Takaaki Sugimoto

Hyogo College of Medicine, Nishinomiya, Hyōgo, Japan

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Publications (12)57.4 Total impact

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    ABSTRACT: A 63-year-old woman had been observed for a hepatic cyst for about 8 months. In June, 2009, her CA19-9 level was found to be elevated and she was admitted to our hospital. Abdominal ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI) showed a multilocular cystic tumor in the left lobe of the liver, and they showed a partial wall thickening in the cystic tumor. Fluorodeoxyglucose positron emission tomography (FDG-PET) showed uptake in the cystic tumor. Biliary cystadenocarcinoma was diagnosed and left lobectomy of the liver was performed. Macroscopic findings showed the cystic tumor to be composed of blood and mucin, and wall thickening. Histopathologically, the tumor was cystadenocarcinoma with ovarian-like stroma. The postoperative course was uneventful and she is alive without recurrence for 12 months after surgery. Since biliary cystadenocarcinoma with ovarian-like stroma are rare, we report this case with a review of the literature.
    No preview · Article · Jan 2011 · Nippon Shokaki Geka Gakkai zasshi
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    ABSTRACT: A 55-year-old man who had undergone transarterial embolization (TAE) elsewhere for hepatocellular carcinoma (HCC) evidenced by a SI liver lesion (2cm in diameter) in May 2004 was seen for right hypochondrial pain in August 2005. Abdominal computed tomography (CT) showed a hematoma of the gallbladder, diagnosed as acute hemorrhagic cholecystitis requiring cholecystectomy. Clots had accumulated of clots in the gallbladder and the mucosa was mildly inflamed. He suffered back pain, melena, and jaundice in November 2005, and endoscopic retrograde cholangiopancreatography (ERCP) showed hemobilia. Abdominal contrast CT showed a mass (3cm in diameter) having ill-defined border in the caudate lobe. Based on HCC recurrence suspected, we conducted intraoperative cholangioscopy used for hemobilia and observed a tumor embolus proceeding from the bile duct branch of Spiegel's lobe into the left branch of the intrahepatic bile duct. Based on a diagnosis of HCC invasion to the bile duct, we totally resected the left hepatic and caudate lobes. Although few cases develop hemobilia due to HCC invasion to the bile duct, this should be considered in HCC follow-up.
    No preview · Article · Oct 2010 · Nippon Shokaki Geka Gakkai zasshi
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    ABSTRACT: Accurate preoperative estimation of remnant liver function is critically important for hepatic surgery, and the expression of asialoglycoprotein receptors (ASGPR) is associated with hepatic function. Thirty-two patients with hepatocellular carcinoma who underwent surgical resection were studied. To estimate the expression of ASGPR in the remnant liver, simulated surgery was performed on fusion images that combined data from (99m)technetium-galactosyl human serum albumin ((99m)Tc-GSA)/single photon emission computed tomography (SPECT) and computed tomography (CT) scanning. The liver uptake ratio (LUR) of (99m)Tc-GSA and the functional liver volume (FLV) in the remnant liver were predicted and were compared with postoperative liver function parameters. The LUR of (99m)Tc-GSA was strongly correlated with the extent of hepatic ASGPR expression (r = 0.944, p = 5.01 x 10(-16)), being confirmed to be a reliable parameter for the evaluation of liver function. The estimated remnant LUR, but not the estimated remnant FLV, was significantly correlated with postoperative liver function parameters, such as serum total bilirubin (r = -0.430, p < 0.05), prothrombin activity (r = 0.515, p < 0.01), and serum cholinesterase activity (r = 0.546, p < 0.01) at 1 week. Preoperative estimation of the extent of ASGPR expression in the remnant liver on CT/GSA-SPECT fusion images correlated well with postoperative liver function parameters, suggesting its usefulness for surgical decisions.
    Full-text · Article · Sep 2010 · Journal of Hepato-Biliary-Pancreatic Sciences

  • No preview · Article · Jan 2010 · Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)

  • No preview · Article · May 2009 · Gastroenterology
  • Takaaki SUGIMOTO · Kohshi OH · Jiro FUJIMOTO

    No preview · Article · Jan 2009 · Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
  • Takaaki Sugimoto · Tadamichi Hirano · Norihiro Nakai · Jiro Fujimoto

    No preview · Article · Jan 2009 · Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
  • Kazuhiro Suzumura · Takaaki Sugimoto · Jiro Fujimoto
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    ABSTRACT: A 66-year-old man with hepatitis B virus-related liver cirrhosis was admitted to our hospital because of fever and vomiting. We diagnosed a cholecystitis and treated with antibiotics. He developed bleeding lesions and bullae on his bilateral lower extremities one day after admission. Gram-negative rods were detected from the bulla. CT showed an air density in the muscle of lower extremity, leading to a diagnosis of necrotic fascitis, and we performed amputations of the bilateral lower extremities. In spite of intensive care, he died of sepsis one day after operation. Aeromonas hydrophila was detected in the bulla, blood and fascia afterward. A. hydrophila infection is known to become very serious in immuno-compromised hosts. We here report a fatal case of A. hydrophila infection that occurred in a patient with decompensated liver cirrhosis.
    No preview · Article · Jan 2007 · Kanzo
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    ABSTRACT: In living-donor liver transplantation, accurate assessments of liver graft volume and anatomical variation are mandatory for the preoperative planning of safe donor hepatectomy and successful recipient implantation. The aim of this study was to assess the feasibility and accuracy of novel three-dimensional (3-D) virtual hepatectomy simulation software in living-donor liver transplantation. We developed the hepatectomy simulation software, which was programmed to analyze detailed 3-D vascular structure and to predict liver graft volume, based on hepatic circulation. In 101 individuals, including 4 living donors, the predicted liver resection volumes revealed a significant correlation with the actual value (P < 0.0001), with a mean difference of 7.9 ml. The drainage area by the individual hepatic vein branch was quantified to achieve reconstruction of the corresponding venous branch. The application of multidetector computed technology scanning and virtual cholangioscopy facilitated more detailed visualization of the 3-D hilar anatomy in a left trisectoral graft transplantation. This hepatectomy simulation software reliably predicted accurate liver graft volume and the drainage volume of hepatic vein branches. This software may contribute to the preoperative planning of safe donor hepatectomy and implantation with satisfactory graft viability.
    No preview · Article · Sep 2006 · Journal of Hepato-Biliary-Pancreatic Surgery
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    ABSTRACT: Hepatectomy is a complicated operative procedure because of its anatomical complexity, vascular variability, and impaired hepatic function due to associated hepatitis or cirrhosis. Thus preoperative detailed topography and precise liver resection volume measurements should be obtained for a curative hepatectomy. The aim of this study was to assess the feasibility and accuracy of a novel three-dimensional (3D) virtual hepatectomy simulation software in patients who underwent liver resection or living donor liver transplantation. We developed the hepatectomy simulation software, which was programmed to analyze detailed 3D vascular structure and to predict liver resection volume and margins. In 72 patients receiving hepatectomy, the predicted liver resection volumes and margins revealed a significant correlation with the actual value with a mean difference of 9.3 mL (P < .0001) and 1.6 mm (P < .01), respectively. The drainage area by hepatic veins was quantified to achieve reconstruction of the corresponding venous branch. In conclusion, this hepatectomy simulation software reliably predicted an accurate liver resection volume, the cancer-free margin, and the drainage volume of hepatic vein branches. This software may promote curative hepatectomy and may be used for other interventional therapies in the treatment of liver disease.
    Preview · Article · Jun 2005 · Hepatology
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    ABSTRACT: Interleukin (IL)-18 was originally regarded to induce T helper cell (Th)1-related cytokines. In general, factors favoring interferon (IFN)-gamma production are believed to abolish allergic diseases. Thus, we tested the role of IL-18 in regulation of bronchial asthma. To avoid a background response of host-derived T cells, we administered memory type Th1 or Th2 cells into unsensitized mice and examined their role in induction of bronchial asthma. Administration of antigen (Ag) induced both airway inflammation and airway hyperresponsiveness (AHR) in mice receiving memory Th2 cells. In contrast, the same treatment induced only airway inflammation but not AHR in mice receiving memory Th1 cells. However, these mice developed striking AHR when they were coadministered with IL-18. Furthermore, mice having received IFN-gamma-expressing Th1 cells sorted from polarized Th1 cells developed severe airway inflammation and AHR after intranasal administration of Ag and IL-18. Thus, Th1 cells become harmful when they are stimulated with Ag and IL-18. Newly polarized Th1 cells and IFN-gamma-expressing Th1 cells, both of which express IL-18 receptor alpha chain strongly, produce IFN-gamma, IL-9, IL-13, granulocyte/macrophage colony-stimulating factor, tumor necrosis factor alpha, regulated on activation, normal T cell expressed and secreted, and macrophage inflammatory protein 1alpha upon stimulation with Ag, IL-2, and IL-18 in vitro. Thus, Ag and IL-18 stimulate memory Th1 cells to induce severe airway inflammation and AHR in the naive host.
    Full-text · Article · Mar 2004 · Journal of Experimental Medicine
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    ABSTRACT: Interleukin (IL)-18 synergizes with IL-12 to promote T helper cell (Th)1 responses. Somewhat paradoxically, IL-18 administration alone strongly induces immunoglobulin (Ig)E production and allergic inflammation, indicating a role for IL-18 in the generation of Th2 responses. The ability of IL-18 to induce IgE is dependent on CD4+ T cells, IL-4, and signal transducer and activator of transcription (stat)6. Here, we show that IL-18 fails to induce IgE both in CD1d-/- mice that lack natural killer T (NKT) cells and in class II-/- mice that lack conventional CD4+ T cells. However, class II-/- mice reconstituted with conventional CD4+ T cells show the capacity to produce IgE in response to IL-18. NKT cells express high levels of IL-18 receptor (R)alpha chain and produce significant amounts of IL-4, IL-9, and IL-13, and induce CD40 ligand expression in response to IL-2 and IL-18 stimulation in vitro. In contrast, conventional CD4+ T cells express low levels of IL-18Ralpha and poorly respond to IL-2 and IL-18. Nevertheless, conventional CD4+ T cells are essential for B cell IgE responses after the administration of IL-18. These findings indicate that NKT cells might be the major source of IL-4 in response to IL-18 administration and that conventional CD4+ T cells demonstrate their helper function in the presence of NKT cells.
    Full-text · Article · May 2003 · Journal of Experimental Medicine

Publication Stats

310 Citations
57.40 Total Impact Points

Institutions

  • 2003-2011
    • Hyogo College of Medicine
      • • Department of Surgery
      • • Department of Immunology and Medical Zoology
      Nishinomiya, Hyōgo, Japan