Li Wang

Jiangnan University, Wu-hsi, Jiangsu, China

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Publications (803)2050.29 Total impact

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    ABSTRACT: Stellera chamaejasme, a famous toxic herb, has been used in traditional Chinese medicine for treatment of various diseases. For decades, increasing attentions of modern pharmacological studies have being drawn to S. chamaejasme because of its potential anti-tumor, anti-virus and anti-fungus activities. However, due to the intrinsic complexity of chemical constitutes, hardly any investigations formed an overall recognition for the chemical profiles of this herb. In this study, a rapid and sensitive ultra high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry method was developed to characterize the chemical components of S. chamaejasme extracts. Based on optimized ultra high performance liquid chromatography and mass spectrometry conditions and systematic fragment ions-based strategy, a total of 47 components including flavones, diterpenes, coumarins and lignans were simultaneously detected and identified or tentatively identified for the first time. And the MS(n) fragmentation patterns of all the characterized compounds in positive or negative electrospray ionization modes were also explored and summarized. These results provided essential data for further pharmacological research on S. chamaejasme. Moreover, the method was demonstrated to be an efficient tool for rapid qualitative analysis of secondary metabolites from natural resources. This article is protected by copyright. All rights reserved.
    No preview · Article · Feb 2016 · Journal of Separation Science
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    ABSTRACT: Purpose: Hippocampus plays an important role in spatial learning and memory. Ghrelin, a brain-gut peptide, participates in the mnestic functions of hippocampus through its receptor growth hormone secretagogue receptor (GHS-R) distributed in hippocampus. This study was to investigate whether there was a correlation between the changes of ghrelin system in hippocampus and the spatial cognitive impairment caused by chronic renal failure (CRF). Methods: Sprague-Dawley rats (male, 180 ± 10 g, 7-8 weeks old) were randomly classified into CRF group and control group (n = 18 per group). The CRF model was constructed by 5/6 nephrectomy and the controls treated with sham operation. By the 8th week after the surgery, the spatial cognitive function of rats was assessed by Morris water-maze test (MWM), the protein expression of ghrelin and GHS-R in the hippocampus by immunohistochemistry, and the mRNA expression by real-time PCR. Statistical analysis was performed using ANOVA, Student-Newman-Keuls-q test and Pearson correlation analysis, and P < 0.05 was considered significant. Results: Compared with the controls, the time spent in "platform" quadrant (TSPQ) of rats with CRF was decreased, but the escape latency (EL) was increased significantly in MWM, and meanwhile the protein and mRNA expression of ghrelin and GHS-R in hippocampus was also increased significantly (P < 0.05 or P < 0.01). Correlation analysis suggested that the TSPQ was negatively but the EL was positively correlated with the mRNA expression of ghrelin and GHS-R (P < 0.01). Conclusion: The CRF-caused changes of ghrelin system in hippocampus might be correlated with the CRF-caused cognitive function impairment.
    No preview · Article · Feb 2016 · International Urology and Nephrology
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    ABSTRACT: In this paper, the effects of rice dreg protein hydrolysates (RDPHs) obtained by various proteases on hydrogen peroxide-induced oxidative stress in HepG-2 cells were investigated. Cell cytotoxicity was evaluated through the aspects of cell viability, ROS level, antioxidant enzyme activity, and production of malondialdehyde (MDA). Cell apoptosis was assessed by flow cytometry. Molecular weight distribution was analyzed by gel permeation chromatography, and amino acid composition was measured using an automatic amino acid analyzer. The survival of cells and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were significantly increased through the pre-incubation of HepG-2 cells with RDPHs before H2O2 exposure. Additionally, these pretreatments also resulted in a reduction in ROS and MDA levels. As a result, apoptosis and loss of mitochondrial membrane potential of the HepG-2 cells were alleviated. Furthermore, the protective effects of protein hydrolysates obtained by various proteases were noticeably distinct, in which RDPHs prepared by alkaline protease showed higher antioxidant activities. The difference in the protective effects might be attributed to the specific peptide or amino acid composition. Therefore, enzymatic hydrolysis with different enzymes studied here could attenuate H2O2-induced cell damage, and the type of protease greatly influenced the anti-oxidative activity. Particularly, optimum use of Alcalase could produce peptides with higher antioxidant activity.
    No preview · Article · Feb 2016
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    ABSTRACT: A novel single-armed Salamo-type bisoximes (H3L) has been designed and synthesized firstly. A new application of Salamo-type bisoximes in ion recognition is investigated in detail. H3L can act as a relay-sensor for ratiometric recognition of Zn2+/Cu2+ with high selectivity and sensitivity. The Zn2+ and Cu2+ complexes behave successive sensing of H+/OH− through fluorescence intensity increasing (ON) and decreasing (OFF). Meanwhile, the crystal structures of the Zn2+ and Cu2+ complexes based on H3L, [Zn(L)(μ-OAc)Zn] and [Cu(L)(μ-OAc)Cu], have been determined by X-ray crystallographic analyses, respectively.
    No preview · Article · Feb 2016 · Sensors and Actuators B Chemical

  • No preview · Article · Feb 2016 · Pathology - Research and Practice

  • No preview · Article · Feb 2016
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    ABSTRACT: The effects of calcination temperature on the physicochemical properties of manganese oxide catalysts prepared by a precipitation method were assessed by X-ray diffraction, N2 adsorption-desorption, X-ray photoelectron spectroscopy, H2 temperature-programmed reduction, O2 temperature-programmed desorption, and thermogravimetry-differential analysis. The catalytic performance of each of these materials during the selective oxidation of cyclohexane with oxygen in a solvent-free system was subsequently examined. It was found that the MnOx-500 catalyst, calcined at 500 °C, consisted of a Mn2O3 phase in addition to Mn5O8 and Mn3O4 phases and possessed a low surface area. Unlike MnOx-500, the MnOx-400 catalyst prepared at 400 °C was composed solely of Mn3O4 and Mn5O8 and had a higher surface area. The pronounced catalytic activity of this latter material for the oxidation of cyclohexene was determined to result from numerous factors, including a higher concentration of surface adsorbed oxygen, greater quantities of the surface Mn4+ ions that promote oxygen mobility and the extent of O2 adsorption and reducibility on the catalyst. The effects of various reaction conditions on the activity of the MnOx-400 during the oxidation of cyclohexane were also evaluated, such as the reaction temperature, reaction time, and initial oxygen pressure. Following a 4 h reaction at an initial O2 pressure of 0.5 MPa and 140 °C, an 8.0% cyclohexane conversion and 5.0% yield of cyclohexanol and cyclohexanone were achieved over the MnOx-400 catalyst. In contrast, employing MnOx-500 resulted in a 6.1% conversion of cyclohexane and 75% selectivity for cyclohexanol and cyclohexanone. After being recycled through 10 replicate uses, the catalytic activity of the MnOx-400 catalyst was unchanged, demonstrating its good stability. © 2016 Dalian Institute of Chemical Physics, the Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.
    No preview · Article · Jan 2016 · Chinese Journal of Catalysis
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    ABSTRACT: Considering the wide existence of mycotoxin deoxynivalenol (DON) in wheat and derived products, finding ways to detoxify DON in wheat grains as original resources for food-chain contamination is very important to protect human health and reduce economic losses. This study aimed to evaluate the effectiveness of destroying DON in wheat via ozonation under different conditions, such as moisture content (MC), ozone concentration, exposure time, and form of raw-material. The achieved data showed that DON reduction significantly improved with increased ozone concentration and exposure time. The whole wheat flour (WWF) was easier to degrade than the wheat kernels. Higher MC decreased larger amounts of DON. The maximum reduction of DON was 20.10% for the MC group, compared with the 11.79% and 16.29% for the other MC groups. DON concentration decreased from 3.89 mg/kg to 0.83 mg/kg under the generally recognized Maximum Residue Limit (MRL) level of 1 mg/kg, when WWF was treated with 100 mg/L of ozone treatment for 60 min. The first-order kinetic model established in this work showed a good R-squared value (R2 > 0.877) and was consistent with the results. Therefore, ozonation is an effective and rapid way to degrade DON in wheat, especially in whole wheat flour.
    No preview · Article · Jan 2016
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    ABSTRACT: Deoxynivalenol (DON) is a secondary metabolite produced by Fusarium fungi, which is found in a wide range of agricultural products, especially in wheat, barley, oat and corn. In this study, the distribution of DON in the wheat kernel and the effect of exposure time to ozone on DON detoxification were investigated. A high concentration of toxin was found in the outer part of the kernel, and DON was injected from the outside to the inside. The degradation rates of DON were 26.40%, 39.16%, and 53.48% after the samples were exposed to 75 mg/L ozone for 30, 60, and 90 min, respectively. The effect of ozonation on wheat flour quality and nutrition was also evaluated. No significant differences (P > 0.05) were found in protein content, fatty acid value, amino acid content, starch content, carbonyl and carboxyl content, and swelling power of ozone-treated samples. Moreover, the ozone-treated samples exhibited higher tenacity and whiteness, as well as lower extensibility and yellowness. This finding indicated that ozone treatment can simultaneously reduce DON levels and improve flour quality.
    Preview · Article · Jan 2016 · PLoS ONE
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    ABSTRACT: Objective: The Obstetrics and Gynecology Hospital of Fudan University (OGHFU) in Shanghai is the largest academic women's hospital in China. Between 2009 and 2014, the use of liquid-based cytology (LBC) significantly increased while gradually adopting the Bethesda System (TBS), and in 2012 local regulations mandated that pathologists replace technicians to sign out Pap tests. Design: A retrospective OGHFU database search documented all Pap test reports between 2009 and 2014 by specimen type, either LBC or conventional Pap smears (CPS), and final reporting category. A total of 1,224,785 Pap reports were analyzed to document variations in Pap test reporting during a period of major change in cervical screening in China. Results: LBC gradually replaced CPS, which declined from over 65% of Pap tests in 2010 to 6.4% in 2014. Of 514,811 Pap reports using the traditional class system, class I (negative) reports accounted for 98.3% of results. With the introduction of TBS reporting, pathologist reviews and substantial replacement of CPS by LBC, the laboratory abnormal Pap test rate increased significantly to almost 5%. Conclusions: Changes in cervical cytology reporting between 2009 and 2014 in China's largest academic women's hospital reflected both increased use of LBC and the introduction of pathologist TBS reporting. Abnormality rates increased significantly and fell within CAP benchmark ranges.
    No preview · Article · Jan 2016
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    ABSTRACT: This study evaluated the antilisterial activity of hops beta acids (HBA) and their impact on the quality and sensory attributes of ham. Commercially cured ham slices were inoculated with unstressed- and acid-stress-adapted (ASA)-L. monocytogenes (2.2 to 2.5 log CFU/cm(2) ), followed by no dipping (control), dipping in deionized (DI) water, or dipping in a 0.11% HBA solution. This was followed by vacuum or aerobic packaging and storage (7.2 °C, 35 or 20 d). Samples were taken periodically during storage to check for pH changes and analyze the microbial populations. Color measurements were obtained by dipping noninoculated ham slices in a 0.11% HBA solution, followed by vacuum packaging and storage (4.0 °C, 42 d). Sensory evaluations were performed on ham slices treated with 0.05% to 0.23% HBA solutions, followed by vacuum packaging and storage (4.0 °C, 30 d). HBA caused immediate reductions of 1.2 to 1.5 log CFU/cm(2) (P < 0.05) in unstressed- and ASA-L. monocytogenes populations on ham slices. During storage, the unstressed-L. monocytogenes populations on HBA-treated samples were 0.5 to 2.0 log CFU/cm(2) lower (P < 0.05) than control samples and those dipped in DI water. The lag-phase of the unstressed-L. monocytogenes population was extended from 3.396 to 7.125 d (control) to 7.194 to 10.920 d in the HBA-treated samples. However, the ASA-L. monocytogenes population showed resistance to HBA because they had a higher growth rate than control samples and had similar growth variables to DI water-treated samples during storage. Dipping in HBA solution did not adversely affect the color or sensory attributes of the ham slices stored in vacuum packages. These results are useful for helping ready-to-eat meat processors develop operational procedures for applying HBA on ham slices.
    No preview · Article · Jan 2016 · Journal of Food Science
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    Gang Li · Wei-Min Zhou · Li-Chun Zhu · Li Wang
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    ABSTRACT: C19H15NO3, monoclinic, P21/n, a = 9.1811(4) Å, b = 16.0396(6) Å, c = 10.1330(5) Å, β = 98.640(5)° V = 1475.27(11) Å3, Z = 4, Rgt(F) = 0.0539, wRref(F2) = 0.1373, T = 294.29(10) K.
    Preview · Article · Jan 2016 · Zeitschrift für Kristallographie. New crystal structures
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    ABSTRACT: A novel refractive index (RI) sensor head is proposed and experimentally demonstrated in this paper. The proposed sensor head is composed of a segment of bared single-mode fiber and a fiber holder that is fabricated by a 3D printer. The mechanism of the sensor head is based on dual polarized Mach–Zehnder interference. According to the aforementioned mechanism, we derived that the RI responses of the resonance dips possess an exponential functional manner when the E field is along the fast or slow axes. In addition, based on the finite element method, we found that the resonance dips wavelength responses are more sensitive when the input E field is along the fast axis. A confirmation experiment was performed, and the results confirmed our hypothesis. The maximum arithmetic mean value of RI response is about 657.895 nm∕RIU for the proposed sensor head when the ambient RI changes from 1.3350 to 1.4110. Moreover, in the case of the proposed liquid RI sensor head, aligning the E field along the fast axis is the potentially needed condition for polarization.
    Full-text · Article · Dec 2015 · Applied Optics
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    ABSTRACT: Three isomorphic lanthanide metal–organic frameworks (Ln-MOFs) have been constructed from lanthanide formate skeletons and 3,5-bis(4′-carboxy-phenyl)-1,2,4-triazole (H2bct) connectors. Further, by adjusting the co-doping ratio of different Ln3+ ions into the framework, two doped Ln-MOFs are synthesized and show tunable luminescence emission including white-light emission.
    No preview · Article · Dec 2015 · RSC Advances
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    ABSTRACT: Background Congenital heart defects (CHDs) are the most common fetal defects and the most important cause of child mortality and morbidity. Objective To investigate the association between growth/differentiation factor 1 (GDF1) polymorphisms and fetal CHDs, by evaluating the association of GDF1 rs4808863 with fetal CHDs. Design A case–control study. Setting Beijing, China. Participants We selected 124 fetuses with a CHD and a normal karyotype and normal array-based comparative genomic hybridisation analysis and compared them with 124 normal fetuses matched for gestational age and sex. Fetuses with a CHD, from 20 to 32 weeks of gestation were included. Fetuses with any chromosomal abnormalities, and fetuses from multiple pregnancies and those carried by pregnant women with chronic diseases, were excluded from this research. DNA extraction and genotyping were carried out for all cases to investigate the genotype distributions of GDF1 rs4808863. Results A significant difference was noted for the CT phenotype of GDF1 rs4808863 between the controls and the fetuses with CHDs using homozygote and heterozygote comparisons. The minor allele (T allele) of GDF1 rs4808863 was associated with an increased risk of CHD (p<0.05). A statistically significant difference between controls and fetuses with CHDs was noted in a comparison with the mutation genotype CT+TT and wild-type genotype CC (p<0.05) using dominant modal analysis. After stratification analysis, the CT phenotype, the minor allele (T allele) and the mutation genotype CT+TT of the rs4808863 polymorphism were associated with atrioventricular septal defect (AVSD), left ventricular outflow tract obstruction (LVOTO) and left–right laterality defects (p<0.05). Conclusions Our results suggest that the GDF1 rs4808863 polymorphism contributes to an increased risk of fetal CHDs, especially the subtypes of AVSD, LVOTO and left–right laterality defects.
    Preview · Article · Dec 2015 · BMJ Open
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    ABSTRACT: Koumiss is a traditionally fermented mare’s milk described with health-promoting potentials for decades. However, only a few studies focused on the probiotic strains isolated from koumiss. In this study, we collected koumiss samples from Inner Mongolian pasturing area of China and selected a promising strain of Lactobacillus helveticus, isolate NS8, based on the survival abilities in gastrointestinal tract (GIT) and adhesion to intestinal endothelial cells in vitro. As the ability to positively modulate host immune response is a feature of increasing importance in measuring the probiotic potential of a bacterial strain, our study mainly focus on the immunomodulatory properties of L. helveticus NS8 by using in vivo and ex vivo analyses. L. helveticus NS8 was identified by molecular-typing methods, both at genus and species levels. As a typical food niche-specific bacteria, NS8 showed a moderate survival ability in GIT environment in vitro. However, an excellent binding capacity to the human intestinal epithelial cells, along with significant autoaggregation and cell-surface hydrophobicity was observed. Additionally, the presence of S-layer protein was responsible for the cell surface properties of this strain. NS8 was found to be rather protective against TNBS (2,4,6-trinitrobenzene sulfonic acid)-induced murine colitis. In the meantime, co-culture with NS8 induced an increased level of secretion of anti-inflammatory cytokine IL-10 in peripheral blood mono-nuclear cells (PBMCs). Furthermore, NS8 was also able to diminish the proinflammatory effects of lipopolysaccharide (LPS) in mouse macrophage cell line RAW264.7 by inducing higher levels of IL-10. Specially, adding of the purified S-layer protein didn’t influence the production of IL-10. The specific ligand-host receptor interactions on the NS8 specific immune responses need to be learned further. In summary, L. helveticus NS8 exhibited good probiotic and particularly immunomodulatory properties, with a potential for development of functional food commercially or therapeutic adjuvant for inflammatory diseases.
    Preview · Article · Dec 2015 · BMC Microbiology
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    ABSTRACT: To investigate the typing for HLA class I in Chinese patients with Type 1 diabetes as a complement screening for HLA class II. A total of 212 Type 1 diabetic patients and 200 healthy controls were enrolled. The genetic polymorphisms of HLA class I and II were examined with a high-resolution polymerase chain reaction-sequence-based typing method. The haplotype, A*33:03-B*58:01-C*03:02(A33), was associated with Type 1 diabetes (p=1.0×10-4, OR 3.2[1.738-5.843]). The A33-DR3 and A33-DR9 haplotypes significantly enhanced the risk of Type 1 diabetes (A33-DR3, OR 5.1[2.40-10.78]), p=4.0×10-6; A33-DR9, OR 13.0[1.69-100.32], p=0.004). In Type 1 diabetic patients, compared to A33-DR3-negative carriers, A33-DR3-positive carriers had significantly lower percentages of CD3+CD4+ T cells (42.5±7.72 vs. 37.0±8.35%, p=0.023), higher percentages of CD3+CD8+ T cells (27.4±7.09 vs. 32.8±5.98%, p=0.005) and T-cell receptor(TCR)α/β T cells (70.0±7.00 vs. 73.6±6.25%, p=0.031), and lower CD4/CD8 ratios (1.71±0.75 vs.1.16±0.35, p=0.003). It's the first time that the haplotypes A33-DR3 and A33-DR9 was found with enhanced predisposition to Type 1 diabetes in Han Chinese. A33-DR3 was associated with a reduction in the helper-to-cytotoxic cell ratio and preferential increase of TCRα/β T cell. The typing for HLA class I and its immunogenetic effects are important for more accurate HLA class II haplotype risk prediction and etiology research in Type 1 diabetic patients. This article is protected by copyright. All rights reserved.
    Preview · Article · Dec 2015
  • Lanlan Shen · Lu Yang · Yong Fan · Li Wang · Jianing Xu
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    ABSTRACT: A series of new lanthanide metal–organic frameworks (Ln-MOFs) [Ln2(L)3(H2O)4]·2H2O (1) (Ln = Eu, Tb, Gd), and [Gd2(H2O)4(L)(C2O4)2]·3H2O (2) were synthesized based on 4-hydroxypyridine-2,6-dicarboxylic acid (H2L) under hydrothermal conditions. 1 exhibits isomorphous 2D wave-like networks constructed by paddle-wheel [Ln(L)3] units and LnO4(H2O)4 polyhedra. 2 shows a (4,4)-connected 3D framework with a Schlafli symbol of 66. Oxalic acid in the resulting framework of 2 is formed in situ under hydrothermal conditions. Luminescence studies indicate that 1-Eu and 1-Tb show characteristic red and green emissions of the corresponding Ln3+ ions, respectively, while 1-Gd and 2 exhibit blue emission arising from the H2L ligand. Then, by adjusting the co-doping ratio of three different Ln3+ ions into the same framework as that of 1, a novel doped Ln-MOF, [(Eu0.0073Tb0.0007Gd0.992)2(H2O)4(L)3]·2H2O (3), is successfully designed and synthesized, which shows white light emission upon excitation at 340 nm and its emission can also be switched between different colors. In addition, 1-Gd shows weak ferromagnetic interactions.
    No preview · Article · Dec 2015 · CrystEngComm
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    ABSTRACT: Background: In light of the growing number of cancer survivors, the incidence of cardiovascular complications in these patients had also increased, while the effect of apatinib on the pharmacokinetic of cardioprotective drug (carvedilol) in rats or human is still unknown. The present work was to study the impact of apatinib on the metabolism of carvedilol both in vitro and vivo. Methods: A specific and sensitive ultra-performance liquid-chromatography tandem mass spectrometry method was applied to determine the concentration of carvedilol and its metabolites (4'-hydroxyphenyl carvedilol [4'-HPC], 5'-hydroxyphenyl carvedilol [5'-HPC] and o-desmethyl carvedilol [o-DMC]). Results: The inhibition ratios in human liver microsomes were 10.28, 10.89 and 5.94% for 4'-HPC, 5'-HPC and o-DMC, respectively, while in rat liver microsomes, they were 3.22, 1.58 and 1.81%, respectively. The data in vitro of rat microsomes were consistent with the data in vivo that the inhibition of 4'-HPC and 5'-HPC formation was higher than the control group. Conclusion: Our study showed that apatinib could significantly inhibit the formation of carvedilol metabolites both in human and rat liver microsomes. It is recommended that the effect of apatinib on the metabolism of carvedilol should be noted and carvedilol plasma concentration should be monitored.
    Full-text · Article · Nov 2015 · Pharmacology
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    ABSTRACT: The chemical fingerprint and metabolic profile of traditional Chinese medicine is very complicated and has been a great challenge. In the present study, chemical fingerprint of ethyl acetate fraction of Gastrodia elata (EtAcGE) and metabolic profile of rat plasma sample after intragastric administration of EtAcGE (2.5g/kg) were investigated using ultra-high performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UPLC/Q-TOF MS). A total of 38 chemical constituents of EtAcGE were identified by comparing their retention time, accurate molecular mass and characteristic fragment ions with those of references, or tentatively characterized by comparing molecular formula, fragment ions with that of known compound or information available in literature. And 40 compounds were detected in dosed rat plasma sample, including 16 prototypes and 24 metabolites underwent metabolic process of glucuronidation, glucosylation, sulfation, methylation, hydroxylation, dehydrogenation or mixed modes. The metabolic "soft spots" was hydroxyl or carboxy group. This is the first research for chemical fingerprint and metabolic profile of EtAcGE, which lay a foundation for the further investigation of EtAcGE.
    No preview · Article · Nov 2015 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Publication Stats

8k Citations
2,050.29 Total Impact Points

Institutions

  • 2007-2016
    • Jiangnan University
      • School of Food Science and Technology
      Wu-hsi, Jiangsu, China
    • Yangtze University
      • School of Food Science and Technology
      Hu-pei-ts’un, Shanxi Sheng, China
    • Beijing Cancer Hospital
      Peping, Beijing, China
  • 2015
    • Northwestern Polytechnical University
      • State Key Laboratory of Solidification Processing
      Xi’an, Liaoning, China
    • Capital Medical University
      Peping, Beijing, China
  • 2014-2015
    • Zhengzhou University
      Cheng, Henan Sheng, China
    • Auburn University
      AUO, Alabama, United States
    • Beijing University of Technology
      Peping, Beijing, China
  • 2013-2015
    • Hangzhou Normal University
      Hang-hsien, Zhejiang Sheng, China
    • Hefei Institute of Physical Sciences, Chinese Academy of Sciences
      Luchow, Anhui Sheng, China
    • Ocean University of China
      • College of Chemistry and Chemical Engineering
      Tsingtao, Shandong Sheng, China
    • Wenzhou University
      Yung-chia, Zhejiang Sheng, China
    • Xuzhou Medical College
      Suchow, Jiangsu Sheng, China
    • Ruijin Hospital North
      Shanghai, Shanghai Shi, China
    • Sun Yat-Sen University Cancer Center
      • Department of Radiation Oncology
      Shengcheng, Guangdong, China
    • China Agriculture University-East
      Peping, Beijing, China
  • 2012-2015
    • Nankai University
      • Institute of Modern Optics (IMO)
      T’ien-ching-shih, Tianjin Shi, China
    • Xi'an Jiaotong University
      • School of Medicine
      Ch’ang-an, Shaanxi, China
    • Natural History Museum, London
      • Department of Botany
      Londinium, England, United Kingdom
    • Sun Yat-Sen University
      Shengcheng, Guangdong, China
    • Northeastern University (Shenyang, China)
      Feng-t’ien, Liaoning, China
    • Huazhong University of Science and Technology
      • Key Laboratory of Environment and Health, MOE
      Wuhan, Hubei, China
    • Liaoning ShiHua University
      Fu-shan, Liaoning, China
  • 2011-2015
    • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
      Hua-yang, Sichuan, China
    • Shanghai Institute of Planned Parenthood Research
      Shanghai, Shanghai Shi, China
    • China Agricultural University
      • College of Biological Sciences
      Peping, Beijing, China
    • South China Institute Of Environmental Sciences
      Shengcheng, Guangdong, China
    • Shenzhen Center for Disease Control and Prevention
      Shen-ch’üan-shih, Zhejiang Sheng, China
  • 2008-2015
    • Chinese Academy of Medical Sciences
      • Institute of Basic Medical Sciences (IBMS)
      Peping, Beijing, China
    • Peking University
      • • Institute of Molecular Medicine
      • • Health Science Center
      Peping, Beijing, China
    • University of Michigan
      • Department of Radiation Oncology
      Ann Arbor, Michigan, United States
  • 2007-2015
    • East China University of Science and Technology
      • School of Materials Science and Engineering
      Shanghai, Shanghai Shi, China
    • Lanzhou Jiaotong University
      Kao-lan-hsien, Gansu Sheng, China
  • 2006-2015
    • Fudan University
      • • Hospital of Obstetrics and Gynecology
      • • Department of Pathology
      • • Department of Physiology and Pathophysiology
      • • Department of Obstetrics and Gynecology
      • • Department of Integrated Traditional Chinese Medicine and Western Medicine
      Shanghai, Shanghai Shi, China
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
  • 2005-2015
    • Peking Union Medical College Hospital
      Peping, Beijing, China
    • Academy of Military Medical Sciences
      T’ien-ching-shih, Tianjin Shi, China
    • Beijing Institute of Microbiology and Epidemiology
      Peping, Beijing, China
  • 2004-2015
    • Tongji University
      • • Medical School
      • • Department of Physics
      Shanghai, Shanghai Shi, China
  • 2003-2015
    • Jilin University
      • • College of Chemistry
      • • State Key Laboratory of Inorganic Synthesis and Preparative
      • • Department of Chemistry
      • • Department of Immunology
      • • State Key Lab of Theoretical and Computational Chemistry
      Yung-chi, Jilin Sheng, China
  • 2001-2015
    • Chinese Academy of Sciences
      • • Institute of Physics
      • • Institute of Psychology
      • • State Key Laboratory of Organic Geochemistry
      • • Laboratory of Analytical Chemistry for Life Science
      • • Institute of Biophysics
      • • Dalian Institute of Chemical Physics
      • • State Key Laboratory of Molecular Reaction Dynamics
      • • Institute of Genetics and Developmental Biology
      Peping, Beijing, China
    • Shandong University of Technology
      Chi-nan-shih, Shandong Sheng, China
  • 2013-2014
    • Zhejiang Normal University
      Jinhua, Zhejiang Sheng, China
  • 2012-2014
    • Fourth Military Medical University
      • • Department of Pathology and Pathophysiology
      • • Department of Clinical Aerospace Medicine
      Xi’an, Liaoning, China
  • 2011-2014
    • Dalian Medical University
      • • College of Pharmacy
      • • School of Pharmacy
      • • Department of Pharmacology
      Lü-ta-shih, Liaoning, China
    • Guangdong University of Petrochemical Technology
      Hsin-p’o, Guangdong, China
  • 2010-2014
    • Jiangsu University
      • School of Pharmacy
      Chenkiang, Jiangsu Sheng, China
    • Academy of Chinese Culture of Health Sciences
      Florida, United States
    • Liaocheng Teachers University
      Tungchangfu, Shandong Sheng, China
    • China University of Mining Technology
      Suchow, Jiangsu Sheng, China
    • Beihua University
      Yung-chi, Jilin Sheng, China
    • Hebei Medical University
      Chentow, Hebei, China
  • 2009-2014
    • Sichuan University
      • • State Key Laboratory of Biotherapy
      • • Laboratory of Transplant Engineering and Immunology
      Hua-yang, Sichuan, China
    • Harbin Institute of Technology
      • School of Municipal and Environmental Engineering
      Charbin, Heilongjiang Sheng, China
    • Prince Henry's Institute
      Melbourne, Victoria, Australia
  • 2006-2014
    • Shanghai Jiao Tong University
      • • School of Medicine
      • • School of Agriculture and Biology
      • • Department of Plastic and Reconstructive Surgery
      • • Department of Cardiology (Renji)
      Shanghai, Shanghai Shi, China
  • 1998-2014
    • Dalian Institute of Chemical Physics
      Lü-ta-shih, Liaoning, China
  • 2012-2013
    • Lanzhou University
      Kao-lan-hsien, Gansu Sheng, China
    • Shantou University
      • Marine Biology Institute
      Swatow, Guangdong, China
    • Henan Provincial People’s Hospital
      Cheng, Henan Sheng, China
  • 2011-2013
    • Yangzhou University
      • College of Horticulture and Plant Protection
      Peping, Beijing, China
  • 2009-2012
    • University of South Florida
      • Department of Cell Biology, Microbiology and Molecular Biology
      Tampa, Florida, United States
    • Beijing Medical University
      • Department of Pediatrics
      Peping, Beijing, China
    • Tsinghua University
      • • School of Medicine
      • • Department of Electronic Engineering
      Peping, Beijing, China
  • 2008-2012
    • USF Health Byrd Alzheimer's Institute
      Tampa, Florida, United States
    • University of Southampton
      • • Department of Electronics and Computer Science (ECS)
      • • Faculty of Physical and Applied Sciences
      Southampton, England, United Kingdom
  • 2007-2012
    • Renji Hospital
      Shanghai, Shanghai Shi, China
  • 2005-2012
    • Second Military Medical University, Shanghai
      • Department of Chemical-defence Medicine
      Shanghai, Shanghai Shi, China
  • 2010-2011
    • Nanjing Agricultural University
      • College of Animal Science and Technology
      Nan-ching, Jiangsu, China
  • 2009-2011
    • Georg-August-Universität Göttingen
      Göttingen, Lower Saxony, Germany
  • 2009-2010
    • University of Science and Technology Liaoning
      Аньшань, Liaoning, China
  • 2007-2010
    • China Pharmaceutical University
      • Department of Pharmaceutical Analysis
      Nan-ching-hsü, Jiangxi Sheng, China
  • 2006-2010
    • South China University of Technology
      • • Department of Chemical Engineering
      • • Key Lab for Special Functional Materials, Ministry of Education
      • • Institute of Polymer Optoelectronic Materials Components
      Shengcheng, Guangdong, China
  • 2005-2010
    • Dalian University of Technology
      • • State Key Laboratory of Fine Chemicals
      • • School of Chemical Engineering
      Lü-ta-shih, Liaoning, China
  • 2006-2009
    • Tianjin University
      • • School of Electrical Engineering and Automation
      • • Department of Electronic Information Engineering
      T’ien-ching-shih, Tianjin Shi, China
  • 2006-2008
    • Shanghai Institutes for Biological Sciences
      • Institute of Health Sciences
      Shanghai, Shanghai Shi, China
  • 2004-2005
    • Beijing Jiaotong University
      • Institute of Optoelectronics Technology
      Beijing, Beijing Shi, China
  • 2002-2004
    • Keio University
      • Department of Applied Chemistry
      Edo, Tōkyō, Japan