Pelin Zorlu

Dr. Sami Ulus Children's Hospital, Engüri, Ankara, Turkey

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Publications (32)21.68 Total impact

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    ABSTRACT: To determine different clinical presentations of vitamin B12 deficiency in infants. Infants at the age of 1-20 mo admitted to infancy clinic of authors' hospital between January 2011-2013 with various clinical presentations due to vitamin B12 deficiency were included in the study. Hospital records of all the patients were evaluated by means of history, physical, laboratory, imaging examinations and treatment. The diagnosis was based on a nutritional history of mothers and infants, clinical findings, hematological evaluation, and low level of serum vitamin B12. A total of 20 patients with a mean age of 6.65 ± 4.5 mo were included in the study. The weight and height were below the third percentile in four patients. The most common symptoms of the patients were; infections in 30 %, pallor in 25 %, hypotonia and neuro-developmental delay in 25 %, refusal to solid food or to suck in 20 %, failure to thrive in 15 %, fatigue in 10 %. Twenty-five percent of patients had neurologic signs and symptoms. Anemia was found in 16/20 (80 %) patients. Three (15 %) patients had leukopenia, 7 (35 %) had neutropenia, 2 (10 %) patients had thrombocytopenia. All of the mothers had vitamin B12 deficiency. All of the patients were fed with breast milk. Cyanocobalamin was administered to all the patients and mothers. After the treatment, clinical and laboratory findings of all the patients improved. Vitamin B12 deficiency should be considered in the differential diagnosis of some hematological, neurological, and gastrointestinal disturbances of infants.
    No preview · Article · Apr 2015 · The Indian Journal of Pediatrics
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    ABSTRACT: Hamartoma of the larynx is a very rare lesion, and the number of reported cases is limited. Signs and symptoms include stridor, changes in voice, eating and respiratory complaints. Stridor is a sign of upper airway obstruction. Patients presenting with stridor and severe respiratory distress necessitate urgent otolaryngologic evaluation. Herein, we report a case of laryngeal hamartoma presenting with recurrent pneumonia and persistent stridor in a 7-month-old patient. He was admitted to hospital with the initial diagnosis of recurrent pneumonia and persistent stridor. Stridor was not responsive to cool mist, nebulised epinephrine or dexamethasone. Cervical computed tomography (CT) revealed a solid, nodular mass on the posterolateral wall of larynx. The mass was excised surgically. After surgical removal of the hamartoma, the child was relieved of the obstruction. We want to emphasise that patients presenting with persistent stridor and severe distress necessitate urgent otolaryngologic evaluation.
    No preview · Article · Dec 2014 · Balkan Journal of Medical Genetics
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    P Zorlu · A S Eksioglu · M Ozkan · T Tos · S Senel
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    ABSTRACT: Wolf-Hirschhorn syndrome is caused by a deletion of the distal portion of the short arm of chromosome 4, and is characterized by psychomotor retardation, seizures, congenital malformations, and typical facial appearance including 'Greek warrior helmet' appearance of the nose. The form and the severity of clinical manifestations vary according to the size and location of the deletion. Major complications are severe growth retardation, developmental delay, seizures, feeding difficulties due to hypotonia, and predisposition to respiratory infections. Patients will benefit from supportive therapy and special education. It is important in terms of prognosis to provide counseling to families in this respect. We present here a case with Wolf-Hirschhorn Syndrome in order to remind its rarity and the ability of the patients' progress in the areas of motor skills, speech, social interaction.
    Full-text · Article · Nov 2014 · Genetic counseling (Geneva, Switzerland)
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    S. Ucar · P. Zorlu · NESE Yarali · G. Tanir
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    ABSTRACT: Background and aims Hemophagocytic lymphohistiocytosis (HLH) is a rare, life threatening disorder characterizedby uncontrolled activation of T-helper 1 lymphocytes and macrophages and overproductionof inflammatory cytokines. Visceral leishmaniasis (VL), is a multisystem infection caused by the dissemination of Leishmania throughout the reticuloendothelial system. HLH associated VL is a rare and difficult to diagnose clinicopathological condition leading to delayed treatment. We report a rare case of HLH associated Visceral Leishmaniasis in a patient who presented with persistent high fever, hepatosplenomegaly and pancytopenia. Case A 11 month-old baby with persistent high fever for more than 3 weeks and hepatosplenomegaly was assessed. Laboratory testing revealed pancytopenia, hypertriglyceridemia, hyperferritinemia and hypofibrinogenemia. Bone marrow examination revealed hemophagocytosis. A diagnosis of hemophagocytic syndrome was made according to the HLH-2009 diagnostic criteria. Prior to establishing the diagnosis of Leishmaniasis by indirect fluorescent antibody testing, several potential infectious agents were excluded. Treatment with pentavalent antimonials provided relief of all signs and symptoms within ten days. Conclusion HLH should be included in the differential diagnosis of patients who present with persistent high fever, hepatosplenomegaly and pancytopenia. Besides, physicians should keep in mind Leishmaniasis among the potential etiologic factors of secondary HLH.
    Full-text · Article · Oct 2014 · Archives of Disease in Childhood
  • F N Oz · S B Koca · G Tanır · D Ciçek · M Acar · P Zorlu

    No preview · Article · Aug 2014 · Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ
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    ABSTRACT: OBJECTIVES: Stridor is a sign of upper airway obstruction. In children, laryngomalacia is the most common cause of chronic stridor, while croup is the most common cause of acute stridor. Stridor may be inspiratory, expiratory, or biphasic. In this study, we aimed to present clinical features and treatments of patients admitted with chronic stridor and recurrent pulmonary infections. MATERIAL AND METHODS: Twelve patients hospitalized because of chronic stridor and recurrent pneumonia were analyzed clinically, radiologically and with regard to treatment methods. Early onset, frequent recurrence, and persistence of the symptoms, poor improvement in coexistent respiratory distress inspite of appropriate treatment, and also the presence of stridor pushed us to further evaluation. Patients presenting with acute stridor and mild laryngomalacia were excluded from the study. RESULTS: Five patients were diagnosed with vascular ring, where as other seven patients presented with tracheomalacia, severe laryngomalacia, laryngeal hamartoma, cervical bronchogenic cyst, foreign body aspiration, H-type tracheoesophagial fistula, and congenital subglottic stenosis. CONCLUSION: Noisy breathing that begins in the newborn and infancy periods, recurrent lower respiratory tract infections and associated symptoms of airway obstruction should suggest structural and functional abnormalities of the lungs and airways. In patients with recurrent respiratory problems accompanied by stridor, diagnosis can be made with comprehensive physical examination and radiological methods.
    No preview · Article · Jul 2014

  • No preview · Article · Jun 2014 · Journal of Clinical Research in Pediatric Endocrinology
  • Saliha Senel · Pelin Zorlu · Burcin Dogan · Mehtap Acar

    No preview · Article · May 2014 · The Indian Journal of Pediatrics
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    ABSTRACT: Niemann-Pick hastalığı, belirli dokularda, özellikle retiküloendotelyel hücrelerde, sfingolipidlerin biriktiği, konjenital lipidoz grubundan otozomal resesif kalıtılan bir hastalıktır. Klinik fenotip olarak akut neonatal formdan geç başlangıçlı erişkin forma kadar aralığı oldukça değişkendir. Karaciğer ve dalak büyüklüğü şikayetiyle kliniğimize başvuran Niemann-Pick hastalığı tip A ve tip B tanıları alan iki hasta sunuldu.
    No preview · Article · Jan 2014 · Marmara Medical Journal
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    Şit UÇAR · Pelin ZORLU · Emine POLAT
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    ABSTRACT: Objective: Cystic fibrosis is the most common autosomal recessive disorder with an incidence of 1/ 2000-3500 in live births and a heterozygocity prevalence of 1/25 among Caucasians. In this study, we evaluated patients diagnosed with cystic fibrosis, who admitted with different clinical features. We aimed to contribute to our country’s data with these clinical and laboratory findings. Material and Methods: The clinical and laboratory findings of 78 cystic fibrosis patients who had been followed between January 2001 and March 2008 at Dr. Sami Ulus Women Obstetrics and Child Health Research and Education Hospital were evaluated retrospectively. Results: In this study, the clinical and laboratory findings of 44 male and 34 female cystic fibrosis patients were evaluated. Seventy-four patients are still alive and the remaining four died during the follow up period. Sweat chloride levels of all patients were above 60 mEq/L, except for 1 patient. Forty-one patients’ parents were relatives. Ten patients had a history of sibling death with symptoms resembling cystic fibrosis, and 18 patients siblings had a diagnosis of cystic fibrosis (among them 12 are dead, 6 are alive). Among these patients, the most frequent symptoms of attendance were recurrent respiratory infection, and gastrointestinal findings, respectively. Anemia, hypoelectrolitemia and hypoalbuminemia were the most common laboratory findings. Malnutrition and dehydratation were discovered in 58% and 28% of the patients, respectively. The most frequent X-ray findings were hyperinflation and peribronchial infiltration, respectively. Pseudo-Bartter’s syndrome was found in 34,6% of the cases. The most frequent mutation was δF508. Pseudomonas aeruginosa was the most frequently cultured microorganism in sputum cultures. Conclusion: Patients with cystic fibrosis may have different clinical features. However, patients who admitted with pulmonary and/or gastrointestinal symptoms have to be diagnosed early, and have to be referred to “Cystic Fibrosis Follow Up Centers” without any delay.
    Preview · Article · Jan 2014 · Turkiye Klinikleri Journal of Medical Sciences
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    Full-text · Article · Dec 2013
  • Meltem Erdem · Pelin Zorlu · Mehtap Acar · Saliha Senel

    No preview · Article · Sep 2013
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    ABSTRACT: Abusive head trauma (AHT) is perpetrated when an infant or young child is shaken violently by an abuser, resulting in injuries to various intracranial structures, historically called "shaken baby syndrome" (SBS). Three cases of AHT with different constellations of clinical symptoms are presented here. Case 1- Three-month-old female infant was admitted with recurrent seizures, drowsiness, and low grade fever. Ophthalmologic examination revealed retinal hemorrhages (RH) in the left eye. Computed tomography of cranium showed left frontal intra-parenchymal subdural hematoma (SDH). Case 2- Twelve-month-old male infant was admitted with a history of favoring left leg. Ophthalmologic examination revealed RH in the right eye. Cranial magnetic resonance imaging (MRI) revealed subacute SDH in the right frontoparietal region. Case 3- Three-month-old male infant was admitted with irritability and seizures. Ophthalmologic examination revealed bilateral disseminated RH. Cranial MRI scan showed bilateral frontoparietal subacute SDH. All cases were reported to Child Protective Services, who decided not to remove children from homes, but evaluated psychosocial risks and developed a safety plan, including home visits and family education. Physicians must be aware of possibility of AHT in infants presenting both subtle and overt neurologic symptoms. It is important to provide training on AHT to staff involved in the management of these cases.
    No preview · Article · May 2013 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES
  • Mehtap Acar · Saliha Senel · Pelin Zorlu

    No preview · Article · Jun 2011 · International journal of pediatric otorhinolaryngology
  • Sit Uçar · Pelin Zorlu · Ozge Metin · Utku Arman Orün
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    ABSTRACT: Vascular rings are a group of aortic arch anomalies and usually presents with dispnea, stridor and feeding difficulties after birth. Pulmonary artery sling is created by anomalous origin of the left pulmonary artery from the posterior aspect of the right pulmonary artery. The anomalous left pulmonary artery compresses the lower trachea and right mainstem bronchus, producing upper airway symptoms. We presented a seven-month-old male patient who admitted to our clinic because of recurrent wheezing, stridor, and frequent lower respiratory tract infections.
    No preview · Article · Jul 2010 · Tuberkuloz ve toraks
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    Sinan SARI · Pelin ZORLU · Ülker ERTAN
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    ABSTRACT: Aim: The aim of the present study was to determine the relative frequency of recurrent pneumonia in children and to describe its underlying illnesses. Materials and methods: Children between 3 months and 16 years old who had a history of 2 or more episodes of pneumonia per year, or 3 or more episodes in a lifetime were investigated retrospectively at Doctor Sami Ulus Children's Training and Research Hospital between January 2002 and December 2004. Results: Out of 595 children admitted for pneumonia, 62 (10.42%) met the criteria for recurrent pneumonia. An underlying illness was demonstrated in 56 patients (90.32%). In this study, the underlying illness was diagnosed during recurrence in all patients. The patients with persistent pneumonia were excluded from the study. Underlying diseases were bronchial asthma (30.64%), immune deficiency disorders (17.75%), aspiration syndromes (17.75%), and congenital anomalies (16.12%). No predisposing illness could be demonstrated in 6 patients (9.68%). Conclusion: Approximately 1 in 10 children with pneumonia in our hospital had recurrent pneumonia. Most of these children had an underlying illness, which was demonstrated. Bronchial asthma was the most common underlying illnesses for undiagnosed recurrent pneumonia in children.
    Preview · Article · Feb 2010 · Turkish Journal of Medical Sciences
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    ABSTRACT: Congenital syphilis is a rare, serious disease that continues to be a major health-care problem. The infected neonate may be asymptomatic or multiple-organ system involvement may occur. Anemia and thrombocytopenia are common hematological findings. Hemophagocytic lymphohistiocytosis (HLH) is a clinicopathological condition characterized by activation and uncontrolled nonmalignant proliferation of T lymphocytes and macrophages. The authors report an infant with congenital syphilis as a very rare cause of hemophagocytic syndrome. The reason for anemia and thrombocytopenia in congenital syphilis is not clear. The authors suggest that hemophagocytosis may play role in pathogenesis of cytopenia, particularly thrombocytopenia in patients with congenital syphilis.
    No preview · Article · Oct 2009 · Pediatric Hematology and Oncology
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    ABSTRACT: Jeune syndrome or asphyxiating thoracic dystrophy is a rare autosomal recessive skeletal dysplasia characterized by a small thorax, short-limbed dwarfism, renal and hepatic anomalies. It is estimated to occur in 1 per 100.000-130.000 live births. Radiological confirmation of diagnosis is essential. Prognosis of the disease is due to the severity of chest deformities and most of the patients are lost in their first year because of respiratory problems. We presented a 19-month-old female patient who admitted to our clinic because of recurrent lower respiratory tract infections and diagnosed as Jeune syndrome and reported due to its rarity.
    No preview · Article · Jan 2009 · Tuberkuloz ve toraks
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    ABSTRACT: Transfusion-related acute lung injury (TRALI) is a life-threatening adverse effect of transfusion that should be considered in the differential diagnosis of all patients who develop respiratory distress during or within 6 h of transfusion. Two children with TRALI are presented and the diagnosis, pathophysiology, treatment, and need for understanding and recognition to reduce morbidity and mortality are discussed.
    No preview · Article · Jul 2008 · Pediatric Hematology and Oncology
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    ABSTRACT: The aim of the present study was to evaluate cases of Shigella and determine the pattern of antimicrobial resistance of shigella species in central Turkey. One hundred and ninety-eight patients with shigella gastroenteritis presenting to Sami Ulus Children's Hospital from June 2002 to December 2002 were included in the study. The clinical and laboratory data of the patients with shigellosis were collected by chart review. Male/female ratio was 1.35 and mean age was 4.83 +/- 3.2 years (range: 1-16 years). Shigella sonnei (83.3%) was the most common serogroup. This was followed by S. flexneri (10.1%), then S. dysenteria (5.1%), and S. boydii (1.5%). The antibiotic susceptibility of the shigella strains was determined. Most strains of Shigella species were resistant to trimethoprim-sulfamethoxazole (90.4%). All strains were found to be sensitive to ciprofloxacin (100%). Ampicillin susceptibility was 86.4% and cefotaxim (and/or ceftriaxon) susceptibility was 98%. Ampicillin is the drug of choice in the treatment of shigella infection in this region of Turkey. Cefotaxim or ceftriaxon was the second choice of antibiotics. Thus, Shigella is an important etiologic agent of diarrhea in Turkey. To determine the antibiotic susceptibility of the Shigella strains and appropriate empiric antibiotic treatment in Turkey, further studies will be needed.
    Full-text · Article · Nov 2007 · Pediatrics International