Hervé Devanne

University of Lille Nord de France, Lille, Nord-Pas-de-Calais, France

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Publications (44)

  • Céline Tard · Hervé Devanne · Luc Defebvre · Arnaud Delval
    [Show abstract] [Hide abstract] ABSTRACT: Objective: To investigate the efficiency of intermittent theta-burst stimulation (iTBS) to alleviate the symptoms of freezing of gait (FoG) in Parkinson's disease (PD). Methods: We performed a cross-over, sham-controlled study of patients with severe PD, bilateral motor signs and debilitating, severe FoG, that was levodopa-sensitive but not controlled by optimal dopatherapy. We applied iTBS to the left premotor cortex and measured FoG, gait initiation and continuous gait, before and immediately after the iTBS session. All patients received sham and true iTBS with a one-week interval and in randomized order. Results: 15 patients were included in the study. Recordings were performed under usual medication and all patients always showed unresponsive freezing. The pre- and post-stimulation gait trajectories did not differ in terms of the mean trajectory completion time or the percent time with FoG. The percent time with FoG was 6% greater after sham stimulation and 3% lower after iTBS (p>0.05). Visual cueing modified gait initiation and continuous gait but these latter were not influenced by rTMS. Conclusions: The present study provides Class I evidence that iTBS of the left premotor cortex does not alleviate FoG in PD.
    Article · Jun 2016 · Neuroscience Letters
  • P. Bocquillon · C Charley-Monaca · E. Houdayer · [...] · H. Devanne
    [Show abstract] [Hide abstract] ABSTRACT: • Restless legs syndrome (RLS) features both motor and sensory symptoms (primarily in the evening).
    Article · Jun 2016
  • Article · Apr 2016 · Neurophysiologie Clinique/Clinical Neurophysiology
  • C. Tard · H. Devanne · L. Defebvre · A. Delval
    Article · Nov 2015 · Neurophysiologie Clinique/Clinical Neurophysiology
  • [Show abstract] [Hide abstract] ABSTRACT: Objective: To identify possible electroencephalographic (EEG) markers of donepezil's effect on cortical activity in young, healthy adult volunteers at the group level. Methods: Thirty subjects were administered a daily dose of either 5. mg donepezil or placebo for 15. days in a double-blind, randomized, cross-over trial. The electroencephalogram during an auditory oddball paradigm was recorded from 58 scalp electrodes. Current source density (CSD) transformations were applied to EEG epochs. The event-related potential (ERP), inter-trial coherence (ITC: the phase consistency of the EEG spectrum) and event-related spectral perturbation (ERSP: the EEG power spectrum relative to the baseline) were calculated for the target (oddball) stimuli. Results: The donepezil and placebo conditions differed in terms of the changes in delta/theta/alpha/beta ITC and ERSP in various regions of the scalp (especially the frontal electrodes) but not in terms of latency and amplitude of the P300-ERP component. Conclusion: Our results suggest that ITC and ERSP analyses can provide EEG markers of donepezil's effects in young, healthy, adult volunteers at a group level. Significance: Novel EEG markers could be useful to assess the therapeutic potential of drug candidates in Alzheimer's disease in healthy volunteers prior to the initiation of Phase II/III clinical studies in patients.
    Article · Nov 2015 · Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology
  • [Show abstract] [Hide abstract] ABSTRACT: Recent research suggests that long-interval intracortical inhibition (LICI) is followed by a transitory period of late cortical disinhibition (LCD) that can even lead to a net increase in cortical excitability. The relationship between LICI/LCD and voluntary drive remains poorly understood. Our study aims at investigating the influence of index abduction on LICI and LCD in an actively engaged muscle and a neighboring muscle, while varying the intensity of the conditioning stimulus. Motor-evoked potentials (MEPs) were recorded from the first dorsal interosseus (FDI) and abductor digiti minimi (ADM) muscles in 13 subjects. Paired-pulses were delivered with 10 different interstimulus intervals (ranging from 60 ms to 290 ms). Whatever the condition (relaxed or active FDI), the test stimulus was set to evoke an MEP of 1 mV. The time course of conditioned MEPs amplitude was compared for relaxed and active conditions when the conditioning stimulus (CS) intensity was set to (i) 130% of the rest motor threshold (RMT) or (ii) to evoke the same size of MEP under both conditions. LICI lasted longer (i.e. disinhibition occurred later) at rest than during abduction when evoked either by similar or matched conditioning stimuli. No post-LICI facilitation was observed at rest - even when the CS intensity was set to 160% RMT. In contrast, long-interval intracortical facilitation was observed in the quiescent ADM when the FDI was active. Long-interval intracortical facilitation may then be associated with voluntary activity albeit with a lack of topographic specificity. Copyright © 2015. Published by Elsevier Ltd.
    Article · Apr 2015 · Neuroscience
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    [Show abstract] [Hide abstract] ABSTRACT: A group of European experts was commissioned to establish guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) from evidence published up until March 2014, regarding pain, movement disorders, stroke, amyotrophic lateral sclerosis, multiple sclerosis, epilepsy, consciousness disorders, tinnitus, depression, anxiety disorders, obsessive-compulsive disorder, schizophrenia, craving/addiction, and conversion. Despite unavoidable inhomogeneities, there is a sufficient body of evidence to accept with level A (definite efficacy) the analgesic effect of high-frequency (HF) rTMS of the primary motor cortex (M1) contralateral to the pain and the antidepressant effect of HF-rTMS of the left dorsolateral prefrontal cortex (DLPFC). A Level B recommendation (probable efficacy) is proposed for the antidepressant effect of low-frequency (LF) rTMS of the right DLPFC, HF-rTMS of the left DLPFC for the negative symptoms of schizophrenia, and LF-rTMS of contralesional M1 in chronic motor stroke. The effects of rTMS in a number of indications reach level C (possible efficacy), including LF-rTMS of the left temporoparietal cortex in tinnitus and auditory hallucinations. It remains to determine how to optimize rTMS protocols and techniques to give them relevance in routine clinical practice. In addition, professionals carrying out rTMS protocols should undergo rigorous training to ensure the quality of the technical realization, guarantee the proper care of patients, and maximize the chances of success. Under these conditions, the therapeutic use of rTMS should be able to develop in the coming years.
    Full-text available · Article · Jun 2014 · Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology
  • M. Rambour · H. Devanne · L. Defebvre · A. Delval
    Conference Paper · Apr 2014
  • Alexandre Caux-Dedeystère · Mélanie Rambour · Alain Duhamel · [...] · Hervé Devanne
    [Show abstract] [Hide abstract] ABSTRACT: The objective of the present study was to investigate the time course of long-interval intracortical inhibition (LICI) and late cortical disinhibition (LCD) as a function of the motor task (index abduction, thumb-index precision grip). Motor-evoked potentials were recorded from the first dorsal interosseus (FDI) muscle of the dominant limb in 13 healthy subjects. We used paired-pulse transcranial magnetic stimulation (TMS) paradigms in which a test pulse was preceded by a suprathreshold priming pulse (130% of the resting motor threshold) with varying interstimulus intervals (ISIs). In each task, double pulses were delivered with ISIs ranging from 30% of the corresponding silent period (SP; ~ 45 ms) to 220% of the SP (~ 330 ms). In both tasks, we found that LICI was followed by LCD (namely a period of increased cortical excitability lasting until ~ 200% of the SP). The time-dependent modulation of LICI and LCD differed in the two tasks; LICI was shorter (i.e. disinhibition occurred earlier) and LCD was more intense during precision grip than during index abduction. Long-interval intracortical inhibition disappeared well before the end of the SP in the precision grip task, suggesting that the mechanisms underlying these two inhibitory phenomena are distinct. Our data suggest that disinhibition might reflect adaptation of neural circuit excitability to the functional requirements of the motor task.
    Article · Feb 2014 · European Journal of Neuroscience
  • C. Tard · H. Devanne · L. Defebvre · [...] · A. Delval
    Conference Paper · Jan 2014
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    Adrian Degardin · David Devos · Luc Defebvre · [...] · Hervé Devanne
    [Show abstract] [Hide abstract] ABSTRACT: High-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) has been shown to reduce akinesia in Parkinson's disease (PD). Given that the processing of sensory afferents is deficient in PD and might be involved in akinesia, we sought to determine whether or not the application of very HF rTMS [intermittent theta-burst stimulation (iTBS) protocol] over the M1 affected sensorimotor integration (SMI) and akinesia. The experiments were carried out in: (i) 11 patients taking their usual dopaminergic treatment ('on-drug'); (ii) eight of the latter patients after withdrawal of dopaminergic treatment ('off-drug'); and (iii) 10 de novo (drug-naive) patients. Sham stimulation was applied in 11 other patients in the 'on-drug' condition. SMI was investigated by conditioning a supra-threshold transcranial magnetic stimulation pulse in the motor region controlling the abductor pollicis brevis with a nerve shock over the median nerve at time intervals corresponding to short- and long-latency afferent inhibition (SAI and LAI) and afferent-induced facilitation (AIF). Akinesia was assessed with a pointing test. In on-drug, off-drug and de novo patients, akinesia in the contralateral arm was lower after iTBS. Sham stimulation had no effect. In on-drug patients (but not other groups), SMI was also influenced by iTBS, with an increase in AIF. No changes in SAI and LAI were observed. Our data suggest that iTBS might improve both akinesia and sensory processing in patients with PD taking levodopa.
    Full-text available · Article · Jun 2012 · European Journal of Neuroscience
  • A Delval · K Dujardin · C Tard · [...] · L Defebvre
    [Show abstract] [Hide abstract] ABSTRACT: Step initiation is associated with anticipatory postural adjustments (APAs) that vary according to the speed of the first step. When step initiation is elicited by a "go" signal (i.e. in a reaction time task), the presentation of an unpredictable, intense, acoustic startling stimulus (engaging a subcortical mechanism) simultaneously with or just before the imperative "go" signal is able to trigger early-phase APAs. The aim of the present study was to better understand the mechanisms underlying APAs during step initiation. We hypothesized that the early release of APAs by low-intensity, non-startling stimuli delivered long before an imperative "go" signal indicates the involvement of several different mechanisms in triggering APAs (and not just acoustic reflexes triggering brainstem structures). Fifteen healthy subjects were asked to respond to an imperative visual "go" signal by initiating a step with their right leg. A brief, binaural 40, 80 or 115 dB auditory stimulus was given 1.4 s before the "go" signal. Participants were instructed not to respond to the auditory stimulus. The centre of pressure trajectory and the electromyographic activity of the orbicularis oculi, sternocleidomastoid and tibialis anterior muscles were recorded. All three intensities of the auditory stimulus were able to evoke low-amplitude, short APAs without subsequent step execution. The louder the stimulus, the more frequent the elicitation. Depending on the intensity of the stimulus, APAs prior to step initiation can be triggered without the evocation of a startle response or an acoustic blink. Greater reaction times for these APAs were observed for non-startling stimuli. This observation suggested the involvement of pathways that did not involve the brainstem as a "prime mover".
    Article · May 2012 · Neuroscience
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    Nezha Kouchtir-Devanne · Charles Capaday · François Cassim · [...] · Hervé Devanne
    [Show abstract] [Hide abstract] ABSTRACT: The purpose of this study was to determine whether task-dependent differences in corticospinal pathway excitability occur in going from isolated contractions of the index finger to its coordinated activity with the thumb. Focal transcranial magnetic stimulation (TMS) was used to measure input-output (I/O) curves--a measure of corticospinal pathway excitability--of the contralateral first dorsal interosseus (FDI) muscle in 21 healthy subjects performing two isometric motor tasks: index abduction and precision grip. The level of FDI electromyographic (EMG) activity was kept constant across tasks. The amplitude of the FDI motor evoked potentials (MEPs) and the duration of FDI silent period (SP) were plotted against TMS stimulus intensity and fitted, respectively, to a Boltzmann sigmoidal function. The plateau level of the FDI MEP amplitude I/O curve increased by an average of 40% during the precision grip compared with index abduction. Likewise, the steepness of the curve, as measured by the value of the maximum slope, increased by nearly 70%. By contrast, all I/O curve parameters [plateau, stimulus intensity required to obtain 50% of maximum response (S(50)), and slope] of SP duration were similar between the two tasks. Short- and long-latency intracortical inhibitions (SICI and LICI, respectively) were also measured in each task. Both measures of inhibition decreased during precision grip compared with the isolated contraction. The results demonstrate that the motor cortical circuits controlling index and thumb muscles become functionally coupled when the muscles are used synergistically and this may be due, at least in part, to a decrease of intracortical inhibition and an increase of recurrent excitation.
    Full-text available · Article · Dec 2011 · Journal of Neurophysiology
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    [Show abstract] [Hide abstract] ABSTRACT: During the past decade, a large amount of work on transcranial magnetic stimulation (TMS) has been performed, including the development of new paradigms of stimulation, the integration of imaging data, and the coupling of TMS techniques with electroencephalography or neuroimaging. These accumulating data being difficult to synthesize, several French scientific societies commissioned a group of experts to conduct a comprehensive review of the literature on TMS. This text contains all the consensual findings of the expert group on the mechanisms of action, safety rules and indications of TMS, including repetitive TMS (rTMS). TMS sessions have been conducted in thousands of healthy subjects or patients with various neurological or psychiatric diseases, allowing a better assessment of risks associated with this technique. The number of reported side effects is extremely low, the most serious complication being the occurrence of seizures. In most reported seizures, the stimulation parameters did not follow the previously published recommendations (Wassermann, 1998) [430] and rTMS was associated to medication that could lower the seizure threshold. Recommendations on the safe use of TMS / rTMS were recently updated (Rossi et al., 2009) [348], establishing new limits for stimulation parameters and fixing the contraindications. The recommendations we propose regarding safety are largely based on this previous report with some modifications. By contrast, the issue of therapeutic indications of rTMS has never been addressed before, the present work being the first attempt of a synthesis and expert consensus on this topic. The use of TMS/rTMS is discussed in the context of chronic pain, movement disorders, stroke, epilepsy, tinnitus and psychiatric disorders. There is already a sufficient level of evidence of published data to retain a therapeutic indication of rTMS in clinical practice (grade A) in chronic neuropathic pain, major depressive episodes, and auditory hallucinations. The number of therapeutic indications of rTMS is expected to increase in coming years, in parallel with the optimisation of stimulation parameters. Copyright © 2011 Elsevier Masson SAS. All rights reserved.
    Full-text available · Article · Dec 2011 · Neurophysiologie Clinique/Clinical Neurophysiology
  • [Show abstract] [Hide abstract] ABSTRACT: Ce texte est fondé en grande partie sur l’article récemment publié par Rossi et al. (2009) [101] présentant les conclusions d’une conférence de consensus, qui a eu lieu à Sienne (Italie) du 7 au 9 mars 2008. Cette conférence réunissant 30 experts internationaux avait eu pour objectif d’actualiser les recommandations concernant les règles de sécurité pour l’utilisation de la stimulation magnétique transcrânienne (ou transcranial magnetic stimulation, TMS) dans les applications cliniques et de recherche. Au cours de la dernière décennie, un très grand nombre de travaux de TMS et de TMS répétitive (rTMS) ont été effectués, avec notamment l’élaboration de nouveaux paradigmes de stimulation, l’intégration des données d’imagerie, et le couplage de techniques de TMS et d’électroencéphalographie (EEG) neuroimagerie. Des séances de TMS ont été réalisées chez des milliers de sujets sains ou des patients souffrant de diverses maladies neurologiques ou psychiatriques, permettant une meilleure évaluation des risques relatifs liés à cette technique. Le nombre d’effets secondaires rapportés est extrêmement faible, la complication la plus sérieuse étant la survenue de crises d’épilepsie. Dans la plupart des crises rapportées, les paramètres de stimulation ne suivaient pas les recommandations précédemment publiées (Wassermann, 1998 [130]) et souvent il existait un traitement médicamenteux qui pouvait abaisser le seuil épileptogène. Les recommandations sur la sécurité d’utilisation de la TMS/rTMS ont été récemment actualisées (Rossi et al., 2009 [101]), fixant les contre-indications et établissant de nouvelles limites concernant les différents paramètres de stimulation. Cet article présente le travail de consensus d’un groupe d’experts français de TMS/rTMS qui a adapté ces recommandations pour un public francophone. La question des indications cliniques de la rTMS fera l’objet du travail suivant de ce groupe d’experts.
    Article · Aug 2011 · Neurophysiologie Clinique/Clinical Neurophysiology
  • Adrian Degardin · David Devos · François Cassim · [...] · Hervé Devanne
    [Show abstract] [Hide abstract] ABSTRACT: Sensorimotor performance declines with normal aging. The present study explored age-related changes in sensorimotor integration by conditioning a supra-threshold transcranial magnetic stimulation pulse with a peripheral nerve shock at different interstimulus intervals. Cortical motor threshold of the abductor pollicis brevis muscle, intracortical inhibition and facilitation were measured. We also assessed the influence of median nerve stimulation on motor cortex excitability at intervals which evoked short- and long-latency afferent inhibition (SAI and LAI, respectively) and afferent-induced facilitation (AIF). We observed a marked decrease of the long latency influence of proprioceptive inputs on M1 excitability in the elderly, with the loss of AIF and LAI. The SAI, motor thresholds and intracortical inhibition and facilitation were not age-related. Decreased sensorimotor performance with aging appears to be associated with a decrease in the influence of proprioceptive inputs on motor cortex excitability at longer intervals (probably via higher order cortical areas).
    Article · Jul 2011 · Neuroscience Letters
  • Hervé Devanne · Adrian Degardin · Louise Tyvaert · [...] · François Cassim
    [Show abstract] [Hide abstract] ABSTRACT: Sensory inputs from cutaneous and limb receptors are known to influence motor cortex network excitability. Although most recent studies have focused on the inhibitory influences of afferent inputs on arm motor responses evoked by transcranial magnetic stimulation (TMS), facilitatory effects are rarely considered. In the present work, we sought to establish how proprioceptive sensory inputs modulate the excitability of the primary motor cortex region controlling certain hand and wrist muscles. Suprathreshold TMS pulses were preceded either by median nerve stimulation (MNS) or index finger stimulation with interstimulus intervals (ISIs) ranging from 20 to 200 ms (with particular focus on 40-80 ms). Motor-evoked potentials recorded in the abductor pollicis brevis (APB), first dorsalis interosseus and extensor carpi radialis muscles were strongly facilitated (by up to 150%) by MNS with ISIs of around 60 ms, whereas digit stimulation had only a weak effect. When MNS was delivered at the interval that evoked the optimal facilitatory effect, the H-reflex amplitude remained unchanged and APB motor responses evoked with transcranial electric stimulation were not increased as compared with TMS. Afferent-induced facilitation and short-latency intracortical inhibition (SICI) and intracortical facilitation (ICF) mechanisms are likely to interact in cortical circuits, as suggested by the strong facilitation observed when MNS was delivered concurrently with ICF and the reduction of SICI following MNS. We conclude that afferent-induced facilitation is a mechanism which probably involves muscle spindle afferents and should be considered when studying sensorimotor integration mechanisms in healthy and disease situations.
    Article · Sep 2009 · European Journal of Neuroscience
  • L Tyvaert · E Houdayer · H Devanne · [...] · C Monaca
    [Show abstract] [Hide abstract] ABSTRACT: Restless legs syndrome (RLS) is characterized by closely interrelated motor and sensory disorders. Two types of involuntary movement can be observed: periodic leg movements during wakefulness (PLMW) and periodic leg movements during sleep (PLMS). Basal ganglia dysfunction in primary RLS has often been suggested. However, clinical observations raise the hypothesis of sensorimotor cortical involvement in RLS symptoms. Here, we explored cortical function via movement-related beta and mu rhythm reactivity. Twelve patients with idiopathic, primary RLS were investigated and compared with 10 healthy subjects. In the patient group, we analyzed event-related beta and mu (de)synchronization (ERD/S) for PLMS and PLMW during a suggested immobilization test (SIT). An ERD/S analysis was also performed in patients and controls during self-paced right ankle dorsal flexion at 8:30 PM (i.e., the symptomatic period for patients) and 8:30 AM (the asymptomatic period). Before PLMS, there was no ERD. Intense ERS was recorded after PLMS. As with voluntary movement, cortical ERD was always observed before PLMW. After PLMW, ERS had a diffuse scalp distribution. Furthermore, the ERS and ERD amplitudes and durations for voluntary movement were greater during the symptomatic period than during the asymptomatic period and in comparison with healthy controls, who presented an evening decrease in these parameters. Patients and controls had similar ERD and ERS patterns in the morning. On the basis of a rhythm reactivity study, we conclude that the symptoms of RLS are related to cortical sensorimotor dysfunction.
    Article · Jun 2009 · Sleep Medicine
  • C. Rossi-Durand · A. Boyadjian · H. Devanne · F. Tyc
    Article · Jul 2008 · Brain Stimulation
  • H. Devanne · A. Degardin · L. Tyvaert · [...] · F. Cassim
    Article · Jul 2008 · Brain Stimulation

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  • 2014
    • University of Lille Nord de France
      Lille, Nord-Pas-de-Calais, France
  • 2005
    • Centre Hospitalier Régional Universitaire de Lille
      Lille, Nord-Pas-de-Calais, France
  • 1995
    • Laval University
      Québec, Quebec, Canada