Carlotta Gurioli

University of Bologna, Bolonia, Emilia-Romagna, Italy

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Publications (18)24.7 Total impact

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    ABSTRACT: Introduction: This mono-center randomized, controlled, double-blind study evaluates the safety and efficacy of MD2011001 cream versus placebo, in mild-to-moderate atopic dermatitis (AD). MD2011001 is a nonsteroidal topical cream containing vitamin E, epigallocatechin gallate and grape seed procyanidins. Methods: Patients with AD (corresponding to an IGA score of 2 or 3), involving the face, the perioral/periocular area and/or the neck, were enrolled. Patients were randomized 1:1 ratio to receive MD2011001 or placebo before the start of the study (D0), then evaluated after 7 days, and after 28 days. The study was approved by the Local Independent Ethics Committee and conducted according to the Declaration of Helsinki and local regulations. The statistical tests used were the Wilcoxon test and the Mann-Whitney U-test. Results: Forty-four patients (29F and 15M) were enrolled. The IGA values showed a statistically significant reduction during the treatment period obtaining a favorable safety profile and local tolerance for both the products. The reduction in the surface area affected by AD was significantly faster with MD2011001. Discussion: This study focuses on very sensitive areas known to be particularly susceptible to local complications. Conclusions: These results suggest the usefulness of an emollient treatment for mild/moderate AD.
    Full-text · Article · Dec 2015 · Journal of Dermatological Treatment
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    ABSTRACT: No abstract is available for this article.
    No preview · Article · Dec 2015 · Journal der Deutschen Dermatologischen Gesellschaft

  • No preview · Article · Nov 2015 · Journal der Deutschen Dermatologischen Gesellschaft
  • B M Piraccini · C Gurioli · F Bruni · A Patrizi

    No preview · Article · Oct 2015

  • No preview · Article · May 2015 · Journal der Deutschen Dermatologischen Gesellschaft
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    ABSTRACT: No abstract is available for this article.
    No preview · Article · May 2015 · Journal der Deutschen Dermatologischen Gesellschaft
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    Annalisa Patrizi · Carlotta Gurioli · Emi Dika

    Full-text · Article · Mar 2015 · Dermatologic Therapy
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    A Patrizi · C Gurioli · I Neri
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    ABSTRACT: Granuloma annulare (GA) is a self--limited benign inflammatory dermatosis of unknown origin characterized by the development of papules arranged in an annular, circinate pattern, mainly involving the extensor surfaces of lower and upper extremities. The diagnosis depends on clinical and histological features. There are 4 main variants of GA: localized GA (LGA), subcutaneous GA (SGA), generalized GA (GGA) and perforating GA (PGA) and 2 uncommon subtypes: papular umbilicated GA and linear or segmental GA. Children most commonly present with the localized and subcutaneous forms. The aim of this review is to provide an update on the etiology, diagnosis and management of GA focusing on the pediatric age.
    Full-text · Article · Oct 2014 · Giornale italiano di dermatologia e venereologia: organo ufficiale, Societa italiana di dermatologia e sifilografia
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    ABSTRACT: Skin adverse events associated with D-Penicillamine (DPA) are common and multi-faceted, although the presence of DPA or its metabolites has never been documented in the skin, because of inherent difficulties in determining its tissue levels. Thus, the association between DPA and DPA-related dermatoses has been only hypothesized on the basis of careful history, clinical observation and typical histopathological findings. To detect DPA in biopsy specimens in a unique case of 25-year-late-onset elastosis perforans serpiginosa and pseudo-pseudoxanthoma elasticum associated with a history of long-term high dose DPA, by applying a recently described analytical method to assess the presence of DPA in skin. We used a reliable analytical method based on high-performance liquid chromatography coupled with amperometric detection to look for the presence of DPA in skin biopsy specimens. A chromatographic peak corresponding to DPA was evidenced in some affected skin samples collected from the patient. We documented the effective presence and the persistence after 25 years of DPA in the skin of a woman affected by elastotic cutaneous change due to a long-term therapy with DPA. This report provides further evidence of the relationship between DPA deposit in affected skin and clinical manifestation.
    Full-text · Article · Jan 2014 · Journal of the European Academy of Dermatology and Venereology
  • A Patrizi · F Giacomini · C Gurioli · I Neri
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    ABSTRACT: Pediatric inflammatory vulvitis (PIV) is clinically characterized by itching, soreness and inflammation and can be due to both an infective process and a non-specific irritative process, especially in atopic patients. Sometimes these non-specific PIVs, that tend to be recurrent, can be overinfected, with exacerbation of the clinical features. The importance of the cleansers, emollients, and the kind of textiles that enter in direct contact all day long with the inflamed skin, is well known. The study objective is the evaluation of the safety and efficacy of the transpiring, slightly elastic knitted silk briefs, with anti-bacterial and non-irritating properties, registered as Dermasilk®, in recurrent PIV. The study we conducted was a prospective cohort study of 12 pre-pubertal girls, aged between 2 and 10 years, affected by recurrent PIV, that used Dermasilk® briefs in association to conventional treatments. Dermasilk® briefs have proven to be an effective and safe adjuvant product available for use in association with conventional drugs for the treatment of recurrent PIV. Dermasilk® briefs play an important role in the management of the flares of recurrent PIV, proven by an earlier resolution of symptoms, as well as in the maintenance of the remission and in the prevention of overinfections.
    No preview · Article · Oct 2011 · Giornale Italiano di Dermatologia e Venereologia
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    ABSTRACT: A 13-year-old boy presented to us for the evaluation of a slowly growing mass over the left preauricular region. Physical examination showed a nodular swelling, firm on palpation. The patient had no lymphadenopathy. The findings of magnetic resonance imaging (MRI) and vascular MRI led us to suspect a vascular growth. An incisional biopsy was performed and revealed an angiomatoid fibrous histiocytoma (AFH). Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of the soft tissue with fibrohistiocytic and vascular differentiation that shows an intermediate malignancy grade, mainly occurs in patients younger than 20 years of age, and is usually localized on the extremities. Angiomatoid fibrous histiocytoma is considered to be a tumor of intermediate malignancy because of its less aggressive course in contrast to conventional malignant fibrous histiocytoma (MFH). Our case of AFH is peculiar because of its localization in the pre auricular region and because it appeared in a young patient. Surgical excision with maxillo-facial, chest-abdomen, and neck CT and prolonged follow-up is recommended because rare cases of metastasizing AFH have been reported.
    No preview · Article · May 2010 · Dermatology online journal
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    Annalisa Patrizi · C Gurioli · M Medri · I Neri
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    ABSTRACT: Lichen sclerosus (LS) shows a predilection for the genital area and occurs mostly in postmenopausal women and in prepubertal girls. We conducted a retrospective review of 15 young girls whit genital LS with onset before the menarcheal age and treated with topical clobetasol propionate 0.05%. The mean duration of follow-up was 4.7 years with relapses in nine patients after approximately 1 year from the first clearing. At the end of the study we observed that (i) potent topical steroids are safe and effective in childhood, (ii) an early aggressive treatment gives the best therapeutic response, (iii) one follow-up visit a year is required to monitor for relapsing.
    Full-text · Article · Jan 2010 · Pediatric Dermatology
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    ABSTRACT: Primary cutaneous large B-cell lymphoma, leg-type (PCLBCL-LT), is a large B-cell lymphoma primarily involving the skin. It is distinguished from the other 3 subsets of this lymphoproliferative disorder by its immunohistopathological features, configuring confluent sheets of medium-sized to large B lymphocytes with round nuclei provided with evident nucleoli, resembling centroblasts or immunoblasts, which express Bcl-6, Bcl-2. Prevalently appearing on the lower limbs, as a single or multicentric and frequently ulcerated skin nodule or plaque, PCLBCL-LT has a worse prognosis than the other large B-cell lymphomas. Moreover, the age of onset is delayed (7th decade) compared to those of the other 3 subtypes (6th decade); it presents a slight female predominance (2:1), and a higher percentage of positivity to Bcl-2. We present a 52-year-old man who showed a 2-year standing, non-ulcerated, round, 4 cm in diameter, red plaque, medially located on the dorsum. After biopsy the diagnosis of PCLBCL-LT was made on histopathological and immunohistochemical studies, the latter showing positivity to CD20, Bcl-2, and Bcl-6. After treatment with radiotherapy the patient has shown a 4.4-year follow-up free of disease.
    Full-text · Article · Nov 2009 · Case Reports in Dermatology
  • A Patrizi · C Gurioli · I Neri · C D'Acunto

    No preview · Article · Aug 2009 · The Journal of Clinical Pharmacology
  • A Patrizi · F Savoia · F Giacomini · M Tabanelli · C Gurioli
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    ABSTRACT: The aim of this study was to investigate the effect of sunlight during summer holidays and to assess the seasonability of atopic dermatitis in 43 consecutive patients with mild-moderate atopic dermatitis referring to the Pediatric Outpatient Clinic of the University of Bologna. Patients had to answer an open questionnaire. The collected data showed that 74.4% of the patients affected by mild-moderate atopic dermatitis had complete resolution during summer holidays, 16.3% had improvement and only 9.3% had no modification of atopic dermatitis severity, confirming the seasonability of the disease, with improvement during summertime and worsening in the other seasons. Seaside holidays produced a significantly greater improvement than mountains holidays, with complete resolution of the disease in 91.2% versus 11.1% of patients, P<0.01. Conclusion. These data support the hypothesis on the positive effect of UV radiation on atopic dermatitis in patients without eczema after local therapy with corticosteroids or immunomodulators, but are in contrast with those reported by other authors from Northern Europe. This discrepancy is probably due to the latitude and different climate. In the Mediterranean area and in southern locations greater improvements are observable.
    No preview · Article · Aug 2009 · Giornale Italiano di Dermatologia e Venereologia
  • Carmine D'Acunto · Carlotta Gurioli · Iria Neri
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    ABSTRACT: Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL), a non-Hodgkin lymphoma characterized by proliferation of atypical epidermotrophic helper/memory T cells in the skin. Therapeutic management includes topical therapy such as topical corticosteroids, topical chemotherapy or phototherapy; or systemic therapy such as photochemotherapy (psoralen and ultraviolet A [PUVA]), extracorporeal phototherapy, radiation, and mono or polychemotherapy. Herein we report one case of MF unresponsive to conventional therapy, subsequently treated with bexarotene and narrow-band ultraviolet B (UVB-NB). Bexarotene belongs to a new subclass of retinoids, binding primarily the nuclear hormone receptors RXRs. Bexarotene has the same effect as its natural counterpart: 9-cis-retinoic acid. Bexarotene may be used alone or in association with interferon alfa, interferon gamma, extracorporeal photophoresis and PUVA. We utilized 75 mg/day of bexarotene associated with 0.3 J/cm(2) UVB-NB as an initial dose. The sessions were three times weekly and the irradiation was increased by 30% at each session to reach a maximum of 1.6 J/cm(2). After 8 week treatment, clinical lesions markedly improved without recording hypercholesterolemia or hypothyroidism. During the follow-up no relapses were detected. We suggest that the combined therapy UVB-NB and bexarotene may be considered as an alternative treatment to PUVA and bexarotene.
    No preview · Article · Feb 2009 · Journal of Dermatological Treatment
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    Full-text · Article · Feb 2009 · Acta Dermato Venereologica
  • A. Patrizi · B. Raone · C. Gurioli · C. Neri
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    ABSTRACT: Perianal Streptococcal Dermatitis (PSD) is a well known infection primarily affecting children. PSD is clinically characterized by a sharply demarcated erythematous patch and is most commonly caused by group A beta-hemolytic Streptococcus (GABHS). PSD usually occurs as an isolated dermatosis, however familial cases have been rarely described. Herein we report three brothers with a diagnosis of PSD with a herpes simplex-like presentation in one case.
    No preview · Article · Jan 2009 · European Journal of Pediatric Dermatology