F. Cherif

La Rabta Hospital Tunis, Tunis-Ville, Tūnis, Tunisia

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Publications (84)48.26 Total impact


  • No preview · Article · Mar 2011 · Archives de Pédiatrie
  • Faika Cherif · Inès Zaraa
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    ABSTRACT: Background: No therapy can remove acne scars completely, but the discerning use of lasers can help to relieve patients of related symptoms. Electro-optical synergy (ELOS), a technology that combines radiofrequency (RF) with optical energy, shows multiple application potential, including hair removal and reversal of photoaging. Objective: Using the case reported here as an example, we discuss the role of the ELOS technology in the treatment of acne scars. Case report: The acne scars of a female patient (age 34, Fitzpatrick skin type IV) were treated with ELOS. The patient was treated monthly for a total of 4 sessions with a Matrix IR™ system (Syneron Medical Ltd.), a combination of a fractional diode laser (915nm) and bipolar conducted RF energy, using the following parameters: 60J/cm2 (laser energy) and 80J/cm3 (RF energy). Acne scars were markedly reduced 1-3 months after the final treatment. Conclusion: This technology encompasses a combination of optical and RF energies which are simultaneously applied to the tissue and demonstrate the safety and efficacy in the treatment of acne scars.
    No preview · Article · Feb 2011 · Medical Laser Application
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    ABSTRACT: Transient neonatal pustular melanosis is a common, benign, but little known dermatosis in newborns. Diagnosis of transient neonatal pustular melanosis is made clinically, by the presence of vesiculopustular and pigmented macular skin lesions. This benign spontaneously regressive dermatosis should be distinguished from several serious infectious neonatal diseases. We report a case of transient neonatal pustular melanosis and discuss the nosologic problems and differential diagnosis of this entity.
    No preview · Article · Jan 2011 · Archives de Pédiatrie

  • No preview · Article · Feb 2010 · Journal of dermatological science

  • No preview · Article · Jun 2009 · Annales de Dermatologie et de Vénéréologie
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    ABSTRACT: Dystrophic epidermolysis bullosa (DEB) is a clinically heterogeneous blistering disorder of the skin and mucous membranes. DEB is caused by mutations in the COL7A1 gene encoding type VII collagen, the major component of anchoring fibrils. On the basis of the mode of inheritance and the clinical manifestations, DEB is classified into two major subtypes: one dominant (DDEB) and one recessive (RDEB). We report, here, clinical, histological and genetic investigation of a large Tunisian family presenting with a wide range of clinical manifestations of DEB and a pedigree suggestive for a pseudodominant pattern of inheritance of a recessive mutation. Indirect immunofluorescence (IF) with the antibody LH7:2 against collagen VII and electron microscopy (EM) analyses were performed. The members of the family were genotyped with five markers flanking COL7A1, and screening for the deleterious mutation by DHPLC and direct sequencing. The family presented four pretibial DEB patients and one generalized RDEB. Molecular investigation showed that all family members, unaffected and affected by the pretibial form, were heterozygous for the c.7178delT mutation, except for the member with the generalized form who was homozygous. IF showed that heterozygous individuals, independently of their clinical status, have a slightly reduced staining, and the homozygous individual with generalized DEB has markedly reduced staining at the dermal-epidermal junction. These results are suggestive for an autosomal semidominant model of inheritance with incomplete penetrance and variable expression for the identified mutation. No genotype phenotype correlation was observed suggesting the existence of other genetic determinants influencing dermo-epidermal junction cohesion.
    No preview · Article · Jun 2009 · Journal of dermatological science

  • No preview · Article · Oct 2008 · La Tunisie médicale
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    ABSTRACT: We report on a case of macrocystic lymphatic malformation of the forearm. A male infant, without any medical history, was followed up in our department since the age of 7 months because of a subcutaneous, soft, painless mass of the left forearm. Ultrasonography and the magnetic reasonance imaging (MRI) were evocative of a macrocystic lymphatic malformation. Five sessions of sclerotherapy led to the reduction of the size of the mass but another axillary tumor appeared afterwards. A surgical excision, unfortunately incomplete, was performed rapidly followed by a recurrence of the macrocystic lymphatic malformation. Macrocystic lymphatic malformations are localized in the neck in 75% and axilla in 20% of the cases. Involvement of the upper extremity and particularly the forearm is very rare. MRI is useful for the diagnosis and the definition of tumor limits. The treatment is usually challenging because of their location and rough delimitation.
    No preview · Article · Sep 2008 · Archives de Pédiatrie
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    ABSTRACT: We report on a case of macrocystic lymphatic malformation of the forearm. A male infant, without any medical history, was followed up in our department since the age of 7 months because of a subcutaneous, soft, painless mass of the left forearm. Ultrasonography and the magnetic reasonance imaging (MRI) were evocative of a macrocystic lymphatic malformation. Five sessions of sclerotherapy led to the reduction of the size of the mass but another axillary tumor appeared afterwards. A surgical excision, unfortunately incomplete, was performed rapidly followed by a recurrence of the macrocystic lymphatic malformation. Macrocystic lymphatic malformations are localized in the neck in 75% and axilla in 20% of the cases. Involvement of the upper extremity and particularly the forearm is very rare. MRI is useful for the diagnosis and the definition of tumor limits. The treatment is usually challenging because of their location and rough delimitation.
    No preview · Article · Aug 2008 · Archives de Pédiatrie

  • No preview · Article · Jul 2008 · La Tunisie médicale
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    ABSTRACT: The Malassezia yeasts are among the normal human cutaneous flora in adults. They are also reported as part of the microflora of male genital region, mostly in uncircumcised males. The prevalence of Malassezia yeast colonization on the glans penis of circumcised males is discussed in multiple studies. We report the case of a male patient with extensive pityriasis versicolor that does not involve the preputial space.
    Preview · Article · Jul 2008 · Acta dermatovenerologica Alpina, Panonica, et Adriatica
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    ABSTRACT: Dystrophic epidermolysis bullosa (DEB) is a rare genodermatosis caused by mutations in the type VII collagen gene COL7A1. Clinical diagnosis of DEB should be confirmed by histopathological and electron microscopy analysis, which is not always accessible. We report here a genetic investigation of DEB consanguineous families in Tunisia. A total of 23 EB families were genotyped with 5 microsatellite markers overlapping the COL7A1 gene. Among these families, 19 presented with the dystrophic form of EB, 9 were diagnosed by histopathological examination, 2 had the simplex form, 1 had a junctional EB, and 1 was affected by an unclassified form of EB. The informativeness of the markers was studied and allowed us to select three markers for genetic testing of DEB in Tunisian families at risk. Haplotype analysis and homozygosity by descent suggest that all families classified clinically as having DEB and the patient who presented with an unclassified form of EB are likely linked to the COL7A1 gene, and showed evidence for exclusion for the simplex and junctional cases. For COL7A1 linked families, two main haplotypes were shared by eight families. For all the other cases, haplotypic heterogeneity was observed, thus suggesting a mutational heterogeneity among Tunisian DEB families. The genetic results matched with the ultrastructural analysis in all the DEB families and with the clinical examination in 94.7% of all studied DEB families. This study is to our knowledge the first genetic investigation of DEB in the Maghrebian population. We propose a selection of informative markers and show the importance of haplotype analysis as a relatively easy and cost and time effective method for carrier screening and prenatal diagnosis of DEB in consanguineous families at risk.
    Full-text · Article · Jun 2008 · Archives for Dermatological Research
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    ABSTRACT: Erythema nodosum (EN) is the most frequent acute nodular hypodermatitis. Etiologies of EN are varied although a similar clinical presentation. The aim of our study is to establish epidemio-clinical characteristics of EN in 103 patients. (62 in care (january 1980-december 2005) and 41 consultants (january 1991-december 2005) were seen on the dermatology unit of the Rabta hospital. We have only included patients that had done: blood count, chest X-Ray, ASLO, tuberculin intradermoreaction, transaminase, inflammation marker. We had 86 women and 17 men with a mean age of 36,5 years. Lesions were located in lower limbs in 88 cases. The main etiologies were: post streptococcal infections (42 cases), tuberculosis (8 cases), Crohn disease (8 cases), Behçet disease (7 cases) and sarcoidosis (5 cases). EN was idiopathic in 23 patients. The most common provoking agent of EN varies from a country to another and even in the same country from a study to another. In Tunisia, post streptococcal infections and Behçet disease still frequent etiologies for EN, sarcoidosis and inflammatory colites are more and more found unlike tuberculosis which is less incriminated than before. In case of EN it is reasonable to begin etiological enquiry by common causes.
    No preview · Article · Jan 2008 · La Tunisie médicale
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    ABSTRACT: Porokeratoses (PK) represent a less common group of dermatoses that are acquired or hereditary, of unknown pathogenesis, characterized by keratinization disorder. Different clinical forms have been identified and the most frequent are the Mibelli's porokeratosis (MP) and the Disseminated Superficial Actinic Prokeratosis (DSAP). In this retrospective study, we analysed the observations of PK collected in the Dermatology Department of La Rabta Hospital over a 16-year period. Six cases of PK were collected: 4 females and 2 males, with no medical history with a mean-age of 42.7. Only a female patient had (PK) familial history. All our patients had typical clinical aspects with lesions in annular plaques, of atrophic center, surrounded by keratotic border. The histological aspect was consistent with PK, showing the typical cornoid slide. In our series, there are 3 cases of (MP) and 3 cases of (DSAP). PK lesions usually appear during the childhood and the third and fourth decades for the DSAP. In MP, there is one or some large, unilateral, annular plaques. DSAP is characterized by numerous small annular lesions of the photo-exposed regions. Their prognosis is on the whole, favourable but remains conditioned by malignant transformation. Treatment is difficult aiming at reducing that risk of degeneration.
    No preview · Article · Oct 2007 · La Tunisie médicale
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    ABSTRACT: Lichen planus pemphigoides (LPP) is a skin disorder characterized by a mixture of clinical, histological and immunological features of both lichen planus (LP) and bullous pemphigoid (BP). We report, in this study, 2 cases of LPP. Case 1: a 48-year old woman, treated for diabetes and hypertension, having LP since 4 months, presented a 2-day bullous eruption. Case 2: a 41-year old man, having a 2-month history of LP treated by prednisone, presented a bullous eruption. In both cases, skin biopsies and direct immunofluorescence showed typical changes of LP and BP. Drugs and viral hepatitis were not involved. LPP is a disease characterized by bullae arising on LP papules and on uninvolved skin. It's a rare auto-immune skin disorder. It's pathogenesis is still unknown. We must keep in mind that LPP may be due to intake of drugs. It usually has a benign course; however, some cases of LPP in association with neoplasia have been reported.
    No preview · Article · Jul 2007
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    ABSTRACT: Superficial leiomyosarcomas are rare malignant tumors that may be subdivided into cutaneous and subcutaneous cases. A 58 year-old man was seen for a lower lip tumor that appeared 3 years earlier. Histopathologic and immunohistochemical examinations showed features of cutaneous leiomyosarcoma. Cutaneous leiomyosarcoma may derive from the arrector pili, smooth muscle of sudoral glands or genital dartoic muscle. The subcutaneous form arises from smooth muscle wall of blood vessels. Superficial leiomyosarcomas occur frequently in the extensor surface of the lower extremities and involve the mucosal area in rare cases. Only five cases arising in the lips have been described. Lip cutaneous leiomyosarcoma may derive from ectopic sweat glands of the lips or from a hypodermic tumor that extends to the lip.
    No preview · Article · Jan 2007 · Annales de Dermatologie et de Vénéréologie
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    ABSTRACT: Background Superficial leiomyosarcomas are rare malignant tumors that may be subdivided into cutaneous and subcutaneous cases.Case-reportA 58 year-old man was seen for a lower lip tumor that appeared 3 years earlier. Histopathologic and immunohistochemical examinations showed features of cutaneous leiomyosarcoma.DiscussionCutaneous leiomyosarcoma may derive from the arrector pili, smooth muscle of sudoral glands or genital dartoic muscle. The subcutaneous form arises from smooth muscle wall of blood vessels. Superficial leiomyosarcomas occur frequently in the extensor surface of the lower extremities and involve the mucosal area in rare cases. Only five cases arising in the lips have been described. Lip cutaneous leiomyosarcoma may derive from ectopic sweat glands of the lips or from a hypodermic tumor that extends to the lip.
    No preview · Article · Dec 2006 · Annales de Dermatologie et de Vénéréologie
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    ABSTRACT: Basal cell carcinoma (BCC) is the most common malignant tumour of the skin frequently located on the head and chiefly on the nose. Cryosurgery is one of the methods to treat BCC. To determine the efficacy of cryosurgery of 17 BCC of the nose in terms of recurrence rates and cosmetic results. 15 patients were included with a median age of 73 years and a photo type III or IV in 86% of cases. Mean size of tumours was 12 mm. Lesions were chiefly located on the alae nasi (70.5%). Complications were few and minor. After an average follow-up of 13.5 months, recurrence rate was about 5.8% (one case). Cosmetic results were good or excellent in 14 cases/17; only one patient had developed a notch of the nose. Cryosurgery is a rapid, of a low cost technique and chiefly with good oncological and cosmetic results.
    No preview · Article · Sep 2006 · La Tunisie médicale
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    ABSTRACT: The eccrine poroma is a rare benign sudoral tumour, which creates a fleshy formation. The diagnosis is made according to the anatomopathological study. The usual site is the sol, but in rare cases, other sites have also been reported. The authors report three cases of eccrine poroma localised in the scalp with literature review.
    No preview · Article · Jul 2006 · La Tunisie médicale
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    ABSTRACT: Blastomycosis is a rare mycotic infection in Africa. Isolated cutaneous disease is extremely rare. We report three cases of cutaneous blastomycosis confirmed by istologic and mycologic examination. No visceral involvement was found. Blastomycosis is rare in Tunisia. The most common site of involvement is the lung. The three cases reported presented with skin involvement only, suggesting a cutaneous inoculation of Blastomyces dermatitidis. The diagnostic criteria of cutaneous blastomycosis are discussed.
    No preview · Article · Jun 2006 · Médecine et Maladies Infectieuses