[Show abstract][Hide abstract] ABSTRACT: WormBase (www.wormbase.org) is a central repository for research data on the biology, genetics and genomics of Caenorhabditis elegans and other nematodes. The project has evolved from its original remit to collect and integrate all data for a single species,
and now extends to numerous nematodes, ranging from evolutionary comparators of C. elegans to parasitic species that threaten plant, animal and human health. Research activity using C. elegans as a model system is as vibrant as ever, and we have created new tools for community curation in response to the ever-increasing
volume and complexity of data. To better allow users to navigate their way through these data, we have made a number of improvements
to our main website, including new tools for browsing genomic features and ontology annotations. Finally, we have developed
a new portal for parasitic worm genomes. WormBase ParaSite (parasite.wormbase.org) contains all publicly available nematode and platyhelminth annotated genome sequences, and is designed specifically to support
helminth genomic research.
Full-text · Article · Nov 2015 · Nucleic Acids Research
[Show abstract][Hide abstract] ABSTRACT: WormBase (http://www.wormbase.org/) is a highly curated resource dedicated to supporting research using the model organism Caenorhabditis elegans. With an electronic history predating the World Wide Web, WormBase contains information ranging from the sequence and phenotype
of individual alleles to genome-wide studies generated using next-generation sequencing technologies. In recent years, we
have expanded the contents to include data on additional nematodes of agricultural and medical significance, bringing the
knowledge of C. elegans to bear on these systems and providing support for underserved research communities. Manual curation of the primary literature
remains a central focus of the WormBase project, providing users with reliable, up-to-date and highly cross-linked information.
In this update, we describe efforts to organize the original atomized and highly contextualized curated data into integrated
syntheses of discrete biological topics. Next, we discuss our experiences coping with the vast increase in available genome
sequences made possible through next-generation sequencing platforms. Finally, we describe some of the features and tools
of the new WormBase Web site that help users better find and explore data of interest.
Full-text · Article · Nov 2013 · Nucleic Acids Research
[Show abstract][Hide abstract] ABSTRACT: Since its release in 2000, WormBase (http://www.wormbase.org) has grown from a small resource focusing on a single species and serving a dedicated research community, to one now spanning
15 species essential to the broader biomedical and agricultural research fields. To enhance the rate of curation, we have
automated the identification of key data in the scientific literature and use similar methodology for data extraction. To
ease access to the data, we are collaborating with journals to link entities in research publications to their report pages
at WormBase. To facilitate discovery, we have added new views of the data, integrated large-scale datasets and expanded descriptions
of models for human disease. Finally, we have introduced a dramatic overhaul of the WormBase website for public beta testing.
Designed to balance complexity and usability, the new site is species-agnostic, highly customizable, and interactive. Casual
users and developers alike will be able to leverage the public RESTful application programming interface (API) to generate
custom data mining solutions and extensions to the site. We report on the growth of our database and on our work in keeping
pace with the growing demand for data, efforts to anticipate the requirements of users and new collaborations with the larger
Full-text · Article · Nov 2011 · Nucleic Acids Research
[Show abstract][Hide abstract] ABSTRACT: WormBase (http://www.wormbase.org) is a central data repository for nematode biology. Initially created as a service to the Caenorhabditis elegans research field, WormBase has evolved into a powerful research tool in its own right. In the past 2 years, we expanded WormBase to include the complete genomic sequence, gene predictions and orthology assignments from a range of related nematodes. This comparative data enrich the C. elegans data with improved gene predictions and a better understanding of gene function. In turn, they bring the wealth of experimental knowledge of C. elegans to other systems of medical and agricultural importance. Here, we describe new species and data types now available at WormBase. In addition, we detail enhancements to our curatorial pipeline and website infrastructure to accommodate new genomes and an extensive user base.
Full-text · Article · Nov 2009 · Nucleic Acids Research
[Show abstract][Hide abstract] ABSTRACT: WormBase (www.wormbase.org) is the major publicly available database of information about Caenorhabditis elegans, an important system for basic biological and biomedical research. Derived from the initial ACeDB database of C. elegans genetic and sequence information, WormBase now includes the genomic, anatomical and functional information about C. elegans, other Caenorhabditis species and other nematodes. As such, it is a crucial resource not only for C. elegans biologists but the larger biomedical and bioinformatics communities. Coverage of core areas of C. elegans biology will allow the biomedical community to make full use of the results of intensive molecular genetic analysis and functional
genomic studies of this organism. Improved search and display tools, wider cross-species comparisons and extended ontologies
are some of the features that will help scientists extend their research and take advantage of other nematode species genome
Full-text · Article · Feb 2008 · Nucleic Acids Research
[Show abstract][Hide abstract] ABSTRACT: WormBase (http://wormbase.org), a model organism database for Caenorhabditis elegans and other related nematodes, continues to evolve and expand. Over the past year WormBase has added new data on C.elegans, including data on classical genetics, cell biology and functional genomics; expanded the annotation of closely related nematodes
with a new genome browser for Caenorhabditis remanei; and deployed new hardware for stronger performance. Several existing datasets including phenotype descriptions and RNAi
experiments have seen a large increase in new content. New datasets such as the C.remanei draft assembly and annotations, the Vancouver Fosmid library and TEC-RED 5′ end sites are now available as well. Access to
and searching WormBase has become more dependable and flexible via multiple mirror sites and indexing through Google.
Full-text · Article · Feb 2007 · Nucleic Acids Research
[Show abstract][Hide abstract] ABSTRACT: WormBase (http://wormbase.org), the public database for genomics and biology of Caenorhabditis elegans, has been restructured for stronger performance and expanded for richer biological content. Performance was improved by accelerating
the loading of central data pages such as the omnibus Gene page, by rationalizing internal data structures and software for
greater portability, and by making the Genome Browser highly customizable in how it views and exports genomic subsequences.
Arbitrarily complex, user-specified queries are now possible through Textpresso (for all available literature) and through
WormMart (for most genomic data). Biological content was enriched by reconciling all available cDNA and expressed sequence
tag data with gene predictions, clarifying single nucleotide polymorphism and RNAi sites, and summarizing known functions
for most genes studied in this organism.
Full-text · Article · Feb 2006 · Nucleic Acids Research