Tayfun Alper

Ondokuz Mayıs Üniversitesi, Djanik, Samsun, Turkey

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Publications (46)53.43 Total impact

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    [Show abstract] [Hide abstract] ABSTRACT: Hysterectomy is the most common major gynecologic operation, together with bilateral salpingo-oophorectomy in the majority of women over the age of 45. To investigate whether surgical menopause affects female sexual performance differently from natural menopause. The study included 121 women who had undergone surgical menopause and 122 women who had undergone natural menopause. All the women had similar economic, sociocultural, and personal demographic profiles, had been postmenopausal for at least 1 year, and were between the ages of 45 and 65. The women were asked to complete a six-question survey of sexual performance parameters (sexual desire, coital frequency, arousal, orgasm frequency, dyspareunia, and vaginal lubrication). These sexual performance parameters were compared between the surgical and natural menopause groups. With the exception of vaginal lubrication, sexual performance parameters were not statistically different between the two groups (P > 0.05). Vaginal lubrication in the surgically menopausal group was lower than in the naturally menopausal group (P < 0.05). Serum dehydroepiandrosterone sulphate, prolactin, and thyrotropin levels were not statistically different between the groups (P > 0.05), whereas serum estradiol and total testosterone levels in the surgically menopausal group were lower than those of the naturally menopausal group (P < 0.05). The results of this study showed that surgical menopause did not affect female sexual performance differently from natural menopause, with the exception of vaginal lubrication. Kokcu A, Kurtoglu E, Bildircin D, Celik H, Kaya A, and Alper T. Does surgical menopause affect sexual performance differently from natural menopause? J Sex Med **;**:**-**. © 2015 International Society for Sexual Medicine.
    Full-text · Article · Apr 2015 · Journal of Sexual Medicine
  • [Show abstract] [Hide abstract] ABSTRACT: Aim: The aim of this study was to investigate the effect of vitamin C on the growth of experimental endometri-otic cysts. Material and Methods: The endometrium of the uterine horn wall (diameter, 4 mm) was implanted onto the inner surface of the anterior abdominal wall of 40 Wistar albino adult female rats, by laparotomy. The day after the implantation, the rats were randomly assigned into four groups (control group and experimental groups [V1, V2, and V3]) comprising 10 rats each. For 6 weeks, the control group (Group C) received 1 mL distilled water, whereas the experimental groups (Groups V1, V2, and V3) received 0.5 mg, 1.25 mg, and 2.5 mg of vitamin C in 1 mL of distilled water, respectively. The doses were given via oral gavage once per day. At the end of the administration, a second laparotomy was performed and endometriotic cyst volumes and weights of rats among the groups were compared. In addition, the stromal and glandular tissue and the natural killer cell contents of the cysts were compared among the groups. Results: The cyst volume in Group V3 and the cyst weights in Groups V2 and V3 were significantly lower than those in Group C. The natural killer cell content in Groups V1, V2, and V3 was significantly lower than that in Group C. Stromal and glandular tissue contents of the groups were not significantly different. Conclusions: The dose-dependent vitamin C supplementation significantly reduced the volumes and weights of the endometriotic cysts.
    No preview · Dataset · Jun 2013
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    [Show abstract] [Hide abstract] ABSTRACT: Aim: The aim of this study was to investigate the effect of vitamin C on the growth of experimental endometriotic cysts. Material and methods: The endometrium of the uterine horn wall (diameter, 4 mm) was implanted onto the inner surface of the anterior abdominal wall of 40 Wistar albino adult female rats, by laparotomy. The day after the implantation, the rats were randomly assigned into four groups (control group and experimental groups [V1, V2, and V3]) comprising 10 rats each. For 6 weeks, the control group (Group C) received 1 mL distilled water, whereas the experimental groups (Groups V1, V2, and V3) received 0.5 mg, 1.25 mg, and 2.5 mg of vitamin C in 1 mL of distilled water, respectively. The doses were given via oral gavage once per day. At the end of the administration, a second laparotomy was performed and endometriotic cyst volumes and weights of rats among the groups were compared. In addition, the stromal and glandular tissue and the natural killer cell contents of the cysts were compared among the groups. Results: The cyst volume in Group V3 and the cyst weights in Groups V2 and V3 were significantly lower than those in Group C. The natural killer cell content in Groups V1, V2, and V3 was significantly lower than that in Group C. Stromal and glandular tissue contents of the groups were not significantly different. Conclusions: The dose-dependent vitamin C supplementation significantly reduced the volumes and weights of the endometriotic cysts.
    Full-text · Article · May 2013 · Journal of Obstetrics and Gynaecology Research
  • [Show abstract] [Hide abstract] ABSTRACT: The aim of this study was to measure interleukin-6 (IL-6) levels in maternal serum of women undergoing preterm labor without a clear infection. Twenty two pregnant women with diagnosis of preterm labor who presented to the outpatient clinic of 19 Mayis University Faculty of Medicine from July 2011 through December 2011 were enrolled in the study group. Twenty two healthy pregnant women who were at the same gestational age as the study group were selected as the control group. Gestational age in the study and control groups varied from 24 weeks and 4 days to 34 weeks and 6 days. In the study group, 11 patients (50%) underwent preterm birth. Pregnant women in preterm labor were compared to healthy pregnant women with regards to serum IL-6 levels. No significant difference was found in the IL-6 levels of maternal serum between the 2 groups. In this study we have shown that there is no increase in lL-6 levels in patients undergoing preterm labor without clinical or biochemical infection signs.
    No preview · Article · May 2013 · Ginekologia polska
  • No preview · Article · Jan 2013 · European journal of nuclear medicine and molecular imaging
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    [Show abstract] [Hide abstract] ABSTRACT: To evaluate the predictive value of random serum anti-Müllerian hormone (AMH) in the assessment of ovarian response in patients with diminished ovarian reserve (DOR; diagnosed after the observation of elevated baseline levels of early follicular follicle-stimulating hormone [FSH]) who were undergoing intracytoplasmic sperm injection-embryo transfer (ICSI-ET) and to compare the random serum AMH and baseline FSH levels in these patients for the prediction of poor ovarian response. Retrospective study. University hospital. One hundred and thirty-nine patients who were undergoing ICSI-ET cycles with early follicular FSH level >9 IU/mL. None. Poor ovarian response in ICSI-ET cycles. For the identification of women at risk of cycle cancellation, an AMH cut-off level ≤1.2 ng/mL had 97.3 % sensitivity, 31.3 % specificity, 33.9 % positive predictive value, and 96.9 % negative predictive value in the women with high baseline FSH levels. An AMH cut-off level ≥1 ng/mL had a sensitivity of 58.7 % and specificity of 95.1 % for prediction of retrieval of 4 or more oocytes. By using a serum AMH cutoff level of 1.5 ng/mL, the ongoing pregnancies were predicted with 83.3 % sensitivity and 82.5 % specificity and yielded a positive predictive value of 31.2 % and a negative predictive value 98.1 %. Measurement of random serum AMH level is a useful tool in the prediction of ovarian response in patients with high serum early follicular FSH levels.
    Preview · Article · May 2012 · Journal of Assisted Reproduction and Genetics
  • Handan Celik · Bahattin Avcı · Tayfun Alper
    [Show abstract] [Hide abstract] ABSTRACT: The aim of this study was 2 fold: (1) to compare the maternal serum levels of IL-10, IL-12, and IL-2 in preeclamptic and normal pregnant women, and (2) to study the serum levels of these cytokines in preeclamptic pregnancies with and without intrauterine growth retardation. Forty women with singleton pregnancies complicated by preeclampsia (32 severe and 8 mild) and 29 normotensive healthy pregnant women were included in the study. Preeclamptic patients were further divided into 2 groups according to the presence or absence of intrauterine growth retardation. Maternal serum levels of IL-10, IL 12, and IL-2 were compared between these groups using enzyme-linked immunosorbent assays. Maternal serum levels of IL-10 were significantly higher in the preeclampsia group than in controls (p<0.001). There were no statistically significant differences in maternal serum concentrations of IL-2 and IL-10 between the study and control groups (p>0.05). Serum levels of IL-2 and IL-10 in the patients with preeclampsia complicated by IUGR were elevated in comparison with the uncomplicated preeclampsia group. These differences were statistically significant (p<0.05 for both). IL-10 may be involved in the pathologic process of preeclampsia. Increased serum levels of IL-10 and IL-2 in preeclampsia complicated with IUGR suggests a possible role of these cytokines in IUGR. Copyright © 2011 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
    No preview · Article · Jan 2012 · Pregnancy Hypertension
  • [Show abstract] [Hide abstract] ABSTRACT: Objective. The link between preeclampsia and inflammation has directed the research to the investigation of inflammatory markers in preeclampsia. The present study aimed to evaluate serum amyloid A (SAA) levels in preeclamptic and healthy pregnant women detecting the relationship between the preeclampsia and SAA levels. Methods. Twenty preeclamptic women and eighteen pregnant women without any medical history, which constitute the control group, having between 35th to 41st gestational weeks, were included in the present study. For the analysis of SAA levels, maternal blood samples were collected within two hours before caesarean section, and the umbilical cord blood samples were collected at birth. SAA levels were measured using the enzyme linked immunosorbent assay method. Results. No significant difference was observed between the preeclamptic women and healthy pregnant women in terms of SAA levels (286.46 ng/mL versus 83.24 ng/mL; p> .144, median values). Furthermore, the same results were found in the umbilical cord blood SAA levels between the babies born from preeclamptic women and those born from healthy pregnant women (7.66 ng/mL versus 7.84 ng/mL; p= .725, median values). Conclusions. An elevated plasma level of SAA in healthy and preeclamptic women should be considered pathologic, and in this respect, the response of relationship between the preeclampsia and SAA levels could be caused by an inflammatory condition other than preeclampsia.
    No preview · Article · Jan 2012 · Gineco.ro
  • [Show abstract] [Hide abstract] ABSTRACT: To investigate if it was necessary to dilate the cervix routinely during elective cesarean section and to determine the effects of this traditional maneuver on maternal morbidity. A total of 150 patients meeting eligibility criteria were enrolled in this prospective, randomized controlled study. Patients were allocated randomly into cervical dilatation group or non-dilated group. In the cervical dilatation group, the surgeon performed cervical dilatation by inserting a double-gloved index finger into the cervical canal of the patients after extraction of placenta and membranes. Endometrial cavity thickness of the patients at postoperative 24 h, development of postoperative febrile-infectious morbidity and postoperative hemoglobin levels were evaluated and compared between the groups. The two groups were comparable with regard to demographic and clinical properties. Mean postoperative endometrial cavity thickness of the dilated group was significantly less than the non-dilated group (6.87 ± 2.50, 9.51 ± 3.35 respectively, p < 0.0001). The level of hemoglobin reduction was comparable between the groups (p = 0.37). Febrile morbidity was seen in one patient in the dilated group. Endometritis or wound infection was not encountered in either group during the puerperium. Cervical dilatation seems to be an unnecessary intervention during the cesarean section.
    No preview · Article · Jul 2011 · Archives of Gynecology
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    A Kokcu · M Tosun · T Alper · M Sakinci
    [Show abstract] [Hide abstract] ABSTRACT: We present a case of squamous cell carcinoma arising in the neovagina of a woman in whom we performed vaginoplasty 20 years before. To the best of our knowledge, this is the 23rd case of total carcinoma arising in the neovagina constructed because of vaginal agenesis, and the 3nd case of carcinoma arising in the neovagina performed without using a graft.
    Full-text · Article · Jan 2011 · European journal of gynaecological oncology
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    [Show abstract] [Hide abstract] ABSTRACT: Peritoneal tuberculosis predominantly involves the omentum, intestinal tract, liver, spleen, and genitourinary tract and occurs in 1-4% of patients with pulmonary tuberculosis. Peritoneal tuberculosis may mimic a pelvic mass in imaging studies and also may increase CA-125 levels. Peritoneal tuberculosis may also produce massive ascites, and intraperitoneal gross appearance might be similar to the peritoneal carcinomatosis. Therefore, peritoneal tuberculosis is often confused with advanced-stage epithelial carcinoma because of similar clinical, radiologic, and laboratory findings and later intraoperative findings. The pathology records between January 2000 and August 2008 were retrospectively reviewed at 19 Mayis University Hospital. Twenty-two patients were found to have peritoneal caseating necrosis. A total of 13 out of 22 patients were found to have high CA 125 level. Among these 13 patients, 8 patients received/are receiving anti-tuberculous therapy after they were incidentally diagnosed with peritoneal tuberculosis. Increased CA 125 levels should be evaluated carefully prior to aggressive surgical approach, especially in premenopausal women and frozen section evaluation should be done before extensive surgical procedure if there is any suspicion.
    Full-text · Article · Dec 2010 · Archives of Gynecology
  • [Show abstract] [Hide abstract] ABSTRACT: The aim of this study was to investigate the relationship of maternal and umbilical cord interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha) serum levels with the existence and severity of preeclampsia. A particular objective was the comparison of normal umbilical serum levels to preeclamptic values. The study group consisted of 24 patients with third trimester singleton pregnancies complicated by preeclampsia (15 severe and 9 mild preeclampsia). The gestational age-matched 19 healthy pregnant women were compared by study group. Maternal and umbilical serum IL-6, IL-8, and TNF-alpha were calculated by using enzyme-linked immunosorbent assay. Significantly increased maternal and umbilical serum levels of IL-6, IL-8, and TNF-alpha were found in preeclamptic patient group in comparison with the control group. Maternal serum IL-8 and TNF-alpha concentration were significantly higher in patients with severe preeclampsia than in mild preeclampsia. Increased umbilical serum levels of IL-6 and IL-8 were found in severe preeclampsia than in mild preeclampsia. There were significantly higher levels of maternal serum IL-8 and TNF-alpha in patients with preeclampsia with IUGR than in patients with preeclampsia with normal fetal growth. Our findings suggest that increased concentrations of IL-6, IL-8, and TNF-alpha in the maternal and umbilical serum play a significant role in pathogenesis of preeclampsia. Alterations in maternal and umbilical serum levels of IL-6, IL-8, and TNF-alpha may also play role in preeclampsia complicated by intrauterine growth retardation. These associations may offer insight into the etiology and pathogenesis of preeclampsia.
    No preview · Article · May 2010 · The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • [Show abstract] [Hide abstract] ABSTRACT: Objective: We aimed at measuring levels of knowledge of pregnant about Down syndrome, triple screening test, amniocentesis, and other tests performed during pregnancy . Material and methods: Our study includes 300 pregnant women between gestational weeks 16-20 and 35 gynecologists that we applied to their opinions. STAI anxiety test measuring conditional anxiety was performed. Questions related to the levels of information of the pregnant women about Down syndrome, screening tests and amniocentesis and their communication with physicians. Attitude of physicians about the screening tests were questioned. Results: The average age of patients was 28±5 and of them, a group comprising 37,3% was primipara while the other group comprising 62,7% was multipara. When the pregnant women, by taking into regard their groups as to education and age, were analyzed with respect to their anxiety levels, no statistical differences were observed among the groups. When a question such as "What would you do if your baby has been diagnosed as Down Syndrome" was posed 181 patients (60,3%) answered that they have not yet given any decision in this regard. When we analyzed the pregnants with respect to their educational levels, we recorded a significant statistical difference among the university graduates group and other groups (p<0,05). When the patients were analyzed with respect to risk and age groups, we observed the fact that the gynecologist were before and aware of the decision especially given by the high risk group. Conclusion: Patients who will not terminate their pregnancies even after being informed about the diagnosis of Down syndrome unnecessary spending of the limited resources, transferred to the healthcare system can be prevented and these amounts can be used for more rational purposes.
    No preview · Article · Jan 2010 · Turk Jinekoloji ve Obstetrik Dernegi Dergisi
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    Arif Kökçü · Cazip Ustün · Tayfun Alper · Bedri Kandemir
    [Show abstract] [Hide abstract] ABSTRACT: Fetal mediastinal cystic masses occur rarely. We present a case in which a large fetal mediastinal cystic mass was visualized at the first antenatal visit in the third trimester of pregnancy. A 4-week ultrasonographic follow-up demonstrated the slow growth of the mass until delivery, when the fetus was considered to he mature. Removal of the entire cyst was performed 8 h after abdominal delivery, and the newborn did well postoperatively. The histopathologic examination of the removed cystic mass showed an enteric cyst. We also reviewed the differentia! diagnosis of the fetal mediastinal masses.
    Full-text · Article · Jul 2009 · Journal of Maternal-Fetal and Neonatal Medicine
  • [Show abstract] [Hide abstract] ABSTRACT: Objective. To evaluate the role of mid-trimester total human chorionic gonadotropin (hCG), alfa-fetoprotein (AFP) and unconjugated estriol (uE3) in the prediction of pre-eclampsia. Method. We carried out a retrospective analysis of hCG, AFP, uE3 levels taken between 16-18 weeks of gestation from 278 women. None of these women had abnormal karyotype fetuses or malformations. The levels of maternal serum hCG, AFP, uE3 were compared between 20 severe pre-eclampsia, 96 mild pre-eclampsia and 112 controls. Results. Levels of hCG in the second trimester triple test result from women who later developed severe pre-eclampsia were significantly elevated than control group (p=0.001, p<0.01). The mean gestational age at birth and mean birth weight of patients whose hCG were higher than 2 MoM (n=32) in triple test were significantly lower than patients with hCG equal or lower than 2 MoM (p<0.01). Conclusion. Increased hCG was found to be significantly associated with severe pre-eclampsia developing later in pregnancy.
    No preview · Article · May 2009 · Gineco.ro
  • [Show abstract] [Hide abstract] ABSTRACT: Congenital mesoblastic nephroma is a rare renal tumor of early infancy with a favorable outcome after complete surgical removal. It consists of a heterogeneous group of spindle cell tumors. Early and accurate prenatal diagnosis of the renal tumor may improve the outcome of affected pregnancies by implementing the best strategy for prenatal management and delivery. But detection of congenital mesoblastic nephroma in a fetus is rare. To the authors' knowledge, there are fewer than 30 reports of a prenatal diagnosis of a mesoblastic nephroma in the literature. This case describes the prenatal sonographic diagnosis of cellular congenital mesoblastic nephroma.
    No preview · Article · Mar 2009 · Journal of Diagnostic Medical Sonography
  • [Show abstract] [Hide abstract] ABSTRACT: Pulmonary atresia with intact ventricular septum is a rare cardiac malformation which is present at live birth of 0.58 per 10,000. Because of the prognosis is poor in most severe right heart hypoplasia cases,early diagnosis is critical.
    No preview · Article · Jan 2009 · Ondokuz Mayis Universitesi Tip Dergisi
  • [Show abstract] [Hide abstract] ABSTRACT: Perinatal mortality in Ondokuz Mayis University Faculty of Medicine between 2004-2006 was prospectively analyzed with the collaboration of Neonatology, Obstetrics and Gynecology, Pediatric Genetic and Pathology Departments. Perinatal mortality rates in 2004, 2005 and 2006 were 87.5, 73.2 and 73.0 respectively. The most important cause of perinatal death according to modified Wigglesworth classification in these three years was stillbirths. Early neonatal death ratio has decreased nearly to half from 2003.
    No preview · Article · Jan 2007 · Ondokuz Mayis Universitesi Tip Dergisi
  • [Show abstract] [Hide abstract] ABSTRACT: The incidence of ectopic pregnancy has increased in the recent years and it has been the most important cause of maternal mortality and morbidity in the first trimester. The management of ectopic pregnancy changes regarding the factors such as, the hemodynamic stability of the patient at the initial diagnosis, desire to maintain fertility and the degree of the tubal injury. In our study, 68 patients diagnosed with ectopic pregnancy in the last five years in Gynecology and Obstetrics Department of Ondokuz Mayis University, Faculty of Medicine were retrospectively examined. The ratios of operative as well as nonoperative methods applied to the patients, the success rates and the factors affecting the achievement were evaluated. A total of 57 patients were operated and 11 patients had non operative treatment. It was concluded that ectopic pregnancy should be frequently considered in the early and differential diagnosis to decrease the morbidity and cost rates as well as to increase the percentage of nonoperative management.
    No preview · Article · Jan 2007 · Ondokuz Mayis Universitesi Tip Dergisi
  • [Show abstract] [Hide abstract] ABSTRACT: Impetigo herpetiformis is one of the rare and serious pustular dermatosis that mostly occurs in pregnancy. Early recognition is important to reduce both of maternal and fetal morbidity and mortality. In this article we discussed the management of a pregnant case of 23-year-old at her first pregnancy and presenting with impetigo herpetiformis.
    No preview · Article · Jan 2007