rats infected or uninfected with Trichinella spiralis (Nematoda) and supplemented or unsupplemented with Sel-plex (Alltech) was tested through blood biomarkers. Sel-plex was applied to restore antioxidant defense system. The oxidative marker was malondialdehyde (MDA) concentration. The antioxidant markers were superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and concentrations of Se and vitamin E. The animals were allocated into four groups. The experiment covered 8 weeks post infection. A mathematical model was proposed for the time course of host body weight. The model solutions were in good agreement with the experimental data. The relative rates of body weight gain were determined as growth kinetic parameters. The supplementation of the rats with dietary Se improved their antioxidant status. Increases by 10% in SOD activity, 6% in GPx activity, 13% in vitamin E concentration, 17% in plasma Se concentration, and 19% in liver Se concentration, respectively, and a decrease by 18% in serum MDA concentration were recorded in the infected and supplemented towards infected and unsupplemented rats. The reduction of muscle larvae after Sel-plex application was 63%. The mortality in infected and uninfected animals did not differ significantly. No statistically significant differences were established between the growth of the control and infected rats. At week 8, the body weight gain in the supplemented rats (both uninfected and infected) was 30% higher, compared to that in unsupplemented ones. Diet with Se could be beneficial in the treatment of diseases correlated with considerable oxidative stress, particularly parasitoses.
    No preview · Article · Feb 2010 · Parasitology Research
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    ABSTRACT: The effect of sodium selenite on the antioxidant status in broiler chickens infected with Eimeria acervulina was studied. Antioxidant status was measured via blood plasma malonyl dialdehyde (MDA), serum glutathione peroxidase (GPx), erythrocyte catalase (CAT) and superoxide dismutase (SOD) activities and plasma levels of selenium (Se), vitamins A, C and E with respect to parasitological and production traits. The study was performed on 100, 20-day old broiler chickens. Four groups of chickens were formed: the 1st – control, the 2nd – control and received Na2SeO3(0.3 mg/kg diet for 10 days), the 3rd - infected with 3x105 sporulated E. acervulina oocysts and the 4th – infected with E. acervulina oocysts and received the same dose Na2SeO3. Blood samples were taken on the day 8 after the first inoculation. Increased MDA and CAT, reduced SOD and GPx and Se content, and hypovitaminoses A, C and E in the infected chicks, compared to the healthy controls were observed. The changes in the small intestine, lesion scores and oocyst index, and body weight were indicative for a severe E. acervulina infection. Inorganic Se supplementation increased vitamin E and Se content and pGPx-activity, improved body weights but it did not influence the parasitological indices.
    Full-text · Conference Paper · Jan 2009
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    ABSTRACT: The aim of our study was to assess the liver antioxidant status (SOD, GPx, vitamins A, C and E, Se, Zn, MDA), body weights and parasite burden in male Wistar rats experimentally infected per os with Fasciola hepatica (25 metacercariae) and treated with a daily dose of 6 mg 2Gly.ZnCl2.2H2O. During the acute (4 weeks) and chronic stage (6-10 weeks) of fasciolosis, antioxidant/oxidant imbalance occurred. SOD activity, levels of vitamins A, C, E Zn and Se were reduced whereas the amount of MDA was increased. Body weights were lower in the infected rats during the acute an chronic stages. Application of 2Gly.ZnCl2.2H2O increased the enzyme activities, the levels of vitamin E and A, Zn and Se, and reduced MDA concentration. Body weights increased but the parasite burden was not changed after treatment. The compound did not show antiparasitic action.
    No preview · Article · Dec 2008 · Trace Elements and Electrolytes
  • Margarita Gabrashanska · Svetla E Teodorova · Milena Anisimova
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    ABSTRACT: The oxidative-antioxidant status of male Wistar rats infected or uninfected with Fasciola hepatica (Trematoda) and supplemented or unsupplemented with 2Gly.ZnCl(2).2H(2)O was tested through liver biomarkers. The oxidative marker was malondialdehyde concentration. The antioxidant markers were glutathione peroxidase activity and concentrations of zinc, selenium, vitamin A, vitamin C, and vitamin E. The animals were allocated into four groups. The experiment covered 8 weeks post infection. The gain in the host body weight and rats' mortality were also studied. A mathematical model was elaborated to describe the kinetics of concentrations of liver zinc. The kinetic parameters calculated reflect the peculiarities in zinc absorption in different conditions. Also, a model was proposed for the time course of host body weight. The model solutions were in good agreement with the experimental data. The supplementation of the rats with dietary Zn improved their antioxidant status. Increases by 9% in GPX activity, 6% in Vitamin A concentration, 3% in Vitamin C concentration, 35% in Vitamin E concentration, 17% in liver Zn concentration, and 11% in liver Se concentration, respectively, and a decrease by 30% in liver MDA concentration were recorded in the infected and supplemented towards infected and unsupplemented rats. Also, an increase by 6% in body weight in supplemented animals was established.
    No preview · Article · Sep 2008 · Parasitology Research
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    ABSTRACT: The activity of selenium-dependent glutathione peroxidase (GPX), liver concentration of vitamin E, and plasma and liver selenium levels were used for estimation of the antioxidant status of broiler chickens infected with Ascaridia galli. These biomarkers were recorded in an experiment covering 70 days p.i. At the same time the establishment rate of A. galli in chicken intestines, gain in the host body weight and chicken survival were studied. Broiler chickens (Cobb hybrids) were infected with 1450 embryonated A. galli eggs and treated with Sel-plex. A mathematical model was applied to determine the rate of nematode reduction and the relative rate of gain of host body weight, which are essential kinetic parameters of parasite-host interaction. The activity of GPX increased with both elevated selenium and reduced infection levels. The concentrations of selenium and vitamin E, and the GPX activity in the infected chickens demonstrated a similar pattern of change with time after day 30 p.i. The supplementation of the broilers with dietary selenium in the form of Sel-plex improved their antioxidant status. Increases by 29% in vitamin E concentration, 15% in GPX activity, and 22% in liver selenium concentration, respectively, were recorded in the infected and treated, compared to infected and untreated broilers.
    No preview · Article · Jan 2008 · Journal of Helminthology
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    ABSTRACT: The effect of selenium–yeast (Sel-plex 50, Alltech) on the antioxidant defense system (vitamins E, C, A, and Se content and Se-GPx-activity) in chicks experimentally infected with Eimeria tenella (Protozoa) was studied by us. The study was performed on 100 broiler chicks divided into four groups: first group - control, second - control and supplemented with Selplex, third group - infected with E. tenella, and fourth group - infected with E. tenella and supplemented with Sel-Plex. The chicks were fed a standard diet without antibiotics and coccidiostats. The second and fourth groups were fed on the diet to which Sel-Plex 50 was added - 0.3 mg/kg diet. The third and fourth groups were infected with 10.84 sporulated E. tenella oocysts. Serum and liver Se content was determined by a fluorimetric method. The content of liver vitamins C, E, and A was established by HPLC systems. Serum Se-GPx activity was determined spectrophotometrically. An antioxidant imbalance was developed due to the E. tenella infection. It was expressed by reduced vitamins A, C, and E levels, and Se content and reduced GPx activity. The Sel-Plex administration almost restored vitamin E and Se losses and increased GPx activity in the infected chickens. The observed changes in the small intestine, lesions, and oocyst indices, body weight gain, and feed conversion ratio were indicative of a severe E. tenella infection. They were correlated with oxidative stress. Administration of Sel-Plex resulted in significant increase in weight gain, improved feed conversion ratios, and increased GPx activity, Se, and vitamin E liver level in the control and infected chicks. The oocyst and lesion indices were slightly reduced after the treatment in the infected chicks. The experiment was approved by the Committee on Animal Experimentation at Trakia University, Stara Zagora, Bulgaria and was performed according to the recommendations of the Directive 86/609/EC.
    No preview · Article · Jan 2008 · Cell Biology and Toxicology
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    ABSTRACT: Aim: This aim of this study was to assess the antioxidant status (vitamin C, E, A, zinc, copper, superoxide dismutase, catalase, glutathione peroxidase and malondialdehyde) of rat liver in chronic stage of fasciolosis after treatment with Zn-Cu mixed basic salt. Methods: White Wistar rats were infected per os with 25 metacercariae of fasciola hepatica. Application of (Zn xCu1-x)2(OH)3Cl salt started 6 weeks after the infection and was performed during 10 consecutive days. Results: During the chronic stage of fasciolosis in the liver, a decrease of concentrations of vitamins C, E, A and of the trace elements Zn and Cu were observed together with a reduction of the Cu,Zn-superoxid dismutase (SOD) activity and an increase of catalase and glutathione peroxidase activities. Malondialdehyde concentration was elevated. Application of (Zn xCu1-x)2(OH)3Cl salt increased the concentrations mainly of vitamin E, but also of vitamin C and of the trace element Zn. On the other hand, only the activity of SOD was enhanced after salt treatment. Conclusions: It seems that antioxidant imbalance was developed in the fasciola hepatica infected liver rats during the chronic fasciolosis and that Zn-Cu salt improved the antioxidant defense abilities.
    No preview · Article · Mar 2007 · Trace Elements and Electrolytes
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    V. Koinarski · N. Georgieva · M. Gabrashanska
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    ABSTRACT: The effect of a newly synthesized Zn salt (2Gly.ZnCl2.2H2O) co-administered with an antioxidant drug, maduramycin, on the antioxidant status of broiler chickens infected with E. tenella were investigated through measurements of plasma MDA (malondialdehyde) concentrations and of erythrocyte SOD (Superoxide Dismutase) and CAT (Catalase) activities. A total of 80 healthy Cobb 500 chickens were divided into 4 groups. In the group I, animals were not infected and not treated (negative controls). In the 3 other groups, birds, aged of 13 days, were infected with E. tenella (8.104 oocysts) and were not treated (group II, positive controls) or were orally treated for 9 days by only maduramycin (5 ppm) (group III) and by maduramycin (5 ppm) and Zn salt (2Gly.ZnCl2.2H2O) (0.12g Zn2+/kg of food/day) (group IV). A markedly stunted grouth and increase of FCR (food conversion ratio) were observed in positive controls, whereas the 2 treatments partially reduced the adverse effects of the E. tenella infection on growth. Compared to the negative controls, SOD activities were significantly reduced and CAT activities enhanced in all infected birds, and these changes were more intense in the 2 treated birds, particularly in birds receiving maduramycin and Zn salt. However, contrary to therapy with maduramycin alone, the cotreatment with Zn salt did not limit ROS formation: in this group, plasma MDA concentrations remained significantly elevated and similar to values observed in positive controls. These results confirm that the Eimeria tenella infection induces an oxidative stress in broiler chickens and that antioxidant therapy (maduramycin ± Zn salt) partially restored the growth, but they also suggest that Zn salt (2Gly.ZnCl2.2H2O) may present adverse effects on lipid peroxidation.
    Full-text · Article · May 2006 · Revue de médecine vétérinaire
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    V. KOINARSKI · M. GABRASHANSKA · N. GEORGIVA · P. PETKOV
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    ABSTRACT: The effect of 2Gly.ZnCl2.2H2O compound on the antioxidant status in chicks infected experimentally with Eimeria acervulina was studied. Antioxidant status was measured via determination of blood plasma malonyl dialdehyde (MDA) reactive products, activity of superoxide dismutase (SOD) and catalase (CAT) as well as blood concentrations of carotene, vitamins A, C, and E, and zinc. The results showed increased MDA and CAT-activity, decreased SOD activity, hypovitaminosis C, A and E, and reduced Znlevel in the infected chicks. An antioxidant imbalance was developed due to the E. acervulina infection. The 2Gly.ZnCl2.2H2O oral administration restored vitamin E and zinc losses, and reduced CAT-activity. However, SOD activity, vitamins C and A, carotene and MDA levels in the infected chicks were not statistically changed. The observed changes in the small intestine, lesion and oocyst index, and economical parameters (body weight gain and feed conversion ratio) were indicative for a severe E. acervulina infection. They were correlated with the oxidative stress. Administration of 2Gly.ZnCl2.2H2O increased body weight gain of the infected chicks. The oocyst and lesion indices as well as the feed conversion ratio did not respond to the treatment. 2Gly.ZnCl2.2H2O enhanced the antioxidant balance and performance of chicks with eimeriosis.
    Full-text · Article · Jan 2006 · Bulletin- Veterinary Institute in Pulawy
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    V. KOINARSKI · M. GABRASHANSKA · N. GEORGIVA · P. PETKOV
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    ABSTRACT: The antioxidant status of broiler chickens (Cobb 500 hybrids) experimentally infected with E. acervulina was monitored via determination of blood plasma malonyl dialdehyde (MDA) reactive products, the activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), as well as blood carotene, vitamin A and vitamin C concentrations. The results of the experiment showed a statistically significant increase of MDA concentrations (a marker of radical-induced damage) in E. acervulina-infected birds compared to healthy chickens (p<0.05). A decreased SOD activity was also observed in infected birds (p<0.001), whereas significant increase of CAT activities were obtained (p<0.001). Carotene, vitamin A and vitamin C concentrations were dramatically reduced in infected chickens (p<0.001, p<0.01 and p<0.05 respectively). The observed deviations in studied enzymes and non-enzymatic parameters evidence the occurrence of oxidative stress following the infection and impaired antioxidant status of broiler chickens infected with E. acervulina. The observed changes in small intestine, the oocyst production and the economical parameters (weight gain and feed conversion ratio) were indicative for a severe infection, in which the oxidative stress was also involved during pathogenesis.
    Full-text · Article · Oct 2005 · Revue de médecine vétérinaire
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    ABSTRACT: Hisex chickens were infected with 1,450 embryonated Ascaridia galli eggs and treated with a new synthesized basic mixed salt (Zn(x)Co(y)Mn(1-x-y)) x (OH)6SO4 x 2H2O). The worm burden was determined and sex ratios for A. galli of M:F = 1.4 and M:F = 2 in untreated and treated chickens, respectively, were found. A decrease in the mean establishment rate of A. galli in treated chickens was observed. The levels of zinc, cobalt and manganese were determined in liver and muscle of the host and in male and female A. galli. The survival of the chickens and gain in body weight were improved, and the restoration of microelement content was observed by treatment with the salt. A positive effect of the basic Zn-Co-Mn salt was also observed in the nematode microelement levels. Significant differences were found between the levels of zinc, cobalt and manganese in male and female A. galli.
    No preview · Article · Jul 2004 · Parasitology Research
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    ABSTRACT: A newly synthesized basic mixed salt (Zn(x)Co(y)Mn(1-x-y)) x (OH)6SO4 x 2H2O) was administered to chickens with ascaridiosis. Improvement in survival, gain in body weight (of 19.03%) and restoration of microelement content were observed in the treated chickens. An increase in the gain in body weight of 7.62% in uninfected treated chickens was also observed. The establishment of Ascaridia galli populations in chickens, and chicken growth in control and infected hosts, untreated and treated, were modelled mathematically. Some kinetic parameters (the rate of reduction of the nematode population nu and the relative rate mu of gain in body weight of the host) were determined. The values of nu =0.027 day(-1) and nu* =0.032 day(-1) were calculated for the reduction rates in infected, untreated chickens and in infected, treated chickens, respectively. The worm burden in infected, treated chickens was 20.4% lower than in infected, untreated chickens.
    No preview · Article · Jul 2004 · Parasitology Research

Publication Stats

106 Citations
29.68 Total Impact Points

Institutions

  • 1993-2015
    • Bulgarian Academy of Sciences
      • • Institute of Experimental Morphology, Pathology and Anthropology with Museum
      • • Institute for Nuclear Research and Nuclear Energy (INRNE)
      Ulpia Serdica, Sofia-Capital, Bulgaria
  • 2006
    • Trakia University
      • Department of Pharmacology, Animal Physiology and Physiological Chemistry
      Eski Zagra, Stara Zagora, Bulgaria