[Show abstract][Hide abstract] ABSTRACT: Hydroxyurea is commonly used in the treatment of myeloproliferative syndromes. A unique lichenoid eruption acral in location has followed long- term administration of the drug. We report a new case of hydroxyurea dennopathy observed in a 51 year old woman with chronic myelogenous leukemia. The cutaneous lesions vanished as the drug was stopped. 5km changes secondary to hydroxyurea therapy are considered rare. However, these lesions may be more common than they are usually believed.
No preview · Article · Jan 1999 · Medicina cutánea ibero-latino-americana
[Show abstract][Hide abstract] ABSTRACT: An unusual case of Maffucci's syndrome confined to an extremity with an additional superficial lymphangioma in the same limb is described. The patient, a 47-year-old woman, presented with several painful subcutaneous spindle cell hemangioendotheliomas (SCHs) and multiple lytic bone lesions, some calcified, in the left leg. She has been followed for two years and continues to do well. The combination of SCHs and multiple enchondromas (ENCHs) should be searched in any patient who presents with SCHs or multiple ENCHs, because there is a significant risk of malignant transformation.
No preview · Article · May 1998 · General & diagnostic pathology
[Show abstract][Hide abstract] ABSTRACT: A new histologic variant of dermatofibroma, only briefly alluded to in dermatological literature is reported. This tumor was located in the back of a 24-year-old man. It was present for about 2 years and had a history of trauma 2 months before excision. The lesion showed similar characteristics to those of conventional dermatofibroma as well as the presence of groups of granular cells identical to those seen in granular cell tumors. It is important to recognize dermatofibroma with granular cells because it may be confused with a variety of benign or malignant soft tissue tumors containing similar granular cells that entail different significance or prognosis. The immunohistochemical study supports a granular cell change in a dermatofibroma instead of a granular cell tumor that has been traumatized, with secondary formation of a dermatofibroma reaction.
No preview · Article · Jan 1997 · Journal of Cutaneous Pathology
[Show abstract][Hide abstract] ABSTRACT: Glandular inclusions in inguinal hernia sacs are not frequent. We present six cases of inguinal hernia with this finding, which represents an incidence of 2.6% in males and shows a predominance in the prepubertal stage. Five patients showed cryptorchidism and two cases were related to congenital malformations of the single umbilical artery type and 47,XY chromosome disorder with chromosomal marker. The most important differential diagnosis must be made with normal histological structures such as the vas deferens or epididymis. The mean diameter of the inclusions was 0.1988 mm and there was a significant difference in size between the inclusions and the vas deferens, but not the epididymis. Differentiation from the latter is based on the absence of a well-developed muscular coat in the wall of the inclusions. It is important to recognize that these inclusions can occur in hernia sacs because of the clinical and medicolegal implications that arise if they are confused with true epididymis or vas deferens. They may arise from paratesticular embryonal remnants.
No preview · Article · Jan 1994 · Pediatric pathology / affiliated with the International Paediatric Pathology Association