D Lipsker

Hopitaux Civils De Colmar, Kolmar, Alsace, France

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Publications (275)648.35 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Objective: To assess the prevalence of systemic sclerosis (SSc) in Eastern France and its spatial variation. Methods: Alsace, region of eastern France, is home to approximately 2 million inhabitants benefiting from high access to healthcare and an accreditedreferral center for SSc. Seeking outside care is difficult because of peculiar geography. SSc patients were retrieved through three separate sources: i) all general practitioners and community specialists, ii) capillaroscopy centers, iii) all public and private hospital records. Surviving patients, residing in Alsace onJanuary 1(st) 2008 and fulfilling the ACR and/or LeRoy & Medsger criteria were included. Clinical characteristics were also assessed. Potential incomplete case ascertainment was corrected by capture-recapture analyses. Geographical disparities were assessed through spatial-cluster analysis along with comparison of results with other geographical areas in the world for which data from similarly-derived methodology were available. Results: The review of 499 potential cases retrieved a total of 244 SSc patients. A trend for a West-East gradient was recorded although did not reach statistical significance. Log-linear modeling estimated that 83.87 additional cases were missed. Thus, SSc prevalence was 228.42 [95% CI 203.70-253.14] per million adult inhabitants, which was significantly higher than in two other regions of France while comparable with the prevalence reported in Detroit-USA. Conclusion: The stringent methodology used in the present study is very likely to provide an accurate estimation of SSc prevalence. Design similarity with three other surveys extends the scope of the results by pointing geographical disparities that were previously indistinguishable due to methodological differences. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Arthritis and Rheumatology
  • R Goussot · C Wettlé · C Le Coz · B Cribier · D Lipsker
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    ABSTRACT: Introduction: Edematous dermatomyositis is a rare entity with localized or generalized subcutaneous edema and only 21cases have been reported in the literature. It is considered to be a severe form of dermatomyositis which needs quick therapeutic decision. We report 2cases with difficult therapeutic decisions. Observations: Two patients aged 23 and 80years were admitted in hospital for DM with typical cutaneous and muscular involvement without any sign of gravity and which have been treated by steroids: methylprednisolone bolus and prednisone. They both then developed severe edema of the upper limbs as well as worsening of the cutaneous and muscular symptoms with dysphagia. The addition of mycophenolate mofetil and intravenous immunoglobulin has permitted in the case of the first patient the disappearance of the cutaneous symptoms in particular the edema with restitution of the muscular force and withdrawal of the dysphagia and swallowing symptoms. The therapeutic failure for the second patient was due to a refusal of the treatment and a probable paraneoplastic context. Conclusion: Subcutaneous edema localized or generalized must not be confused with periorbital erythematous edema, classically observed in DM, nor with DM with mucinosis. Potential marker of gravity, it is often associated to important muscular weakness and dysphagia. In this case, an aggressive treatment associating corticosteroids, immunosuppressive therapy and intravenous immunoglobulin is necessary.
    No preview · Article · Dec 2015 · Annales de Dermatologie et de Vénéréologie
  • R. Goussot · C. Wettle · C. Le Coz · B. Cribier · D. Lipsker
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    ABSTRACT: La dermatomyosite œdémateuse (DMO) est une variété clinique rare de dermatomyosite (DM), caractérisée par la présence d’œdèmes sous-cutanés localisés ou généralisés. Seuls 21 cas ont été décrits dans la littérature médicale. Il s’agit d’une forme habituellement grave, imposant souvent une prise en charge thérapeutique rapide. Nous en rapportons deux observations illustrant la difficulté de cette prise en charge.
    No preview · Article · Dec 2015 · Annales de Dermatologie et de Vénéréologie

  • No preview · Article · Dec 2015 · Annales de Dermatologie et de Vénéréologie

  • No preview · Article · Dec 2015 · Joint, bone, spine: revue du rhumatisme
  • A. Kieny · B. Cribier · D. Lipsker

    No preview · Article · Dec 2015 · Annales de Dermatologie et de Vénéréologie
  • L. Gusdorf · D. Bessis · D. Lipsker

    No preview · Article · Dec 2015 · Annales de Dermatologie et de Vénéréologie
  • C. Moulinas · H. Dollfus · D. Lipsker

    No preview · Article · Dec 2015 · Annales de Dermatologie et de Vénéréologie
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    ABSTRACT: The nosology of bullous lesions or equivalents (vesicles, erosions, and crusts) in patients with lupus erythematosus (LE) is rarely addressed. The primary aim of this study was to draw up a precise phenotypic inventory of such skin lesions; the secondary objective was to assess a potential relationship between the different types of loss of epidermis and extracutaneous lupus manifestations. We conducted a retrospective multicenter study including 22 patients with definite LE and bullous lesions or equivalents. All biopsies were reviewed. Patients were recruited in the dermatology departments of 6 centers. Patients were included if they met the diagnosis of systemic LE according to American College of Rheumatology and/or Systemic Lupus International Collaborating Clinics criteria or diagnosis of cutaneous LE based on classic clinical criteria and/or histological ascertainment of LE. Patients were recruited through clinician's memory and photographic collections. Three clinico-pathological patterns could be individualized. First, toxic epidermal necrolysis (TEN)-like, sheet-like, skin detachment; sun-exposure, mild mucosal involvement, and dermal mucin deposition allow differential diagnosis with classical Lyell syndrome. Second, vesiculo-bullae and/or crusting occurring on typical lesions of subacute cutaneous lupus erythematosus or chronic cutaneous lupus erythematosus. Third, tense vesicles and/or blisters with an underlying neutrophilic dermatosis and a usual response to dapsone. A careful analysis of 22 LE patients with epidermal detachment reveals 2 main pathomechanisms: a classic LE interface dermatitis, which can be hyperacute and lead to TEN-like skin detachment; and a neutrophilic dermatosis, with tense vesicles and/or blisters, including classic bullous LE.
    Preview · Article · Nov 2015 · Medicine
  • A.-J. Jung · S. Soskin · F. Paris · D. Lipsker
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    ABSTRACT: Le syndrome de McCune-Albright est une maladie sporadique rare, définie par la triade : taches café-au-lait, dysplasie fibreuse des os et endocrinopathie. Le diagnostic est souvent posé sur l’atteinte osseuse ou endocrinienne, mais doit être suspecté sur la morphologie particulière des taches café-au-lait. Nous rapportons un cas de syndrome de McCune-Albright diagnostiqué uniquement sur ces signes cutanés.
    No preview · Article · Nov 2015 · Annales de Dermatologie et de Vénéréologie
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    ABSTRACT: We report a didactic and typical case of distal bone sarcoidosis studied by (18) F-FDG PET/CT in a 34-year-old North-African man with mediastinal and cutaneous histologically proven sarcoidosis. Physical examination only revealed a painful swelling of the 4(th) and 5(th) fingers of the right hand and the 2(nd) , 3(rd) and 4(th) fingers of the left hand (A). X-rays showed characteristic pseudocystic lytic lesions limited to a few phalanges, and a grid appearance of the cancellous bone due to thickened trabeculae (B). Surprisingly, (18) F-FDG PET/CT revealed a striking bilateral (18) F-FDG uptake in almost all phalanges, all metacarpals and both ulnar heads
    Full-text · Article · Oct 2015 · Arthritis and Rheumatology
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    ABSTRACT: Oculocutaneous albinism (OCA) is an autosomal recessive disease affecting 1/17,000 person in the general population. It is characterized by hypopigmentation of the skin, hair and eyes. The main handicap in patients is at the ophthalmologic level (nystagmus, reduced visual acuity, photophobia, foveal hypoplasia). There are nowadays 6 known OCA genes (TYR, OCA2, TYRP1, SLC45A2, SLC24A5, C10ORF11) (OCA1, 2, 3, 4, 6, 7 respectively). An OCA5 locus has been localized, but the gene is not known yet. Apart from the OCA types, an X-linked ocular albinism gene (OA1, GPR143) and 10 genes involved in syndromic forms (Hermansky-Pudlak Syndrome, HPS1-9, and Chediak-Higashi Syndrome, CHS) of albinism have been identified (for a review see Montoliu et al. 2014). This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    No preview · Article · Aug 2015 · Pigment Cell & Melanoma Research
  • M. Huther · C. Gronier · D. Lipsker
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    ABSTRACT: Nous rapportons le cas d’un volumineux hémangiome infantile segmentaire du tronc associé à des anomalies cardiovasculaires, tableau similaire à celui du syndrome PHACE, mais de localisation extra-faciale.
    No preview · Article · Jun 2015 · Annales de Dermatologie et de Vénéréologie
  • A Kieny · C Wettlé · D Lipsker · B Cribier

    No preview · Article · Jun 2015 · Annales de Dermatologie et de Vénéréologie
  • M. Freysz · G.B.E. Jemec · D. Lipsker
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    ABSTRACT: The diagnosis of Hidradenitis Suppuratva (HS) is clinical and relatively straightforward for an experienced clinician. However, the terminology needed for a detailed and precise description of the lesions is more problematic. The aim of this study was to identify, enumerate and clearly define the primary lesions described in HS so as to compile a glossary that can be used to define clinical patient profiles. A review of the literature in English was performed on Medline (Pubmed), extending from 1949 to October 2013. This review targeted semantic aspects. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    No preview · Article · Jun 2015 · British Journal of Dermatology
  • C. Moulinas · H. Dollfus · D. Lipsker

    No preview · Article · May 2015 · Annales de Dermatologie et de Vénéréologie
  • F Bourlond · B Cribier · D Lipsker · C Velter

    No preview · Article · Apr 2015 · Annales de Dermatologie et de Vénéréologie
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    ABSTRACT: Some authors consider that morphoea and systemic sclerosis (SSc) could be part of the same disease spectrum. The aim of this study was to analyse the prevalence of signs indicative of SSc in a cohort of patients with morphoea. This is a prospective multi-centre study performed in four French academic dermatology departments: 76 patients with morphoea and 101 age- and sex-matched controls, who underwent complete clinical examination, were enrolled. A systemic search for signs indicative of SSc (e.g. Raynaud's phenomenon, reflux) was performed with the help of a standardised questionnaire. There were 58 women and 18 men (ration =3/1) with a median age of 59 years. Mean age at diagnosis was 54 years (extremes, 13-87). 49 subjects had plaque morphoea, 9 had generalised morphoea and 18 had linear morphoea. Mean duration of morphoea was 7.9 years. Signs possibly indicative of SSc were noted in four patients of the control group and in 8 patients with morphoea. This difference was not statistically significant (p=0.129). Further investigations ruled out SSc in all patients. Signs indicative of SSc are statistically not more frequently present in patients with morphoea than in controls and this study does not support the view that those 2 entities are part of a common disease spectrum.
    No preview · Article · Mar 2015 · Clinical and experimental rheumatology
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    ABSTRACT: Neutrophilic dermatoses (NDs) are inflammatory skin conditions that are not associated with infection. The classification and clinical approach to these conditions in children is poorly described. This review classifies these conditions into five nosological subtypes: Sweet's syndrome, pyoderma gangrenosum, aseptic pustules, neutrophilic urticarial dermatoses, and Marshall's syndrome. In addition, we review the various secondary diseases that need to be excluded in the clinical management of the NDs of childhood, with a focus on the autoinflammatory conditions that the reader may not be familiar with. We propose a practical clinical approach to these disorders. © 2015 Wiley Periodicals, Inc.
    No preview · Article · Feb 2015 · Pediatric Dermatology
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    ABSTRACT: Lyme disease is the most important vector-borne disease in the Northern hemisphere and represents a major public health challenge with insufficient means of and reliable diagnosis. Skin is rarely investigated in proteomics but constitutes in the case of Lyme disease the key interface where the pathogens can enter, persist and multiply. Therefore, we investigated proteomics on skin samples to detect Borrelia proteins directly in cutaneous biopsies in a robust and specific way. We first set up a discovery Ge-LC-MS/MS approach on a murine model infected by B. burgdorferi sensu stricto that allowed the identification of 25 Borrelia proteins among more than 1300 mouse proteins. Then we developed a targeted Ge-LC-SRM assay to detect 9/33 Borrelia proteins/peptides in mice skin tissue samples using heavy labeled synthetic peptides. We successfully transferred this assay from the mouse model to human skin biopsies - naturally infected by Borrelia - and we were able to detect two Borrelia proteins: OspC and flagellin. Considering the extreme variability of OspC, we developed an extended SRM assay to target a large set of variants. This assay afforded the detection of nine peptides belonging to either OspC or flagellin in human skin biopsies. We further shortened the sample preparation and showed that Borrelia is detectable in mouse and human skin biopsies by directly using a liquid digestion followed by LC-SRM analysis without any prefractionation. This study thus shows that a targeted SRM approach is a promising tool for the early direct diagnosis of Lyme disease with high sensitivity (<10 fmol OspC per mg of human skin biopsy). Copyright © 2015, The American Society for Biochemistry and Molecular Biology.
    Full-text · Article · Feb 2015 · Molecular & Cellular Proteomics

Publication Stats

3k Citations
648.35 Total Impact Points

Institutions

  • 2015
    • Hopitaux Civils De Colmar
      Kolmar, Alsace, France
  • 1998-2015
    • University of Strasbourg
      • Faculty of Medicine
      Strasburg, Alsace, France
  • 2012-2014
    • CHRU de Strasbourg
      Strasburg, Alsace, France
  • 2009
    • Assistance Publique – Hôpitaux de Paris
      Lutetia Parisorum, Île-de-France, France
  • 2008
    • Hôpital Tenon (Hôpitaux Universitaires Est Parisien)
      • Service de Dermatologie - Allergologie
      Paris, Ile-de-France, France
  • 2002-2003
    • Etablissement Français du Sang Alsace
      Strasburg, Alsace, France
    • Etablissement Français du Sang (EFS)
      Lutetia Parisorum, Île-de-France, France
  • 2001
    • Curium-LUMC
      Leyden, South Holland, Netherlands