H. Schwann

Rehabilitationszentrum Meidling, Wien, Vienna, Austria

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Publications (26)17.98 Total impact

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    ABSTRACT: Adherence to medical advice, driven by high patient motivation, could lead to a significant reduction in risk factors during cardiac rehabilitation. During a 1-year period, 9082 patients were admitted to six cardiac rehabilitation centres. A total of 1195 highly motivated subjects were selected based on their reliable completion of a survey regarding cardiac risk factors. Study subjects had lower risk factors at baseline compared with a contemporary Austrian database. At discharge from the rehabilitation programme subjects showed further reductions in median weight, low-density lipoprotein cholesterol, blood pressure and resting pulse rate (due to increased levels of daily exercise). Smoking also decreased. Most of these changes were still significant after 1 year. The risk factors in these highly motivated patients were low to begin with and were further reduced by an inpatient rehabilitation programme. The content and method of delivery of this programme seem to be effective. Efforts should focus on increasing motivation.
    No preview · Article · Jan 2015 · Wiener Medizinische Wochenschrift
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    ABSTRACT: Practice Guidelines for Exercise Testing. Exercise testing is a standard procedure in cardiology. This has not changed with newer diag-
    No preview · Article · Jan 2014 · Atemwegs- und Lungenkrankheiten
  • W. Kullich · B. Stritzinger · M. Arnold · H. Schwann · E. Mur

    No preview · Article · Jun 2013 · Physikalische Medizin Rehabilitationsmedizin Kurortmedizin
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    ABSTRACT: Introduction: Smoking cessation programs are offered in the rehabilitation centers (RC) of the Austrian Pension Insurance Company (PVA) for several years. The evaluation of the success, however, revealed diverse standards in implementation. Therefore, the smoking cessation program in the RC was standardized due to the guidelines of the Austrian Society for Pneumology (ÖGP). Methods: In a time interval of 6 months all smoking patients in 13 RC of the PVA who volunteered for the standardized smoking withdrawal were included in a study about the outcome of this program. The following measures were administered for documentation: measurement of exhaled CO and Fagerström test at T1 (baseline, before rehabilitation), questionnaires about restart of smoking, about smoking habits, and about used supporting means in withdrawal at T2 and T3 (T2 = after 3-4 weeks, at the end of the inpatient rehabilitation; T3 = after 1 year). Statistical analyses were performed in the Ludwig Boltzmann Institute for Rehabilitation in Saalfelden using the program package SYSTAT, Vs. 11 (Systat Software, USA). Results: 605 smokers (387 men, 218 women; mean age 51.6 ± 10.3 years) took part in the program and could be included within a half year. The recorded Fagerström tests for assessment of nicotine dependence resulted in 4.74 points (mean). After 3-4 weeks (T2) 272 patients (45%) had become non-smokers, 237 (39.2%) reduced smoking, 83 (13.7%) went on smoking unchanged, and 13 (2.2%) even enhanced their cigarette consumption. After 1 year 517 (85.5%) of the 605 patients - a really high percentage - could be reached for telephone or paper-and- pencil interviews. 30% were non-smokers, 70% continued or restarted smoking. Summary: In the rehabilitation centers the PVA provides the majority of inpatient smoking withdrawal in Austria. Our investigations with a representative collective of more than 600 smokers document that the success rate of the launched standardized smoking cessation program using ÖGP guidelines corresponds to international published experiences, and confirm the efficiency of the smoking cessation program in the RC of the PVA.
    No preview · Article · Aug 2011 · Atemwegs- und Lungenkrankheiten
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    ABSTRACT: The goal of cardiac rehabilitation programs is not only to prolong life but also to improve physical functioning, symptoms, well-being, and health-related quality of life (HRQL). The aim of this study was to document the long-term effect of a 1-month inpatient cardiac rehabilitation intervention on HRQL in Austria. Patients (N = 487, 64.7% male, age 60.9 ± 12.5 SD years) after myocardial infarction, with or without percutaneous interventions, coronary artery bypass grafting or valve surgery underwent inpatient cardiac rehabilitation and were included in this long-term observational study (two years follow-up). HRQL was measured with both the MacNew Heart Disease Quality of Life Instrument [MacNew] and EuroQoL-5D [EQ-5D]. All MacNew scale scores improved significantly (p < 0.001) and exceeded the minimal important difference (0.5 MacNew points) by the end of rehabilitation. Although all MacNew scale scores deteriorated significantly over the two year follow-up period (p < .001), all MacNew scale scores still remained significantly higher than the pre-rehabilitation values. The mean improvement after two years in the MacNew social scale exceeded the minimal important difference while MacNew scale scores greater than the minimal important difference were reported by 40-49% of the patients. Two years after rehabilitation the mean improvement in the EQ-5D Visual Analogue Scale score was not significant with no significant change in the proportion of patients reporting problems at this time. These findings provide a first indication that two years following inpatient cardiac rehabilitation in Austria, the long-term improvements in HRQL are statistically significant and clinically relevant for almost 50% of the patients. Future controlled randomized trials comparing different cardiac rehabilitation programs are needed.
    Full-text · Article · Dec 2009 · Health and Quality of Life Outcomes
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    ABSTRACT: Objects: Verification of efficiency concerning the cardiac rehabilitation outcome during a four-week inpatient stay subsequent to an acute cardiac event. Methods: Prospectively, a total of 650 patients were assessed in the 6 cardiologic rehabilitation centres of the pension insurance company in Austria who joined the study for a period of 12 weeks per center in the years 2004 and 2005. The study included patients with conditions after acute coronary syndrome respectively myocardial infarction, after aortocoronary bypass surgery, and after valvular heart surgery. The evaluation of the efficiency of rehabilitation concerned physical ability, blood pressure, metabolic parameters, and cigarette smoking at admission to and at discharge from the rehabilitation stay. Results: The inpatient rehabilitation stay resulted in a significant improvement of physical ability as measured by diagnostic ergometry as well as bicycle ergometer training. Systolic and diastolic blood pressure could be lowered almost to the optimal values regarding the ESH/ ESC guidelines. The parameters of the lipid metabolism - total cholesterol, LDL-cholesterol, and triglycerides - improved significantly. Conclusions: A multi-professional rehabilitation team can noticeably improve physical ability, cardiac risk factors, and quality of life in cardiac patients by a well-structured and personalised rehabilitation program, establishing a basis for a long-lasting change in lifestyle.
    No preview · Article · Jan 2009 · Journal fur Kardiologie
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    ABSTRACT: ZusammenfassungHintergrund: Die alarmierende Zunahme chronischer Schmerzen des Stütz- und Bewegungsapparates gibt Anlass zur Suche nach neuen kausalorientierten, präventiven, insbesondere kostenreduzierenden Massnahmen. Hierzu gehören neben der reinen Schmerzbehandlung auch präventive Massnahmen zur Beeinflussung der die Grösse der Infarktareale beeinflussenden Adhäsionsmoleküle (PECAM-1, Platelet-endothelial Cell Adhesion Molecule, und P-Selektin). Zielsetzung: Ausgerichtet auf die Behandlung von Patienten mit chronischem Kreuzschmerz sollte in diesem Zusammenhang untersucht werden, ob und inwieweit eine zu etablierten, standardisierten Rehabilitationsverfahren additive nicht-invasive Intervention mit speziell konzipierten elektromagnetischen Stimulationssignalen grosser spektraler Bandbreite hier hinsichtlich der folgenden Zielparameter zu Verbesserungen führen kann: schmerzende Störungen des Stütz- und Bewegungsapparates, Depression, Angst, Schlafqualität, Infarktareale beeinflussende Adhäsionsmoleküle (PECAM-1 und P-Selektin). Methoden: An der randomisierten, doppelblind placebokontrollierten Duo-Center-Studie (GCP-Standard, Untersuchungszeitraum 3 Wochen) beteiligten sich 44 Patienten mit chronischen Rückenschmerzen (low-back pain). Die elektromagnetische Intervention erfolgte additiv zu einem standardisierten Rehabilitationskonzept über flexible Ganzkörper-Elektromagnetfeldmatten. Zur Bewertung wurden validierte Beweglichkeitsmessungen, Fragebögen und enzymimmunologische Analysen herangezogen. Ergebnisse: In beiden Gruppen zeigten sich signifikante Verbesserungen von Ruhe-, Bewegungs-, Druckschmerz, Angst und Depression. Die elektromagnetische Behandlung führte darüberhinaus zu einer weiteren signifikanten Verbesserung der Beweglichkeit (Finger-Fussbodenabstand) und der Schlafqualität sowie einer signifikanten Verminderung des Adhäsionsmoleküls PECAM-1 in beiden Gruppen, nicht aber des P-Selektins. Schlussfolgerungen: Die erfolgreichen Therapiemassnahmen im Verlauf des 3-wöchigen Rehabilitationsaufenthaltes dürften die Wirkungen der elektromagnetischen Intervention teilweise maskieren. Trotz der gefundenen signifikanten Effekte der elektromagnetischen Behandlung sind diese für eine praxisrelevante Anwendung jedoch noch nicht ausreichend genug. Neben einer verlängerten Anwendungsdauer von mehr als 3 Wochen könnte sich auch auf Grund derzeitiger Forschungs- und Weiterentwicklung der gewählten Signalform eine Optimierung der Therapie einstellen. Insofern erscheint eine derartige Behandlungsform als adjuvante Massnahme zur Verbesserung von Schmerz, Schlaf und schmerzbedingter Angst und Depression bei chronischem Kreuzschmerz geeignet.
    No preview · Article · Jan 2009
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    ABSTRACT: Exercise testing is a standard procedure in cardiology. This has not changed with newer diagnostic procedures. The purpose of this recommendation is to give a practical overview about ergometry. It contains physiologic fundamentals as well as an overview about assumptions, indications, contraindications and criteria about interruption. Recommendations about the procedure, valuation of measured parameters and different influences are given.
    No preview · Article · Jan 2008 · Journal fur Kardiologie
  • W Kullich · N Fagerer · H Schwann
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    ABSTRACT: Osteoarthritis (OA) of the knee is a secondary inflammatory, painful disease of the knee joint with increasing destruction of the articular cartilage. In the inflammatory process the formation of free radicals (reactive oxygen species, ROS) plays a major role in progression of disease and in the subsequent destruction of joint cartilage. The aim of this pilot study was to examine the antioxidative potency of the non-steroidal anti-inflammatory drug (NSAID) nimesulide on glutathione S-transferase (GST), an enzymatic free radical scavenger. In addition, the effects on matrix metalloproteinase MMP-3 and its antagonist tissue inhibitor of matrix-metalloproteinase 3 (TIMP-1) were determined. This was an open-pilot study on 20 patients (aged 41-71 years old) suffering from painful OA of the knee, treated for 3 weeks with nimesulide 100 mg b.i.d. Twenty-three healthy subjects (aged 23-57 years), not age matched, served as a comparison group. GST, MMP-3 and TIMP-1 were measured by enzyme-immunoassays. Clinical symptoms and joint function were measured using the WOMAC Index. During the 3-week treatment period with nimesulide 100 mg b.i.d., both scavenger GST and the TIMP-1/MMP-3 ratio significantly increased. This change was accompanied by significant clinical improvement in terms of pain reduction, stiffness and joint function. Two adverse events occurred possibly related to nimesulide treatment: one case of moderate eyelid swelling, and one case of moderate diarrhea with no abnormality in the endoscopic examination. These results confirm the antioxidative properties of the study drug, indicating that nimesulide, beside its known anti-inflammatory properties, also shows an evident antioxidative activity that adds further supportive evidence to its key role in the treatment of OA patients (thanks to the absence of degenerative effects on cartilage).
    No preview · Article · Sep 2007 · Current Medical Research and Opinion
  • N. Fagerer · H. Schwann · W. Kullich
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    ABSTRACT: Introduction: Substances contained in the smoke act prooxdidative leading to formation of free radicals which damage biomolecules, reduce radical scavenger activitiy and increase oxidative stress. Aim of the study was to analyse changes in oxidative stress as a consequence of ban on smoking during 3-week inpatient rehabilitation. Method: In 72 patients (44.4% smokers, 55.6% nonsmokers) suffering from cardiovascular or rheumatic disease, oxidative stress was examined within the rehabilitation stay with measurement of lipidperoxides, peroxidases and pseudoperoxidases, adaptive radical scavengers and gluathione S-transferase π. Results: Smokers had enhanced oxidative stress compared to nonsmokers at the beginning of rehabilitation, measured by increased lipidperoxide concentration, lower peroxidase and significantly reduced glutathione S-transferase concentrations. Smokers peroxidase concentrations increased significantly during 3-week rehabilitation, nonsmokers didn't show any difference. In case of smokers and nonsmokers, lipidperoxides could be significantly decreased and glutathione S-transferase could be increased. Conclusion: A ban on smoking within a medical facility can help to reduce patients oxidative stress and consequently can improve success of medical attendance.
    No preview · Article · Sep 2007 · Pravention und Rehabilitation
  • N. Fagerer · H. Schwann · W. Kullich

    No preview · Article · Jul 2007 · Atemwegs- und Lungenkrankheiten
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    ABSTRACT: An objective of exercise-based cardiac rehabilitation is improvement in patient-reported outcomes such as health-related quality of life as well as anxiety and depressive symptoms. There are no direct comparisons of the effectiveness of inpatient and outpatient exercise-based cardiac rehabilitation programmes on patient-reported outcomes. In this non-randomized study we collected patient-reported outcomes data with the MacNew Heart Disease health-related quality of life questionnaire and the Hospital Anxiety and Depression Scale at baseline, 1 month and again 3 months after admission to exercise-based cardiac rehabilitation in a cohort of 216 consecutive patients enrolled either in a 4-week inpatient exercise-based cardiac rehabilitation (n=62) or a 3-month outpatient exercise-based cardiac rehabilitation (n=87) and in a usual care group (n=67) to document the natural course in patient-reported outcome variables without exercise-based cardiac rehabilitation. Although MacNew health-related quality of life scores improved more with inpatient than outpatient exercise-based cardiac rehabilitation by month 1, the improvement was still significant in both groups at month 3 and also in the usual care group when compared to baseline. The health-related quality of life scores in the inpatient group, however, decreased between month 1 and 3 whereas they continued to improve in the outpatient group. The significant reduction in both anxiety and depressive symptoms in both exercise-based cardiac rehabilitation groups by month 1 was maintained at month 3 only with outpatient exercise-based cardiac rehabilitation. No significant changes over the 3 months were observed in the usual care group. Significant improvements of 1-month patient-reported outcomes are achieved in patients attending inpatient as well as outpatient exercise-based cardiac rehabilitation when compared with no exercise-based cardiac rehabilitation. In contrast to inpatient exercise-based cardiac rehabilitation, however, outpatient exercise-based cardiac rehabilitation leads to a further improvement of patient-reported outcomes. These results suggest that, if patients have to be admitted for inpatient exercise-based cardiac rehabilitation, this programme should be followed by an outpatient exercise-based cardiac rehabilitation to further improve and stabilize these patient-reported outcome variables.
    No preview · Article · Jul 2007 · European Journal of Cardiovascular Prevention and Rehabilitation
  • N. Fagerer · H. Schwann · W. Kullich
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    ABSTRACT: Introduction: Substances contained in the smoke act prooxdidative leading to formation of free radicals which damage biomolecules, reduce radical scavenger activitiy and increase oxidative stress. Aim of the study was to analyse changes in oxidative stress as a consequence of ban on smoking during 3-week inpatient rehabilitation. Method: In 72 patients (44.4% smokers, 55.6% nonsmokers) suffering from cardiovascular or rheumatic disease, oxidative stress was examined within the rehabilitation stay with measurement of lipidperoxides, peroxidases and pseudoperoxidases, adaptive radical scavengers and gluathione S-transferase π. Results: Smokers had enhanced oxidative stress compared to nonsmokers at the beginning of rehabilitation, measured by increased lipidperoxide concentration, lower peroxidase and significantly reduced glutathione S-transferase concentrations. Smokers peroxidase concentrations increased significantly during 3-week rehabilitation, nonsmokers didn't show any difference. In case of smokers and nonsmokers, lipidperoxides could be significantly decreased and glutathione S-transferase could be increased. Conclusion: A ban on smoking within a medical facility can help to reduce patients oxidative stress and consequently can improve success of medical attendance.
    No preview · Article · Jul 2007 · Atemwegs- und Lungenkrankheiten
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    ABSTRACT: The goal of cardiac rehabilitation programs is not only to prolong life, but also to improve physical functioning, symptoms, wellbeing and health-related quality of life (HRQL). The aim of the study was to document short-term outcomes of cardiac rehabilitation programs in Austria. Consecutive patients (N = 487, 64.7% male, age 60.9 +/- 12.5 SD years) after myocardial infarction (MI), with or without percutaneous interventions (PCI), coronary artery bypass grafting (CABG) or heart valve surgery (HVS), referred to the six inpatient rehabilitation centers of the Austrian PVA insurance company, were included in the study. Exercise capacity, risk factors and HRQL (MacNew Heart Disease Quality of Life Instrument [MacNew] and EuroQoL-5D [EQ-5D]) were measured at the beginning and end of the 4-week inpatient cardiac rehabilitation program. Global HRQL (MacNew) improved significantly over time in all patients combined (+0.75 +/- 0.88 SD, T = -16.99, df = 394, p < .001) and exceeded the minimal important difference. Patients with CABG, HVS or MI without PCI showed the greatest improvements in global HRQL after cardiac rehabilitation (p < .02). Blood pressure, cholesterol, triglyceride, body mass index, waist circumference improved significantly (all p < .001). These findings provide evidence that the improvements in HRQL and risk factors following cardiac rehabilitation in Austria are clinically important. HRQL should become a standard outcome parameter in cardiac rehabilitation.
    No preview · Article · Dec 2006 · Wiener klinische Wochenschrift

  • No preview · Article · May 2006 · European Journal of Cardiovascular Prevention and Rehabilitation
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    G Klein · W Kullich · J Schnitker · H Schwann
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    ABSTRACT: The objective of this study was to establish the non-inferiority of an oral enzyme therapy (Phlogenzym-(PE)) as compared to the non-steroidal anti-inflammatory drug (NSAID) diclofenac (DC) in patients with osteoarthritis (OA) of the hip. Ninety patients presenting with painful episodes of OA of the hip were treated for 6 weeks in one study centre in a phase III, randomised, double blind, parallel group trial. Altogether, 45 patients were treated in the PE group and 45 patients were treated in the DC group. Primary efficacy criteria were: WOMAC dimensions pain, joint stiffness and function, and Lequesne index as multiple endpoint according to O'Brien. The efficacy criteria were analysed applying the test of non-inferiority with regard to mean changes and frequencies, t-test, U test, ANCOVA and descriptive methods. Within the 6 weeks observation period, the adjusted changes from baseline to endpoint of the target parameters worked out as follows (adjusted differences, mean +/- SEM): WOMAC subscale pain (PE -10.3 +/- 1.2, DC -9.5 +/- 1.2), WOMAC subscale joint stiffness (PE -3.9 +/- 0.5, DC -3.6 +/- 0.5), WOMAC subscale physical function (PE -31.7 +/- 3.5, DC -29.7 +/- 3.5), Lequesne's index (PE -2.89 +/- 0.47, DC -2.27 +/- 0.47). Non-inferiority of PE as compared to DC with regard to the O'Brien's global sum of the standardised adjusted changes from baseline to endpoint in pain, stiffness, physical function, and Lequesne's index was established with p = 0.0025. PE was simultaneously non-inferior as compared to DC with regard to the 4 single endpoints: WOMAC subscale pain (p = 0.0033), WOMAC subscale joint stiffness (p = 0.0061), WOMAC subscale physical function (p = 0.0039), Lequesne's index (p = 0.0008) (closed test procedure). The equivalence tests remained insignificant due to comparatively lower effects of DC. For 71.1% of the PE patients and for 61.4% of the DC patients rates of good or very good global investigator assessments of efficacy were calculated (test of non-inferiority: p = 0.0011). In the majority of patients, tolerability was judged in both drug groups as very good or good. This trial showed significant non-inferiority from 6 weeks treatment with PE in patients with OA of the hip with regard to the WOMAC dimensions pain, stiffness and physical function, to Lequesne's index, to the investigator and patients assessments of efficacy, and to the responder rates based on pain, physical function, and patient assessment of efficacy. With regard to drug tolerability some tendencies in favour of PE were detected. However, in this study there was no real difference between PE and DC 100 mg/day, implying an equal benefit-risk relation between the substances. PE may well be recommended for the treatment of patients with osteoarthritis of the hip with signs of inflammation as indicated by a high pain level.
    Preview · Article · Jan 2006 · Clinical and experimental rheumatology
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    ABSTRACT: Additionally to a standardized physiotherapy programme, a treatment system basing on nuclear resonance (MBSTR - Nuclear Resonance Therapy was used in therapy of 62 rehabilitation patients suffering from chronic Low Back Pain. The study was performed double blind, placebo-controlled and randomised. Examinations were made at baseline, 1 week, and 3 months after application of a five-day Nuclear Resonance Therapy series. The intensity of pain was established by means of the Visual Analogue Scale (VAS), and restrictions by Low Back Pain were evaluated by means of the Oswestry Disability Questionnaire. VAS measurements showed significant reduction of pain during rehabilitation in favour of MBSTR after 3 months. The Oswestry total score improved significantly in both groups - standardized rehabilitation programme with and without nuclear resonance application - 1 week after therapy. 3 months after therapy, the Oswestry total score of the MBSTR group remained significantly improved (p<0.01) as compared with the placebo group. Major improvements were especially gained in the Oswestry section "personal care". The condition of none of the patients with MBSTR was worse after 3 months. Hence, in future the MBSTR - Nuclear Resonance Therapy may represent an additional treatment in rehabilitation of patients suffering from Low Back Pain. This additional treatment allows to further enhance the significant success in rehabilitation of spine related complaints.
    No preview · Article · Jan 2006
  • W. Kullich · H. Schwann · J. Walcher · K. Machreich
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    ABSTRACT: A new treatment system using nuclear resonance as its active principle was applied, as an adjunct to a normal standardized physiotherapy programme. This novel NuclearResonanceTherapy (MBST® or MBS-Therapy) was applied for one hour on five successive days. The study was performed double blind, placebo-controlled and randomised on 62 rehabilitation patients suffering from chronic Low Back Pain at baseline, after one week and after 3 months. The pain measurements using the Visual Analogue Scale (VAS) showed a distinct reduction of pain after active MBST® and placebo. The Roland & Morris Disability Index (RM) total score also improved significantly in both groups, but the improvement was more distinct in MBST® patients compared to placebo. After three months, the positive effect of MBST® on the RM total score was still significant (p < 0.00001) whereas this was not the case for the placebo-treatment. The significant improvement in the MBST®-group was primarily evident in the RM-questions regarding incapacities caused by Low Back Pain, particularly sleeping problems, fatigue, bending ability, and the time required to get dressed. NuclearResonanceTherapy as a complementary treatment can improve the outcome obtained by inpatient rehabilitation programmes after 3 months.
    No preview · Article · Jan 2006 · Journal of Back and Musculoskeletal Rehabilitation
  • W. Kullich · N. Fagerer · H. Schwann
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    ABSTRACT: Osteoarthritis (OA) of the knee is a degenerative, often painful disease of the knee joint with increasing destruction of the articular cartilage. In the inflammatory process the formation of free radicals (ROS, Reactive Oxygen Species) plays a major role in progression of disease and in the subsequent destruction of joint cartilage. The aim of the pilot study was to examine the antioxidative potency of the nonsteroidal anti-inflammatory drug (NSAID) nimesulide on glutathione transferase (GST), an enzymatic free radical scavenger. In addition, the effects on matrix-metalloproteinase MMP-3 and its antagonist TIMP-1 (Tissue Inhibitor of Matrix-metalloproteinase 3) were determined. GST, MMP-3 and TIMP-1 were measured by enzyme-immunoassays. A 3 weeks treatment with nimesulide significantly increased the scavenger GST parallel to clinical improvement and increase of TIMP/MMP-3 ratio. The results indicate that nimesulide additionally to its known anti-inflammatory properties shows also an evident antioxidative activity further supporting its key role in the treatment of OA patients thanks to the absence of negative effects on the cartilage.
    No preview · Article · Jan 2006 · Journal fur Mineralstoffwechsel
  • W Kullich · H Neff · G Pöllmann · K Machreich · H Schwann
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    ABSTRACT: In rheumatoid arthritis (RA) the adhesion molecule ICAM-1 mediates the adhesion of leucocytes following subsequent transendothelial migration including interactions and adhesion of several cell types such as fibroblasts, T-lymphocytes and synoviocytes. Significantly increased ICAM-1 levels were measured in the acute phase of RA. The correlation of ICAM-1 levels with the pteridine neopterin (p < or = 0.01) may reflect the role of this adhesion molecule in modulation of immune responses. Despite the significantly higher levels of acute phase reactions parallel to the elevated ICAM-1 levels, no correlations were found between ICAM-1 and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and serum-Amyloid A (SAA). During an in-patient multidisciplinary rehabilitation programme the levels of ICAM-1 in serum and the majority of all investigated laboratory and clinical parameters such as ESR, CRP, SAA, fibrinogen, pain, swollen and painful joint count, morning stiffness and health assessment questionnaire improved.
    No preview · Article · Feb 1999 · Wiener Medizinische Wochenschrift