L C Galvão

University of São Paulo, San Paulo, São Paulo, Brazil

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Publications (28)29.66 Total impact

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    ABSTRACT: To analyse aspects of mineral metabolism, bone mineral density (BMD), bone remodelling activity and serum IGF-1 levels in children with chronic cholestatic disease (CCLD). A total of 13 children with chronic cholestatic liver disease (CCLD; mean age 7.2 +/- 4.8 years) and 22 control subjects (mean age 7.6 +/- 4.5 years) were studied. Serum osteocalcin, bone alkaline phosphatase (BAP), 25-hydroxyvitamin D, PTH and IGF-1 levels and urinary deoxypyridinoline were determined. BMD was measured by dual-energy X-ray absorptiometry in the lumbar spine, total hip and whole body. Lumbar spine areal BMD was converted mathematically to apparent volumetric BMD (aBMD) and corrected for the bone age of the patient. Z-score of lumbar spine BMD was lower in CCLD patients than in controls and the difference was maintained when BMD was expressed as aBMD (control = 0.107 +/- 0.02 vs. CCLD = 0.092 +/- 0.02 g/cm(3), P < 0.05) and after conversion for bone age. All participants showed normal 25-hydroxyvitamin D levels, with no significant differences in serum levels of 25-hydroxyvitamin D and PTH between groups. IGF-1 levels were significantly lower in the CCLD group (control = 19.6 +/- 16.8 vs. CCLD = 6.4 +/- 7.6 nmol/l, P < 0.05) and a positive correlation was observed between whole body BMD and IGF-1 in this group. These results indicate that CCLD limits bone mass gain in children. A reduction in hepatic IGF-1 production might be responsible, at least in part, for the low bone mass of these patients.
    No preview · Article · May 2007 · Clinical Endocrinology
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    ABSTRACT: Celiac disease (CD) is an underdiagnosed disease occurring in different clinical forms. This study aimed to determine the prevalence of CD among blood donors from Ribeirão Preto, Brazil, and to study some demographic characteristics of celiac patients. Blood samples from 3000 blood donors were tested for the presence of tissue transglutaminase antibody and positive samples were tested for endomysial antibody. Donors positive to both tests were referred for clinical evaluation and for a jejunal biopsy. Twenty-four samples were moderately/strongly positive for transglutaminase, with 9 of them being endomysial negative and 15 positive. Of the 13 biopsies obtained from 12 females and 1 male, 1 was classified as Marsh grade IV, 4 as grade III, 2 as grade II, 4 as grade I, and 2 as grade 0. Estimated prevalence was therefore 1:273 (0.33%; 95% CI, 0.127 to 0.539). The 1:273 estimated prevalence of CD detected indicates that the disease is not rare in Brazil. The frequency was higher among females and among individuals of European descent, with a significantly higher frequency for a family history of digestive tract cancer or epilepsy.
    No preview · Article · Jun 2006 · Digestive Diseases and Sciences
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    ABSTRACT: The anorectal manometry is a very utilized and well recognized examination in children with chronic functional constipation. The major manometric findings in these children are: anal hypotonia, anal hypertonia, paradoxal contraction of the external anal sphincter, decreased ability of internal anal sphincter to relax during rectal distension and alterations in rectal contractility, sensibility and compliance. To evaluate the anal basal pressure and the relaxation reflex before and after standard treatment for a better understanding of the physiopathologic mechanisms involved in pediatric chronic functional constipation. Anorectal manometry was performed before treatment on 20 children with chronic functional constipation aged 4 to 12 years and the results were compared to those obtained after standard treatment, with a good outcome. There was a reduction in anal basal pressure after treatment, but no differences were detected between the anorectal manometries performed before and after treatment in terms of amplitude and duration of relaxation, residual pressure, latency time, or descent and ascent angle. We conclude that the anal basal pressure decreased in children recovering from chronic functional constipation, but the standard treatment did not provide all the conditions necessary for the relaxation reflex of constipated children to return to the values described in normal children.
    Preview · Article · Sep 2005 · Arquivos de Gastroenterologia
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    ABSTRACT: RACIONAL: Estudos demonstram mudança na forma de apresentação clínica da doença celíaca, com aumento da ocorrência de formas atípicas tanto em crianças, como em adultos. OBJETIVO: Verificar este fato em crianças atendidas em serviço universitário especializado (Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, SP.). MÉTODOS: Foram estudados pacientes celíacos em dois períodos: de janeiro de 1978 a dezembro de 1987 (grupo 1 = G1) e janeiro de 1988 a dezembro de 1997 (grupo 2 = G2). Foram analisados: tempo de doença, idade ao diagnóstico, estado nutricional e formas clínicas. Considerou-se forma típica se o paciente tinha pelo menos dois dos seguintes sinais/sintomas: diarréia, distensão abdominal, perda de peso, associados ou não a outros. A análise estatística foi realizada pelos testes exato de Fisher e de Wilcoxon. RESULTADOS: Mediana de idade ao diagnóstico: 23 meses (G1) e 21 (G2). Intervalo entre início de sintomas e diagnóstico: 13 meses (G1) e 11 (G2). Estado nutricional (%) Gomez: G1:eutrofia = 23,8; DI = 47,61; DII = 23,8 e DIII = 4,76. G2: eutrofia = 20,68, DI = 48,27, DII = 27,58 e DIII = 3,44. Waterloo: G1: eutrofia = 23,8, emaciação = 14,28 baixa estatura = 28,57 e crônico = 33,33. G2: eutrofia = 20,68, emaciação = 13,79, baixa estatura = 34,48 e crônico = 31,03. Formas clínicas (%) - G1: típica 57,14 e atípica 42,85. G2: típica 55,18 e atípica 44,82. Nenhum dado foi estatisticamente diferente nos dois grupos. CONCLUSÕES: No estudo não se encontrou mudança nas formas de apresentação e demais características clínicas da doença celíaca. Cogita-se que essa hipótese poderia ser decorrente de características populacionais, de diferenças na abordagem nos serviços de saúde ou de diferentes períodos de observação, em comparação com os demais estudos.
    Preview · Article · Dec 2004 · Arquivos de Gastroenterologia
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    ABSTRACT: Adult-type hypolactasia (AH) is the most common form of disaccharidase deficiency in humans, with a prevalence that varies among ethnic groups. In Brazil, the few available studies suggest a high prevalence of this condition. The objective of this study was to determine the prevalence of AH in Brazilian patients at the Ribeirão Preto University Hospital, and to study its morphologic and functional expression. One hundred fifteen patients between 5 and 60 years undergoing upper gastrointestinal endoscopy were included. Mucosal biopsy specimens were obtained from the second portion of the duodenum. AH was defined by the disaccharidase activity (lactase/sucrase ratio) of the duodenal mucosa. The morphologic expression of lactase was studied by immunohistochemistry. The mean age of the subjects was 28.8 +/- 14.8 years. Seventy of the 115 subjects (60.8% prevalence) had AH by enzyme activity measurements. Milk drinking was common and similar in patients with and without AH. Among the patients, 91.3% of the nonwhite and 53.2% of the white individuals had hypolactasia (P = 0.002). Immunohistochemistry revealed the presence of lactase in 73.3% of individuals with normal lactase activity. Two different expression patterns were found in patients with AH. The prevalence of AH was high in our subjects and similar to that reported in other Brazilian studies. Hypolactasia was more common among nonwhites. Immunohistochemistry permitted the identification of two phenotypes of AH, the first characterized by the absence of both stainable lactase and lactase activity, and the second by the presence of stainable lactase without significant activity.
    Full-text · Article · Nov 2004 · Journal of pediatric gastroenterology and nutrition
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    ABSTRACT: Objective: To evaluate the impact of anorectal manometry in the appraisal of fecal incontinence and on the diagnosis of Hirschsprung disease at the Gastroenterology Unit of the Pediatric Department (HCRP-USP). Methods: Retrospective analyses of the records of 130 children submitted to anorectal manometry in the investigation of intestinal constipation (group I) and of fecal incontinence (group II), correlating the manometric findings to barium enema, rectal biopsy, and clinical outcome. Results: In group I, the opaque barium enema was normal in 55%, the anorectal manometry demonstrated relaxation reflex in 80%, and the anorectal biopsy showed neurons in 52%. With these exams and clinical evolution, the children could be subdivided into the following groups: functional constipation (87), Hirschsprung's disease (11), and intestinal pseudobstruction (5). The 12 remaining children had stomas, eight of them due to enterocolitis, and four, due to temporary treatment of the anorectal malformation. In these children, the evaluation with barium enema, anorectal manometry and biopsy made possible to rule out the Hirschsprung's disease. In group II, one had meningomyelocele, two had fecal soiling, seven were in the post-surgical period of anorectal malformation, three in the post-surgical period for Hirschsprung, and two had chronic diarrhea. The mean basal anal pressure in a child in the post-surgical period for anorectal malformation was 50 mmHg and in two other children, it was < 20 mmHg. In one child in the post-surgical period for Hirschsprung, the pressure was 52 mmHg and in the children with fecal soiling, it was 55 mmHg. Conclusions: Anorectal manometry is an excellent method in the investigation of paediatric intestinal disorders. It can be used to rule out Hirschsprung disease and to evaluate fecal incontinence, because when the result is normal more invasive exams can be avoided.
    No preview · Article · Nov 2004 · GED - Gastrenterologia Endoscopia Digestiva
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    ABSTRACT: Several studies have demonstrated changes in the forms of clinical presentation of celiac disease in children and adults, with an increased occurrence of atypical forms. To determine this fact in Clinical Hospital, Ribeirão Preto, SP, Brazil. Celiac patients were studied over two different periods of time, from January 1978 to December 1987 (group 1 = G1) and from January 1988 to December 1997 (group 2 = G2). Time of disease, age at diagnosis and nutritional status and clinical forms were investigated. The typical form was considered to be present if the patient had at least two of the following signs/symptoms: diarrhea, abdominal distention, and weight loss, associated or not with others. Clinical forms (%) - G1: typical 57.14 and atypical 42.85. G2: typical 55.18 and atypical 44.82. Median age at diagnosis: 23 months (G1) and 21 months (G2). Interval between the onset of symptoms and the diagnosis: 13 months (G1) and 11 months (G2). Gomez nutritional status G1: Eutrophy = 23.8, DI = 47.61, DII = 23.8 and DIII = 4.76. G2: Eutrophy = 20.68, DI = 48.27, DII = 27.58 and DIII = 3.44. Waterloo G1: Eutrophy = 23.8, Wasting = 14.28, Stunting = 28.57 and Chronic = 33.33. G2: Eutrophy = 20.68, Wasting = 13.79, Stunting = 34.48 and Chronic = 31.03. No statistically significant differences occurred between the groups for any of these parameters. No change in the forms of presentation or remaining clinical characteristics of celiac disease occurred in our service. This may be due to the population characteristics or to differences among health services, or to different periods of observation.
    Preview · Article · Oct 2004 · Arquivos de Gastroenterologia
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    ABSTRACT: Background: Adult-type hypolactasia (AH) is the most common form of disaccharidase deficiency in humans, with a prevalence that varies among ethnic groups. In Brazil, the few available studies suggest a high prevalence of this condition. The objective of this study was to determine the prevalence of AH in Brazilian patients at the Ribeirão Preto University Hospital, and to study its morphologic and functional expression. Methods: One hundred fifteen patients between 5 and 60 years undergoing upper gastrointestinal endoscopy were included. Mucosal biopsy specimens were obtained from the second portion of the duodenum. AH was defined by the disaccharidase activity (lactase/sucrase ratio) of the duodenal mucosa. The morphologic expression of lactase was studied by immunohistochemistry. Results: The mean age of the subjects was 28.8 ± 14.8 years. Seventy of the 115 subjects (60.8% prevalence) had AH by enzyme activity measurements. Milk drinking was common and similar in patients with and without AH. Among the patients, 91.3% of the nonwhite and 53.2% of the white individuals had hypolactasia (P = 0.002). Immunohistochemistry revealed the presence of lactase in 73.3% of individuals with normal lactase activity. Two different expression patterns were found in patients with AH. Conclusions: The prevalence of AH was high in our subjects and similar to that reported in other Brazilian studies. Hypolactasia was more common among nonwhites. Immunohisto-chemistry permitted the identification of two phenotypes of AH, the first characterized by the absence of both stainable lactase and lactase activity, and the second by the presence of stainable lactase without significant activity.
    Full-text · Article · Sep 2004 · Journal of Pediatric Gastroenterology and Nutrition
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    Rosa H. M. Bigélli · Maria I. M. Fernandes · Lívia C. Galvão

    Preview · Article · Jan 2004
  • R.H.M. Bigélli · M.I.M. Fernandes · L.C. Galvão
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    ABSTRACT: Objective: To present an update review of intestinal constipation in children, analysing the principal clinic characteristics and its diagnostic and therapeutic approachs. Methods: Recent articles on the topic were reviewed, supplemented by the clinical experience of the Gastroenterology Unit, of the Pediatric Departement- HCRP- USP Results: The intestinal constipation is a commun problem in the pediatric clinics. Its definition is based on the elimination of painful, difficulted and dry feces. Infants usually present crying during the evacuations. In some children it can be observed important facael retention with or without soiling. The diagnosis is based on a deitailed clinical history and physical examination of the children. The diagnosis in the most of the cases may be done with a carefully clinical history and phisical examination. The treatment must be done according to the basal cause and in the most of the cases dietetic and comportamental changes are necessary. Conclusões: The diagnosis of the intestinal constipation must be done earlier because it is important for the therapeutic sucess, that depends on a adequate diet and a behavioral program to regulate bowel habits.
    No preview · Article · Jan 2004
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    ABSTRACT: To study the frequency of chronic constipation in childhood at a Primary Health Care Unit and to observe its characteristics in this population. The sample consisted of 313 children aged between one and 10 years treated at the Centro de Saúde Escola, in the district of Tibério, in the town of Ribeirão Preto. Among these, 84 children with chronic constipation were selected. The chi-squared test was used to compare the groups of constipated and nonconstipated children (p=0.01). The prevalence of chronic constipation was 26.8%. In the group of chronic constipation, 85.7% of the children had hardened stools, 25% showed reduction in fecal mass, 17.9% had an interval between evacuations longer than 2 days (constipated children), 14.3% revealed fecal soiling and 21.4% presented blood in stools. The prevalence of chronic constipation was high and the interval between evacuations was as an important diagnostic criterion for the selection of constipated children.
    Full-text · Article · Nov 2002 · Jornal de Pediatria
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    ABSTRACT: ABSTRACT: Objective: to analyze some clinical and laboratory characteristics in children with Hirschsprung’s disease. Methods: a retrospective study of all 53 children with Hirschsprung’s disease attended at the University Hospital, Faculty of Medicine of Ribeirão Preto, USP, from January 1981 to December 1999. Some clinical parameters were investigated at the first visit (patients distribution by gender, age at onset of signs and symptoms, at the first visit and at the time of diagnosis, main signs and symptoms, and nutritional status), as well as laboratory tests that permitted the diagnosis (some characteristics observed by barium enema, anorectal manometry and rectal biopsy) and the evolution of the patients after surgical treatment. Results: 42 children (79.2%) were boys. The first signs and symptoms occurred during the first month of life in 43 cases (81.1%), the average age at the first visit was 7 months and age at the time of diagnosis was 8.8 months. The main clinical manifestations were: abdominal distension in 83.0%, intestinal constipation in 73.6%, delayed passage of meconium in 60.7%. No important deficit in weight and height was observed. A barium enema showed a transition zone in 47.2% (17/36) and anorectal manometry revealed the absence of the relaxation reflex of the internal anal sphincter in 73.7% (14/19). All anorectal biopsies demonstrated aganglionosis. One child was submitted to clinical treatment and 52 to surgical treatment. Colostomy was performed in 22/52 children (42.3%) and definitive surgical treatment in 49 (Duhamel Haddad surgery in 77.6%, Soave surgery in 20.4% and Lestar Martin surgery in 2.0%). The most frequent complications before surgery were intestinal obstruction in 28.3% and enterocolitis in 11.3%. The major complications after colostomy were eventration and/or prolapse and/or stenosis in 22.7%, and the major complications after definitive surgical treatment were soiling and/ or fecal incontinence in 28.6%, infection and/or dehiscence of the surgical wound in 22.4%, and enterocolitis and/or diarrhea in 20.0%.Three children were not submitted to surgical treatment. Ten (18.9%) received ambulatory discharge, 14 (26.0%) are still being followed up and 27 (50.9%) abandoned the service. There was a death (1.9%) by enterocolitis some time after definitive surgical treatment and one child (1.9%) is still being followed up in another service, after reconstruction of the transit. Conclusions: there was a discrepancy between the age at onset of symptoms and the age at diagnosis, demonstrating a delay in patient referral for diagnostic confirmation. The late diagnosis probably determined the high percentage of presurgical complications of Hirschsprung’s disease, i.e.,: intestinal obstruction (28.3%) and enterocolitis (11.3%) which are the most frequent and continue to be the major causes of morbidity and mortality in this disease.
    Full-text · Article · Mar 2002
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    ABSTRACT: Patients with Aids (n = 39) were followed up for a maximum period of 36 weeks, after which the types and topographies of infectious complications presented and patient survival were analyzed and correlated with the vitamin A levels presented by the patients at the beginning of clinical follow-up. Twenty-one (53,8%) patients presented serum retinol levels below 1.6 micromol/L, 12 (57%) of whom had values lower than 1.05 micromol/L. There was no correlation between low serum vitamin A levels and the types or topographies of the infectious complications that occurred during the follow-up period. Although mean survival at the end of the 36 months follow-up period was similar for the two groups, patients with retinol deficiency presented a lower probability of survival during the first 24 months of follow-up compared to patients without hypovitaminosis A (8.44 x 1.42 months; p = 0.003).
    No preview · Article · Sep 2001 · Revista da Sociedade Brasileira de Medicina Tropical
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    ABSTRACT: Celiac disease (CD) is a permanent gluten intolerance disorder characterized by malabsorption, intestinal mucosa villus atrophy, and crypt hyperplasia. Clinical and histologic features improve in persons consuming a gluten free diet. The pathogenesis of CD involves environmental, genetic, and immunologic factors. The frequencies of human leukocyte antigen (HLA) class II alleles were evaluated in white Brazilian patients who had CD and compared with those observed in healthy individuals from the same geographical area (Ribeirão Preto, São Paulo) and of similar ethnic background. Twenty-five patients with CD, 11 females and 14 males, and 91 control individuals were studied. The HLA class II alleles were typed using amplified DNA hybridized with sequence-specific primers. Statistical analysis was performed using the two-tailed Fisher exact test. The relative risk (RR), etiologic fraction (EF), and preventive fraction (PF) were also estimated. The EF represents the attributable risk for the development of CD at the population level, whereas PF represents the protective risk. The frequency of the HLA-DRB1*03, HLA-DRB1*07, and HLA-DQB1*02 alleles was significantly increased in patients. The RR conferred by these alleles was 5.35, 7.15, and 10.6, respectively, and the EF was 48.7%, 44.7%, and 76%, respectively. The frequency of HLA-DQB1*06 alleles was significantly decreased in CD patients, conferring an RR of 0.08 and a PF of 48%. The results show that HLA-DRB1*03, HLA-DRB1*07, and HLA-DQB1*02 alleles conferred susceptibility to CD in Brazilian patients. In contrast, HLADQB1*06 alleles conferred protection against development of the disease.
    No preview · Article · Nov 2000 · Journal of Pediatric Gastroenterology and Nutrition
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    E C Dornelas · M I Fernandes · L C Galvão · G A Silva
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    ABSTRACT: OBJECTIVE: To characterize the involvement of the respiratory apparatus of patients with cystic fibrosis in order to obtain a comprehensive view of their pulmonary picture.METHODS: Data were obtained retrospectively from the medical records of 16 patients with cystic fibrosis; arterial gas and spirometry data were obtained prospectively for the same patients, who were not in an acute pulmonary situation. The patients were subjects of both sexes aged 6 years or older who were followed up at the Pediatrics Outpatient Clinic of the University Hospital, Faculty of Medicine of Ribeirão Preto, USP.RESULTS: Median patient age was 114 months (9 years and 6 months) ranging between 72 - 360 months, and 68.75% were males. Productive cough was the most frequent symptom observed in 75% of the population studied. All patients had positive sputum culture obtained at least one year before, with Pseudomonas aeruginosa being detected in 81.25% of the cases. Arterial gases revealed some abnormalities in 81.25% of the patients and spirometry revealed abnormalities in 56.25%.CONCLUSION: All patients presented at least one type of pulmonary alteration. Measurement of arterial gases detected a larger number of patients with altered pulmonary function than did spirometry, but the two examinations complemented each other for a good evaluation of pulmonary function.
    Preview · Article · Jul 2000 · Jornal de pediatria
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    M.R. Vieira · L.C. Galvão · M.I.M. Fernandes
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    ABSTRACT: Hypolactasia associated with severe iron-deficiency anemia has been reported in several studies. The objective of the present study was to determine whether hypolactasia is associated with the degree and duration of iron-deficiency anemia. Newly weaned male Wistar rats were divided into a control group receiving a diet supplemented with iron (C) and an experimental group (E) receiving a diet not supplemented with iron (iron-deficiency diet). The animals were studied on the 3rd, 5th, 7th, 14th, 21st, 28th and 35th days of the experiment, when overall and iron nutritional status and disaccharidase activity in the small intestine were determined by the Dahlqvist method. A reduction in weight occurred in the anemic animals starting on the 5th day of the study. Anemia was present in the experimental animals, with a progressive worsening up to the 14th day (hemoglobin: C = 13.27 and E = 5.37) and stabilizing thereafter. Saccharase and maltase activities did not differ significantly between groups, whereas lactase showed a significant reduction in total (TA) and specific activity (SA) in the anemic animals starting on the 21st day of the study. Median lactase TA for the C and E groups was 2.27 and 1.25 U on the 21st day, 2.87 and 1. 88 U on the 28th day, and 4.20 and 1.59 U on the 35th day, respectively. Median lactase SA was 0.31 and 0.20 U/g wet weight on the 21st day, 0.39 and 0.24 U/g wet weight on the 28th day, and 0.42 and 0.23 U/g wet weight on the 35th day, respectively. These findings suggest a relationship between the enzymatic alterations observed and both the degree and duration of the anemic process. Analysis of other studies on intestinal disaccharidases in anemia suggests that the mechanism of these changes may be functional, i.e., that the enterocytes may suffer a reduction in their ability to synthesize these enzymes.
    Preview · Article · Jun 2000 · Brazilian Journal of Medical and Biological Research
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    ABSTRACT: Capillaria hepatica is a helminth that may cause an extremely rare condition of parasitic hepatitis. Only 29 cases have been published, 2 of them in Brazil. We report here 3 cases of children in Brazil with massive hepatic capillariasis who presented the characteristic triad of this type of infection, i.e., persistent fever, hepatomegaly, and eosinophilia. The diagnosis was made by liver biopsy. All children responded well after treatment with thiabendazole (case 1), albendazole (case 3), and albendazole in combination with a corticoid (case 2). Case 1 has been followed-up for 24 years, an event not previously reported in the literature.
    Full-text · Article · Nov 1999 · The American journal of tropical medicine and hygiene
  • L Carvalho Galvão · M I Machado Fernandes · L C Peres · R Pérsio Sawamura
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    ABSTRACT: An 11-year-old boy was admitted to our service with a 1-month history of diarrhea and abdominal pain. He had sporadic vomiting on the first 3 days. Ten days later, anorexia developed with weight loss, asthenia, and then edema, starting in the legs and progressing to the abdomen and face. He had no fever. He reported having a history of two or three similar episodes of short duration each year since he was 2 years of age. Physical examination revealed a boy with a normal general appearance, with weight and stature under the 3rd percentile. He had cold and depressible edema on the legs, genitals, and abdomen. The findings in the chemistry profile were normal, except for total protein (4.8g/dl) and albumin (1.7 g/dl). The hematologic study showed only mild anemia (Hb 9.8 g/dl). Urine was normal. Three stool examinations for parasites and bacteria were negative. Chest roentgenogram was normal. Immunologic investigation was negative. Abdominal computed tomographic scan showed mesentery adenomegaly. Endoscopy of the digestive tract showed a duodenum with friable mucosa with prominent aspect. The colon contained multiple granulated and raised lesions, with central ulceration covered with fibrin, as well as scattered pseudopolyps. A jejunal biopsy was performed. What was the diagnosis?
    No preview · Article · Apr 1999 · Journal of Pediatric Gastroenterology and Nutrition

  • No preview · Article · Mar 1999 · Journal of Pediatric Gastroenterology and Nutrition
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    ABSTRACT: Iron-deficiency anemia is the nutritional deficiency most frequently occurring throughout the world, which manifests as a complex systemic disease involving all cells, affecting enzyme activities and modifying protein synthesis. In view of these considerations, the objective of the present study was to determine the effects of iron-deficiency anemia on disaccharidases and on the epithelial morphokinetics of the jejunal mucosa. Newly weaned male Wistar rats were divided into 4 groups of 10 animals each: C6w received a standard ration containing 36 mg elemental iron per kg ration for 6 weeks; E6w received an iron-poor ration (5-8 mg/kg ration) for 6 weeks; C10w received an iron-rich ration (36 mg/kg ration) for 10 weeks; E10w received an iron-poor ration for 6 weeks and then an iron-rich ration (36 mg/kg) for an additional 4 weeks. Jejunal fragments were used to measure disaccharidase content and to study cell proliferation. The following results were obtained: 1) a significant reduction (P < 0.001) of animal weight, hemoglobin (Hb), serum iron and total iron-binding capacity (TIBC) in group E6w as compared to C6w; reversal of the alterations in Hb, serum iron and TIBC with iron repletion (E10w = C10w); animal weights continued to be significantly different in groups E10w and C10w. 2) Sucrase and maltase levels were unchanged; total and specific lactase levels were significantly lower in group E6w and this reduction was reversed by iron repletion (E10w = C10w). 3) The cell proliferation parameters did not differ between groups. On the basis of these results, we conclude that lactase production was influenced by iron deficiency and that this fact was not related to changes in cell population and proliferation in the intestinal mucosa.
    Preview · Article · Jul 1997 · Brazilian Journal of Medical and Biological Research

Publication Stats

163 Citations
29.66 Total Impact Points

Institutions

  • 1997-2007
    • University of São Paulo
      • • Ribeirão Preto School of Medicine (FMRP)
      • • Department of Clinical Medicine (VCM)
      • • Departamento de Puericultura e Pediatria (Ribeirão Preto)
      San Paulo, São Paulo, Brazil
  • 1995
    • Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
      San Paulo, São Paulo, Brazil