Publications (37)47.27 Total impact

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    ABSTRACT: ABSTRACT Background: Different systems have been used for the preparation of Platelet Rich Plasma (PRP), but platelet collection efficiencies of these systems are not clear. Objective: To evaluate the platelet collection efficiencies of three different PRP preparation systems. Materials and Methods: Blood samples were obtained from the same 16 volunteers for each system. The samples were centrifuged and PRP was prepared by three systems. The ratio of the total number of platelets in PRP to the total number of platelets of the venous blood sample of the patient expressed in percentage was named as platelet collection efficiency and calculated for each system. Results: Mean platelet collection efficiencies were 66.6 (min.56.9, max.76.9), 58.3(min.27.3, max.102.8), 50.8(min.27.2, max.73) for top and bottom bag system, system using citrated tube and the system using tube with ficoll and cell extraction kit respectively. Statistically significant difference was only found between the platelet collection efficiencies of systems using the tube with ficoll and cell extraction kit and the top and bottom bag system (p=0.002). Conclusions: All three systems could be used for PRP preparation but top and bottom bag system offers a slight advantage over the system using ficoll and cell extraction kit regarding the platelet collection efficiency.
    No preview · Article · Dec 2014 · Journal of Cosmetic and Laser Therapy
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    ABSTRACT: Introduction: Platelet-rich plasma (PRP) has been used for rapid healing and tissue regeneration in many fields of medicine. This study was conducted to evaluate the effects of PRP application procedure on human facial skin. Methods: PRP was applied thrice at 2-week intervals on the face of ten healthy volunteers. It was applied to individual's forehead, malar area, and jaw by a dermaroller, and injected using a 27-gauge injector into the wrinkles of crow's feet. Participants were asked to grade on a scale from 0 to 5 for general appearance, skin firmness-sagging, wrinkle state and pigmentation disorder of their own face before each PRP procedure and 3 months after the last PRP procedure. While volunteers were evaluating their own face, they were also assessed by three different dermatologists at the same time by the same five-point scale. Results: There was statistically significant difference regarding the general appearance, skin firmness-sagging and wrinkle state according to the grading scale of the patients before and after three PRP applications. Whereas there was only statistically significant difference for the skin firmness-sagging according to the assessment of the dermatologists. Conclusion: PRP application could be considered as an effective procedure for facial skin rejuvenation.
    No preview · Article · Jul 2014 · Journal of Cosmetic and Laser Therapy
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    ABSTRACT: The aim of this study was to evaluate the histologic effects of acute paroxetine administration on wound healing in healthy and streptozotocin-induced diabetic rats. This study has a randomized controlled experimental design. Healthy (n = 32) and diabetic (n = 32) rats were further divided into 2 groups of saline or paroxetine administration. Sixty-four male Sprague-Dawley rats were used in this study. Paroxetine was injected intraperitoneally every day. Full-thickness excision wounds were created with a 4-mm dermal punch on the back of all rats. The healing wound area was removed with a 6-mm dermal punch at postwounding days 1, 3, 7, and 14. Polymorphonuclear leukocyte, mononuclear inflammatory cell, fibroblast, and blood vessel counts and epithelialization were evaluated under light microscope. There was no statistically significant difference observed in the polymorphonuclear leukocyte, mononuclear inflammatory cell, and blood vessel counts in the healthy and diabetic rats with and without paroxetine administration. The number of fibroblasts was significantly higher at postwounding day 14 of the paroxetine-administered healthy rats compared with the saline-administered healthy rats (P = .04). However, the number of fibroblasts did not show any difference by paroxetine administration in the diabetic rats. There was no statistically significant difference in epithelialization regarding all the postwounding days, but complete epithelialization was observed in all rats on postwounding day 14 in the healthy and paroxetine-administered group. Short-term paroxetine administration may enhance cutaneous wound healing by increasing the number of fibroblasts and causing better epithelialization over time in healthy rats but not in diabetic rats.
    Full-text · Article · May 2014 · Advances in skin & wound care
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    ABSTRACT: The coronary slow flow phenomenon (CSFP) is the delayed opacification of coronary arteries in the absence of significant stenosis. The pathogenesis of CSFP has not been completely understood yet. There are several proposed mechanisms such as the structural and functional abnormalities in coronary microcirculation. Nail fold capillaroscopy is a simple, noninvasive examination of the microvasculature and suggested to be a useful technique for analysis in various inflammatory and autoimmune diseases. In this study; we hypothesized that; CSFP is a part of systemic vascular entity rather than a problem confined to coronary vasculature and our aim was to investigate the nail fold capillaries of the patients with CSFP and compare to those with normal coronary flow (NCF). The study was designed as a case-control study and total 25 patients (10 male, mean age 55 ± 9 years) with documented CSFP, and 24 patients (15 male, mean age 55 ± 11 years) with NCF were recruited. Nail fold capillaroscopy examinations were performed by video dermatoscopy in all patients and results were compared between two groups. The demographic and clinical characteristics were similar between patients of CSFP and NCF groups. Nail fold capillary abnormalities including dilatation, tortuosity and microhemorrhage were present in 15 (60%) patients in CSFP group and 5 (21%) patients in NCF group (p < 0.05 OR: 5.7 95% C.I 1.602-20.279). In this study, we found that the abnormalities in nail fold capillaries suggesting the presence of inflammation and anatomical changes were significantly higher in patients with CSFP.
    No preview · Article · Apr 2014 · International Journal of Clinical and Experimental Medicine
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    ABSTRACT: Background Psoriasis is a systemic inflammatory disease associated with increased risk of cardiovascular diseases. The heart rate recovery index (HRRI) is an indicator of autonomic nervous system function and is an independent prognostic risk factor for cardiovascular diseases. The aim of this study was to evaluate the heart rate recovery indices in patients with psoriasis. Material/methods Thirty-three psoriasis patients (22 male; mean age 41±11 years) and 26 healthy individuals (15 male; mean age 39±11 years) as a control group were included in the study. Baseline electrocardiography, transthoracic echocardiographic examinations, and exercise stress tests were performed in psoriasis and control groups. The heart rate recovery of the psoriasis group at 1, 2, 3, 4, and 5 minutes after maximal exercise were calculated and compared to those of the control group. Results Baseline demographic and clinical characteristics of psoriasis and control groups including age, sex, body mass index, systolic blood pressure, and echocardiographic parameters were similar. Total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels were significantly higher and high-density lipoprotein cholesterol levels were significantly lower in the psoriasis group (p<0.05). Heart rate recovery at 1, 2, 3, 4, and 5 minutes after maximal exercise were found to be significantly lower in the psoriasis group (p<0.05). Additionally, baseline heart rates before exercise were significantly higher in the psoriasis group (p<0.05). Conclusions We found that impaired HRRI in psoriasis patients, which indicates the underlying autonomic nervous system dysfunction, is a pathophysiologic mechanism for increased cardiovascular disease risk.
    Full-text · Article · Mar 2014 · Medical science monitor: international medical journal of experimental and clinical research
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    ABSTRACT: Abstract Pellagra is caused by deficiency of niacin or its precursor tryptophan. While cutaneous lesions are the most prominent feature of the disease, gastrointestinal, neurological and psychiatric signs and symptoms are the other characteristics of the disease. In this case report, we present a 29-year-old female patient with discoloration of hands and feet diagnosed with pellagra.
    No preview · Article · Mar 2014 · Cutaneous and Ocular Toxicology
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    ABSTRACT: BACKGROUND/OBJECTIVES: Psoriasis is a chronic, immune-mediated disease and associated with a higher prevalence of cardiovascular problems. In the present study, left ventricular (LV) systolic and diastolic functions in psoriasis patients were evaluated according to two-dimensional and tissue Doppler echocardiographic parameters. METHODS: Forty-two psoriasis patients and 31 healthy controls were included in the study. From transmitral inflow velocities, peak early (E) and late (A) diastolic velocities, and E/A ratios were measured. Myocardial performance index (MPI) was calculated using conventional Doppler parameters. For tissue Doppler analysis, peak systolic (Sm), peak early diastolic (Em) and peak late diastolic (Am) velocities were measured. In addition, Em/Am and E/Em ratios were calculated. RESULTS: Em from both septal and lateral sides of the mitral annulus were significantly lower in psoriasis patients. Em/Am ratios from septal and lateral sides of the mitral annulus were also significantly lower than control subjects. Sm from the septal side of the mitral annulus was significantly lower in the psoriasis group whereas it was not significantly different on the lateral side. In psoriasis patients, left atrial diameter, left atrial volume, E/Em ratio and MPI were significantly higher than those of control subjects. LV ejection fraction, E and A velocities, and E/A ratios were not significantly different between the two groups. CONCLUSIONS: Left ventricular functions evaluated by more sensitive echocardiographic methods, such as tissue Doppler imaging and MPI, were significantly affected in psoriasis patients compared with healthy subjects. These findings may indicate early changes in cardiac structure and function in psoriasis patients.
    No preview · Article · Sep 2013 · Experimental and clinical cardiology
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    ABSTRACT: Abstract Context: Combination of methotrexate and cyclosporine was used and reported to be effective for recalcitrant psoriasis patients. Also each agent is accused for development of malignancies. Objective: To evaluate the cancer-free survival of psoriasis patients who received methotrexate and cyclosporine treatment at the same time. Methods: Psoriasis patients who had been treated with combination of cyclosporine and methotrexate between March 2000 and April 2005 were questioned in 2011. A diagnosis of new cancer during follow-up period was asked and also each patient was evaluated by a questionnaire. Results: Seventeen psoriasis patients were not treated due to a diagnosis of new cancer during the follow-up period. Also none of them complained of possible symptoms of skin or lymphoproliferative malignancies. The median follow-up time was 76 months. Conclusion: Psoriasis patients who had been treated with methotrexate and cyclosporine combination did not report a detected malignant disease.
    No preview · Article · Aug 2013 · Cutaneous and Ocular Toxicology

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  • No preview · Article · Mar 2012
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    ABSTRACT: Light-based therapies and lasers have been proposed for the treatment of acne vulgaris but the efficacy and application periods of 532-nm KTP laser treatment are not clear. To evaluate the efficacy and safety of 532-nm KTP laser and compare the effects of once and twice weekly applications in the treatment of mild to moderate acne vulgaris. Totally 38 patients were treated once weekly and twice weekly in group I and in group II respectively. One half of the face of each patient was treated with 532-nm KTP and the other half was remained as untreated. Patients were evaluated at the beginning, one and four weeks after the last treatment session with Michaëlsson acne severity grading score (MASS). Statistically significant improvement was found at second control (p = 0.005) in group I, and at the first (p = 0.004), and second (p < 0.001) controls in group II for treated sides. For both groups, changes of MASS were insignificant for untreated sites. Improvement of MASS of treated sides was not statistically significant between two treatment groups for both controls. 532-nm KTP laser treatment may be an alternative method in selected acne vulgaris patients. No significant difference was noted between once and twice weekly applications.
    No preview · Article · Dec 2011 · Journal of Cosmetic and Laser Therapy
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    ABSTRACT: Melasma is a pigmentary disorder often recalcitrant to treatment. Few studies have objectively evaluated the efficacy of treatment colorimetrically. To evaluate the safety and efficacy of a depigmentation cream, including mainly glycolic acid and Rumex occidentalis. Twenty-seven patients applied the cream twice daily for the first 3 months and twice weekly for the following 3 months. L*, C* and h* values of the target lesions and the perilesional area were analyzed at baseline, 12 and 24 weeks colorimetrically. The physician and patient evaluated the clinical response rate. These results were compared statistically between the lesional and perilesional area. There was a significant difference between 0-12, 0-24 (L*, C* and h* values) and 12-24 weeks (L* value) (p <0.001). For C* and h* values, the difference was not significant between 12 and 24 weeks (p = 0.464 and 0.151, respectively). Statistical significance was detected only between 3 and 6 months for C* value (p < 0.05) for the lesional and the perilesional areas. Clinical response rate was significant (p < 0.05). Our depigmentation cream is a moderate effective agent, well tolerated and can be considered as an alternative treatment of melasma. Twice-daily application may enhance the efficacy of treatment instead of twice-weekly application in the maintenance period.
    No preview · Article · Jul 2011 · Journal of Cosmetic and Laser Therapy
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    ABSTRACT: Laser therapy is the treatment of choice for cherry angiomas since it is more effective and has better cosmetic results. There is no comparative study about the treatment efficacies with KTP and Nd:YAG lasers for cherry angiomas. To compare the efficacy and side effects of 532-nm KTP and 1064-nm Nd:YAG lasers for the treatment of cherry angiomas. Two comparable lesions of the same patient were chosen. One of them was treated with the KTP laser while the other was treated with the Nd:YAG laser. Sessions were repeated every 4 weeks until complete clearance was achieved. Side effects were evaluated using a severity scale (0 to 4). The number of sessions was significantly higher with the KTP than with the Nd:YAG laser (p = 0.002). Erythema, edema, pain and scar formation were higher in the Nd:YAG laser group (erythema: p = 0.001; edema: p < 0.001; pain: p < 0.001; scar: p < 0.001). The hyperpigmentation rate was statistically higher with the KTP laser (p = 0.01). Both KTP and Nd:YAG lasers were found to be effective methods. The Nd:YAG laser offered fewer treatment sessions, but a higher risk of scar formation. The KTP laser seems more advantageous, but in dark-skinned patients the Nd:YAG laser may be preferable.
    No preview · Article · Jun 2011 · Journal of Cosmetic and Laser Therapy
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    ABSTRACT: The Nd:YAG laser has been considered the gold standard of treatment for leg veins, but pain and side effects have fueled physicians to use treatment alternatives. To compare the clinical efficacy of the long-pulsed 1064-nm Nd:YAG laser with KTP laser irradiation in the treatment of leg telangiectasia. A series of 16 patients with size-matched superficial telangiectases of the lower extremities were randomly assigned to receive three consecutive monthly treatments with the long-pulsed 1064-nm Nd:YAG on one leg and 532-nm KTP laser irradiation on the other. For the 16 patients who completed the study, 64 leg vein sites were treated. Average clinical improvement scores were 1.94 and 1.25 for the KTP laser-treated leg and 3.38 and 3.50 for the Nd:YAG laser-treated leg with thin (≤ 1 mm) and large (1-3 mm) vessels, respectively. After the third treatment session, average improvement scores of 2.44, 1.31 and 3.75, 3.23 were given for the KTP and Nd:YAG laser-treated sides, respectively. Both the 1064-nm Nd:YAG and KTP lasers are effective in the treatment of lower extremity telangiectases. However, the KTP laser has very low efficacy with vessels larger than 1 mm and should not be elected when treating such vessels.
    Full-text · Article · Jun 2011 · Journal of Dermatological Treatment
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    ABSTRACT: Objective: Standard KOH preparation and fungal culture are the most preferred methods used for the diagnosis of onychomycosis. Alternatively used methods are histopathological examination and KOH preparation for 24 hours. Our aim was to assess the sensitivity of standard KOH preparation, KOH preparation for 24 hours, fungal culture and histopathological examination for the diagnosis of onychomycosis. Material and Methods: Nail samples were taken from 58 patients with a clinical suspicion of onychomycosis. Standard KOH preparation, KOH preparation for 24 hours, fungal culture and histopathological examination were searched for presence of fungal elements. Results: Onychomycosis was diagnosed in 46 samples. Samples of 8 patients were negative by all methods. Fungal elements were observed by standard KOH preparation in 27 patients (50%), by KOH preparation for 24 hours in 37 patients (68.5%), by culture method in 14 patients (25.9%) and by histopathological examination in 40 (74.1%) patients. The sensitivity values of these methods were 58%, 80.4%, 30.4%, and 87% respectively. Conclusion: This study showed that histopathological examination and KOH preparation for 24 hours methods are more sensitive than the KOH preparation and fungal culture.
    No preview · Article · Jun 2011
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    ABSTRACT: Hypereosinophilic syndrome (HES) is a multi-organ disease (heart, eye, lungs or nervous tissue). The etiology and pathogenesis of HES is still unknown. It is characterized by 1500 eosinophils/μl of eosinophils in peripheral blood observed during at least six months without any evidence for other known causes of eosinophilia. The skin manifestations of the disease were pruritic, erythematous macules, papules, plaques or nodules and rarely urticaria, angioedema, livedo reticularis, eosinophilic cellulitis, cutaneous necrotizing eosinophilic vasculitis, retiform purpura. Among the skin lesions erythroderma is a rare complication of HES and has only been reported in a few cases (Launay et al., 2002, Granjo et al., 2002). We report here a 78-yrs-old man with pruriginous erythroderma leading to the diagnosis of hypereosinophilic syndrome. In dermatological examination erythrodermia and mild desquamation was noticed entire the body surface with bilateral ectropion.
    No preview · Article · May 2011
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    ABSTRACT: Molluscum contagiosum is an infectious disease presenting with flesh-colored, dome-shaped, umblicated papules. A few atypical presentations have been reported in immunodeficient patients. A 5-year-old boy with acute lymphoblastic leukemia, presented with bright white-colored papular lesions with no umblications on the chin during his continuation chemotherapy. Increased number of the lesions covered almost his entire chin in months. Topical therapies did not improve the lesions. After his bone marrow relapse, induction chemotherapy was withheld because of bronchopneumonia after febrile neutropenia. After initiation of a combination of systemic parenteral antibiotic and antifungal therapies, his parents squeezed one of his papular lesions. Meanwhile, systemic acyclovir was added to his therapy, because of herpes labialis. Despite the large spectrum of his therapies, in 1.5 months, this small lesion progressed to a large lesion with erythematous ground and a central ulceration. Etiology of the lesion could not be enlightened until a skin biopsy that was compatible with the molluscum contagiosum. A partial resolution was achieved by cryotherapy. In conclusion, molluscum contagiosum may present as an ulcerating lesion during childhood leukemia treatment. A skin biopsy should be performed for the accurate diagnosis of atypical cutaneous lesions in immunocompromised patients.
    No preview · Article · Mar 2011 · Journal of Pediatric Hematology/Oncology

  • No preview · Article · Nov 2010 · The Journal of Dermatology
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    ABSTRACT: Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent inflammatory febrile attacks, abdominal, chest or joint pain, myalgia, and erysipelas-like skin lesions. Several types of vasculitis are associated with FMF such as polyarteritis nodosa and Henoch-Schönlein purpura. We aimed to determine microvascular abnormalities in FMF patients via nailfold capillaroscopy using a dermoscope. Thirty-one FMF patients were assessed; capillary enlargement, tortuosity, avascular areas and microhemmoraghes were investigated. Capillary enlargement was found in five patients and microhemorrhages in one patient. Our study supports that nailfold capillary abnormalities, which are nonspecific, can be seen in FMF patients, but more studies are needed to clarify the importance of these findings.
    No preview · Article · Oct 2010 · Clinical Rheumatology
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    ABSTRACT: Narrow-band ultraviolet therapy has been used successfully for the treatment of inflammatory skin disorders and generalized pruritus. We have prospectively evaluated seven consecutive patients with resistant psychogenic excoriation (PE) treated with narrow-band ultraviolet B (NB-UVB). Approximately 70% of all patients showed improvement in their condition. NB-UVB therapy was well tolerated, with no serious side effects. We may conclude that, when treating a patient with PE, NB-UVB in combination with other approaches may provide extra benefit in resistant cases.
    No preview · Article · Jun 2010 · Photodermatology Photoimmunology and Photomedicine