Hao-ran Sun

Tianjin Medical University, Charbin, Heilongjiang Sheng, China

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Publications (6)8.41 Total impact

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    ABSTRACT: To evaluate the value of diffusion-weighted imaging (DWI) in the differentiation of axillary inflammatory hyperplastic and metastatic lymph nodes. Forty female New Zealand white rabbits were divided randomly into 2 groups (n = 20 each). And the animal models of axillary inflammatory hyperplastic and metastatic lymph nodes were established. All successfully implanted models received conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) examinations. The features of signal intensity and shapes of lymph nodes were observed in two groups. The sizes of lymph nodes were measured on the selected axial T(2)WI. The signal intensity and appearance diffusion coefficient (ADC) value of lymph nodes and dorsal muscle at the same slice were measured on the selected T(2)WI, DWI and ADC map respectively. The relative signal intensity (rSIT(2)WI, rSIDWI) and relative ADC (rADC) value of lymph nodes to dorsal muscle were calculated and compared. The diagnostic efficacy of differentiating benign and malignant lymph nodes was analyzed with rADC value through the receiver operating characteristic curve. The correlation between rADC value and cell density was assessed with pathological findings as reference standard. The differences of size, rSIT(2)WI and rSIDWI were not statistically significant between two groups. The rADC value of inflammatory lymph nodes was greater than that of metastatic lymph nodes (0.91 ± 0.14 vs 0.64 ± 0.18). Significant difference existed (t = 3.879, P = 0.03). But there was a little overlap between two groups. With 0.78 as the diagnostic threshold of rADC value, the sensibility and specificity was 86.2% and 74.4% respectively. The correlation between rADC value and cell density of inflammatory hyperplastic and metastatic lymph nodes was significantly inverse (r = -0.53, P = 0.003). As compared with the routine MRI sequence, rADC value has a higher diagnostic efficacy in the differentiation of benign and malignant lymph nodes. Cell density may be the most important influencing factor for the differences of rADC value between two groups of lymph nodes.
    No preview · Article · Mar 2012 · Zhonghua yi xue za zhi
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    ABSTRACT: Uterine leiomyosarcoma is an uncommon malignant neoplasm of smooth muscle origination and is associated with a poor prognosis. We report two cases of uterine leiomyosarcoma that presented with pulmonary metastases. 2-deoxy-2-(¹⁸F)fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) was performed to identify the primary carcinoma and found the focus located in the uterus. The follow-up magnetic resonance imaging (MRI) confirmed the diagnosis was uterine leiomyosarcoma.
    No preview · Article · Jul 2011 · Chinese medical journal
  • Hai-yan Qin · Hao-ran Sun · Ya-jun Li · Bao-zhong Shen
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    ABSTRACT: CT perfusion imaging has been used in diagnosis and classification of tumors widely and in assess tumor angiogenesis in some organs. However, there are few reports describing CT perfusion imaging of adrenal gland tumors. This study aimed to evaluate the application of CT perfusion imaging in analysis of angiogenesis in adrenal tumors and in diagnosis of adrenal tumors. Forty four patients with adrenal gland tumors (26 with adenomas and 18 with nonadenomas) were enrolled in this study. CT scan of adrenal glands was performed with the perfusion of non-ionic contrast medium Ultravist. The obtained images were processed with deconvolution algorithms-based perfusion software and then perfusion parameter maps and values (blood flow, blood volume, mean transit time, and permeability surface-area production) were generated and analyzed respectively. Univariate multivariate logistic regression indicated that blood volume (OR: 1.261, 95% CI: 1.056, 1.505, P=0.010) was associated with the likelihood of adrenal adenoma. Receiver operating characteristic analysis showed that the blood volume value of ≥9.325 ml min(-1) 100 g(-1) predicted adrenal adenoma with sensitivity of 76.9% and specificity of 73.2%. In addition, permeability surface-area production in adenoma was higher than in non-adenoma (27.11±15.45 vs. 16.76±14.44 ml min(-1) 100 g(-1), P<0.05). The other parameters had no clear prognostic significance. CT perfusion imaging can quantitatively distinguish adrenal gland tumors with different histological characteristics. Especially, blood volume can be used in differentiating adrenal adenomas from nonadenomas.
    No preview · Article · Feb 2011 · European journal of radiology
  • Jun-ping Wang · Hao-ran Sun · Ya-jun Li · Ren-ju Bai · Shuo Gao

    No preview · Article · Oct 2009 · Chinese medical journal
  • Jun-Ping Wang · Ren-Ju Bai · Hao-Ran Sun · Xin Zhao · Ya-Jun Li · Jing Yang
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    ABSTRACT: To investigate the correlation between MR diffusion weighted imaging with cellularity and PCNA-LI of rabbit liver VX2 tumor models in different periods. 38 successful implanted rabbits were assigned randomly into 2 equal groups and were performed MR DWI in different periods (14 and 21 d) after implantation respectively. Specimens of all tumors were stained with HE and PCNA-LI after MR examination. (1) The ADC value (x 10(-3) mm2/s) in surrounding solid components of liver VX2 tumors in the group of 21 d was lower than that of the group of 14 d (0.77 +/- 0.19 vs 1.00 +/- 0.24, P = 0.007); (2) the cellularity and PCNA-LI in surrounding solid components of liver VX2 tumors in the group of 21 d were higher than those of the group of 14 d respectively (63% +/- 7% vs 43% +/- 10%, P = 0.011; 80% +/- 11% vs 56% +/- 8%, P = 0.008); (3) there were negative correlation between ADC value and cellularity, PCNA-LI of the solid components of the tumors (r = - 0.695, P = 0.000; r = -0. 698, P = 0.000). The cellularity may be the most important factor that affects ADC value in solid components of liver VX2 tumors. Since the degree of malignancy is closely connected with cellularity and PCNA labeling index, ADC value measurement may be a new method which could predict the degree of malignancies in vivo.
    No preview · Article · Aug 2009 · Zhonghua yi xue za zhi
  • Ya-Jun Li · Li Cai · Hao-Ran Sun · Shuo Gao · Ren-Ju Bai
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    ABSTRACT: A case of isolated bilateral adrenal tuberculosis is presented. A 49-year-old man was admitted to the hospital due to fatigue, progressive anorexia accompanied with nausea and vomiting, weight loss, and pigmentation. Ultrasound and CT showed soft tissue masses in bilateral adrenal glands. Whole-body FDG PET-CT showed bilateral adrenal masses with increased FDG uptake. These unique manifestations indicated that the masses were primary malignancies or tuberculosis. MRI demonstrated irregular low signal intensity in the left adrenal mass on T2WI, which suggested tuberculosis, and histopathology confirmed the diagnosis. This uncommon case underscores the necessity of keeping adrenal tuberculosis in mind as a possible differential diagnosis in bilateral adrenal masses.
    No preview · Article · Apr 2008 · Clinical Nuclear Medicine

Publication Stats

41 Citations
8.41 Total Impact Points


  • 2009-2011
    • Tianjin Medical University
      • Department of Radiology
      Charbin, Heilongjiang Sheng, China