G Brassier

Université de Rennes 1, Roazhon, Brittany, France

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Publications (111)125.58 Total impact


  • No preview · Article · Dec 2010 · Neurochirurgie
  • Philippe Mercier · Gilles Brassier

    No preview · Article · Jul 2010 · Journal of neurosurgery. Spine
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    ABSTRACT: Olfactory ensheathing cell tumour (OECT) and olfactory groove schwannoma (OGS) are among the rarest intracranial tumour types that develop within anterior cranial fossa. These tumours share several similarities, including radiological and histological aspects, and only immunohistochemical staining can differentiate between them. We report a case of OECT occurring in a 28-year-old woman with a history of complex partial seizures, emotional lability and anosmia. Radiological features showed a predominantly left subfrontal extra-axial mass. Total excision of the tumour, connected to the cribriform plate and contiguous to the left olfactory bulb, was performed. Histological examination suggested an atypical schwannoma; however, immunohistochemical staining was strongly positive for S-100 protein but negative for both epithelial membrane antigen (EMA) and CD 57 (Leu-7). The final diagnosis was olfactory ensheathing cell tumour. We describe the third case of OECT and emphasize the important role of immunohistochemical staining in diagnosis: awareness of this entity, and use of immunohistochemistry help to distinguish it from OGS.
    No preview · Article · Apr 2010 · Journal of Neuro-Oncology
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    ABSTRACT: In this chapter, we report the results of orbital tumor management in a few neurosurgical departments and compare it to a Paris neurosurgical department that has developed a close relation with an ophthalmological department. These departments' activity is quite low, treating mainly sphenoorbital meningiomas. Other tumor groups are unequally and sporadically managed.
    No preview · Article · Mar 2010 · Neurochirurgie
  • P Mercier · G Brassier · H-D Fournier · M Delion · X Papon · P Lasjaunias
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    ABSTRACT: One hundred brains (first injected in cerebral arteries and veins with latex neoprene or India ink and studied under optic magnification) illustrate this anatomic chapter concerning the microsurgical anatomy of the cisternal segment, the neurovascular relationships, and the blood supply of the IIIrd to the XIIth cranial nerves.
    No preview · Article · Apr 2009 · Neurochirurgie
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    ABSTRACT: We report the results of an investigation carried out on the activity of functional neurosurgery of the cranial nerves in the French-speaking countries, based on the analysis of a questionnaire addressed to all the members of the SNCLF. Eighteen centers responded to this questionnaire, which showed that activities and indications varied greatly from one unit to another. The results appear homogeneous and comparable with those reported in the literature. The questionnaire sought to provide a global perspective, open to the comments and questions of all responders on the various techniques raised, with the objective of establishing a common decisional tree for these pathologies and providing if possible to a consensus for better dissemination of these therapies.
    No preview · Article · Apr 2009 · Neurochirurgie
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    ABSTRACT: The subthalamic nucleus (STN) has become an effective target of deep-brain stimulation (DBS) in severely disabled patients with advanced Parkinson’s disease (PD). Clinical studies have reported DBS-induced adverse effects on cognitive functions, mood, emotion and behavior. STN DBS seems to interfere with the limbic functions of the basal ganglia, but the limbic effects of STN DBS are controversial. We measured prospectively resting regional cerebral metabolism (rCMb) with 18-fluorodeoxyglucose and PET, and resting regional cerebral blood flow (rCBF) with HMPAO and SPECT in six patients with Parkinson’s disease. We compared PET and SPECT 1month before and 3months after STN DBS. On cerebral MRI, 13 regions of interest (ROI) were manually delineated slice by slice in frontal and limbic lobes. We obtained mean rCBF and rCMb values for each ROI and the whole brain. We normalized rCBF and rCMB values to ones for the whole brain volume, which we compared before and following STN DBS. No significant difference emerged in the SPECT analysis. PET analysis revealed a significant decrease in rCMb following STN DBS in the superior frontal gyri and left and right dorsolateral prefrontal cortex (p<0.05). A non-significant decrease in rCMb in the left anterior cingulate gyrus appeared following STN DBS (p=0.075). Our prospective SPECT and PET study revealed significantly decreased glucose metabolism of the two superior frontal gyri without any attendant perfusion changes following STN DBS. These results suggest that STN DBS may change medial prefrontal function and therefore the integration of limbic information, either by disrupting emotional processes within the STN, or by hampering the normal function of a limbic circuit. KeywordsDeep brain stimulation-Functional imaging-Limbic system-Parkinson’s disease-Subthalamic nucleus
    Full-text · Article · Mar 2009 · Journal of Neurology
  • M. Messerer · M. Nouri · S. Saikali · G. Brassier · A. Hamlat
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    ABSTRACT: Metastatic spreading is a rare complication of meningioma. We report a subcutaneous metastasis from an atypical meningioma of the tentorium. A 69-year-old man presented with a meningioma of the tentorium. The tumor was totally resected. The histological diagnosis was atypical meningioma. The tumor recurred two years later and was irradiated. Despite irradiation, the tumor progressed and was resected three years later. Five months following the second surgery, an isolated subcutaneous mass developed at the skin incision and was resected. The histological examination of the subcutaneous tumor showed histological features of atypical meningioma. Surgery of atypical meningioma carries the risk of iatrogenic metastasis, despite previous irradiation.RésuméNous rapportons le cas d’un patient ayant présenté une métastase sous-cutanée d’un méningiome atypique de la tente du cervelet. Il s’agit d’un homme de 69 ans, opéré d’un méningiome de la tente du cervelet avec exérèse totale (Simpson II). Deux ans après, la tumeur a récidivé. Le patient a été irradié après refus d’une nouvelle intervention. Trois ans après la radiothérapie, et devant la poursuite évolutive tumorale, le patient a été réopéré avec une exérèse totale (Simpson I). Cinq mois plus tard, il est réopéré pour une masse sous-cutanée en regard de la voie d’abord. L’examen histologique confirme le diagnostic de métastase d’un méningiome atypique. La chirurgie des méningiomes atypiques comporte un risque de métastases iatrogènes, même après une radiothérapie préalable.
    No preview · Article · Aug 2008 · Neurochirurgie
  • M Messerer · M Nouri · S Saikali · G Brassier · A Hamlat
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    ABSTRACT: Metastatic spreading is a rare complication of meningioma. We report a subcutaneous metastasis from an atypical meningioma of the tentorium. A 69-year-old man presented with a meningioma of the tentorium. The tumor was totally resected. The histological diagnosis was atypical meningioma. The tumor recurred two years later and was irradiated. Despite irradiation, the tumor progressed and was resected three years later. Five months following the second surgery, an isolated subcutaneous mass developed at the skin incision and was resected. The histological examination of the subcutaneous tumor showed histological features of atypical meningioma. Surgery of atypical meningioma carries the risk of iatrogenic metastasis, despite previous irradiation.
    No preview · Article · Jul 2008 · Neurochirurgie
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    ABSTRACT: The aim of this report is to illustrate the successful surgical management of five patients with suprasellar retrochiasmatic and diencephalo-mesencephalic tumours, using a trans-amygdala extension of the trans-temporal/trans-choroidal fissure approach. The procedure is described for five surgically treated patients with such lesions that includes three retrochiasmatic craniopharyngiomas, one hypothalamic hamartoma, and one pilocytic astrocytoma in the left crus cerebri. The management procedure included computed tomography scan (CT scan) and magnetic resonance imaging (MRI). The trans-temporal/trans-choroidal fissure approach enabled us to perform total tumour resection in four patients and a subtotal resection in one. Some technical aspects and pitfalls of the procedure are discussed. This method creates optimum conditions for a radical excision of various suprasellar retrochiasmatic and diencephalo-mesencephalic tumours without mortality and only minimum morbidity. However, no single surgical approach can provide access to the entire variety of tumours located in the suprasellar retrochiasmatic and diencephalo-mesencepalic region. Surgical approaches must be tailored to the site, type of lesion, and its extensions. This method is only another surgical option. Its successful use requires a familiarity with the anatomy of these regions and an understanding of its specificity for a radical excision of some selected tumours, as well as its limitations to access others types of lesions. Although, it seems effective, this approach needs to be evaluated by further experience, owing to the small number of patients reported in this series.
    No preview · Article · May 2008 · Acta Neurochirurgica
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    ABSTRACT: This study of 25 brains at the pontomedullary junction defined the different possible origins of the perforating arteries and lateral spinal arteries in relation to the posterior inferior cerebellar arteries (PICAs). - If the PICA emerges from the common trunk of the AICA-PICA coming from the basilar artery, it never gives perforating arteries or a lateral spinal artery on the lateral surface of the brain stem but supplies blood to a part of the ipsilateral cerebellar hemisphere. - If the PICA arises extradurally at C1, it never gives perforating arteries for the lateral surface of the brain stem, but it gives pial branches for the posterior surface of the medulla oblongata and is always the origin of the lateral spinal artery. - If the PICA emerges in the intradural vertebral artery, it is the source of the perforating arteries for the lateral surface of the brain stem and of the blood supply of the ipsilateral cerebellum.
    Preview · Article · Mar 2008 · Interventional Neuroradiology
  • N M Baldé · M M Diallo · J-Y Poirier · M S Sow · G Brassier · Y Lorcy
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    ABSTRACT: There is few published series dealing on the long-term outcome of the adult-onset craniopharyngiomas. We report the long term clinical, tomodensitometric and MRI data outcome of 35 (23 woman and 12 men) consecutive adult-onset cured for craniopharyngiomas between 1983 and 2002, and followed-up in Rennes University Hospital. The operation was performed via frontopterional approach in 59% and transphenoïdal approach in 41% of cases. Their age at the time of diagnosis was 44.7+/-15.1 years (21-74). The average postoperation follow-up was 7.4+/-7.0 years (0.1-19.1). Recurrence of tumour occurred in 8 patients (25.8%) and a tumor progression in 1 case. The delay of recurrence after initial surgery was 4.1+/-1.3 years (1.4-6.3). Two patients had 5 and 6 years treatment by growth hormone (GH), without tumor recurrence. The observed increase of weight after the surgical cure of craniopharyngiomas concerned 22 patients (63%). The average weight gain was 17.5+/-14.7 kg (1.5-58). In 7 cases (20%) neuropsychological disorders were noted, of which 2 with lost of professional activity. Three patients died. In conclusion the craniopharyngiomas recurrence is frequent and can appear in very prolonged deadlines after the initial surgery.
    No preview · Article · Jul 2007 · Annales d Endocrinologie

  • No preview · Article · Jul 2007 · Morphologie
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    ABSTRACT: There is few published series dealing on the long-term outcome of the adult-onset craniopharyngiomas. We report the long term clinical, tomodensitometric and MRI data outcome of 35 (23 woman and 12 men) consecutive adult-onset cured for craniopharyngiomes between 1983 and 2002, and followed-up in Rennes University Hospital. The operation was performed via frontopterional approach in 59% and transphenoïdal approach in 41% of cases. Their age at the time of diagnosis was 44.7±15.1 years (21–74). The average postoperation follow-up was 7.4±7.0 years (0.1–19.1). Recurrence of tumour occurred in 8 patients (25.8%) and a tumor progression in 1 case. The delay of recurrence after initial surgery was 4.1±1.3 years (1.4–6.3). Two patients had 5 and 6 years treatment by growth hormone (GH), without tumor recurrence. The observed increase of weight after the surgical cure of craniopharyngiomas concerned 22 patients (63%). The average weight gain was 17.5±14.7 kg (1.5–58). In 7 cases (20%) neuropsychological disorders were noted, of which 2 with lost of professional activity. Three patients died. In conclusion the craniopharyngiomas recurrence is frequent and can appear in very prolonged deadlines after the initial surgery.
    No preview · Article · Jun 2007 · Annales d Endocrinologie
  • A Hamlat · H Helal · B Carsin-Nicol · G Brassier · Y Guegan · X Morandi
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    ABSTRACT: The authors document a rapid development, within 3 weeks, of hydromyelia in a 12 year-old boy. The boy was admitted to a local hospital because of drowsiness and persistent severe neck pain. Neurological examination disclosed a lethargic boy with no neurological deficit other than Parinaud's sign. During his transfer to our department, he presented a cardio-respiratory arrest with coma and bilateral mydriasis. External ventricular drain and craniocervical decompression achieved excellent clinical and neuroradiological outcomes. The development of hydromyelia in this case is caused by obstruction to the natural cerebrospinal fluid pathway at the craniocervical junction and the cardio-respiratory arrest is provoked by a brain stem compression against the clivus and odontoid process. This report illustrates that hydromyelia may complicate acute obstructive hydrocephalus due to acquired Chiari malformation.
    No preview · Article · Nov 2006 · Acta Neurochirurgica

  • No preview · Article · Oct 2006 · Annales d Endocrinologie

  • No preview · Article · Oct 2006 · Annales d Endocrinologie

  • No preview · Article · Oct 2006 · Annales d Endocrinologie

  • No preview · Article · Oct 2006 · Annales d Endocrinologie
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    ABSTRACT: But de l’étude une meilleure connaissance micro-anatomique du cercle veineux pour permettre l’interprétation des anastomoses veineuses profondes angiographiques. Matériel et méthodes 25 cerveaux préalablement injectés au latex bleu et rouge. Dissection micro-anatomique sous microscope opératoire Wild Leitz et Zeiss. Photographies 2D et 3D. Résultats le cercle veineux est formé par 2 systèmes anastomotiques transversaux antérieurs et postérieurs (veines communicantes antérieure et postérieure) et 2 vaisseaux longitudinaux paramédians (les veines basales) qui comportent 4 portions distinctes) et se terminent en arrière dans la grande veine cérébrale. La veine communicante antérieure court sur le chiasma optique en arrière de son homologue artériel. La veine communicante postérieure située en arrière de l’artère basilaire réunit les 2 veines mésencéphaliques latérales à la veine mésencéphalique antérieure. L’absence fréquente d’une partie de la veine basale peut entraîner un drainage veineux vers le sinus caverneux ou vers le sinus pétreux inférieur homo ou controlatéral. Conclusions cette étude micro-anatomique du cercle veineux de la base du cerveau permet de comprendre les variations du drainage veineux cérébral profond.
    No preview · Article · Jun 2006 · Morphologie

Publication Stats

884 Citations
125.58 Total Impact Points

Institutions

  • 2001-2012
    • Université de Rennes 1
      • Faculty of Medicine
      Roazhon, Brittany, France
  • 2006-2007
    • Centre Hospitalier Universitaire de Rennes
      • Service de neurochirurgie
      Roazhon, Brittany, France
  • 1999-2004
    • Université de Rennes 2
      Roazhon, Brittany, France
  • 1988-2004
    • CHRU de Strasbourg
      Strasburg, Alsace, France