P Cugini

Sapienza University of Rome, Roma, Latium, Italy

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Publications (264)253.46 Total impact

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    ABSTRACT: Diabetes mellitus (DM) can be complicated by an involvement of Neurovegetative System (NVS), conventionally and non-invasively diagnosed by the means of Ewing's test and Heart Rate Variability (HRV) analysis. It is well known that the NVS is physiologically responsible, via biological clocks, for the regulation of Circadian Rhythms (CR) characterizing the majority of biological functions. Therefore, this study is aimed at investigating the CR of Heart Rate (HR) and Blood Pressure (BP) in DM, postulating that the diagnosis of Silent Cardiac Dysautonomia (SCD) could be facilitated by detecting anomalous rhythmometric changes, including the worse one, i.e., the lose of a CR. The study has been performed on 30 clinically healthy subjects (CHS), 10 patients with DM1 and 30 patients with DM2, who underwent an ambulatory BP monitoring (ABPM) collecting data equidistantly every 30 minutes, under standardized conditions of lifestyle. The group specific monitored values of systolic (S), diastolic (D) BP, as well as HR have been analyzed via: 1. a conventional analysis of their intradiem variability; 2. a chronobiometric analysis (Cosinor method) of their CR. The conventional analysis disclosed that in CHS, DM1 and DM2, both the HR and BP show an intradiem variability that is significant (p less than 0.001). The chronobiological analysis showed that in CHS and DM2, both the HR and BP show a significant CR (p less than 0.001), viceversa in DM1 HR is characterized by a non significant CR (p=0.124), notwithstanding that the SBP and DBP maintain a significant CR (p less than 0.001). The disappearance of HR CR in DM1 reveals the involvement of neurovegetative biological clock that selectively controls the HR CR, as it is demonstrated by the pathophysiological finding of an internal desynchronization between the HR and BP CR. The selective lose of HR CR in DM1 leads to conclude that the ABPM, along with its Cosinor analysis, might be a practical, repeatable, low cost, low risk technique for diagnosing the SCD, at least in DM1.
    No preview · Article · Jan 2010 · La Clinica terapeutica
  • P Cugini
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    ABSTRACT: In this article it is reported a historical-philosophical "excursus" on the schools of thought followed by science in order to provide the highest degree of truth to the knowledge of natural reality.
    No preview · Article · Jan 2009 · La Clinica terapeutica
  • P Cugini
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    ABSTRACT: Presently, the ambulatory (A) blood (B) pressure (P) monitoring (M) is mainly used for diagnosing arterial hypertension (AH) in some special clinical conditions in which the causal sphygmomanometry appears not to be enough exhaustive. However, it must be pointed out that the actual approach to ABPM is almost simplistic, only consisting in a biometric analysis of discrete raw temporal values for systolic (S) and diastolic (D) BP and heart rate (HR). It must be stressed that BP and HR are hemodynamic variables characterized by a well established circadian rhythm (C) in their 24-h physiological values. Therefore, an appropriate chronobiometric approach, via Single Cosinor method, can improve the diagnostic value, its optimal oscillatory curve reducing all the biometric information to three parameters, i.e., MESOR (M, mean level of oscillation), Amplitude (A, extent of oscillation from M) and Acrophase (phi, timing of A with respect to local midnight). Accordingly, one can detect whether the BP CR is still manifest, as it is in essential hypertension (EH), or altered , as it is in secondary hypertension (SH). Therefore, by using the discriminant analysis for the three multivariate parameters, M, A, phi, of the BP cosine curve, one can statistically predict whether a new monitored hypertensive patient has a significant probability to be affected by EH or SH. Interestingly, by applying a further chronobiometric integration analysis, i.e., the Cosint analysis, it is possible to estimate the area under the BP oscillatory curve, for calculating the overall, diurnal, nocturnal, hourly pressure load (Baric Impact, BI) in terms respectively of mm2 Hg/24-h, mm2 Hg/16-h, mm2Hg/8-h, mm2 Hg/1-h. By comparing the overall BI of the new monitored hypertensive patient to its upper reference limit, one can estimate how much is the Baric Excess (Hyperbaric Impact, HI) caused by the personal hypertensive regimen. Finally, by using the chaos method of fractal interpolation to BP 24-h values, it is possible to establish whether or not the monitored hypertensive subject is presumably at risk of unpredictable high BP values (presumable risk of hypertensive crisis).
    No preview · Article · Nov 2008 · La Clinica terapeutica
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    ABSTRACT: To prevent iodine deficiency disorders, the World Health Organization, United Nations Children's Fund, and International Council for the Control of Iodine Deficiency Disorders established that for a given population median urinary iodine concentrations (UIC) must be 100-199 microg/L in clinically healthy subjects and 150-249 microg/L in clinically healthy pregnant women. We evaluated whether in the urban area of Rome, Italy, where a salt iodination program (30 mg/kg) was introduced since 2005, an increased demand of iodine during pregnancy is guaranteed. During 2006, 51 pregnant women at first trimester of a physiologic gestation were consecutively enrolled on presentation to evaluate UIC in morning spot urine samples. As controls, 100 age-matched clinically healthy non-pregnant women were evaluated. The median UICs were 182 microg/L (range 85-340 microg/L) and 74 microg/L (range 17-243 microg/L), respectively, in the control and pregnant groups. This difference was highly significant (P < 0.001). In particular, the UIC was found to be lower than adequate in 4% of control women compared with 92% of pregnant women. This difference of occurrences was highly significant (P < 0.001). This observational study demonstrated that, despite the adequate supplementation of iodine intake, most pregnant women appear not to be protected against iodine deficiency. If confirmed in larger case studies, this finding claims the attention of relevant professionals to monitor iodine nutrition during gestation, assuming that ordinary supplementation of iodine intake seems to be sufficient only in non-gestational conditions.
    No preview · Article · May 2008 · Nutrition
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    ABSTRACT: Introduction: This study is a systematic revision of scientific articles regarding the epidemiological, clinical and therapeutic aspects of cardiomyopathy associated with celiac disease. Material and methods: 1193 adult cases of cardiomyopathy and 15890 clinically healthy control subjects have been scrutinized. Results: The prevalence of celiac disease in cardiomyopathy patients was found higher vs control (3.36 vs. 0.425%, P=0.004). The risk of association was 2-3 times higher than expected. Mean age a 42 years ejection fraction was 25%. A gluten free diet induced an improvement in cardiac performance. Conclusions: In patients with cardiomyopaty may be the real risk of a concomitant celiac disease. The study protocol is not able to provide inferences on the causeeffect relationship existing between two diseases. Gluten free diet can improve cardiac performance in patients with this association. In patients with cardiomyopathy, an appropriate screening of celiac disease should be routinely performed.
    No preview · Article · Feb 2008 · Archives of Medical Science
  • P. Cugini · S. Fontana
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    ABSTRACT: Aim. The present study is a crìitical approach to the validity of time-qualified reference limits (RL) for systolic (S) and diastolic (D) blood pressure (BP) obtained by subjects, whose normotension was established via the causual sphygmomanometry. Materials and Methods. The study enroles 427 normotensives stratified by age from 16 to 102 years. Each subject underwent, via a previous informed consent, a noninvasive ambulatory BP monitoring with automatic measurements at 30 min intervals. The time-qualified RL for SBP and DBP were computed in each stratum as 95% Confidence Limits (95%CL) around the mean for each sampling time as well as for the parameters of BP circadian rhythm (CR). Results. From the results it can be seen that the SBP and DBP RL show a time-qualified variability in each stratified group, with a trend to progressively increase with age, and upper limits that not rarely show values above the WHO limits of 140/90 mmHg. The higher upper RL were also detect for the mesor and amplitude of SBP and DBP CR. Conclusions. This study reveals that the time-qualified upper RF for 24-h BP are higher than expected in subjects diagnosed as normotensives via casual sphygmomanometry. This finding is an evidence convincing that enrolement of normotensives via the casual sphygmomanometry may result in an erroneous computation of time-qualified standards for 24-h BP.
    No preview · Article · Nov 2007
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    ABSTRACT: The scope of this study is to detect whether or not the entropy (E) circadian rhythm (CR) is maintained preserved in sinusal R-R intervals (SRRI), its loss being the expression of a transition to an indeterministic chaos in heart rate variability (HRV). The E of SRRI was estimated in 14 type I diabetic pregnant women (DPW) in the first trimester of an apparently uncomplicated gestation (7 patients - mean age = 30.3 +/- 4.1 y - without clinical and laboratory evidence of cardiac autonomic neuropathy, and 7 patients - mean age = 30.7 +/- 3.6 y - with positive tests for a cardiac dysautonomia). The E CR was studied via the single cosinor method, and summarized via the population-mean cosinor method. The E CR was found not to be preserved in both the investigated type I DPW, despite the occurrence of the SRRI CR. The loss of the E CR confirms that in type I DPW there is a transition to an indeterministic disorder in HRV due to the lack of an autocorrelated periodic chaos in cardiac pacing. Such an unphysiological neurovegetative regulation suggests a new silent cardiac dysautonomic syndrome, that we intend to call "minimum delirium cordis syndrome" (MDCS). Can the MDCS be regarded as a condition of cardiovascular risk? To answer this question, it seems justified to suggest that the study of the E CR should be added to the routine tests that are presently applied to clinical analysis of the Holter ECG, being the classic tests of linear analysis not methodologically suitable for detecting the indeterministic chaos of the MDCS.
    No preview · Article · Jul 2007 · Acta cardiologica
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    ABSTRACT: Objective - The scope of this study is to detect whether or not the entropy (E) circadian rhythm (CR) is maintained preserved in sinusal R-R intervals (SRRI), its loss being the expression of a transition to an indeterministic chaos in heart rate variability (HRV). Methods - The E of SRRl was estimated in 14 type I diabetic pregnant women (DPW) in the first trimester of an apparently uncomplicated gestation (7 patients - mean age = 30.3 +/- 4.1 y - without clinical and laboratory evidence of cardiac autonomic neuropathy, and 7 patients - mean age = 30.7 +/- 3.6 y - with positive tests for a cardiac dysautonomia). The E CR was studied via the single cosinor method, and summarized via the population-mean cosinor method. Results - The E CR was found not to be preserved in both the investigated type I DPW, despite the occurrence of the SRRI CR. Conclusions - The loss of the E CR confirms that in type I DPW there is a transition to an indeterministic disorder in HRV due to the lack of an autocorrelated periodic chaos in cardiac pacing. Such an unphysiological neurovegetative regulation suggests a new silent cardiac dysautonomic syndrome, that we intend to call "minimum delirium cordis syndrome" (MDCS). Can the MDCS be regarded as a condition of cardiovascular risk? To answer this question, it seems justified to suggest that the study of the E CR should be added to the routine tests that are presently applied to clinical analysis of the Holter ECG, being the classic tests of linear analysis not methodologically suitable for detecting the indeterministic chaos of the MDCS.
    No preview · Article · Jun 2007 · Acta cardiologica
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    ABSTRACT: Not Available Bibtex entry for this abstract Preferred format for this abstract (see Preferences) Find Similar Abstracts: Use: Authors Title Return: Query Results Return items starting with number Query Form Database: Astronomy Physics arXiv e-prints
    No preview · Article · Dec 2006 · Annals of the New York Academy of Sciences
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    ABSTRACT: Idiopathic dilated cardiomyopathy (IDCM) and coeliac disease (CD) are two pathological conditions which may lead, by different mechanisms, to malabsorption of various micronutrients, including carnitine, active in cardiac metabolism. The aim of the present investigation was primarily to evaluate differences in serum concentrations of total carnitine between IDCM patients and patients with IDCM associated with CD and then also to evaluate, in the latter, the effect of a gluten-free diet on serum concentrations of total carnitine. Serum carnitine was determined by enzymatic spectrophotometric assay in three groups of individuals: group A, 10 patients (5 males, 5 females), mean age 46.5+/-10.8 years, presenting isolated IDCM; group B, 3 patients (2 males, 1 female), mean age 34+/-8 years, with IDCM+CD; and group C, 10 healthy subjects (5 males, 5 females), mean age 38.6+/-11.1 years. All patients with IDCM belonged to class NYHA I-II. Mean concentrations of total serum carnitine in the group of patients with isolated IDCM (group A) were found to be lower than in the controls (group C). The concentrations in patients with IDCM associated with CD (group B) were lower than in the control group and also lower than in the isolated IDCM (group A). After 2 years on a gluten-free diet, patients presenting IDCM associated with CD showed a progressive increase in mean serum carnitine levels compared to values observed prior to the diet. Patients presenting IDCM associated with CD show a greater decrease in serum total carnitine levels than patients presenting the isolated form of IDCM. A gluten-free diet, in these patients, leads to a progressive increase in serum levels of this substance.
    Full-text · Article · Sep 2005 · Nutrition Metabolism and Cardiovascular Diseases
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    ABSTRACT: The study estimates the unpredictable disorder (chaos) within the 24 h pattern of sinus R-R intervals (SRRI) in clinically healthy pregnant women (CHPW) and clinically healthy non-pregnant women (CHNPW), in order to evaluate the early gestational changes in neurovegetative cardiac pacing. SRRI were provided by the 24-h Holter ECG of 10 CHPW and 10 CHNPW. SRRI were investigated by descriptive conventional statistics by means of the Time and Frequency Domain Analysis, and subsequently, in their chaotic component by means of entropy analysis. Both the SRRI and entropy were tested via the Cosinor method to better decipher whether or not the periodic disorder in heart rate variability is modified in pregnancy as a result of a gestational tonic resetting of the cardiac sympatho-vagal regulation. Cosinor analysis documented that the circadian rhythm of both the SRRI and entropy were preserved in CHNPW and CHPW. However, the circadian rhythm of SRRI and entropy in CHPW exhibited a significantly decreased 24 h mean. Via the analysis of the rhythmicity of entropy, this study has documented that the chaos in the 24 h pattern of SRRI is less prominent in CHPW than in CHNPW. Such a reduction of level in the deterministic periodic chaos of heart rate variability provides evidence that, in early pregnancy, a tonic elevation of the sympathetic activity regulates cardiac pacing.
    No preview · Article · Feb 2005 · Chronobiology International
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    ABSTRACT: This study explores the heart rate (HR) variability (V) in order to detect whether the chaotic component of the sinusal R-R intervals (SRRI) can be interpreted as an early indicator of a silent cardiac neurovegetative dysautonomia in apparently uncomplicated Type 2 diabetic patients (DP). The SRRI were provided by the 24-h Holter ECG of 10 Type 2 DP (5 M and 5 F, mean age = 41 +/- 5 years). Control data were obtained by the 24-h Holter ECG of 10 clinically healthy subjects (CHS, 5 M and 5 F, mean age = 38 +/- 6 years). The chaotic component of HRV was investigated via the correlation dimension (CD) analysis (A) of the SRRI, performed per each hour of the ECG recording. The hourly-qualified series of SRRI, HR and CD index (I) were, in turn, analyzed via methods of conventional statistics and chronobiology, the latter ones for assessing the circadian rhythm (CR). The CDI CR was found to peak during the night in CHS, and to be unphysiologically rotated to the diurnal hours of the day in Type 2 DP. The diurnal inversion of the CDI CR in Type 2 DP suggests that the chaotic component of HRV shows an abnormal rhythnic pattern over the day-night period. Considering that the investigated Type 2 DP were lacking of documentable signs of cardiac neuropathy, it is hypothesized that the diurnal phase of shift CDI CR might be a potential indicator of a silent autonomic cardiac dysfunction in Type 2 DP. Such a hypothesis waits for further confirmations.
    No preview · Article · Jan 2005 · La Clinica terapeutica
  • P Cugini · P Lucia
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    ABSTRACT: The renin-angiotensin-aldosterone system (RAAS) is characterized by a circadian rhythm (CR) whose acrophase is detectable early in the morning. The prorenin and angiotensin converting enzyme (ACE) show a CR as well. However, while the prorenin is in phase with the RAAS the ACE shows its circadian acrophase in the afternoon suggesting a negative feed-back. The RAAS CR is influenced by many factors. Its mesor is modified by sodium intake. The physical activity and rest affect both the mesor and acrophase. The variations in mesor amplitude and acrophase in aged subjects are conditioned by sex and physical activity. Moreover, the RAAS CR seems to be influenced by the race. In addition, it is abolished by the beta-adrenergic blockade, suggesting the existence of an adrenergic clock. Interestingly, the RAAS CR seems not to be a pacemaker for the blood pressure CR, whose acrophase is early in the afternoon. The RAAS CR is not substantially modified has in essential hypertension. However, the CR of plasma renin activity is disappeared in the low-renin essential hypertension, while the CR of plasma aldosterone is detectable. On the contrary, the aldosterone CR is not detectable in ascitic liver cirrhosis; but, it is restored when the ascites is removed by peritoneal-jugular shunt. No significant variation of the RAAS CR seems to occur in obesity and Cushing's syndrome. The RAAS CR has disappeared in Conn's disease as well as in Bartter's syndrome and Liddle's syndrome. The administration of indomethacine in Bartter's syndrome and of triamterene in Liddle's syndrome is able to restore the RAAS CR. Finally, the RAAS CR is not detectable in the heart or kidney transplanted patients; such a phenomenon could be attributed to cyclosporine and corticosteroids administration and to the denervation of the transplanted organs.
    No preview · Article · Jul 2004 · La Clinica terapeutica
  • P Cugini
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    ABSTRACT: Claude Bernard has been a great medical physiologist of the ninenteenth century, who was able to convince biologists and physicians that the "experimental method" can and must be applied to the phenomena of living matter, as it is applied in physics and chemistry. With the concept of the "universality of the experimental method", the Modern Experimental Medicine begun to exist. However, C. Bernard deserves of further honor, having identified and promulgated a law of the living matter, i.e., the law concerning the "constancy of the interior biological environment". Such a law was later consacrated in 1929 by G.W. Cannon with the term "homeostasis". The homeostatic conception of biological functions had a great epistemological impact in the history of biology and medicine. As a matter of fact, all the modern biologists and physicians are today educated at the light of the homeostatic systems. Accordingly, C. Bernard is celebrated in his fame as the tutor of scientific medicine. Reading, however, what C. Bernard has written on the personalism and the eponimy of scientific ideas, one is prone to think that he would have not appreciated the dogmatic exaltation, the cult of his ideas on the biological constancy. He was aware that "... it is a fundamental rule in science to modify and change the ideas going on". And again "... But, since these ideas are not immutable verities, one must be ready to abandon and modify them when they cease to represent the reality". And again "The systems and doctrines are personal and pretend to be immortal and to preserve their personality. The experimental method, however, is impersonal; it zeroes the individuality and sacrifices the particular ideas of the a single person in favor of a general verity, which is established by means of the experimental criterion". And again "The great persons have never been promoters of absolute ed eternal verities in experimental sciences". And again "Any person who made the science to proceed, never pretended to define the limits; this person is destined to be surpassed and left apart by the progress of the future generations". And again "One of the most important obstacle that is encountered by humans along the course of knowledge is represented by the tendency of human acquisitions to be transformed into systems". With the discovery of chaos and biological systems in living matter, the law of homeostasis must be now revised.
    No preview · Article · May 2004 · La Clinica terapeutica
  • M Cilli · R De Rosa · C Pandolfi · K Vacca · P Cugini · Zh Ceni · S Bella
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    ABSTRACT: The aim of this study was to quantify the degree of sub-clinical anxiety and depression in essentially obese patients (EOP) and normoponderal healthy subjects (NHS) in order to identify quantitative differences based on mean scores and percentages (the latter in cases showing a tendency towards pathological anxiety and depression indicated by a score of > or = 8). The study involved 69 EOP (age: 13-72 years; BMI: > 25.0 and < 35.0 kg/m2) and 66 NHS (age: 18-68 years; BMI: > 18.5 and < or = 25.0 kg/m2). The scores, expressed in Anxiety Units (AU) and Depression Units (DU), were computed using ad hoc questionnaires (the ASQ and CDQ) validated for the Italian population. The mean scores of sub-clinical anxiety and depression in the EOP were significantly higher (both p = 0.001) than those of the NHS (6.33 +/- 2.38 vs 5.02 +/- 2.22 AU; 6.42 +/- 2.42 vs 5.02 +/- 2.03 DU), as were the percentages of cases with a tendency towards pathological anxiety and depression (42% vs 18%, and 43% vs 12%) (both p = 0.001). The significantly higher mean sub-clinical anxiety and depression score in the EOP indicate that a worse mood status is associated with obesity in a non-random manner. The significantly higher percentages of EOP with a tendency towards pathologic anxiety and depression indicate that obesity is a clinical condition that predisposes to the development of clinically relevant affective disorders.
    No preview · Article · Dec 2003 · Eating and weight disorders: EWD
  • P Cugini
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    ABSTRACT: The experimental observation has clarified that the majority of biological functions show a pattern of periodic type. Chronobiology was born as the discipline devoted to investigate the periodicity in biological phenomena, Time being regarded as a systematic variable of the dynamism in living matter. The present article provides short notions of this discipline, regarding the classification and meaning of biological rhythms, and concerning the methods for analyzing the periodicity in biosystems.
    No preview · Article · Nov 2003 · La Clinica terapeutica
  • P Cugini · G Spera · R De Rosa · S Falcone · C Pandolfi · M Badiali
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    ABSTRACT: The present study investigated the orexigram, the time-qualified self-rated estimate of hunger sensation (HS), in patients affected by morbid obesity (MO) with the aim of detecting how daily HS behaves before morbidly obese patients (MOP) undergo bariatric surgery (BS). This article is therefore a preliminary report as it is necessary to make subsequent comparisons with post-BS orexigrams. Preoperative orexigrams may be helpful in selecting the MOPs who are candidates for surgical treatment. Ten MOPs (five males and five females, with a mean age of 34 +/- 11 yr and a mean BMI of 49.32 +/- 7.26 kg/m2), and 19 clinically healthy control subjects (CHS: nine males and ten females, with a mean age of 24 +/- 2 yr and a mean BMI of 21.00 +/- 1.70 kg/m2) gave their informed consent to participate in the study. All of the study participants were asked to compile a 24-h orexigram, which was then biometrically analysed by means of: 1) conventional methods for parametric statistics; 2) rhythm analysis for their circadian rhythms; and 3) spectral analysis for their harmonic structure. The orexigrams of the MOPs had significantly increased mean daily levels (daily hyperorexia), retained their circadian periodicity despite an increase in mesor, and were consistently modified in their ultradian spectral harmonic components. The results show that the studied MOPs complain of a daily hyperorexia that is still perceived circadically. This perception is a structured abnormality, as demonstrated by the consistent changes in the spectral analysis, and so MOPs can be diagnosed as being affected by so-called "hyperorectic obesity". It will be interesting to see whether or not presurgical hyperorexia in MOPs is corrected by BS: if so, hyperorexia may become an additional indication, and presurgery orexigrams could be suggested as an additional means of selecting the hyperorectic MOPs who are candidates for surgical treatment.
    No preview · Article · Oct 2003 · Eating and weight disorders: EWD
  • P Cugini · S Bella · M Cilli · R De Rosa · C Pandolfi · V Lucidi · M Castro
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    ABSTRACT: The aim of this study was to investigate the daily pattern of hunger sensation (HS) in patients affected by a non-advanced form of cystic fibrosis (CF) in order to detect how the orectic stimulus (OS) behaves in fibrocystic patients (FP) who are obliged to eat frequently because of their pancreatic exocrine insufficiency. The study involved 27 out-patients (13 males and 14 females; mean age 18 +/- 4 years; mean BMI 18.77 +/- 2.17 kg/m2) with a non-advanced form of CF, and 19 clinically healthy subjects (CHS, 9 males and 10 females; mean age 24 +/- 2 years; mean BMI 21.00 +/- 1.70 kg/m2). The FP were used to eating frequent small meals between the three main meals of breakfast, lunch and dinner. All of the participants were asked to compile an "orexigram"' which was chrono-biometrically analysed by means of: 1) conventional statistical methods; 2) rhythmometric analysis of circadian rhythm (CR); and 3) spectral analysis of the harmonic structure substantiating the within-day variability of HS. HS in FP had 1) a significantly increased daily mean level; 2) a well-established CR, with a significantly increased oscillatory mesor and amplitude; and 3) a modified orexigram power spectrum affecting the ultradian harmonic components. Our results suggest that the orectic perception of CF patients is characterised by "daily hyperorexia", with the maintenance of HS CR. This condition seems to be a structured abnormality insofar as there are visible changes in the orexigram spectral resolution, particular in the ultradian harmonic components whose oscillatory frequency is responsible for the diurnal pattern of HS. The hyperorexia of the investigated FP indicates that their frequent small meals are not sufficient to satisfy their HS, which may cause a vicious circle leading to progressively disrupted mealtime behaviour.
    No preview · Article · Jul 2003 · Eating and weight disorders: EWD
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    ABSTRACT: The present study investigates the properties of blood pressure (BP) circadian rhythm (CR) in newly-diagnosed hypertensives (NDH) as a function of the chronological age in which hypertension became manifest. The study was performed on 141 NDH (71 males and 70 females, ranging in age from 24 year to 79 years), who were monitored in their 24-h BP via a non-invasive, ambulatory, automated recorder. The relation between the properties of BP CR and the age of the development of hypertension was investigated via the Clinospectror method, a trend analysis (periodic-linear regression method) for rhythmic biophenomena. A trend was detected for each one of the three properties of BP CR in relation with the age in which high BP made its appearance. As a matter of fact, the daily mean level (mesor) of BP CR was seen to be progressively less pronounced. The amplitude was found to show a progressive increment of its extent. The acrophase was seen to show a progressive antemeridian rotation of its timing. These trends suggest that hypertension tends to be less severe when its development occurs in subjects older in age. Such a less pronounced severity is, however, accompanied by a more pronounced oscillation of BP values during the 24-h of the day. Such a higher circadian variability, in turn, tends to show its highest expression during the morning hours of the day.
    No preview · Article · Jan 2003 · La Clinica terapeutica
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    ABSTRACT: We studied the within-day determinations of some body composition (BC) parameters in clinically healthy elderly subjects with the aim of investigating their circadian rhythms (CR), which are known to vary in a circadian manner in clinically healthy young adults. The study involved six non-smoking, clinically healthy elderly males (mean age: 75 +/- 4 years; mean weight: 71.07 +/- 10.26 kg; mean height: 170 +/- 5 cm, mean BMI: 24 +/- 1 kg/m2). The BC parameters were determined by means of bioelectrical impedance analysis (BIA) at 2-hour intervals during the day and night, with the subjects lying horizontally in bed. The time-qualified BC estimates were analysed using the Cosinor method. The analysis revealed that the healthy elderly subjects had lost the CR of a number of the BC parameters, including fat body mass, cell body mass, extracellular body mass, total body water, extracellular body water, intracellular body water, and the Na and K exchangeable pools. However, they still retained the CR of body weight and lean body mass, with the expected nocturnal phase of oscillation. The abolition of the CR of the majority of BC parameters in the elderly suggests that human senescence is characterised by consistent changes in the daily rhythmic patterns of fat, water and electrolyte metabolism.
    No preview · Article · Oct 2002 · Eating and weight disorders: EWD

Publication Stats

1k Citations
253.46 Total Impact Points

Institutions

  • 1987-2009
    • Sapienza University of Rome
      • • Department of Internal and Specialized Medicine
      • • Department of Surgical Sciences
      Roma, Latium, Italy
  • 1996-2002
    • Nakamura Gakuen University
      Hukuoka, Fukuoka, Japan
  • 1981-2002
    • The American University of Rome
      Roma, Latium, Italy
  • 1983-1993
    • Kyushu University
      • • Faculty of Medical Sciences
      • • Division of Internal Medicine
      Hukuoka, Fukuoka, Japan
  • 1988-1991
    • Umberto I Policlinico di Roma
      Roma, Latium, Italy
  • 1985
    • University of Rome Tor Vergata
      Roma, Latium, Italy
  • 1975-1985
    • Università Degli Studi Roma Tre
      Roma, Latium, Italy