Patricia Oehlmeyer Nassar

Universidade Estadual do Oeste do Paraná, Cascavel, Paraná, Brazil

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Publications (37)41.37 Total impact

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    Full-text · Article · Jan 2016
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    ABSTRACT: The objective of this research was to evaluate the treatment of periodontal disease and its effects on carotid intima-media thickness (CIMT) and expression of laboratory markers related to atherosclerosis. Twenty-three healthy patients (group 1) and 21 patients with moderate to severe periodontitis (group 2) underwent evaluation of clinical periodontal parameters. The patients were submitted to CIMT measurements and laboratory evaluations at the start of the study (0 months), 6 months, and 12 months. All patients received oral hygiene instruction; patients in group 2 also underwent supragingival and subgingival scaling and root planing. A statistically significant improvement in clinical periodontal parameters occurred in both groups (P < 0.05). Improvements were more evident between the first and second evaluations and were greater in group 2. Both groups experienced a statistically significant decrease in CIMT in the first 6 months (P < 0.05). Treatments-oral hygiene instruction in group 1 and instruction plus mechanical periodontal instrumentation in group 2-were effective in improving clinical periodontal parameters of both groups and promoting reduction in CIMT at 6 months.
    No preview · Article · Jan 2016 · General dentistry
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    Full-text · Article · Apr 2015
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    ABSTRACT: The aim of this study was to establish relationship between restorative resin and periodontal tissues of patients with diabetes mellitus. We selected 30 patients, 15 patients with diabetes mellitus with a total of 30 restorations and 15 patients without diabetes mellitus with a total of 49 restorations and the periodontal parameters and restorations parameters were evaluated. The total period was 12 months. The results showed a significant improvement in periodontal parameters assessed (p < 0.05). It may be concluded that over the 12-month period, there was no adverse reaction to periodontal tissue as a result of various polishing regimes of a restorative resin-based composite in patients with diabetes mellitus.
    No preview · Article · Dec 2014
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    ABSTRACT: Aim The type 2 diabetes (DM2) is a risk factor for periodontal disease, while, on the other hand, periodontitis worsens glycemic control. The treatment of periodontal disease reduces glycemia; however, there is no consensus on which is the best periodontal treatment for diabetic patients. This study aims to evaluate different modalities of periodontal therapy in diabetic patients, i.e., conventional periodontal treatment using scaling and root planning (RAR); and the one-stage full-mouth disinfection (FMD). Subjects and methods 20 patients with DM2 and periodontal disease were selected and divided into two groups: group 1: RAR; group 2: FMD. The analyses were performed at 0, 3 and 6 months, and included clinical periodontal parameters and the quantification of gingival crevicular fluid. Glycated hemoglobin (HbA1c), fasting glucose (FG) and IL1-β expression were measured. Results After 6 months, both groups presented improved FG, clinical periodontal parameters and quantification of gingival crevicular fluid; however, no statistically significant difference was found in the IL-1β expression after 180 days. Conclusion When the types of periodontal therapy were compared, it was possible to observe that conventional periodontal treatment is more effective than one-stage full-mouth disinfection as regards glycemic control, periodontal parameters of bleeding on probing, the amount of gingival fluid, and variation in IL-1β expression, although no significant difference was found between the initial and final values in each group.
    Full-text · Article · Dec 2014
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    ABSTRACT: Objective: To identify the extension in primary health services of attributes for family and community guidance about the health of children health. Methods: This was a quantitative, cross-sectional and evaluation study. We administered 548 questionnaires (Brazilian Primary Care Assessment Tool, child version) to families and/or legal guardians of children younger than 12 years of age who were received care in 24 health units. Data were analyzed using SPSS software, version 17.0. Results: The basic public health services of the studied municipality were below what is considered ideal for primary health care with regard to the attributes of family and community guidance. Score of these attributes were 4.4 and 5.1, respectively. Scores considered satisfactory were >= 6.6. Conclusion: We found that it was difficult for services to integrate families and the community in the care process. This finding reinforces the healing care culture and individual-centered care.
    Full-text · Article · Oct 2014
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    ABSTRACT: The aim of the present study was to evaluate the effect of simvastatin, a potent antiinflammatory drug, on the progression of alveolar bone loss in an experimental model of periodontitis in rats. A cotton ligature was used around the lower right first molar in a submarginal position in order to induce experimental periodontitis. Sixty rats were divided into 12 groups consisting of three control groups, three simvastatin groups, three ligature groups, and three ligature plus simvastatin groups. The distance between the cemento-enamel junction and the alveolar crest was determined at the mesial root surfaces of the lower right first molars by radiographic as well as profilometric analyses. In rats of the experimental periodontitis group (ligature), alveolar bone loss was higher compared to the control groups. However, simvastatin was associated with decreased alveolar bone loss in all treatment groups with experimental periodontitis (p < 0.01). Simvastatin treatment seems to be a beneficial and supporting therapeutic that favors protection against alveolar bone loss in a model of experimental periodontitis in rats.
    Full-text · Article · Apr 2014 · Journal of the International Academy of Periodontology
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    ABSTRACT: It is known that atherosclerosis begins in childhood, a behaviour towards oral health care and metabolic control, since an early age, is essential for patients with cardiovascular disease. The aim of this research was to evaluate the effectiveness of periodontal treatment full-mouth scaling and root planning (FMSRP), applied to children without systemic diseases, correlating with periodontal clinical and blood parameters (lipid profile and inflammatory markers). The 29 patients were divided into two groups, group 1 (14) - scaling and rot planning (SRP), group 2 (15) - FMSRP and the follow-up was conducted among 180 days. The results showed a significant improvement in clinical periodontal parameters (p<0.05) in both groups. In the analyzed blood parameters there was a greater evidence, with a significant improvement (p<0.05), in total cholesterol (TC), triglycerides (TGs), fibrinogen (FGN), and interleukin-6 (IL-6) CONCLUSIONS: Thus, we suggest that both periodontal treatments were effective in children without any systemic diseases.
    No preview · Article · Mar 2014 · Archives of oral biology
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    ABSTRACT: This study compared the effectiveness of 2 surgical root coverage techniques-semilunar coronally positioned flap and coronally advanced flap-using the clinical parameters of periodontal tissues from patients with Miller Class I gingival recession. Twenty patients (20-50 years of age) were selected. Basic periodontal treatment was performed, and plaque index, gingival index, probing depth, clinical attachment level, and height of the attached gingiva were determined. Each patient was placed into 1 of 2 groups: Group 1 patients underwent the semilunar coronally positioned flap technique, and Group 2 patients underwent the coronally advanced flap technique. Patients were assessed for 180 days. Both groups showed significant reduction of plaque and gingival indices and an improvement in clinical attachment levels and probing depth. However, results showed the standard coronally positioned flap technique was deemed more effective due to significant clinical attachment level gains.
    No preview · Article · Mar 2014 · General dentistry
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    ABSTRACT: Atherosclerotic disease (AD) is one of the most important causes of morbidity and mortality in the world. It expresses inflammatory markers such as C-reactive protein (CRP) and can provoke arterial wall thickening, which can be evaluated using Doppler ultrasound. Risk factors associated with AD include diabetes mellitus, systemic arterial hypertension, dyslipidemia and smoking. More recently, periodontal disease (PD) has been identified as a factor related to AD. Periodontal disease has a high prevalence in the global population and the inflammatory process and bacterial activity at the periodontium appear to increase the risk of AD. Encouraging good oral hygiene can reduce expression of inflammatory markers of AD. A review of literature on PD, AD and inflammatory markers and the interrelationships between the two diseases was conducted using data published in articles indexed on the PUBMED, SCIELO and BIREME databases. © 2014, Sociedade Brasileira de Angiologia e Cirurgia Vascular. All rights reserved.
    No preview · Article · Jan 2014 · Jornal Vascular Brasileiro
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    ABSTRACT: Due to the biological associations between periodontal and cardiovascular diseases, as well as the fact that atherosclerosis begins in childhood, behavior based on oral health care and metabolic control from an early age is essential for patients with cardiovascular disease. The aim of this research was to examine the effect of full-mouth scaling and root planing on the reduction of periodontal disease in children with congenital heart disease. In this study, treatments were related to clinical periodontal parameters and also to blood ones, such as lipid profile and inflammatory markers. The patients were divided into two groups: group 1 (n=17), scaling and root planing; and group 2 (n=16), full-mouth scaling and root planing. The results showed a significant improvement in clinical periodontal parameters (P<0.05) in both groups. Considering lipid parameters, total cholesterol, triglycerides, and very-low-density lipoprotein parameters showed significant improvement (P<0.05). There was also an improvement in C-reactive protein (ultrasensitive) in the group treated with scaling and root planing (P<0.05). Fibrinogen and interleukin-6 parameters improved (P<0.05) in both groups. We suggest that both periodontal treatments were effective in children with congenital heart disease, though neither demonstrated superiority.
    Full-text · Article · Nov 2013 · Vascular Health and Risk Management
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    ABSTRACT: There is evidence that the lack of metabolic control of obese patients may accelerate periodontitis. The aim of this study was to evaluate radiographically the effect of cafeteria-diet-induced obesity on alveolar bone loss in rats subjected to periodontal disease. Twenty male Wistar rats were randomly divided into four groups: 1) control group, 2) control and ligature group; 3) cafeteria group; and 4) cafeteria and ligature group. The animals were evaluated for obesity and euthanized, and the mandible of each rat was removed to perform a radiographic evaluation of alveolar bone loss and its effect on diet-induced obesity. The results showed greater alveolar bone loss in the mice in Group 4 (P<0.01). Thus, we concluded that obese mice, on average, showed greater radiographic evidence of alveolar bone loss than mice undergoing induction of obesity.
    Full-text · Article · Oct 2013 · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
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    ABSTRACT: Plaque control is the major consensus during orthodontic treatment to prevent the occurrence of cavities and periodontal inflammation. The mechanic resource of greater effectiveness and frequent use in this control is the oral hygiene. The tooth brushing techniques most used in orthodontic patients are: Ramfjord's method, Modified Stillman technique and Bass method. Since control studies evaluating the effectiveness of usual tooth brushing techniques do not show clear advantage, the objective of this study was to evaluate the effectiveness of three brushing methods, through periodontal clinical parameters of patients with fixed orthodontic appliances. Thirty patients were selected, with ages between 14 and 22 years old, with fixed orthodontic appliances. After basic periodontal treatment the following factors were evaluated: 1 - Plaque index and 2 - Gingival index and each patient was randomly included in one of the three selected groups according to the brushing technique: Group 1 - Scrubbing technique; Group 2 - Modified Stillman technique and Group 3 - Bass technique. Patients were evaluated for 9 months. The results showed a significant reduction of clinical parameters by the end of this period, however there was a very significant reduction of Gingival index on group 3 (13.6%) when compared to the other groups. Thus, it can be suggested that the Bass technique can be effective on the reduction of periodontal clinical parameters of Plaque index and Gingival index in patients with fixed orthodontic appliances.
    Full-text · Article · Jul 2013 · Dental Press Journal of Orthodontics
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    ABSTRACT: Aim The objective of this study was to evaluate the effectiveness of two modalities of treatment through clinical periodontal parameters in glycemic control of patients with diabetes mellitus and periodontal disease. Subjects and methods 40 patients, who had not been submitted to conventional periodontal scaling and root planning, were selected and divided into two groups: (1) conventional periodontal treatment with scaling and root planning plus mechanical control, and (2) periodontal treatment (one-stage full-mouth disinfection) plus mechanical control. The analysis was carried at 0, 3 and 6 months, including probing depth, level of clinical attachment and bleeding on probing with evaluation of glycated hemoglobin. Results Only group 1 showed a significant reduction in bleeding on probing, while only group 2 showed a significant reduction in probing depth. The level of clinical attachment showed improvement in both the groups after 6 months. In the glycated hemoglobin test, only group 1 significantly reduced after 6 months, while for group 2 there was a reduction after 3 months and a significant increase after 6 months. Conclusion We suggest that after a period of 6 months, the basic periodontal treatment is more efficient for glycemic control in patients with type 2 diabetes with periodontal disease.
    No preview · Article · Feb 2013 · Journal of Public Health
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    ABSTRACT: The administration of cyclosporine A (CsA) has been associated with significant bone loss and increased bone remodeling. The present investigation was designed to evaluate the effects of CsA on alveolar bone of rats subjected to experimental periodontitis, using histomorphometric and histological analysis. Twenty-four rats were divided into groups with 6 animals each: 1, control; 2, rats with ligature around the lower first molars; 3, rats with ligature around the lower first molars and that were treated with 10 mg CsA/kg of body weight/d; and 4, rats treated with 10 mg CsA/kg of body weight/d. At the end of 30 days, rats were humanely killed and subjected to a histological processing, with analysis of the distance cemento-enamel junction and alveolar bone crest, bone area, eroded bone area, and cemento surface. All of them were assessed at the mesial region of the alveolar bone. The CsA therapy combined with ligature placement decreased bone area and increased the eroded bone area around the tooth surface. The results at the histological analysis showed the same combination and changes. Therefore, in spite of the lack of a direct effect on the alveolar bone height, the CsA therapy intensified the imbalance of the alveolar bone homeostasia in a rat model of experimental periodontitis.
    No preview · Article · Sep 2012 · Transplantation Proceedings
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    ABSTRACT: The aim of this randomized, controlled, split-mouth, clinical study was to differentiate and clinically qualify the effectiveness of different desensitizing agents in the treatment of painful symptoms caused by cervical dentin hypersensitivity (CDH). Two hundred-and-fifty-two teeth of 42 patients were distributed into seven groups (n = 36): G1 - placebo; G2, G3, G4 and G6 - fluoride varnishes; G5 - sodium fluoride; G7 - potassium oxalate. Three applications were made one week apart. A three-score system (Alfa = 0, Bravo = 2, and Charlie = 3, respectively for no sensitivity, slight sensitivity and high sensitivity) was used to assess CDH after each application and after 30 days. The data were subjected to statistical analysis using the Kruskall-Wallis and Dun tests. After the second week, statistically significant differences were observed for all materials compared with the baseline. After 30 days, Group G7 had presented a significant gradual reduction along all the evaluated time intervals. It was concluded that all the desensitizing agents were capable of reducing dentin hypersensitivity, with the exception of the placebo and the sodium fluoride groups.
    Preview · Article · Jun 2012 · Brazilian oral research
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    ABSTRACT: Diabetes mellitus is a set of metabolic diseases characterized by hyperglycemia resulting from absolute or relative deficiency in insulin secretion by the pancreas and/or impaired insulin action in target tissues. Oral health maintenance through health care, as well as metabolic control are important measures for the overall health of diabetic patients. The objective of this study was to determine the relationship between biocompatibility of composite resin restorations with different nanoparticles, polishing in abfraction lesions in anterior and posterior teeth with periodontal tissues in patients with diabetes mellitus. We selected 20 patients--10 patients with diabetes mellitus and 10 patients without diabetes mellitus-, but with a total of 30 restorations in each group receiving composite resin restorations, who were evaluated for periodontal purposes: Plaque Index, Gingival Index; Probing Depth, Clinical Attachment Level and Bleeding on Probing. In addition, the restorations will receive assessments according to criteria for Marginal Adaptation, Anatomical Shape, Marginal Discoloration, ormation of caries, Post-operative Sensitivity and Retention. The total period was 90 days. The results showed a significant improvement in periodontal parameters assessed (p < 0.05) in both groups. With regard to assessments of the restorations, it was observed that there was no statistically significant difference (p > 0.05) among all criteria evaluated within the 90-day period. Thus, we conclude that in a short period (90 days) there is clinical biocompatibility of composite resin with nanoparticles restorations in abfraction lesions and periodontal tissues of patients with diabetes mellitus, regardless the type of polish these restorations receive.
    Full-text · Article · Jan 2012 · Acta odontológica latinoamericana: AOL
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    ABSTRACT: The objective of this study was to evaluate improvement of lipids and periodontal disease in patients with type 2 Diabetes mellitus, by means of the relationship between blood levels of total cholesterol and its fractions, triglycerides and clinical periodontal parameters. Twenty patients, in age-range 18-70 years, were selected and divided into 2 groups: (1) conventional periodontal scaling and root planing+controlled mechanic; (2) conventional periodontal scaling and root planing+controlled mechanical+maintenance therapy. The analyses were performed on day 0, 180 and 720 days, including plaque index, gingival index, probing depth and clinical attachment level, and evaluation of total cholesterol and its fractions, and triglycerides. The 2 groups presented significant reduction in clinical periodontal parameters, however, probing depth did not diminish significantly only in Group 1. There was significant improvement in all blood parameters in both groups. It was concluded that after 720 days of the experiment, there were significant improvements in clinical and blood parameters, in general. The group that received maintenance therapy also showed a more expressive improvement in clinical periodontal parameters, in general, suggesting that this therapy is important and necessary in patients with type 2 Diabetes mellitus and periodontal disease.
    No preview · Article · Dec 2011 · Diabetes research and clinical practice
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    ABSTRACT: The prevalence of obesity is increasing globally. There is evidence that the uncontrolled energetic metabolism in obese patients can accelerate periodontal disease. Therefore, the aim of this study was evaluate the possible relationship between hypothalamic obesity induced by neonatal treatment with MSG and experimental periodontal disease. Newborn male Wistar rats received subcutaneous injections in the cervical region, of 4g/Kg/day of body weight (BW) of MSG (MSG group) or hypertonic saline solution, 1.25/kg/day BW (control group, CTL). At 70 days of life periodontal disease was induced in these animals. After they were sacrificed, radiographic analyses of alveolar bone resorption and Tumor Necrosis Factor α (TNFα) gene expression in gingival tissue were performed. The neonatal treatment with MSG did not affect the concentration of plasma glucose and cholesterol (CHOL). However, plasma insulin, non-esterified fatty acids (NEFA) and triglycerides (TG) leves were higher in MSG compared with CTL group. The alveolar bone resorption was 44% lower in MSG-obese rats compared with CTL rats. In the presence of periodontal ligature, there was an increase in this parameter in all groups. The TNFα gene expression, an inflammatory marker, in periodontal tissue was similar in obese and CTL rats. The presence of ligature increased TNFα gene expression in both groups, but in a lower extension in MSG-obese rats. In conclusion these results suggested that hypothalamic obesity may produce a protective effect against periodontal disease, however further research is needed to understand the mechanisms involved in this process.
    Full-text · Article · Nov 2011 · Archives of oral biology
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    ABSTRACT: The objective of this study was to evaluate the effects of maintenance therapy with or without the use of 0.12% chlorhexidine in the periodontal tissues of patients with diabetes mellitus who had carious lesions restored with composed resin. Twenty patients were selected, all of whom had diabetes mellitus in addition to carious cervical lesions in previously treated teeth. After 90 days, improvement in plaque and gingival indices and probing depth were noticed among patients in the group that received 0.12% chlorhexidine.
    Full-text · Article · Jul 2011 · General dentistry

Publication Stats

263 Citations
41.37 Total Impact Points

Institutions

  • 2012-2014
    • Universidade Estadual do Oeste do Paraná
      Cascavel, Paraná, Brazil
  • 2009-2011
    • Federal Technological University of Paraná - Brazil
      Curityba, Paraná, Brazil
  • 2002-2009
    • São Paulo State University
      • Department of Physiology
      San Paulo, São Paulo, Brazil
  • 2007
    • Universidade Estadual do Piauí
      Poti, Piauí, Brazil