J M van Ree

Utrecht University, Utrecht, Utrecht, Netherlands

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Publications (535)2012.27 Total impact

  • No preview · Article · Jan 2015 · Drug and Alcohol Dependence
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    ABSTRACT: Background Most studies investigating the role of personality as a risk factor for the development of opioid dependence compare dependent opioid users with healthy controls who never used heroin. In order to understand the potential protective role of personality, it is crucial to compare illicit opioid users who never became dependent with dependent opioid users. Aims This study aims to examine the role of personality as a risk factor for opioid use and as a protective factor for the development of opioid dependence. Methods Comparing personality factors between three groups: (1) 161 never-dependent illicit opioid users who have been using illicit opioids but never became opioid dependent; (2) 402 dependent opioid users in methadone maintenance treatment or heroin-assisted treatment; and (3) 135 healthy controls who never used heroin. Personality was assessed with a short version of Cloninger's Temperament and Character Inventory. Results Never-dependent opioid users reported more Novelty Seeking and Harm Avoidance and less Self-Directedness and Cooperativeness than healthy controls and more Reward Dependence and Self-Directedness, and less Harm Avoidance than dependent opioid users. Furthermore, never-dependent opioid users reported more Self-Transcendence than both dependent opioid users and healthy controls. Conclusions Never-dependent opioid users may have started to use opioids partly due to their tendency to seek novel and/or spiritual experiences (high Novelty Seeking, high Self-Transcendence) and their tendency to avoid aversive stimuli (high Harm Avoidance), whereas they may have been protected against the development of dependence by their need for social approval (high Reward Dependence) and their self-efficacy (high Self-Directedness).
    No preview · Article · Dec 2014 · Drug and Alcohol Dependence

  • No preview · Article · Jan 2013 · Neurophysiologie Clinique/Clinical Neurophysiology
  • David J Nutt · Sven Ove Ögren · Jan M van Ree

    No preview · Article · Oct 2012 · European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology
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    ABSTRACT: Na de start in 1998 van een eerste fase in Amsterdam en Rotterdam is in de loop van 2000 in zes gemeenten in Nederland, te weten de genoemde en Den Haag, Groningen, Heerlen en Utrecht, het onderzoek naar de effectiviteit van heroïne op medisch voorschrift van start gegaan. In dit artikel wordt ingegaan op de achtergrond en onderzoeksopzet van dit multicenter onderzoek en worden enkele eerste ervaringen beschreven.
    Full-text · Article · May 2012
  • Jan van Ree · Wim van den Brink
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    ABSTRACT: Het gebruik van stoffen, al of niet uit planten, en het doen van bepaalde handelingen om de geest te verruimen of althans te beïnvloeden vormen in veel culturen een eeuwenoude traditie. Mensen gebruiken geestbeïnvloedende stoffen om zich goed te voelen ’ dus als genotsmiddel ’ of om zich beter te voelen ’ dus als een vorm van zelfmedicatie. Herhaald en intensief gebruik van (sommige van) dergelijke stoffen kan een verandering in de hersenen teweegbrengen, hetgeen in combinatie met persoonlijkheidskenmerken en omgevingsfactoren, weer kan leiden tot verslaving.
    No preview · Article · Apr 2012
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    ABSTRACT: Motor dominance is well established, but sensory dominance is much less clear. We therefore studied the cortical evoked magnetic fields using magnetoencephalography (MEG) in a group of 20 healthy right handed subjects in order to examine whether standard electrical stimulation of the median and ulnar nerve demonstrated sensory lateralization. The global field power (GFP) curves, as an indication of cortical activation, did not depict sensory lateralization to the dominant left hemisphere. Comparison of the M20, M30, and M70 peak latencies and GFP values exhibited no statistical differences between the hemispheres, indicating no sensory hemispherical dominance at these latencies for each nerve. Field maps at these latencies presented a first and second polarity reversal for both median and ulnar stimulation. Spatial dipole position parameters did not reveal statistical left-right differences at the M20, M30 and M70 peaks for both nerves. Neither did the dipolar strengths at M20, M30 and M70 show a statistical left-right difference for both nerves. Finally, the Laterality Indices of the M20, M30 and M70 strengths did not indicate complete lateralization to one of the hemispheres. After electrical median and ulnar nerve stimulation no evidence was found for sensory hand dominance in brain responses of either hand, as measured by MEG. The results can provide a new assessment of patients with sensory dysfunctions or perceptual distortion when sensory dominance occurs way beyond the estimated norm.
    Full-text · Article · Nov 2011 · Brain Topography
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    ABSTRACT: To investigate in heroin-assisted treatment (HAT) compared to methadone maintenance treatment (MMT): the course of heroin craving and illicit heroin use, their mutual association, and their association with multi-domain treatment response. RCTs on the efficacy of 12 months co-prescribed injectable or inhalable HAT compared to 12 months continued oral MMT. Outpatient treatment in MMT- or specialized HAT-centers in the Netherlands. Chronic, treatment-refractory heroin dependent patients (n=73). STUDY PARAMETERS: General craving for heroin (Obsessive Compulsive Drug Use Scale); self-reported illicit heroin use; multi-domain treatment response in physical, mental and social health and illicit drug use. The course of heroin craving and illicit heroin use differed significantly, with strong reductions in HAT but not in MMT. General heroin craving was significantly related to illicit heroin use. Heroin craving was not and illicit heroin use was marginally related to multi-domain treatment response, but only in MMT and not in HAT. Heroin craving and illicit heroin use were significantly associated and both strongly decreased in HAT but not in MMT. Craving was not related to multi-domain treatment response and illicit heroin use was marginally related to treatment response in MMT, but not in HAT. The latter was probably due to the strong reduction in illicit heroin use in most patients in HAT and the small sample size of the sub-study. It is hypothesized that the strong reductions in craving for heroin in HAT are related to the stable availability of prescribed, pharmaceutical grade heroin.
    Full-text · Article · Jul 2011 · Drug and alcohol dependence
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    ABSTRACT: This study examined whether chronic neuropathic pain, modulated by a local anesthetic block, is associated with cortical magnetic field changes. In a group of 20 patients with pain caused by unilateral traumatic peripheral nerve injury, a local block with lidocaine 1% was administered and the cortical effects were measured and compared with a control group. The global field power (GFP), describing distribution of cortical activation after median and ulnar nerve stimulation, was plotted and calculated. The effects on the affected hemisphere and the unaffected hemisphere (UH) before and after a block of the injured nerve were statistically evaluated. Major differences based on the GFP curves, at a component between 50 ms - 90 ms (M70), were found in patients: in the affected hemisphere the M70 GFP peak values were statistically significantly larger in comparison with the UH, and the GFP curves differed morphologically. Interestingly, the mean UH responses were reduced in comparison with the control group, a finding suggesting that the UH is also part of the cortical changes. At M70, the GFP curves and values in the affected hemisphere were modulated by a local block of the median or the ulnar nerve. The most likely location of cortical adaptation is in the primary somatosensory cortex. Cortical activation is enhanced in the affected hemisphere compared with the UH and is modulated by a local block. The UH in neuropathic pain changes as well. Evoked fields may offer an opportunity to monitor the effectiveness of treatments of neuropathic pain in humans.
    No preview · Article · Jun 2011 · Anesthesiology
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    ABSTRACT: This study aims to asses the influence of inhalable heroin on pulmonary function in chronic heroin-dependent patients treated with inhalable heroin. Among 32 patients (all cigarette smokers), a spirometric test was conducted at baseline and after an average period of 10 months of treatment with medically prescribed heroin. Patients showed a high frequency of pulmonary dysfunction at baseline [34%, with percentage of forced expiratory volume in 1 s (%FEV1)<80%]. However, after excluding those who started pulmonary treatment (n=2) or who used heroin intravenously only (n=2), no statistically significant differences in %FEV1 between baseline and follow-up were observed (n=28; mean %FEV1 86% at baseline vs. 91% at follow-up; p=0.09). This small and relatively brief study suggests that 10 months of co-prescribed inhalable heroine base does not seem to (further) deteriorate pulmonary function in chronic, cigarette smoking treatment refractory heroin addicts. Screening for and treatment of pulmonary dysfunction is recommended for methadone patients with and without co-prescribed heroin.
    No preview · Article · Mar 2011 · European Addiction Research
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    Piotr Popik · Jerzy Vetulani · Adam Bisaga · Jan M. van Ree
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    ABSTRACT: The cue used by an adult resident rat for recognition of a just met juvenile in the social memory paradigm was assessed by manipulating the amount of olfactory information and enhancing the recognition with arginine8-vasopressin (AVP). Social recognition was impaired in anosmic resident rats, suggesting that the recognition cue is olfactory in nature. Washed juveniles were recognized by AVP but not placebo treated residents, independently of whether after washing they were marked with previously collected urine of the residents or not. Preputialectomized juveniles were recognized neither by placebo nor by AVP treated residents. The results suggest that the scents originating from the preputial gland of the juvenile serve as the recognition cue in the social memory paradigm of rats.
    Full-text · Article · Jan 2011 · Journal of basic and clinical physiology and pharmacology
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    ABSTRACT: This monograph describes the history, findings and international context of heroin-assisted treatment (HAT) in the Netherlands. The monograph consists of (1) a short introduction and seven paragraphs describing the following aspects of HAT in the Netherlands: (2) history of HAT studies and implementation of routine HAT in the Netherlands; (3) main findings on efficacy, safety and cost-effectiveness from the two randomized controlled HAT trials in the Netherlands; (4) new findings from a large cohort study on the effectiveness of HAT in routine clinical practice in the Netherlands; (5) unique data on the patient's perspective of HAT; (6) data on the pharmacological and pharmaceutical basis for HAT in the Netherlands; (7) description of the registration process; and (8) account of the international context of HAT. Together, these data show that HAT can now be considered a safe and proven-effective intervention for the treatment of chronic, treatment-resistant heroin dependent patients.
    Full-text · Article · Apr 2010 · European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology
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    ABSTRACT: To describe 4-year treatment retention and treatment response among chronic, treatment-resistant heroin-dependent patients offered long-term heroin-assisted treatment (HAT) in the Netherlands. Observational cohort study. Out-patient treatment in specialized heroin treatment centres in six cities in the Netherlands, with methadone plus injectable or inhalable heroin offered 7 days per week, three times per day. Prescription of methadone plus heroin was supplemented with individually tailored psychosocial and medical support. Heroin-dependent patients who had responded positively to HAT in two randomized controlled trials and were eligible for long-term heroin-assisted treatment (n = 149). Primary outcome measures were treatment retention after 4 years and treatment response on a dichotomous, multi-domain response index, comprising physical, mental and social health and illicit substance use. Four-year retention was 55.7% [95% confidence interval (CI): 47.6-63.8%]. Response was significantly better for patients continuing 4 years of HAT compared to patients who discontinued treatment: 90.4% versus 21.2% [difference 69.2%; odds ratio (OR) = 48.4, 95% CI: 17.6-159.1]. Continued HAT treatment was also associated with an increasing proportion of patients without health problems and who had stopped illicit drug and excessive alcohol use: from 12% after the first year to 25% after 4 years of HAT. Long-term HAT is an effective treatment for chronic heroin addicts who have failed to benefit from methadone maintenance treatment. Four years of HAT is associated with stable physical, mental and social health and with absence of illicit heroin use and substantial reductions in cocaine use. HAT should be continued as long as there is no compelling reason to stop treatment.
    No preview · Article · Nov 2009 · Addiction
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    ABSTRACT: The presence of specific and common genetic etiologies for autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) was investigated for 132 candidate genes in a two-stage design-association study. 1,536 single nucleotide polymorphisms (SNPs) covering these candidate genes were tested in ASD (n = 144) and ADHD (n = 110) patients and control subjects (n = 404) from The Netherlands. A second stage was performed with those SNPs from Stage I reaching a significance threshold for association of p < .01 in an independent sample of ASD patients (n = 128) and controls (n = 124) from the United Kingdom and a Dutch ADHD (n = 150) and control (n = 149) sample. No shared association was found between ASD and ADHD. However, in the first and second ASD samples and in a joint statistical analysis, a significant association between SNP rs167771 located in the DRD3 gene was found (joint analysis uncorrected: p = 3.11 x 10(-6); corrected for multiple testing and potential stratification: p = .00162). The DRD3 gene is related to stereotyped behavior, liability to side effects of antipsychotic medication, and movement disorders and may therefore have important clinical implications for ASD.
    Full-text · Article · Apr 2009 · Biological psychiatry
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    ABSTRACT: Prenatal morphine treatment and emotional stress both have been shown to increase sensitivity to reward-related behaviors. It has been postulated that this increased sensitivity to rewarding stimuli may be the result of an enhanced release of endogenous opioids. In the present study, in vivo autoradiography was employed to investigate the endogenous opioid release in specific brain areas in rats. Pregnant animals were exposed to morphine or saline from day 8 of gestation till birth. Development of pups was monitored and play behavior was tested on postnatal day 21. Adult rats were exposed to repeated emotional stress or control treatment for five consecutive days and tested in a small open field 5 days later. [(3)H]-Diprenorphine was injected following this test to investigate endogenous opioid release. Prenatal morphine treatment increased play behavior and endogenous opioid release in a number of cortical and subcortical brain areas after being subjected to an open field challenge later in life. Emotional stress exposure increased locomotor activity in the open field irrespective of the type of prenatal treatment and increased endogenous opioid release in some specific brain areas. It is suggested that the increased release of endogenous opioids in the substantia nigra, the piriform cortex and the septum observed after both types of treatments is related to the increased sensitivity to reward.
    Full-text · Article · Dec 2008 · Neuroscience
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    ABSTRACT: Traditional behavioral tests, such as the open field test, measure an animal's responsiveness to a novel environment. However, it is generally difficult to assess whether the behavioral response obtained from these tests relates to the expression level of motor activity and/or to avoidance of anxiogenic areas. Here, an automated home cage environment for mice was designed to obtain independent measures of motor activity levels and of sheltered feeding preference during three consecutive days. Chronic treatment with the anxiolytic drug chlordiazepoxide (5 and 10 mg/kg/day) in C57BL/6J mice reduced sheltered feeding preference without altering motor activity levels. Furthermore, two distinct chromosome substitution strains, derived from C57BL/6J (host strain) and A/J (donor strain) inbred strains, expressed either increased sheltering preference in females (chromosome 15) or reduced motor activity levels in females and males (chromosome 1) when compared to C57BL/6J. Longitudinal behavioral monitoring revealed that these phenotypic differences maintained after adaptation to the home cage. Thus, by using new automated behavioral phenotyping approaches, behavior can be dissociated into distinct behavioral domains (e.g., anxiety-related and motor activity domains) with different underlying genetic origin and pharmacological responsiveness.
    Full-text · Article · Sep 2008 · Behavioral Neuroscience
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    ABSTRACT: Behavioural Effects Of γ-MSH and ACTH(1-24)Influence of γ-MSH on β-Endorphin Effects in VivoInfluence of γ-MSH on β-Endorphin Effects in VitroPossible Mode of Action of γ-MSHConcluding RemarksReferencesDiscussionReferences
    No preview · Chapter · May 2008
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    Jan M van Ree · Douwe D Breimer

    Preview · Article · May 2008 · Trends in Pharmacological Sciences
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    ABSTRACT: Heavy ecstasy use has been associated with neurocognitive deficits in various behavioral and brain imaging studies. However, this association is not conclusive owing to the unavoidable confounding factor of polysubstance use. The present study, as part of the Netherlands XTC Toxicity study, investigated specific effects of ecstasy on working memory, attention, and associative memory, using functional magnetic resonance imaging (fMRI). A large sample (n=71) was carefully composed based on variation in the amount and type of drugs that were used. The sample included 33 heavy ecstasy users (mean 322 pills lifetime). Neurocognitive brain function in three domains: working memory, attention, and associative memory, was assessed with performance measures and fMRI. Independent effects of the use of ecstasy, amphetamine, cocaine, cannabis, alcohol, tobacco, and of gender and IQ were assessed and separated by means of multiple regression analyses. Use of ecstasy had no effect on working memory and attention, but drug use was associated with reduced associative memory performance. Multiple regression analysis showed that associative memory performance was affected by amphetamine much more than by ecstasy. Both drugs affected associative memory-related brain activity, but the effects were consistently in opposite directions, suggesting that different mechanisms are at play. This could be related to the different neurotransmitter systems these drugs predominantly act upon, that is, serotonin (ecstasy) vs dopamine (amphetamine) systems.
    Full-text · Article · Feb 2008 · Neuropsychopharmacology
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    ABSTRACT: Het centrale zenuwstelsel bestaat uit het ruggenmerg en de hersenen. In dit hoofdstuk wordt eerst de bouw van deze twee organen besproken. In het kort worden ook de hersenzenuwen, de hersenvliezen en de liquor cerebrospinalis, en de vascularisatie van de hersenen behandeld. Hierna komt in de paragraaf ‘Sensibele vezelsystemen’ ter sprake hoe de impulsen, die via de zenuwen het ruggenmerg en de hersenstam bereiken, in het centrale zenuwstelsel worden verwerkt. Ten slotte wordt in de paragraaf ‘Motorische vezelsystemen’ besproken op welke wijze de hogere centra van het centrale zenuwstelsel invloed kunnen uitoefenen op de motoriek van het lichaam.
    No preview · Article · Jan 2008

Publication Stats

13k Citations
2,012.27 Total Impact Points


  • 1975-2014
    • Utrecht University
      • • Division of Pharmacology
      • • Department of Medical Oncology
      • • Department of Child and Adolescent Psychiatry
      • • Rudolf Magnus Institute
      Utrecht, Utrecht, Netherlands
  • 2013
    • Capital Medical University
      Peping, Beijing, China
  • 2003-2011
    • Netherlands Institute for Neuroscience
      Amsterdamo, North Holland, Netherlands
  • 1977-2011
    • University Medical Center Utrecht
      • • Department of Child and Adolescent Psychiatry
      • • Department of Neurosciences and Pharmacology
      • • Department of Psychiatry
      Utrecht, Utrecht, Netherlands
  • 2006
    • Medicines Evaluation Board, Netherlands
      Utrecht, Utrecht, Netherlands
    • Academisch Medisch Centrum Universiteit van Amsterdam
      • Department of Psychiatry
      Amsterdam, North Holland, Netherlands
  • 2005
    • Institute of Cytology and Genetics
      Novo-Nikolaevsk, Novosibirsk, Russia
  • 1991-2005
    • Netherlands Institute for Space Research, Utrecht
      Utrecht, Utrecht, Netherlands
  • 1993
    • Academic Medical Center (AMC)
      Amsterdamo, North Holland, Netherlands
  • 1989
    • Open Universiteit Nederland
      Heerlen, Limburg, Netherlands
  • 1983
    • University of Szeged
      Algyő, Csongrád, Hungary
    • Leiden University
      Leyden, South Holland, Netherlands