Anat Robinson

Rabin Medical Center, Tell Afif, Tel Aviv, Israel

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Publications (9)17.81 Total impact

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    ABSTRACT: PURPOSE:: The aim of this study was to evaluate the effect of Ex-PRESS Miniature Glaucoma Implant surgery on corneal curvature and anterior segment parameters obtained with the Pentacam rotating Scheimpflug camera (Oculus Inc.). PATIENTS/METHODS:: In this prospective study, a total of 19 eyes of 19 consecutive patients (11 men, 8 women) were evaluated preoperatively, on the first postoperative day, and at 1 week, 1 month, and 3 months postoperatively with the Pentacam. We compared measurements of anterior and posterior corneal curvature, anterior and posterior corneal astigmatism, anterior chamber depth (ACD), anterior chamber volume (ACV), and anterior chamber angle before and after surgery. All study eyes were pseudophakic. RESULTS:: Intraocular pressure decreased significantly from 31.9±10.1 mmHg preoperatively to 6.1±5.7 mmHg on the first postoperative day (P<0.0001) and 15.7±3.6 mmHg at 3 months after surgery (P=0.0011). On the first postoperative day, the anterior corneal astigmatism increased from 2.6±3.3 to 4.7±3.1 D (P=0.19), the posterior corneal astigmatism increased from 0.4±0.2 to 0.9±0.5 D (P=0.008), the ACD decreased from 4.3±0.7 to 3.5±1 mm (P=0.015), and the ACV decreased from 193±35 to 160±49 mm (P=0.006). All of these changes in anterior segment parameters were not statistically significant at 3 months after surgery. CONCLUSIONS:: Ex-PRESS Miniature Glaucoma Implant surgery significantly decreased intraocular pressure and had a transient effect on anterior segment parameters. Corneal curvatures, ACD, ACV, and anterior chamber angle were not affected at 3 months of follow-up.
    No preview · Article · Mar 2012 · Journal of glaucoma
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    ABSTRACT: To search for the genetic cause of juvenile open-angle glaucoma (JOAG) in a Caucasian family and to perform genotype/phenotype correlation studies in the kindred. Six members of a three-generation family originating from Uzbekistan and now living in the Middle East were recruited from one large clinic in Israel. Ophthalmologic investigations comprised of visual field assessments, intraocular pressure measurements, optic disc evaluation, and gonioscopy. Medical charts were obtained to date the onset of glaucoma and to evaluate aggressivity of the trait. We screened the myocilin gene (MYOC, OMIM 601652) by direct genomic sequencing of its three exons in all family members. JOAG segregated as an autosomal dominant trait in four members of the family. The proband, a 14-year-old girl, had been diagnosed with juvenile open-angle glaucoma at 12 years old. Her mother, maternal aunt, and maternal grandfather all had JOAG that started at an early age. The disorder progressed rapidly even under optimal medical treatment, and all four patients had to undergo trabeculectomy. One missense mutation, Y371D (1111t-->g, Tyr [Y] 371 Asp [D]), was identified. This mutation cosegregated with the disorder in all affected members and was absent in 200 Caucasian controls. The Y371D MYOC mutation has not been reported before. One cousin of the proband was a silent heterozygotic carrier of the mutation and was still asymptomatic at nine years of age. We identified a novel mutation (Y371D) in MYOC from a Caucasian family who presented with an aggressive form of JOAG that required early trabeculectomy. Genetic screening of the MYOC mutation was beneficial in predicting one asymptomatic heterozygotic carrier.
    Preview · Article · Sep 2009 · Molecular vision
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    ABSTRACT: To assess the effect of adjunctive intravitreal bevacizumab treatment on neovascular glaucoma (NVG). The medical records of all consecutive patients with NVG treated with intravitreal bevacizumab at our center from May 2006 to February 2008 were reviewed. The data collected included background features, findings on full ophthalmologic examination (including visual acuity, gonioscopy, and intraocular pressure), glaucoma medications prescribed, and additional procedures for glaucoma performed before and after bevacizumab injection.The interval between the diagnosis of NVG and intravitreal bevacizumab treatment was calculated. Eighteen patients (6 male, 12 female; mean age 63-/+13.2 years) met the study criteria. Causes of NVG were proliferative diabetic retinopathy (n=14), central retinal vein occlusion (n=2), occlusive vasculitis (n=1), and panuveitis (n=1). The mean duration of followup was 52 (-/+12) weeks. Mean intraocular pressure decreased from 32.3 (-/+4.99) to 18 (-/+6.1) mmHg (p<0.0001) and mean number of glaucoma medications decreased from 3.16 (-/+1.2) to 2.55 (-/+1.46) (p=0.1938). An interval of less than 6 months between the start of bevacizumab treatment and diagnosis was associated with better final visual acuity than delayed treatment (0.82-/+0.4 logMAR vs 1.88-/+1.1 logMAR, p=0.002) and a better regression of iris neovascularization (22% vs 89%; p=0.015). Intravitreal bevacizumab is beneficial for the treatment of anterior segment neovascularization and NVG when used as an adjunct, making the administration of additional treatment for the underlying cause possible. Bevacizumab should be instituted promptly after diagnosis, before irreversible anatomic and functional damage occurs.
    No preview · Article · Jul 2009 · European journal of ophthalmology
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    ABSTRACT: To describe the outcome of the use of fibrin adhesive (Quixil) in penetrating trabeculectomy in a rabbit model. Fibrin adhesive was used experimentally to attach the conjunctiva and the scleral flap in two groups of 17 New Zealand albino adult rabbits (34 eyes). In the first experiment (20 eyes), the fibrin adhesive was used to reattach the tissue after conjunctival peritomy and scleral flap only in 14 eyes (experiment I). In 6 eyes (controls), the conjunctiva was attached with nylon sutures. In the second experiment (14 eyes), the fibrin adhesive was used after conjunctival peritomy, scleral flap, and penetrating trabeculectomy in 8 eyes (experiment II). In a control group of 6 eyes, nylon sutures were used to attach the scleral flap and the conjunctiva after penetrating trabeculectomy. Biomicroscopy and histopathological examinations were performed on postoperative days 1, 3, 7, 14, 21, and 30. Intraocular pressure was measured before and after surgery in the second experiment. Main outcome measures are histological presence of adhesive in the tissue, degree of capillary congestion, inflammatory reaction, collagen density [scar formation] and clinical (IOP measurements before and after surgery, conjunctival chemosis, anterior chamber reaction, presence of filtering bleb and wound leakage). In experiments I and II, the adhesive was well identified histologically in the tissue as an amorphic eosinophilic substance for up to day 3 and nearly disappeared by day 7. An acute inflammatory reaction was noted for up to 14 days, which converted to chronic inflammation with collagen deposits and scar formation by day 30. Similar inflammatory reaction was observed in the control group. The adhesive had no adverse effects on ocular tissue compared with sutures. One eye in experiment II demonstrated wound dehiscence. Intraocular pressure dropped from 17.35 mmHg preoperatively to 8.28 mmHg on postoperative day 1 in experiment II, and from 17.2 mmHg to 11.5 mmHg in the controls. No significant change in intraocular pressure was noted in experiment I. The fibrin adhesive had no adverse effects on ocular tissue compared with sutures. It might serve as an effective substitute for conjunctival and scleral wound closure in trabeculectomy surgery.
    No preview · Article · Feb 2006 · Current Eye Research
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    ABSTRACT: To compare the efficacy and short-term safety of diclofenac sodium, 0.1% (Voltaren Ophtha; Ciba-Vision) and of sodium chloride, 5% ophthalmic solution, in the treatment of filamentary keratitis (FK) in patients with dry-eye syndrome due to secondary Sjögren's syndrome. Thirty-two patients (64 eyes) with dry-eye syndrome due to secondary Sjögren' syndrome were enrolled in a randomized study (patients and authors were aware of which medication was being used). All patients had FK. Sixteen patients were treated with sodium chloride, 5% drops, and 16 patients received diclofenac sodium, 0.1% eyedrops. Treatment regimen included instillation of 1 drop, 4 times a day for 28 days, for both groups. Clinical assessment was performed once a week during the study period. Data on the efficacy and safety of the different therapeutic regimens were collected and compared. Both medications achieved disappearance of filaments at the end of the study. Treatment with diclofenac sodium, 0.1%, revealed a significantly more rapid improvement of the clinical symptoms as compared with sodium chloride, 5%. No significant adverse effects were observed in both groups. Diclofenac sodium, 0.1%, may be an effective and safe topical therapy in patients with FK caused by secondary Sjögren's disease.
    No preview · Article · Apr 2000 · Cornea
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    ABSTRACT: A 22-year-old man presented after a pentrating knife injury to the left eye, causing prolapse of the iris, ciliary body, and retinal tissue. The wound was repaired, and antibiotic and steroid therapy was started. At that time, the right eye appeared normal. The patient stopped treatment after discharge and was readmitted 2 weeks later with bilateral panuveitis. His injured eye was enucleated. Pathologic examination confirmed the diagnosis of sympathetic ophthalmia.
    No preview · Article · Jan 2000 · Annals of Ophthalmology
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    ABSTRACT: Systemic involvement in hairy cell leukemia (HCL), has rarely been reported but ocular involvement is extremely uncommon. We report an unusual ocular presentation of HCL due to panuveitis with dramatic improvement following treatment with 2-chlorodeoxyadenosine (2-CdA).
    No preview · Article · Mar 1996 · Leukemia and Lymphoma
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    ABSTRACT: To demonstrate that hairy cell leukemia may involve the eye. We examined a patient who had a unique ocular manifestation of hairy cell leukemia with severe panuveitis in one eye and leukemic retinopathy in the fellow eye. Therapy with 2-chloro-deoxy-adenosine, a drug recently introduced for treatment of hairy cell leukemia, led to dramatic improvement of the ocular complications. Hairy cell leukemia may involve the eye and ocular symptoms may respond to systemic treatment with 2-chloro-deoxy-adenosine.
    No preview · Article · Feb 1996 · American Journal of Ophthalmology
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    ABSTRACT: Ceftazidime is a beta-lactam antibiotic highly effective against Pseudomonas aeruginosa infection. Using a rabbit model of Pseudomonas keratitis, 10(3) bacteria (in 20 microliters) were injected unilaterally into the corneal stroma of albino rabbits. Twenty-six hours after inoculation, topical Ceftazidime (50 mg/ml) drops were administered for 48 h, following which the corneal tissue was cultured. Eighteen of 20 corneal cultures (90%) from rabbits treated with Ceftazidime drops were negative. In comparison, all untreated control group cultures showed florid bacterial growth. These results suggest that topical Ceftazidime may be a useful agent in the treatment of P. aeruginosa keratitis.
    No preview · Article · Aug 1994 · Cornea

Publication Stats

100 Citations
17.81 Total Impact Points


  • 2006-2012
    • Rabin Medical Center
      Tell Afif, Tel Aviv, Israel
  • 1996-2000
    • Tel Aviv University
      • Department of Ophthalmology
      Tell Afif, Tel Aviv, Israel