Masahiro Sakaguchi

Fuchu Keijinkai Hospital, Edo, Tōkyō, Japan

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Publications (31)28.9 Total impact

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    ABSTRACT: A 63-year-old woman who presented with chest and back pain underwent an upper gastrointestinal endoscopy which revealed elevated legion in the antrum mucosa. Histologic examinations of gastric biopsies were showing monoclonal proliferation plasma cells containing Russell bodies. Differential diagnosis from B-cell lymphoma and plasmacytoma is difficult, because of monoclonality. Molecular analyses of immunoglobulin heavy chain (IgH) gene demonstrated that gene rearrangement was negative. Thus, diagnosis of Russell body gastritis was made. The Giemsa stains were also showing infection of Helicobacter pylori (H.pylori). After eradication therapy for H.pylori, follow-up upper gastrointestinal endoscopy was performed. She then recovered.
    No preview · Article · Jun 2012 · Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology
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    ABSTRACT: To compare efficacy of proton pump inhibitors (PPIs) with H(2)-receptor antagonists (H(2)RAs) plus prokinetics (Proks) for dysmotility-like symptoms in functional dyspepsia (FD). Subjects were randomized to receive open-label treatment with either rabeprazole 10 mg od (n = 57) or famotidine 10 mg bid plus mosapride 5 mg tid (n = 57) for 4 wk. The primary efficacy endpoint was change (%) from baseline in total dysmotility-like dyspepsia symptom score. The secondary efficacy endpoint was patient satisfaction with treatment. The improvement in dysmotility-like dyspepsia symptom score on day 28 was significantly greater in the rabeprazole group (22.5% ± 29.2% of baseline) than the famotidine + mosapride group (53.2% ± 58.6% of baseline, P < 0.0001). The superior benefit of rabeprazole treatment after 28 d was consistent regardless of Helicobacter pylori status. Significantly more subjects in the rabeprazole group were satisfied or very satisfied with treatment on day 28 than in the famotidine + mosapride group (87.7% vs 59.6%, P = 0.0012). Rabeprazole therapy was the only significant predictor of treatment response (P < 0.0001), defined as a total symptom score improvement ≥ 50%. PPI monotherapy improves dysmotility-like symptoms significantly better than H(2)RAs plus Proks, and should be the treatment of first choice for Japanese FD.
    Full-text · Article · Apr 2012 · World Journal of Gastroenterology
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    ABSTRACT: In Europe and the United States, it is known that obesity, which is increasing, is closely associated with gastroesophageal reflux disease (GERD), but in Japan no definite consensus has been reached on this relationship. Clarification of the relationship between the two is an important issue. After screening, gastrointestinal endoscopic examinations were conducted on 1813 subjects who were surveyed using a questionnaire in which they recorded body weight, height, weight loss or gain, chief complaints, and underlying disease to prospectively examine the relationship between obesity and GERD. Differences in GERD prevalence and esophageal hiatal hernia prevalence in thin (body mass index less than 18.5 kg/m2), normal (18.5 to 25.0), and obese (greater than 25.0) subjects were examined, and the differences in GERD prevalence in patients with weight loss or gain were also investigated. GERD prevalence was 20.96% in the thin group, 24.42% in the normal group, and 31.86% in the obese group, indicating a significantly higher prevalence in the obese group compared with the other groups. The prevalence of hernia was also significantly higher in the obese group. GERD prevalence in the weight gain group was significantly higher than in the unchanged weight group and weight loss group. Both GERD prevalence and the prevalence of hernia were significantly higher in obese subjects, and the prevalence of GERD in subjects who had gained weight was also significantly higher. From these results, it was concluded that obesity is a risk factor for GERD in Japan.
    No preview · Article · Feb 2008 · Journal of Gastroenterology
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    ABSTRACT: A 42-year-old male dialysis patient was infected with hepatitis C virus (HCV), and treated with interferon beta (IFN-beta) for a rapid increase in viral load. After dialysis three times a week, 3 million units of IFN-beta were intravenously infused for 1 h. The treatment was markedly effective, and the virus was eliminated in the sixth week. Therapy was continued for 24 weeks, and HCV negativity has been maintained for more than 6 months after the completion of administration. The blood IFN level slowly decreased immediately after administration. The mean trough level was 37 U/mL, and the half-life was 65 min. No adverse event requiring discontinuation of the treatment occurred, showing that IFN alone may safely eliminate the virus in dialysis patients with high hepatitis C viral load. Many dialysis patients are latently infected with HCV, and the infection affects the prognosis. Therefore, establishment of a therapeutic method is urgently needed.
    No preview · Article · Sep 2007 · Therapeutic apheresis and dialysis: official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

  • No preview · Article · Jan 2006 · Nihon Toseki Igakkai Zasshi
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    ABSTRACT: Helicobacter pylori has been reported to play an important role in the development of gastritis and gastric ulcer. This study included 168 patients with end-stage renal disease (ESRD; 30 non-dialysis patients, 138 patients receiving dialysis; mean duration of dialysis: 57.3 +/- 61.7 months) and 138 control volunteers. We investigated the prevalence of H. pylori infection by measuring H. pylori antibody (IgG) levels. The prevalence of H. pylori infection was 62.3% in the control group, 53.3% in the non-dialysis patients, and 36.9% in the dialysis patients. The percentage decreased with a reduction of renal function. In addition, the proportion of H. pylori-positive patients decreased with the duration of dialysis, and the antibody titre was also significantly decreased. There was no association between long-term oral administration of H2RA (H2 receptor antagonist) and the incidence of H. pylori infection. Among dialysis patients, the proportion of H. pylori-positive patients was low. An aetiological factor other than H2RA agents was suggested. Renal failure or dialysis treatment may influence H. pylori infection.
    No preview · Article · May 2004 · Nephrology
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    ABSTRACT: Perforated duodenal ulcer was clinically evaluated with respect to Helicobacter pylori infection and rate of recurrence in 38 ulcer patients perforated and 154 patients with non-perforated duodenal ulcer who visited our hospital in past 5 years and 6 months. The frequency of occurrence of H. pylori-positivity was 42.1% in patients with perforated duodenal ulcer, significantly lower than that of 92.9% in patients with non-perforated lesions. This result suggests that H. pylori is hardly involved in the development of perforated duodenal ulcer. The rate of recurrence was significantly lower for perforated duodenal ulcer than for non-perforated ulcer. In particular, perforated duodenal ulcer did not recur in the group on maintenance therapy with H2-recepter antagonists. Maintenance therapy using inhibitors of gastric acid secretion seems effective for the prevention of recurrence of perforated duodenal ulcer.
    No preview · Article · Nov 2002 · Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology
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    ABSTRACT: Helicobacter pylori (H. pylori) is considered to cause gastritis and gastric ulcer. In dialysis patients, digestive tract hemorrhage is sometimes fatal. However, in regard to H. pylori infection in patients with end-stage renal disease (ESRD), many issues remain to be clarified. This study included 76 symptom-free patients with ESRD. The subjects consisted of 25 patients with chronic renal failure who had not received dialysis and 51 patients receiving dialysis. On upper digestive tract endoscopy, specimens were taken for analysis of H. pylori. Urease test, culture, and microscopy were performed. In non-dialysed patients, the prevalence of H. pylori-positive patients was 56.0%. In dialysed patients, the percentage was significantly lower (27.5%). In dialysed patients, the mean duration of dialysis was 8.1 +/- 7.5 months (mean +/- SD) in H. pylori-positive patients and 56.2 +/- 60.9 months (mean +/- SD) in H. pylori-negative patients (p < 0.001). 11 of 13 non-dialysed patients with chronic gastritis were positive for H. pylori. However, only 5 of 24 dialysed patients were positive for H. pylori infection. Long-term dialysis decreased the prevalence of H. pylori. The reduction of gastric acid secretion related to chronic gastritis may be involved.
    No preview · Article · Sep 2002 · American Journal of Nephrology
  • KIYOSHI ASHIDA · AKIRA NAGITA · MASAHIRO SAKAGUCHI · KANJI AMEMOTO · HIDEKI TADA
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    ABSTRACT: Endoscopic retrograde cholangiopancreatography (ERCP) has long been used in children. The usefulness of ERCP in paediatric patients with various biliary disorders, however, has not been well documented. Thirty-two sessions of ERCP performed in 29 paediatric patients ranging in age from 1 month to 15 years were evaluated. Endoscopic retrograde cholangiopancreatography was to confirm diagnosis or to obtain detailed information about their pancreaticobiliary system. Cannulation was successful in all patients. Opacification of the biliary tracts was also successful in all except for three patients with extrahepatic biliary atresia. Endoscopic retrograde cholangiopancreatography was assessed to be successful in making a differential diagnosis of neonatal hepatitis from extrahepatic biliary atresia, and in having a confirmed diagnosis of anomalous arrangement of the pancreaticobiliary ductal system associated with choledochal cyst. The procedure was also useful for obtaining detailed information on the pancreaticobiliary system in the other children. No accidents occurred during the endoscopic procedures in any of the paediatric patients. When a confirmed diagnosis or detailed information is needed in paediatric patients with biliary disorders, ERCP is a useful and safe technique.
    No preview · Article · May 1998 · Journal of Gastroenterology and Hepatology
  • A Nagita · K Amemoto · A Yoden · S Aoki · M Sakaguchi · K Ashida · M Mino
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    ABSTRACT: Diurnal variation in intragastric pH in children with peptic ulcers has not been previously reported. Therefore, we monitored intragastric pH during a 24-h period in 82 subjects (10 children with gastric ulcers, 9 children with duodenal ulcers, 58 non-ulcer (comparison group) children, and 5 healthy adults) using a monopolar glass pH electrode. The percent of readings below pH 2, 3, 4, and 5 for each subject was calculated and compared between the comparison group and the two ulcer groups using means and slopes (i.e. changes in percent with age for each group) of percent readings for each pH analysis. In the comparison group children, gastric acidity increased with age and reached adult levels by 14 y. Mean readings for all pH analyses in gastric ulcer children were lower than those in age-adjusted comparison children (p < 0.05). The slopes of the relationships between age and the percent time below any pH for the gastric ulcer group were different from those in the comparison group (p < 0.05) and were negative for all pH analyses. The mean time below pH 2 in children with duodenal ulcers was greater than that in age-adjusted comparison children (p = 0.002). The slope of the relationship between age and the percent time below pH 2 in the duodenal ulcer group was different from that in the comparison group (p < 0.05). Gastric acidity in children with primary gastric ulcers was reduced during childhood, but in children with primary duodenal ulcer, gastric acidity was at or above adult levels.
    No preview · Article · Nov 1996 · Pediatric Research
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    ABSTRACT: We studied the action on acid secretion of lansoprazole compared with famotidine by 24-h intragastric pH monitoring, evaluated its clinical effects prospectively, and assessed the importance of acid inhibition in gastric ulcer patients. Twenty symptomatic patients with active gastric ulcers diagnosed by endoscopy were assigned to a lansoprazole (LAN) group (lansoprazole 30 mg q.d., n = 10) or a famotidine (FAM) group (famotidine 20 mg b.i.d., n = 10). There were no differences between the groups in pretreatment pH profiles or background factors such as age, sex, smoking, previous ulcer therapy, ulcer site, or Helicobacter pylori infection. The FAM group showed a continuous increase in intragastric pH during the night, with low pH values except for a transient increase associated with food intake during the day. However, the LAN group showed a more neutral pH throughout the day, with pH-3 holding time ratios of 99.0% for 24 h, 98.3% at night, and 99.8% during the day, compared with 68.0, 76.5, and 59.4%, respectively, in the FAM group. The healing rate was also higher in the LAN group. We conclude that inhibition of gastric acidity is important in ulcer therapy and that lansoprazole is superior to famotidine in promoting ulcer healing.
    No preview · Article · Feb 1995 · Journal of Clinical Gastroenterology
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    ABSTRACT: We studied the gastric acidity, gastric emptying, and proton pump inhibitor (PPI) plasma levels in 10 patients with PPI-resistant ulcers. The pH3 holding-time ratio was low in nine of these patients, with an average ratio of only 39%. PPI plasma levels in those patients were also much lower than in those with nonresistant ulcers. Gastric emptying, determined by the acetaminophen method, was reduced in all 10 patients. Therefore, PPI-resistant ulcers appear to result from insufficient inhibition of gastric acidity, with reduced gastric emptying interfering with the absorption of PPIs. In patients with mild reductions in gastric emptying, PPI plasma levels increased after a change from single-unit enteric-coated tablets (omeprazole) to multiunit enteric-coated granules in capsules (lansoprazole). This change in formulation markedly inhibited gastric acidity and led to rapid healing. In patients with moderate reductions in gastric emptying, doubling the dose of lansoprazole was effective. In patients with severely reduced gastric emptying, there appeared to be a limit to the effectiveness of oral administration of PPIs. Changing the formulation and doubling the dose to compensate for reduced gastric emptying are effective approaches in the treatment of patients with PPI-resistant ulcers.
    No preview · Article · Feb 1995 · Journal of Clinical Gastroenterology
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    ABSTRACT: A 70-year-old woman was incidentally detected to have a tumor in the upper portion of the right kidney by abdominal ultrasonography which was done before operation for cholecystolithiasis. CT and angiography visualized a hypervascular tumor. It was diagnosed as adrenal angioma from measurements of hormone levels in the blood and urine. Cholecystectomy and removal of the tumor were performed. Histopathologically it was cavernous hemangioma in the adrenal gland. Adrenal hemangioma is a rare disease and this is the 22nd cases seen in the Japanese literature.
    No preview · Article · Jan 1994
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    Full-text · Article · Jan 1993 · Journal of Hepato-Biliary-Pancreatic Surgery
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    ABSTRACT: The superior coagulation capacity of the application of microwave energy in tissue has been established in hepatectomy and endoscopic therapy. We report the application of microwave energy in a case of massive rectal bleeding.Fifty-six year-old man was admitted in our hospital with complaint of massive rectal bleeding from the recurrence of rectal cancer on February 3 1992 who received low anterior resection 2 years ago. Anemia and poor nutrition were seen.We performed microwave coagulation therapy through anal approach under spinal anesthesia and endoscopically. Afther coagulation therapy, rectal bleeding has redused extremely and general condition recovered. The patient discharged on July 7. Merits of postotreated course is pointed following two (1) recovered anemia and malnutorition, (2) able to have high QOF.
    Preview · Article · Jan 1993 · Journal of Microwave Surgery
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    ABSTRACT: We reported a case to perform simultaneous laparoscopic cholecystectomy and fenestration of a liver cyst using a newly deviced microwave scalpel (blade type electrode).A 40-year-old female was admitted our hospital with a chief complaint of upper abdominal discomfort. Abdominal US and CTscan revealed the liver cyst in the left lateral segment of the liver. The cyst was monolocular, 6.1×5.3cm in size, and protruded from liver surface to lateral aspect. At the same time a gall stone was recognized. No communication was detected between the intrahepatic bile duct and the liver cyst by (ERC). On February 18th, 1992, laparoscopic cholecystectomy and fenestration of the liver cyst were performed simultaneously. Using the microwave scalpel, any bleeding was observed during the course of the operation.Laparoscopic fenestration of the liver cyst was a technically easy and useful surgical procedure. The dissection (procedure) was possible with adequate hemostasis using the newly deviced microwave scalpel, and it was possible to perform the operation safely.
    Preview · Article · Jan 1993 · Journal of Microwave Surgery

  • No preview · Article · Jan 1993

  • No preview · Article · Jan 1993
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    ABSTRACT: The report of colonofiberscopic therapy using a microwave coagulator is relatively rare. Recently, we epxperienced colonofiberscopic microwave coagulation therapy for a polypectomy, hemostasis and tumor reduction. We could perform this therapy in 12 cases using by endoscopic microwave probe, ball type and rod type. The complication of this therapy was free. It is presumed that this procedure is useful and recommendable for colonofiberscopic treatment.
    Preview · Article · Jan 1993 · Journal of Microwave Surgery

  • No preview · Article · Jan 1993

Publication Stats

174 Citations
28.90 Total Impact Points

Institutions

  • 2012
    • Fuchu Keijinkai Hospital
      Edo, Tōkyō, Japan
  • 1996-1998
    • Osaka Medical College
      • Second Department of Internal Medicine
      Takatuki, Ōsaka, Japan