Su Jin Jeong

Korea University, Sŏul, Seoul, South Korea

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Publications (103)

  • [Show abstract] [Hide abstract] ABSTRACT: Objectives: Given the mode of transmission of Middle East Respiratory Syndrome (MERS), healthcare workers (HCWs) in contact with MERS patients are expected to be at risk of MERS infections. We evaluated the prevalence of MERS coronavirus (CoV) immunoglobulin G (IgG) in HCWs exposed to MERS patients, and calculated the incidence of MERS-affected cases in HCWs. Methods: We enrolled HCWs from hospitals where confirmed MERS patients had visited. Serum was collected 4-6 weeks after the last contact with a confirmed MERS patient. We performed an enzyme-linked immunosorbent assay (ELISA) to screen for the presence of MERS-CoV IgG, and an indirect immunofluorescence test (IIFT) to confirm MERS-CoV IgG. We used a questionnaire to collect information regarding the exposure. We calculated the incidence of MERS-affected cases by dividing the sum of PCR-confirmed and serology-confirmed cases by the number of exposed HCWs in participating hospitals. Results: In total 1169 HCWs in 31 hospitals had contact with 114 MERS patients, and among the HCWs 15 were PCR-confirmed MERS cases in study hospitals. Serologic analysis was performed for 737 participants. ELISA was positive in five participants and borderline for seven. IIFT was positive for two of these 12 participants (0.3%). Among the participants who did not use appropriate personal protective equipment (PPE), seropositivity was 0.7% (2/294), compared to 0% (0/443) in cases with appropriate PPE use. Conclusions: The incidence of MERS infection in HCWs was 1.5% (17/1169). The seroprevalence of MERS-CoV IgG among HCWs was higher among participants who did not use appropriate PPE.
    Article · Jul 2016 · Clinical Microbiology and Infection
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    [Show abstract] [Hide abstract] ABSTRACT: Background: From May to July 2015, the Republic of Korea experienced the largest outbreak of Middle East respiratory syndrome (MERS) outside the Arabian Peninsula. A total of 186 patients, including 36 deaths, had been diagnosed with MERS-coronavirus (MERS-CoV) infection as of September 30th, 2015. Materials and methods: We obtained information of patients who were confirmed to have MERS-CoV infection. MERS-CoV infection was diagnosed using real-time reverse-transcriptase polymerase chain reaction assay. Results: The median age of the patients was 55 years (range, 16 to 86). A total of 55.4% of the patients had one or more coexisting medical conditions. The most common symptom was fever (95.2%). At admission, leukopenia (42.6%), thrombocytopenia (46.6%), and elevation of aspartate aminotransferase (42.7%) were observed. Pneumonia was detected in 68.3% of patients at admission and developed in 80.8% during the disease course. Antiviral agents were used for 74.7% of patients. Mechanical ventilation, extracorporeal membrane oxygenation, and convalescent serum were employed for 24.5%, 7.1%, and 3.8% of patients, respectively. Older age, presence of coexisting medical conditions including diabetes or chronic lung disease, presence of dyspnea, hypotension, and leukocytosis at admission, and the use of mechanical ventilation were revealed to be independent predictors of death. Conclusion: The clinical features of MERS-CoV infection in the Republic of Korea were similar to those of previous outbreaks in the Middle East. However, the overall mortality rate (20.4%) was lower than that in previous reports. Enhanced surveillance and active management of patients during the outbreak may have resulted in improved outcomes.
    Full-text Article · Jun 2016
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    Hye Il Jin · Yoo Mi Lee · You Jin Choi · Su Jin Jeong
    [Show abstract] [Hide abstract] ABSTRACT: Purpose: Viral gastroenteritis among children is mainly caused by rotavirus, norovirus, astrovirus, or adenovirus strains. However, changing socioeconomic conditions and a rotavirus vaccination program may be affecting the prevalence of these viral infections. Therefore, we aimed to elucidate the season-specific trends in viral infections for facilitating prophylaxis and surveillance in our region. Methods: We evaluated 345 pediatric patients (203 males, 142 females; age, 1 month to 16 years) who visited the CHA Bundang Medical Center because of gastroenteric symptoms between June 2014 and May 2015. The specimens were simultaneously tested for norovirus, rotavirus, astrovirus, and adenovirus via multiplex reverse transcription polymerase chain reaction. Clinical characteristics of patients were analyzed retrospectively. Results: The most common virus was norovirus, followed by rotavirus, adenovirus, and astrovirus. Of all viral infections, 45.2% occurred mainly between 6 and 24 months of age; in particular, norovirus infection mostly occurred in all age groups except those below 6 months of age, when rotavirus was most prevalent. In addition, seasonal variation was observed, such as norovirus infection from December to February, rotavirus infection from February to April, and adenovirus infection from July to October. Conclusion: Our results showed that the most common cause of acute pediatric viral gastroenteritis had changed from rotavirus to norovirus in our patients, because of effective rotaviral vaccination. We recommend the management of food and personal hygiene in accordance with age or seasons as well as active vaccination for preventing viral gastroenteritis.
    Full-text Article · Mar 2016 · Korean Journal of Pediatrics
  • You Jin Choi · Bo Seon Seo · Jun Ho Lee · Su Jin Jeong
    [Show abstract] [Hide abstract] ABSTRACT: Aims: The investigation of fecal retention using objective and patient-friendly tools, rather than the diagnosis of constipation, might be important in the management of overactive bladder (OAB) in children. The present study aimed to evaluate the incidence and grade of fecal retention in children with OAB and to determine the effectiveness of laxative treatment for fecal retention in the management of OAB in children. Methods: This study included 88 children with OAB aged 5-15 years. Fecal retention was defined as type 1/2 feces (Bristol stool form scale) or a Leech score above eight points, and constipation was determined according to the ROME III criteria. Among the 88 children, 71 with fecal retention or constipation were treated with oral laxatives (polyethylene glycol 3,350/4,000 or lactulose) for 2 weeks, and the responses to the treatment were assessed. Results: Among the 88 children, 63 (71.6%) had a Leech score above eight points as assessed by plain abdominal radiography, 52 (59.1%) had type 1/2 feces (Bristol stool form scale), 24 (27.3%) had functional constipation and only 6 (6.8%) had none of either. Among the 71 children who received laxative treatment for 2 weeks, 58 (81.7%) reported an improvement in OAB symptoms. Additionally, the number of children with a Leech score above eight points was significantly higher in the good response group than in the poor response group (P = 0.014). Conclusion: Investigation of fecal retention with the Leech scoring system and laxative treatment might be helpful in the management of OAB in children. Neurourol. Urodynam. © 2016 Wiley Periodicals, Inc.
    Article · Feb 2016 · Neurourology and Urodynamics
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    Hye Won Park · You Jin Choi · Su Jin Jeong
    [Show abstract] [Hide abstract] ABSTRACT: Non-cardiac chest pain is a common disorder that leads to costly evaluations to distinguish it from cardiac pain. The present study aimed to clarify the clinical characteristics of erosive esophagitis in children with non-cardiac chest pain. Ninety nine patients (mean age, 9.55 ± 2.95 years, 49 girls) with non-cardiac chest pain were enrolled. Patients were classified into two groups: erosive esophagitis and non-erosive esophagitis-related non-cardiac chest pain by esophagogastroduodenoscopy. Children in the erosive esophagitis-related non-cardiac chest pain group were significantly older (10.95 ± 2.54 years vs. 8.52 ± 2.83 years). Multivariate logistic regression analysis identified the following predictors of gastroesophageal reflux: chest pain related to sleep (odds ratio = 18.05, 95% confidence interval: 3.18–102.49); unfavorable dietary habits (odds ratio = 7.11, 95% confidence interval: 1.53–32.87); chest pain related to food (odds ratio = 5.09, 95% confidence interval: 1.37–18.86); epigastric pain (odds ratio = 3.73, 95% confidence interval: 1.12–12.33); and nausea, vomiting, and/or regurgitation (odds ratio = 4.35, 95% confidence interval: 1.22–15.54). Gastroesophageal reflux disease should be considered first in children with non-cardiac chest pain. Children with gastroesophageal reflux disease should receive medical treatment and lifestyle modifications.
    Full-text Article · Feb 2016 · Journal of Korean Medical Science
  • Su Jin Jeong · Ji Un Lee · Young Goo Song · [...] · Min Joo Lee
    [Show abstract] [Hide abstract] ABSTRACT: Invasive mucormycosis is an uncommon but increasing life-threatening fungal infection. The present study investigated clinical characteristics and mortality among patients diagnosed as invasive mucormycosis infection. We retrospectively reviewed a total of 24 histologically proven cases of invasive mucormycosis at two tertiary care referral hospitals between November 2005 and February 2014. Overall survival was 50% (n = 12). The time between onset of symptom and diagnostic procedure proved to be associated with mortality (P = 0.009). In addition, preexisting renal failure and thrombocytopenia demonstrated trends toward a poor outcome in our study (P = 0.089 and 0.065, respectively). On multivariate regression analysis, delayed diagnostic procedure (more than 16 days after the onset of symptoms) was an independent predictor of mortality (OR= 12.34, 95% CI, 1.43-10.64; P = 0.022). Mucormycosis is a destructive fungal infection that is associated with high mortality rates, ranging from 40% to 100% depending on the form of disease. When a clinician suspects invasive mucormycosis infection, an early diagnostic procedure performed within 16 days from the onset of symptom and early initiation of antifungal therapy will lead to successful management of this highly fatal disease.
    Article · Nov 2015 · Mycoses
  • Hye Won Park · Hyeil Jin · Su Jin Jeong · Jun Ho Lee
    Article · Oct 2015
  • Su Jin Jeong · Claire M Italiano · Romanee Chaiwarith · [...] · Jun Yong Choi
    [Show abstract] [Hide abstract] ABSTRACT: Many HIV-infected individuals do not enter health care until late in the infection course. Despite encouraging earlier testing, this situation has continued for several years. We investigated the prevalence of late presenters and factors associated with late presentation among HIV-infected patients in an Asian regional cohort. This cohort study included HIV-infected patients with their first positive HIV test during 2003-2012 and CD4 count and clinical status data within 3 months of that test. Factors associated with late presentation into care (CD4 count <200 cells/µL or an AIDS-defining event within +/- 3 months of first positive HIV test) were analyzed in a random effects logistic regression model. Among 3,744 patients, 2,681 (72%) were late presenters. In the multivariable model, older patients were more likely to be late presenters than younger (≤30 years) patients (31-40, 41-50, and ≥ 51 years: odds ratio [OR] = 1.57, 95% confidence interval [CI] 1.31-1.88; OR = 2.01, 95% CI 1.58-2.56; and OR = 1.69, 95% CI 1.23-2.31, respectively; all p ≤ 0.001). Injecting drug users (IDU) were more likely (OR = 2.15, 95% CI 1.42-3.27, p < 0.001) and those with homosexual HIV exposure were less likely (OR = 0.45, 95% CI 0.35-0.58, p < 0.001) to be late presenters compared to those with heterosexual HIV exposure. Females were less likely to be late presenters (OR = 0.44, 95% CI 0.36-0.53, p < 0.001). The year of first positive HIV test was not associated with late presentation. Efforts to reduce the patients who first seek HIV care at the late stage are needed. The identified risk factors associated with late presentation should be utilized in formulating targeted public health intervention to improve earlier entry into HIV care.
    Article · Sep 2015 · AIDS Research and Human Retroviruses
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    [Show abstract] [Hide abstract] ABSTRACT: Sepsis, including severe sepsis and septic shock, is a major cause of morbidity and mortality. Albumin and C-reactive protein (CRP) are considered as good diagnostic markers for sepsis. Thus, initial CRP and albumin levels were combined to ascertain their value as an independent predictor of 180-day mortality in patients with severe sepsis and septic shock. We conducted a retrospective cohort study involving 670 patients (>18 years old) who were admitted to the emergency department and who had received a standardized resuscitation algorithm (early goal-directed therapy) for severe sepsis and septic shock, from November 2007 to February 2013, at a tertiary hospital in Seoul, Korea. The outcome measured was 180-day all-cause mortality. A multivariate Cox proportional hazard model was used to identify the independent risk factors for mortality. A receiver operating characteristic (ROC) curve analysis was conducted to compare the predictive accuracy of the CRP/albumin ratio at admission. The 180-day mortality was 28.35% (190/670). Based on the multivariate Cox proportional hazard analysis, age, the CRP/albumin ratio at admission (adjusted HR 1.06, 95% CI 1.03-1.10, p<0.001), lactate level at admission (adjusted HR 1.10, 95% CI 1.05-1.14, p<0.001), and the Sequential Organ Failure Assessment (SOFA) score at admission (adjusted HR 1.12, 95% CI 1.07-1.18, p<0.001) were independent predictors of 180-day mortality. The area under the curve of CRP alone and the CRP/albumin ratio at admission for 180-day mortality were 0.5620 (P<0.001) and 0.6211 (P<0.001), respectively. The CRP/albumin ratio was an independent predictor of mortality in patients with severe sepsis or septic shock.
    Full-text Article · Jul 2015 · PLoS ONE
  • Su Jin Jeong · Sang Hoon Han · Chang Oh Kim · [...] · June Myung Kim
    [Show abstract] [Hide abstract] ABSTRACT: AimTo evaluate the relationship between human cytomegalovirus (HCMV) antibody status, and hypertension and functional status among elderly Koreans.Methods Patients aged ≥65 years were prospectively enrolled from March 2011 to February 2012 at a 2000-bed university hospital. We collected data including CD4+ and CD8+ T-lymphocyte count, and functional status by measuring basic activities of daily living and instrumental activities of daily living for all patients. In addition, HCMV immunoglobulin G levels were analyzed using enzyme-linked fluorescent assay.ResultsDuring the study period, 103 patients (51 men), who were admitted for treatment of infections or other diseases, were enrolled. Multivariate analysis showed that body mass index and HCMV immunoglobulin G antibody titers were independent factors associated with hypertension in elderly patients (OR 1.347, 95% CI 1.113–1.630, P = 0.002; OR 1.023, 95% CI 1.001–1.047, P = 0.042, respectively). In univariate linear correlations, HCMV antibody levels were positively correlated with systolic blood pressure levels (r = 0.303, P = 0.002), CD8+ T-lymphocyte count (r = 0.313, P = 0.001) and instrumental activities of daily living scores (r = 0.217, P = 0.028). In addition, HCMV immunoglobulin G titers were inversely associated with estimated glomerular filtration rate (r = −0.268, P = 0.006). These four variables remained independently significant in multivariate correlation analysis.Conclusion These findings could provide insight into the important role of HCMV in the pathogenesis of essential hypertension and decreased functional status in the elderly. Geriatr Gerontol Int 2014; ●●: ●●–●●.
    Article · Jun 2015 · Geriatrics & Gerontology International
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    [Show abstract] [Hide abstract] ABSTRACT: The use of cardiac implantable electronic device (CIED; pacemakers, implantable cardioverter-defibrillators [ICD], cardiac re-synchronized therapy [CRT]) implantation, one essential treatment for cardiac arrhythmias, is increasing. Infectious complications related to implants are the main reason for device removal and patient morbidity. We sought to identify the incidence of infectious complications among patients with cardiac device implantation and analyze the risk factors for infectious complications. A retrospective analysis was conducted of 1307 patients (61.5±14.2 years-old, 49.6% male) with cardiac device implantation from January 1990 to April 2013. We analyzed the incidence of infectious complications during the follow-up period. To investigate risk factors associated with infectious complications, we conducted a 1:2 matched case-control study of patients with infectious complications and controls without infectious complications who had the same implantation period and physician. Among 1307 patients, 12 had a confirmed device-related infection: 7 with a pocket infection and 5 with infective endocarditis. Over a total of 9091.9 device-years, the incidence of infectious complications was 1.3/1000 device-years, based on the 12 patients with an infection. ICD (5.1/1000 device-year) had a higher incidence of infectious complications than other cardiac devices, and no infectious complications were observed among patients with CRT implantation. Mean duration from the time of implantation to infection was 2.02±1.65 years. In a multivariate analysis, the number of prior procedures including wound revision or scar revision was an independent risk factor for infectious complications (OR=10.88, 95% CI 1.11->999, p=0.040). Infection was a rare complication of cardiac device implantation, but repeated procedures were associated with infectious complications. Copyright © 2015. Published by Elsevier Ltd.
    Full-text Article · May 2015 · International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases
  • Su Jin Jeong
    Article · Apr 2015
  • Su Jin Jeong · Nam Su Ku · Sang Hoon Han · [...] · June Myung Kim
    [Show abstract] [Hide abstract] ABSTRACT: Recent studies have implicated human cytomegalovirus (HCMV) infection as a possible etiological factor in cardiovascular disease. We assessed whether anti-HCMV antibody levels are associated with carotid atherosclerosis and inflammatory cytokine production in elderly Koreans. Participants (age, ≥65 y) were prospectively enrolled from September 2012 to July 2013 at a 2,000-bed university hospital. During the study period, 71 participants (29 males) were prospectively enrolled, and thirty-five (49.3%) of these individuals were in the group designated as high intima-media thickness (IMT) RESULTS: Multivariate logistic regression analysis revealed three independent risk factors of high IMT: higher levels of anti-HCMV antibody (odds ratio [OR] 1.04, p = 0.003), Framingham score (OR 1.14, p = 0.018), and levels of IL-1β (OR 2.96, p = 0.013). Anti-HCMV antibody levels had a significantly positive correlation with max-IMT (r = 0.523, p < 0.001), free T4 levels (r = 0.315, p = 0.021), and Log(TNF-α) (r = 0.562, p < 0.001) in multivariate correlation analysis. These findings may provide insight into the role of HCMV in the pathogenesis of atherosclerosis and chronic inflammation in elderly individuals. Copyright © 2015. Published by Elsevier B.V.
    Article · Mar 2015 · Clinica chimica acta; international journal of clinical chemistry
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    [Show abstract] [Hide abstract] ABSTRACT: Purpose Over the last 30 years, Serratia marcescens (S. marcescens) has emerged as an important pathogen, and a common cause of nosocomial infections. The aim of this study was to identify risk factors associated with mortality in patients with S. marcescens bacteremia. Materials and Methods We performed a retrospective cohort study of 98 patients who had one or more blood cultures positive for S. marcescens between January 2006 and December 2012 in a tertiary care hospital in Seoul, South Korea. Multiple risk factors were compared with association with 28-day all-cause mortality. Results The 28-day mortality was 22.4% (22/98 episodes). In a univariate analysis, the onset of bacteremia during the intensive care unit stay (p=0.020), serum albumin level (p=0.011), serum C-reactive protein level (p=0.041), presence of indwelling urinary catheter (p=0.023), and Sequential Oran Failure Assessment (SOFA) score at the onset of bacteremia (p<0.001) were significantly different between patients in the fatal and non-fatal groups. In a multivariate analysis, lower serum albumin level and an elevated SOFA score were independently associated with 28-day mortality [adjusted odds ratio (OR) 0.206, 95% confidential interval (CI) 0.044-0.960, p=0.040, and adjusted OR 1.474, 95% CI 1.200-1.810, p<0.001, respectively]. Conclusion Lower serum albumin level and an elevated SOFA score were significantly associated with adverse outcomes in patients with S. marcescens bacteremia.
    Full-text Article · Feb 2015 · Yonsei Medical Journal
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    [Show abstract] [Hide abstract] ABSTRACT: Although the proteasome inhibitor known as bortezomib can modulate the inflammatory process through the nuclear factor-kappa B signaling pathway, the immunomodulatory effect of pre-incubated bortezomib has not been fully evaluated for inflammation by infectious agents. Therefore, we evaluated the effect of bortezomib on the expression of inflammatory cytokines and mediators in macrophage cell lines and on survival in a murine peritonitis sepsis model. Bortezomib was applied 1 hr before lipopolysaccharide (LPS) stimulation in RAW 264.7 cells. The cecal ligation and puncture (CLP) experiments were performed in C57BL/6J mice. Pre-incubation with bortezomib (25 nM or 50 nM) prior to LPS (50 ng/mL or 100 ng/mL) stimulation significantly recovered the number of viable RAW 264.7 cells compared to those samples without pre-incubation. Bortezomib decreased various inflammatory cytokines as well as nitric oxide production in LPS-stimulated cells. The 7-day survival rate in mice that had received bortezomib at 0.01 mg/kg concentration 1 hr prior to CLP was significantly higher than in the mice that had only received a normal saline solution of 1 mL 1 hr prior to CLP. In addition, the administration of bortezomib at 0.01 mg/kg concentration 1 hr before CLP resulted in a significant decrease in inflammation of the lung parenchyma. Collectively, pretreatment with bortezomib showed an increase in the survival rate and changes in the levels of inflammatory mediators. These results support the possibility of pretreatment with bortezomib as a new therapeutic target for the treatment of overwhelming inflammation, which is a characteristic of severe sepsis.
    Full-text Article · Jan 2015 · Yonsei Medical Journal
  • Su Jin Jeong
    [Show abstract] [Hide abstract] ABSTRACT: Background: Invasive mucormycosis is an uncommon but increasing, life-threatening fungal infection. Effective therapy is represented by the combination of surgery and antifungal agent administration and early initiation of the therapy is necessary for favorable outcome. However, the disease is difficult to diagnose and mortality reaches 40% even if treated adequately, and clinical data on clinical course are limited. Methods: We retrospectively reviewed histologically proven cases of invasive mucormycosis in two tertiary care referral hospitals from 2004 to 2013. The clinical and laboratory data were analyzed for all patients. Results: We reviewed total of 28 patients who were histologically diagnosed as invasive mucormycosis. Overall survival was 60% (n = 17). The time from onset of symptom to diagnostic procedure proved to be associated with mortality (P <0.001). In addition, time from onset of symptom to initiation of antifungal therapy was associated with a poor outcome in our study (P = 0.032). On multivariate regression analysis, delayed diagnostic procedure (more than 10 days after onset of symptom) was an independently significant predictor of mortality (odds ratio = 13.28, 95% confidence interval, 1.07-164.62; P= 0.044). Conclusion: Mucormycosis is a destructive fungal infection that is associated with a high mortality, ranging from 40 to 100 % depending on disease form. When a clinician suspects an invasive mucormycosis infection, early diagnostic procedure done within 10 days from the onset of symptom and early initiation of antifungal therapy will lead to successful management of the disease.
    Conference Paper · Oct 2014
  • Su Jin Jeong · Sang Sun Yoon · Il Kwon Bae · [...] · Kyungwon Lee
    [Show abstract] [Hide abstract] ABSTRACT: The incidence of carbapenem-resistant Pseudomonas aeruginosa (CRPA) bacteraemia has increased in recent years, and infections caused by CRPA result in higher mortality than those caused by susceptible strains. This study was performed to evaluate the risk factors for mortality, and to study the impact of virulence factors and bacterial strains on clinical outcomes in patients with CRPA bacteraemia. Data on 63 episodes of CRPA bacteraemia that have occurred between January 1, 2007 and December 31, 2009 in a teaching hospital (2000 beds) in Seoul, Korea were analyzed. The APACHE II score at the time of CRPA bacteraemia and the capacity of CRPA to form biofilm were independent predictive factors for mortality in patients with CRPA bacteraemia. In addition, the biofilm-forming ability and elastase activity of strains were correlated with APACHE II scores to measure the severity of disease and estimate predicted mortality in the patients.
    Article · Oct 2014 · Diagnostic Microbiology and Infectious Disease
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    [Show abstract] [Hide abstract] ABSTRACT: The hypervirulent Clostridium difficile strains, most notably the BI/NAP1/027, have been increasingly emerging in Western countries as local epidemics. We performed a prospective multicenter observational study from December 2011 to May 2012 to identify recent incidences of toxigenic culture-confirmed hospital-onset CDI and their associated clinical characteristics in South Korea. The patients, suspected to have been suffering from CDI more than 48 hours after admission and aged ≥20 years, were prospectively enrolled and provided loose stool specimens. The toxigenic C. difficile culture (anaerobic culture + toxin A/B/binary gene PCR) and PCR ribotyping were performed in one central laboratory. We enrolled 98 toxigenic culture-confirmed CDI-infected patients and 250 toxigenic culture-negative participants from three hospitals. The incidence of toxigenic culture-confirmed hospital-onset CDI cases was 2.7 cases/10,000 patient-days. The percentage of severe CDI cases was relatively low at only 3.1%. UK ribotype 018 was the predominant type (48.1%). There were no hypervirulent BI/NAP1/027 isolates identified. The independent risk factors of toxigenic culture-confirmed hospital-onset CDI were the invasive procedure (OR 7.3, P=0.003) and past CDI history within three months (OR 28.5, P=0.003). In conclusion, the incidence and severity of CDI in our study were not higher than reported in Western countries.
    Full-text Article · Sep 2014 · Journal of Medical Microbiology
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    Ji Hyeon Baek · Chang Oh Kim · Su Jin Jeong · [...] · June Myung Kim
    [Show abstract] [Hide abstract] ABSTRACT: Purpose Fluoroquinolones, rapidly gaining prominence in treatment of Stenotrophomonas maltophilia (SMP), are noted for their potency and tolerability. However, SMP may rapidly acquire resistance to fluoroquinolones. We evaluated associations of clinical factors with acquisition of levofloxacin resistance (LFr) in SMP. Materials and Methods Our retrospective cohort study was based on patient data collected between January 2008 and June 2010. Through screening of 1275 patients, we identified 122 patients with data for SMP antibiotic susceptibility testing in ≥3 serial SMP isolates. Results We assigned the 122 patients to either the SS group (n=54) in which levofloxacin susceptibility was maintained or the SR group (n=31) in which susceptible SMP acquired resistance. In multivariate regression analysis, exposure to levofloxacin for more than 3 weeks [odds ratio (OR) 15.39, 95% confidential interval (CI) 3.08-76.93, p=0.001] and co-infection or co-colonization with Klebsiella pneumoniae resistant to levofloxacin (OR 4.85, 95% CI 1.16-20.24, p=0.030) were independently associated with LFr acquisition in SMP. Conclusion Acquisition of LFr during serial sampling of SMP was related to the levofloxacin exposure.
    Full-text Article · Jul 2014 · Yonsei Medical Journal
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    [Show abstract] [Hide abstract] ABSTRACT: Four models of multivariate analysis of factors associated with early mortality in gram negative bacteremia by logistic regression
    Full-text Dataset · Jun 2014

Publication Stats

425 Citations

Institutions

  • 2014
    • Korea University
      • Department of Statistics
      Sŏul, Seoul, South Korea
  • 2013
    • Korea Institute of Energy Research
      Sŏul, Seoul, South Korea
  • 2007-2012
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2010
    • CHA University
      • Department of Pediatrics
      Sŏul, Seoul, South Korea