T Matsubara

Kansai Medical University, Moriguchi, Ōsaka, Japan

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Publications (28)20.04 Total impact

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    ABSTRACT: To compare the effectiveness of scleral buckling to vitrectomy for the treatment of rhegmatogenous retinal detachment (RRD) due to equatorial retinal tears. Forty-six patients (46 eyes) > or =50 years of age with RRD due to equatorial retinal tears were studied. One group of 23 patients was selected by the randomized envelope method to be treated by scleral buckling and a second group of 23 to be treated by vitrectomy. The rate of retinal reattachment, the visual acuity, optical coherence tomography findings, and postoperative complications were determined. In addition, a questionnaire was filled out by the patients on their subjective assessment of the surgery and recovery. The rate of retinal reattachment was identical in the two groups. The postoperative visual acuity, the number of patients with visual acuity > or =0.8 and the mean visual acuity were significantly better in the vitrectomy group (chi-squared and Mann-Whitney U tests, P < 0.05) within 12 months after surgery. At 24 and 36 months, the differences in the visual acuity were not significant. The answers to the questionnaire given by the patients in the vitrectomy group suggested that their surgical experiences and visual recovery were better than those of patients in the scleral buckling group. In patients > or =50 years of age, vitrectomy was more effective than scleral buckling for obtaining good visual acuity in the short term.
    No preview · Article · Oct 2007 · Japanese Journal of Ophthalmology
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    S Hisao · A Ando · S Hashimoto · T Matsubara · Y Miyahara · Y Shoji
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    ABSTRACT: The 792-MHz HOM of the RF cavity can drive horizontal coupled bunch instability in the NewSUBARU electron storage ring. Detailed characteristics of this instability were investigated by changing the HOM frequency, betatron tune, chromaticity and magnitude of the stored current at the energy of 1 GeV. The experiments were performed under the condition that the only one mode can be excited and the stored current was limited as ~ 3.4 mA/bunch to avoid catastrophic blow up. The measured results showed saw tooth oscillation and were compared with an analytical calculation using a rigid bunch model. The co-existence of the longitudinal modes ; l = 0 and l = ± 1 might produce complicated beam behaviour.
    Full-text · Article · Jan 2006
  • Chiemi Kitagawa · Akira Ando · Takashi Matsubara · Miyo Matsumura
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    ABSTRACT: We treated an adult patient with traumatic glaucoma who exhibited dramatic elasticity in the topography of the optic nerve head, as shown in a Heidelberg Retina Tomograph (HRT) examination after filtering surgery. A 41-year-old man came to us with a right eye injury following an external blow. At the first examination, visual acuity was 0.4 (1.2) and intraocular pressure (IOP) was 11 mmHg in both eyes. Cells in the anterior chamber and angle dialysis were noted in all quadrants of the right eye, but there was no hyphema. Two weeks later, the patient returned to our hospital with pain in the right eye and a headache. Visual acuity in the right eye had decreased to 0.06 (0.1) and IOP was 50mmHg. A cilioconjunctival injection and corneal edema were observed. The patient was treated with medications, but IOP was uncontrollable and the optic disc cupping in the right eye was enlarged. Further, values for Cup Disc Area Ratio (C/D; 0.553) and Cup Volume (CV; 0.548) in the right eye were larger than those of the left (0.287 and 0.168, respectively) in an HRT examination. We performed a non-penetrating trabeculectomy 5 weeks after the injury. Two weeks after surgery, IOP was lowered to 7 mmHg, and C/D 0.122) and CV (0.062) were improved. Six months after the procedure, C/D (0.304) and CV (0.202) were nearly the same as those of the left eye (0.292 and 0.144). Although the duration of high IOP was short, high elasticity in the optic disc morphology of this adult case was shown quantitatively in an HRT examination.
    No preview · Article · Oct 2005 · Nippon Ganka Gakkai zasshi
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    ABSTRACT: We reviewed 39 eyes of 38 patients that developed complications after surgery for retinal detachment using hydrogel (MIRAgel®). All the 39 eyes necessitated removal of hydrogel as buckling material. Their ages ranged from 21 to 78 years, average 51 years. Both genders were equally involved. The buckling material had to be removed due to complications including protrusion, hyperemia, impaired ocular motility or diplopia. The interval between initial surgery and removal of buckling material ranged from 6 to 15 years, average 10.7 years. The incidence of complications is still on the increase. We advocate continued follow-up of patients even after hydrogel was prohibited in 1995.
    No preview · Article · Jan 2005
  • Y. Shoji · S. Hisao · T. Matsubara · T. Asaka · S. Suzuki · Y. Kawashima
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    ABSTRACT: This paper confirms the occurrence of RF synchronized injection from SPring‐8 Linac to the NewSUBARU storage ring. NewSUBARU is a 1.5 GeV storage ring with injection energy of 1.0 GeV. Besides the 1.5 GeV user mode, the ring is often operated at 1.0 GeV for EUV users with the so‐called top‐up injection mode. In this experiment, we use a new synchronization method developed at SPring‐8, wherein an instantaneous synchronization between NewSUBARU RF (500 MHz) and Linac RF (2856 MHz) enables a buckets‐to‐bucket beam transfer. This is one of the key technologies of top‐up operations in a storage ring that uses a linac as an injector. The RF clock and timing trigger signal are sent to the Linac from NewSUBARU, and this clock is used to delay units in order to maintain good synchronicity. This works as a standard because it has a system to compensate for transfer‐time drift. The arbitrary waveform generator is another key module. It produces a clock 1/32 of that of the Linac RF using the NewSUBARU RF clock. With this system, we eliminated beam loss at the injection due to spillage from the ring RF bucket. © 2004 American Institute of Physics
    No preview · Article · May 2004
  • Source
    M Tomita · T Matsubara · H Yamada · K Takahashi · T Nishimura · K Sho · M Uyama · M Matsumura

    Full-text · Article · Mar 2004 · British Journal of Ophthalmology
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    ABSTRACT: The present study was performed to clarify the long-term natural history of polypoidal choroidal vasculopathy (PCV). Prospective, consecutive observational case series. Fourteen eyes of 12 consecutive patients with PCV were prospectively followed in our clinic for at least 2 years without any treatment after a first visit to the clinic between February 1996 and November 1998. All patients underwent complete ophthalmologic examination, color fundus photography, and fluorescein and indocyanine green (ICG) angiography at regular intervals. Inclusion criteria were as follows: eyes had serous and/or hemorrhagic pigment epithelium detachment (PED) and retinal detachment in the posterior pole, and ICG angiography revealed a branching vascular network with polypoidal dilations at the terminals of the network. Exclusion criteria were as follows: other diseases such as exudative age-related macular degeneration, high myopia, angioid streaks, and presumed ocular histoplasmosis syndrome, and patients who previously underwent any ocular surgery. Patients were followed for mean of 39.9 months (range, 24-54 months). PCV was present in 10 (83%) men and two women and in the elderly (mean age 68.1 years), usually unilateral (83%) with vascular lesions located at the macula (93%). The PCV manifested in two patterns, exudative and hemorrhagic. In the exudative pattern, serous PED and retinal detachment were predominant at the macula. The hemorrhagic pattern was characterized by hemorrhagic PED and subretinal hemorrhage at the macula. ICG angiography revealed polypoidal choroidal neovascularization that was changeable in appearance and repeatedly grew and spontaneously regressed, but the vascular network persisted. In some eyes, a collection of small aneurysmal dilations of vessels resembling a cluster of grapes appeared and all of them had marked bleeding and leakage and worse outcome. Polypoidal choroidal vasculopathy is a long persistent chronic disease and the patients had a variable course. Fifty percent of the patients had a favorable course. In the remaining half of the patients, the disorder persisted for a long time with occasional repeated bleeding and leakage, resulting in macular degeneration and visual loss. Eyes with a cluster of grapes-like polypoidal dilatations of the vessels had a high risk for severe visual loss.
    No preview · Article · Jun 2002 · American Journal of Ophthalmology
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    ABSTRACT: PURPOSE: The present study was performed to clarify the long-term natural history of polypoidal choroidal vasculopathy (PCV).DESIGN: Prospective, consecutive observational case series.METHODS: Fourteen eyes of 12 consecutive patients with PCV were prospectively followed in our clinic for at least 2 years without any treatment after a first visit to the clinic between February 1996 and November 1998. All patients underwent complete ophthalmologic examination, color fundus photography, and fluorescein and indocyanine green (ICG) angiography at regular intervals. Inclusion criteria were as follows: eyes had serous and/or hemorrhagic pigment epithelium detachment (PED) and retinal detachment in the posterior pole, and ICG angiography revealed a branching vascular network with polypoidal dilations at the terminals of the network. Exclusion criteria were as follows: other diseases such as exudative age-related macular degeneration, high myopia, angioid streaks, and presumed ocular histoplasmosis syndrome, and patients who previously underwent any ocular surgery.RESULTS: Patients were followed for mean of 39.9 months (range, 24–54 months). PCV was present in 10 (83%) men and two women and in the elderly (mean age 68.1 years), usually unilateral (83%) with vascular lesions located at the macula (93%). The PCV manifested in two patterns, exudative and hemorrhagic. In the exudative pattern, serous PED and retinal detachment were predominant at the macula. The hemorrhagic pattern was characterized by hemorrhagic PED and subretinal hemorrhage at the macula. ICG angiography revealed polypoidal choroidal neovascularization that was changeable in appearance and repeatedly grew and spontaneously regressed, but the vascular network persisted. In some eyes, a collection of small aneurysmal dilations of vessels resembling a cluster of grapes appeared and all of them had marked bleeding and leakage and worse outcome.CONCLUSION: Polypoidal choroidal vasculopathy is a long persistent chronic disease and the patients had a variable course. Fifty percent of the patients had a favorable course. In the remaining half of the patients, the disorder persisted for a long time with occasional repeated bleeding and leakage, resulting in macular degeneration and visual loss. Eyes with a cluster of grapes-like polypoidal dilatations of the vessels had a high risk for severe visual loss.
    No preview · Article · May 2002 · American Journal of Ophthalmology
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    ABSTRACT: A 16-year-old female presented with upper visual field defect in her left eye since 2 months before. Her corrected visual acuity was 20/20 in either eye. Her left eye showed slight vitreous opacity and narrowing of nasal inferior retinal arteries. Perimetry showed enlarged blind spot and visual field defect in the temporal to nasal superior sector. Findings by fluorescein and indocyanine green angiography were inconspicuous. Electroretinography and electrooculography showed reduced responses. These findings led to the diagnosis of acute zonal occult outer retinopathy (AZOOR), Systemic corticosteroid in massive dosis induced improved symptoms the next day. The absolute scotoma disappeared after 37 days of treatment. This case illustrates that systemic corticosteroid may be effective for AZOOR.
    No preview · Article · Jan 2002
  • M. Tomita · T. Matsubara · T. Nishimura · M. Matsumura · M. Uyama
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    ABSTRACT: A 36-year-old female presented with flying flies since one year before. She had also visual disturbance and metamorphopsia for 2 months in her right eye. Her corrected visual acuity was 0.5 right and 1.5 left. Both eyes showed disc neovascularization and numerous hard exudates around the optic disc. Retinal arteries showed aneurysmal dilatations at the sites of branching. Extensive nonperfused area was present in the peripheral retina. Additionally, the right eye showed proliferative retinopathy and vitreous hemorrhage. These findings led to the diagnosis of IRVAN syndrome, comprising idiopathic retinal vasculitis, aneurysms and neuroretinitis. Cure was obtained following oral prednisolone, panretinal photocoagulation to the nonperfused retinal area in both eyes, and vitrectomy in the right eye. She has been doing well during 20 months after treatment with visual acuity of 1.0 right and 1.5 left.
    No preview · Article · Jan 2001
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    ABSTRACT: Purpose: To determine the histological localization of indocyanine green (ICG) in the healthy rat eye and to correlate this with ICG angiographic findings.Methods: After intravenous ICG dye injection, the rat eyes were enucleated and processed by freeze-substitution fixation with acetone. The tissue sections were stimulated with an 805-nm diode laser and observed with an infrared microscope with an intensified charge coupled device camera. The histological examinations of ICG localization were correlated with the ICG angiographic images.Results: ICG dye did not leak from the retinal and iris vessels. However, in the choroid, extravasation of ICG from the choriocapillaris was observed. The extravascular ICG from the choriocapillaris slowly diffused to the choroidal stroma but did not diffuse to the neurosensory retina through the retinal pigment epithelium.Conclusion: Change in the localization of ICG in ocular tissue was demonstrated in the ICG angiographic findings. These results help to interpret clinical ICG angiographic findings.
    No preview · Article · Feb 2000
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    ABSTRACT: To describe the vascular nature and clinical features of idiopathic polypoidal choroidal vasculopathy in Japanese patients. Patients thought to have idiopathic polypoidal choroidal vasculopathy were examined with binocular ophthalmoscopy, slitlamp biomicroscopy with a contact lens, fluorescein angiography, and indocyanine green angiography. From January 1993 to December 1997, 35 eyes in 32 patients were diagnosed as having idiopathic polypoidal choroidal vasculopathy. Men were predominantly affected (22 patients [69%]). Most patients were unilaterally involved (29 patients [91%]) and elderly, with a mean age of 65.7 years (range, 44-82 years). Ocular manifestations were relatively mild, with serous or hemorrhagic detachments of the retinal pigment epithelium and neurosensory retina in the posterior pole. Most patients had a favorable course, although some experienced recurrence, and a few eyes developed disciform scarring. In all patients, indocyanine green angiograms demonstrated branching vascular networks with polypoidal dilations at terminals of the network beneath the retinal pigment epithelium. These lesions were mostly in the macula (33 eyes [94%]), with a few in the peripapillary area. Idiopathic polypoidal choroidal vasculopathy in Japanese patients differs from that in American patients. It seems that this disorder occurs in elderly Japanese patients and should be treated as a distinct clinical entity. It is probably a peculiar form of choroidal neovascularization beneath the retinal pigment epithelium. We propose the term "polypoidal choroidal neovascularization" for this disorder.
    No preview · Article · Sep 1999 · Archives of Ophthalmology
  • T Matsubara · M Uyama · I Fukushima · H Matsunaga · K Takahashi
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    ABSTRACT: To determine the histological localization of indocyanine green (ICG) in the healthy rat eye and to correlate this with ICG angiographic findings. After intravenous ICG dye injection, the rat eyes were enucleated and processed by freeze-substitution fixation with acetone. The tissue sections were stimulated with an 805-nm diode laser and observed with an infrared microscope with an intensified charge coupled device camera. The histological examinations of ICG localization were correlated with the ICG angiographic images. ICG dye did not leak from the retinal and iris vessels. However, in the choroid, extravasation of ICG from the choriocapillaris was observed. The extravascular ICG from the choriocapillaris slowly diffused to the choroidal stroma but did not diffuse to the neurosensory retina through the retinal pigment epithelium. Change in the localization of ICG in ocular tissue was demonstrated in the ICG angiographic findings. These results help to interpret clinical ICG angiographic findings.
    No preview · Article · Aug 1999 · Nippon Ganka Gakkai zasshi
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    ABSTRACT: We used N-methyl-N-nitrosourea (MNU) to induce chorioretinopathy as a model of retinitis pigmentosa, and compared the histological localization of indocyanine green (ICG) with ICG angiographic features. Brown-Norway pigmented rats received a single intraperitoneal injection of MNU (75 mg/kg body weight). At 3 and 21 days after treatment, we compared ICG angiographic findings with histological localization of ICG in the retina and choroid. Histological localization of ICG was observed with an infrared light microscope. 3 days after treatment, destruction of the photoreceptor cells and photoreceptor segments had developed, and the retinal pigment epithelial cells (RPEs) were also damaged. In ICG angiography, diffuse hyperfluorescence was evident. In histological localization of ICG, RPEs were stained by ICG, and ICG was seen in the sensory retina through the damaged RPEs. At 21 days after treatment, the inner nuclear layer directly contact with the choroid. The photoreceptor cells, RPEs and choriocapillaris had disappeared. In ICG angiography, hypofluorescence was seen in the chorioretinal atrophic area. In histological localization of ICG, there was no ICG in the atrophic area, but ICG leaked from the remaining choriocapillaris into the neighboring sensory retina. These results support the precise interpretation of ICG angiographic findings in clinical use.
    No preview · Article · Aug 1999 · Nippon Ganka Gakkai zasshi
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    ABSTRACT: To clarify the pathophysiology of multifocal posterior pigment epitheliopathy (MPPE), or bullous retinal detachment (RD)-an unusual manifestation of central serous chorioretinopathy (CSC)-we evaluated indocyanine green (ICG) angiographic findings of patients with MPPE. Indocyanine green angiography was performed on 45 eyes of 26 patients with MPPE in our clinic during a 4-year period and compared with clinical and fluorescein angiographic (FA) findings. Ophthalmoscopically, in the posterior pole there were multiple yellowish-white retinal exudations, associated with flat, serous RD and bullous RD in the lower periphery. Fluorescein angiography demonstrated multiple massive leakages from the choroid into the subretinal space. These leakage sites corresponded to the retinal exudations. Indocyanine green angiography showed hyperfluorescence in the posterior pole of the choroid. The hyperfluorescence was first seen in the middle phase and became prominent in the late phase. This finding seems to be due to extravasation from the choriocapillaris. After laser photocoagulation of the leakage sites seen on FA, the leakages stopped and the retinal exudations and RD were resolved. Indocyanine green angiography, however, revealed hyperfluorescence in the posterior pole that was seen in active stage. These ICG angiographic findings for MPPE show that hyperpermeability of the choroidal vessels may be the primary causative lesion. This is followed by an intrastromal accumulation of the extravasated choroidal fluid, which may be subclinical. Involvement of the retinal pigment epithelium may be secondary, and then the disease becomes manifest with RD. In MPPE, a severe form of CSC, the retinal pigment epithelium is involved extensively and widely, and prognosis is unfavorable. We conclude that MPPE and CSC represent opposite ends of a common morbid spectrum.
    No preview · Article · Feb 1999 · Retina
  • H Matsunaga · A Ando · T Matsubara · I Fukushima · K Takahashi · H Ohkuma · M Uyama
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    ABSTRACT: We performed an experimental study on choroidal circulatory disturbance to clarify basic problems about interpretation of retino-choroidal lesions in indocyanine green fluorescence angiography (ICG angiography). We severed the posterior ciliary arteries to produce choroidal circulatory disturbance. Fluorescein angiography and ICG angiography were performed at one week, and one month after occlusion. These findings were compared with histopathological findings. One week after occlusion, the area of choroidal infarct showed occlusion of choriocapillaris and proliferation of the retinal pigment epithelial (RPE) cells, this area showed hypofluorescence in the early phase ICG angiography. The hypofluorescence area increased in the late phase. One month after occlusion, the lesion showed loss of choriocapillaris at the center and proliferation of fibroblast-like cells at the edge of the lesion. The subretinal strand showed hyperfluorescence in late phase ICG angiography. Proliferated RPE cells masked ICG fluorescence in the late phase. Fibroblast-like cells showed tissue staining. When reading ICG angiography, we have to take into account that the ICG angiogram is greatly modified by condition of the RPE.
    No preview · Article · Mar 1997 · Nippon Ganka Gakkai zasshi
  • H Matsunaga · A Andou · T Matsubara · I Fukushima · K Takahashi · H Ohkuma · M Uyama
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    ABSTRACT: We performed an experimental study on choroidal circulatory disturbance to clarify basic problems about interpretation of retino-choroidal lesions in indocyanine green fluorescence angiography (ICG angiography). We severed all of the posterior temporal ciliary arteries, to produce choroidal circulatory disturbance. Fluorescein angiography and ICG angiography were performed using scanning laser ophthalmoscope immediately, and 2 days after occlusion. These findings were compared with histopathological findings from the same specimen. Immediately after occlusion, choroidal vessels were filled with the red blood cells in the lesion that showed hypofluorescence in both types of angiography. Two days after occlusion, the fundus had a grayish white edematous appearance which was similar to choroidal infarction. The retinal pigment epithelial cells. (RPEs) in infarcted lesion progressed to liquefied necrosis. Fluorescein angiography showed hyperfluorescence in the lesion, and ICG angiography showed hypofluorescence in the early phase, but hyperfluorescence at the margin of the lesion in the late phase. This result showed that damaged RPEs were stained by ICG dye. In reading ICG angiography, we have to consider that the ICG angiogram is greatly modified by the condition of the RPEs.
    No preview · Article · Feb 1997 · Nippon Ganka Gakkai zasshi
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    ABSTRACT: One hundred forty eyes with choroidal neovascularization (ChNV) in age-related macular degeneration were examined with fluorescein and indocyanine green (ICG) angiography. ChNVs covered with subretinal hemorrhage, and ChNVs with retinal pigment epithelial (RPE) detachment were demonstrated at a higher rate and more clearly with ICG angiography than with fluorescein angiography. On the other hand, ChNVs in serous retinal detachment, and in disciform lesions were demonstrated more clearly with fluorescein angiography than with ICG angiography. These results show that ICG angiography is valuable for delineating "occult ChNVs" with subretinal hemorrhage or RPE detachment in age-related macular degeneration.
    No preview · Article · Nov 1996 · Nippon Ganka Gakkai zasshi
  • H Matsunaga · A Andoh · T Matsubara · I Fukushima · K Takahashi · H Ohkuma · M Uyama
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    ABSTRACT: We performed experiments in 20 monkey eyes in order to clarify basic problems about interpretation of indocyanine green fluorescence angiography (ICG angiography). We severed the temporal group of posterior ciliary arteries to produce choroidal circulatory disturbance. ICG angiography was performed immediately, and 2 days, 4 days, and 2 weeks later. Following each ICG angiography, the eye was studied by plastic vascular cast technique with scanning electron microscopy. Immediately after occlusion, ICG angiography showed filling defect in the temporal choroidal hemisphere during the early phase. In the later phase, this area was gradually filled by the dye from choroidal arteries in the nasal hemisphere and the anterior ciliary arteries. Vascular cast preparations showed filling defect in the temporal choroidal hemisphere, corresponding with the early ICG angiogaphic findings. Both filling delay in ICG angiography and filling defect in vascular casts improved daily after occlusion. Two weeks after occlusion, The area of choroidal infarct temporal to the macula turned into chorioretinal atrophy. This area showed hypofluorescence in the early-phase ICG angiography and filling defect of the choriocapillaris in plastic casts. The early-phase ICG angiographic findings thus corresponded well with observations of vascular casts. We conclude that ICG angiography correctly reflects the actual circulatory disturbances in the choroid.
    No preview · Article · Apr 1996 · Nippon Ganka Gakkai zasshi
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    ABSTRACT: The ultrastructure of experimentally induced choroidal neovascularization was studied in correlation with dye leakage in indocyanine green (ICG) infrared fluorescence angiography. Newly formed vessels which demonstrated leakage of ICG extended into the subretinal space without enclosure of retinal pigment epithelium (RPE), and the endothelial cells were immature. Choroidal neovascularization which did not demonstrate leakage of ICG was enclosed by RPE without retinal detachment, and the endothelial cells were mature. The newly formed vessels with immature endothelium in the subretinal space that were covered with multiple layers of RPE demonstrated no leakage. These results show that ICG leaks form choroidal neovascularization which has immature vessels that are not enclosed by RPE and that extend into the subretinal space.
    No preview · Article · Sep 1995 · Nippon Ganka Gakkai zasshi

Publication Stats

512 Citations
20.04 Total Impact Points

Institutions

  • 1997-2007
    • Kansai Medical University
      • Department of Ophthalmology
      Moriguchi, Ōsaka, Japan
  • 2004
    • Himeji Institute of Technology
      Himezi, Hyōgo, Japan